检索结果-南通市图书馆

The osteogenic niche-targeted arsenic nanoparticles prevent colonization of disseminated breast tumor cells in the bone

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2022年第1期12卷 364-377页

作者： Cong Liu Anzhi Hu Huijuan Chen Jing Liang mancang gu Yang Xiong Chao-Feng Mu School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Center for Synthetic Biochemistry Shenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou Institute of Biomaterials and EngineeringWenzhou 325011China

Up to 70% of patients with late-stage breast cancer have bone metastasis. Current treatment regimens for breast cancer bone metastasis are palliative with no therapeutic cure. Disseminated tumor cells(DTCs) colonize inside the osteogenic niches in the early stage of bone metastasis. Drug delivery into osteogenic niches to inhibit DTC colonization can prevent bone metastasis from entering its late stage and therefore cure bone metastasis. Here, we constructed a 50% DSS6 peptide conjugated nanoparticle to target the osteogenic niche. The osteogenic niche was always located at the endosteum with immature hydroxyapatite. Arsenic-manganese nanocrystals(around 14 nm) were loaded in osteogenic niche-targeted PEG-PLGA nanoparticles with an acidic environment-triggered arsenic release. Arsenic formulations greatly reduced 4 T1 cell adhesion to mesenchymal stem cells(MSCs)/preosteoblasts(pre-OBs) and osteogenic differentiation of osteoblastic cells. Arsenic formulations also prevented tumor cell colonization and dormancy via altering the direct interaction between 4 T1 cells and MSCs/*** chemotactic migration of 4 T1 cells toward osteogenic cells was blocked by arsenic in mimic 3 D osteogenic niche. Systemic administration of osteogenic niche-targeted arsenic nanoparticles significantly extended the survival of mice with 4 T1 syngeneic bone metastasis. Our findings provide an effective approach for osteogenic niche-specific drug delivery and suggest that bone metastasis can be effectively inhibited by blockage of tumor cell colonization in the bone microenvironment.

关键词： Bone metastasis Osteogenic niche Breast cancer Arsenic trioxide Bone marrow Bone colonization Arsenic-manganese nanocrystal Immature hydroxyapatite

Preliminary delivery efficiency prediction of nanotherapeutics into crucial cell populations in bone marrow niche

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2023年第6期18卷 113-125页

作者： Huijuan Chen Anzhi Hu Mengdi Xiao Shiyi Hong Jing Liang Quanlong Zhang Yang Xiong mancang gu Chaofeng Mu School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Center for Synthetic Biochemistry Shenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Several crucial stromal cell populations regulate hematopoiesis and malignant diseases in bone marrow *** regulation of these cell types can remodel niches and develop new *** nanocarriers have been developed to transport drugs into the bone marrow ***,the delivery efficiency of these nanotherapeutics into crucial niche cells is still unknown,and there is no method available for predicting delivery efficiency in these cell ***,we constructed a three-dimensional bone marrow niche composed of three crucial cell populations:endothelial cells(ECs),mesenchymal stromal cells(MSCs),and osteoblasts(OBs).Mimetic niches were used to detect the cellular uptake of three typical drug nanocarriers into ECs/MSCs/OBs in *** than 5%of nanocarriers were taken up by three stromal cell types,and most of themwere located in the extracellular *** efficiency in sinusoidal ECs,arteriole ECs,MSCs,and OBs in vivo was *** correlation analysis showed that the cellular uptake of three nanocarriers in crucial cell types in vitro is positively linear correlated with its delivery efficiency in *** delivery efficiency into MSCs was remarkably higher than that into ECs and OBs,no matterwhat kind of *** overall efficiency into sinusoidal ECswas greatly lower than that into arteriole *** nanocarriers were hard to be delivered into OBs(<1%).Our findings revealed that cell tropisms of nanocarriers with different compositions and ligand attachments in vivo could be predicted via detecting their cellular uptake in bone marrow niches in *** study provided the methodology for niche-directed nanotherapeutics development.

关键词： Bone marrow niche mimicking Drug delivery prediction Nanotherapeutics Bone marrow stromal cells

The Inherent Law of the Unpredictability of Financial Asset Price Fluctuations: Multistability and Chaos

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2024年第2期37卷 776-804页

作者： gu Enguo Huanghe University of Science and Technology Zhengzhou 450006China

This paper aims at understanding the price dynamics generated by the interaction of traders relying on heterogeneous expectations in an asset pricing *** the present work the authors analyze a financial market populated by five types of boundedly rational speculators-two types of fundamentalists,two types of chartists and trend followers which submit buying/selling orders according to different trading *** authors formulate a stock market model represented as a 2 dimensional piecewise linear discontinuous *** proposed contribution to the existing financial literature is two ***,the authors perform study of the model involving a 2 dimensional piecewise linear discontinuous map through a combination of qualitative and quantitative *** authors focus on the existence conditions of chaos and the multi-stability regions in parameter *** border collision bifurcation curves and basins of multi-attractors are also *** authors find that chaos or quasi-period exists only in the case of fixed point being a saddle(regular or flip)and that the coexistence of multiple attractors may exist when the fixed point is an attractor,but it is common for spiral and flip fixed points.

关键词： BCB curve chaos financial market heterogeneous agents multiple attractors piecewise linear discontinuous map

Relaxin-encapsulated polymeric metformin nanoparticles remodel tumor immune microenvironment by reducing CAFs for efficient triple-negative breast cancer immunotherapy

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Pharmaceutical Sciences 2023年第2期18卷 124-136页

作者： Hongyan Zhang Liying Chen Yue Zhao Ningchao Luo Jingbin Shi Shujun Xu Lisha Ma Menglin Wang mancang gu Chaofeng Mu Yang Xiong School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Academy of Chinese Medical Science Zhejiang Chinese Medical UniversityHangzhou 310053China Division of Pharmacoengineering and Molecular Pharmaceutics Eshelman School of PharmacyUniversity of North Carolina at Chapel HillNC 27599United States

Cancer-associated fibroblasts(CAFs)are one of the most abundant stromal cells in the tumor microenvironment which mediate desmoplastic response and are the primary driver for an immunosuppressive microenvironment,leading to the failure of triple-negative breast cancer(TNBC)***,depleting CAFs may enhance the effect of immunotherapy(such as PD-L1 antibody).Relaxin(RLN)has been demonstrated to significantly improve transforming growth factor-β(TGF-β)induced CAFs activation and tumor immunosuppressive ***,the short half-life and systemic vasodilation of RLN limit its in vivo ***,plasmid encoding relaxin(pRLN)to locally express RLN was delivered with a new positively charged polymer named polymeric metformin(PolyMet),which could increase gene transfer efficiency significantly and have low toxicity that have been certified by our lab *** order to improve the stability of pRLN in vivo,this complex was further formed lipid poly-γ-glutamic acid(PGA)/PolyMetpRLN nanoparticle(LPPR).The particle size of LPPR was 205.5±2.9 nm,and the zeta potential was+55.4±1.6 *** displayed excellent tumor penetrating efficacy and weaken proliferation of CAFs in 4T1luc/CAFs tumor spheres in *** vivo,it could reverse aberrantly activated CAFs by decreasing the expression of profibrogenic cytokine and remove the physical barrier to reshape the tumor stromal microenvironment,which enabled a 2.2-fold increase in cytotoxic T cell infiltration within the tumor and a decrease in immunosuppressive cells ***,LPPR was observed retarded tumor growth by itself in the 4T1 tumor bearing-mouse,and the reshaped immune microenvironment further led to facilitate antitumor effect when it combined with PD-L1 antibody(aPD-L1).Altogether,this study presented a novel therapeutic approach against tumor stroma using LPPR to achieve a combination regimen with immune checkpoint blockade therapy against the desmoplastic TNBC model.

关键词： Cancer-associated fibroblasts Plasmid encoding relaxin Lipid nanoparticles Polymeric metformin PD-L1 antibody

固相萃取-高效液相色谱法测定大鼠血浆中β-榄香烯含量的研究

在线全文

学校读者我要写书评

暂无评论

科技通报 2012年第11期28卷 87-90页

作者：谷满仓钱亚芳龚敏操浙江中医药大学杭州310053 浙江省中医院杭州310006

目的:建立一种稳定、准确测定大鼠血浆中β-榄香烯的固相萃取-高效液相色谱检测方法,为进一步系统开展该化合物体内药代动力学研究奠定方法学基础。方法:β-榄香烯血浆样品经固相萃取柱萃取后,采用高效液相色谱法检测,色谱柱为WatersNav... 详细信息

目的:建立一种稳定、准确测定大鼠血浆中β-榄香烯的固相萃取-高效液相色谱检测方法,为进一步系统开展该化合物体内药代动力学研究奠定方法学基础。方法:β-榄香烯血浆样品经固相萃取柱萃取后,采用高效液相色谱法检测,色谱柱为WatersNavpack C18柱(150×3.9mmi.d.,5μm),柱前接Waters C18预柱(8×4mm,i.d.,5μm),流动相为乙腈:水(90:10,v/v),流速1.0 ***-1,柱温30℃,检测波长210nm,内标为蓬莪术环二烯。结果:大鼠血浆中β-榄香烯含量的线性范围为0.147～5.88μ***-1,R=0.998,。方法日内精密度与日间精密度均≤15%,萃取回收率≥71%。结论:本研究建立的β-榄香烯血药浓度测定方法有较高的准确度和灵敏度,适用于该化合物的体内药代动力学研究。

关键词： β-榄香烯高效液相色谱固相萃取大鼠血浆

价值感知、风险规避对粮食种植户气候适应性行为的影响——来自黑豫湘3省1145份农户调研的证据

在线全文

学校读者我要写书评

暂无评论

干旱区资源与环境 2023年第7期37卷 66-74页

作者：谷满仓 Hsiaoping Chien 吴文超赵敏娟西北农林科技大学经济管理学院杨凌712100 Japan International Research Center for Agricultural Sciences 1-1 OhwashiTsukuba Ibaraki305-8686 Japan

气候变化加剧了极端天气发生频度和强度,对粮食生产造成重大损失,严重威胁我国粮食安全,农户采纳气候适应性行为势在必行。基于黑豫湘3省1145份粮食种植户调研数据,利用有序Probit模型实证检验价值感知、风险规避对农户气候适应性行为... 详细信息

气候变化加剧了极端天气发生频度和强度,对粮食生产造成重大损失,严重威胁我国粮食安全,农户采纳气候适应性行为势在必行。基于黑豫湘3省1145份粮食种植户调研数据,利用有序Probit模型实证检验价值感知、风险规避对农户气候适应性行为采纳的影响。研究表明:价值感知对农户适应性行为采纳具有显著影响,其中利益感知促进农户适应性行为采纳,风险感知抑制农户适应性行为采纳。风险规避能强化利益感知对农户适应性行为采纳的促进作用,同时能加剧风险感知对农户适应性行为采纳的抑制作用;价值感知、风险规避对农户适应性行为采纳的影响存在显著规模差异,其中大规模农户更易受到风险规避对气候适应性行为采纳的抑制作用,小农户更易受到利益感知对气候适应性行为采纳的积极作用。因此,为确保粮食种植户气候适应性行为采纳,需提升农户气候适应性行为的利益感知,降低农户气候适应性行为的风险感知,针对不同规模农户精准制定气候适应性行为推广方式。

关键词：气候变化气候适应性行为价值感知风险规避经营规模

Volume of fluid simulation of single argon bubble dynamics in liquid steel under RH vacuum conditions

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2024年第4期31卷 828-837页

作者： gu-jun Chen Sheng-ping He College of Materials Science and Engineering Yangtze Normal UniversityChongqing 400044China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

Single argon bubble dynamics in liquid steel under Ruhrstahl-Heraeus(RH)vacuum conditions were simulated using the volume of fluid method,and the ideal gas law was used to consider bubble growth due to heat transfer and pressure *** simulation with a constant bubble density was also performed to validate the numerical method,and the predicted terminal bubble shape and velocity were found to agree with those presented in the Grace diagram and calculated by drag correlation,*** simulation results under RH conditions indicate that the terminal bubble shape and velocity cannot be *** primary bubble growth occurs within a rising distance of 0.3 m owing to heating by the high-temperature liquid steel;subsequently,the bubble continues to grow under equilibrium with the hydrostatic *** the initial diameter is 8-32 mm,the bubble diameter and rising velocity near the liquid surface are 80-200 mm and 0.5-0.8 m/s,*** bubble rises rectilinearly with an axisymmetric shape,and the shape evolution history includes an initial sphere,(dimpled)ellipsoid,and spherical cap with satellite bubbles.

关键词： Bubble dynamics Liquid steel Volume of fluid Bubble growth Bubble shape Rising velocity

Ultra-simplified diffraction-based computational spectrometer

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2024年第6期13卷 1022-1031页

作者： Chuangchuang Chen Honggang gu Shiyuan Liu State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhanHubei430074China Optics Valley Laboratory WuhanHubei430074China

Miniaturizing spectrometers for compact and cost-effective mobile platforms is a major challenge in current spectroscopy research,where conventional spectrometers are impractical due to their bulky *** miniaturized designs primarily rely on precalibrated response functions of nanophotonic structures to encode spectral information captured in a snapshot by detector *** spectrum reconstruction is achieved through computational techniques,but this requires precise component design,high-precision fabrication,and *** propose an ultra-simplified computational spectrometer that employs a one-to-broadband diffraction decomposition strategy facilitated by a numerical regularized transform that depends only on the spectrum of the diffracted *** key feature of our design is the use of a simple,arbitrarily shaped pinhole as the partial disperser,eliminating the need for complex encoding designs and full spectrum *** spectrometer achieves a reconstructed spectral peak location accuracy of better than 1 nm over a 200 nm bandwidth and excellent resolution for peaks separated by 3 nm in a bimodal spectrum,all within a compact footprint of under half an ***,our approach also reveals a breakthrough in broadband coherent diffractive imaging without requiring any prior knowledge of the broadband illumination spectrum,assumptions of non-dispersive specimens,or correction for detector quantum efficiency.

关键词： simplified spectrum illumination

An internal ballistic model of electromagnetic railgun based on PFN coupled with multi-physical field and experimental validation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第2期32卷 254-261页

作者： Benfeng gu Haiyuan Li Baoming Li National Key Laboratory of Transient Physics Nanjing University of Science and TechnologyNanjing 210094China

To accelerate the practicality of electromagnetic railguns,it is necessary to use a combination of threedimensional numerical simulation and experiments to study the mechanism of bore *** this paper,a three-dimensional numerical model of the augmented railgun with four parallel unconventional rails is introduced to simulate the internal ballistic process and realize the multi-physics field coupling calculation of the rail gun,and a test experiment of a medium-caliber electromagnetic launcher powered by pulse formation network(PFN)is carried *** test methods such as spectrometer,fiber grating and high-speed camera are used to test several parameters such as muzzle initial velocity,transient magnetic field strength and stress-strain of *** the simulation results and experimental data,the damage condition of the contact surface is analyzed.

关键词： Internal ballistic modeling Electromagnetic rail gun Multi-physics field coupling Experimental validation PFN