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Evaluation of Depression and Quality of Life in Patients With Psoriasis

International Journal of Dermatology and Venereology 2022年第1期5卷 27-31页

作者： Sravani Sriramoju Shiva Dunde Venkateshwarlu Eggadi manasa sowmya koppolu Sharavana Bhava Bandaru Seshagiri Department of Clinical Pharmacy&Pharm.D. MGM HospitalVaagdevi College of PharmacyHanamkondaWarangalTelangana 506007India Neuropsychiatric Consultant Manisha Neuropsychiatry Clinic and Counselling CentreHanamkondaWarangalTelangana 506007India

Objective:To measure the prevalence of depression in patients with psoriasis and to evaluate the relationship between the severity of psoriasis and depression and its effect on patients’quality of ***:A total of 154 patients with a confirmed diagnosis of psoriasis were assessed to determine the severity of psoriasis based on the psoriasis area and severity index score,presence,and severity of depression using the patient health questionnaire 9,and quality of life using the dermatology life quality index *** correlation coefficient was used to demonstrate the relationship between continuous variables with 95%confidence intervals(CIs);P<0.00001 was taken to indicate statistical ***:The severity of psoriasis was mild in 36.36%of patients,moderate in 25.97%,severe in 32.47%,and very severe in 5.20%.Of the 154 patients,139(90.3%)had depression;the severity of depression was mild in most affected patients(46.7%)and severe in 2.6%of *** had a moderate effect on the quality of life in 37.01%of patients and a very large effect in 33.77%of *** severity of psoriasis was positively correlated with depression(Pearson correlation coefficient,r=0.42,P<0.00001,95%CI:0.28–0.54)and quality of life(r=0.43,P<0.00001,95%CI:0.29–0.55).Conclusion:Depression is a common comorbidity in patients with *** severity of psoriasis is positively correlated with the severity of depression and is associated with poor quality of life.

关键词： depression dermatology life quality index 10 patient health questionnaire 9 psoriasis psoriasis area and severity index score

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Unsupervised intrusion detection system for in-vehicle communication networks

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Journal of Safety Science and Resilience 2024年第2期5卷 119-129页

作者： Kabilan N Vinayakumar Ravi V sowmya Center for Computational Engineering and Networking(CEN) Amrita School of Artificial InteligenceAmrita Vishwa VidyapeethamCoimbatoreIndia Center for Artificial Intlligence Prince Mohammad Bin Fahd UniversityKhobarSaudi Arabia

In-vehicle communication has been optimized day to day to keep updated of the *** area network(CAN)is used as a standard communication method because of its efficient and reliable ***,CAN is prone to several network level attacks because of its lack in security *** methods have been introduced to incorporate this in *** proposed an unsupervised method of intrusion detection for in-vehicle communication networks by combining the optimal feature extracting ability of autoencoders and more precise clustering using fuzzy C-means(FCM).The proposed method is light weight and requires less computation *** performed an extensive experiment and achieved an accuracy of 75.51%with the ML35o in-vehicle intrusion *** experimental result,the proposed method also works better for other intrusion detection problems like wireless intrusion detection datasets such as WNS-DS with accuracy of 84.05%and network intrusion detection datasets such as KDDCup with accuracy 60.63%,UNSW_NB15 with accuracy 73.62%and Information Security Center of Excellence(Iscx)with accuracy 74.83%.Overall,the proposed method outperforms the existing methods and avoids labeled datasets when training an in-vehicle intrusion detection *** results of the experiment of our proposed method performed on various intru-sion detection datasets indicate that the proposed approach is generalized and robust in detecting intrusions and can be effectively deployed in real time to monitor CAN traffic in vehicles and proactively alert during attacks.

关键词： Controlarea network Intrusiondetection Unsupervised learning Autoencoders Fuzzy C-means

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Cr-induced fusion reactions to synthesize superheavy elements

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Nuclear Science and Techniques 2024年第5期35卷 122-130页

作者： S.Madhu H.C.Manjunatha N.sowmya B.M.Rajesh L.Seenappa R.S.Susheela Department of Physics R V College of EngineeringBangalore 560074India Visvesvaraya Technological University BelagaviKarnataka 590018India Department of Physics Government First Grade CollegeSrinivasapurKarnataka 563135India Department of Physics Government First Grade CollegeDevanahallyKarnataka 562110India Department of Physics Government First Grade CollegeMulbagalKarnataka 563131India Department of Physics Government First Grade collegeNanjangudOoty RoadMysore 571301India

We investigated ^(50,52-54)Cr-induced fusion reactions for the synthesis of the superheavy element in the 104≤Z≤122 *** cross sections produced in this investigation using ^(54)Cr projectiles were compared with those obtained in prior *** estimated cross sections from this analysis are consistent with the findings of prior *** the current study,the predicted cross section was found to be 42fb at 236 MeV for ^(53)Cr+^(243)Am,23.2 fb at 236 MeV for ^(54)Cr+^(247)Cm,95.6 fb at 240 MeV for ^(53)Cr+248Bk,and 1.33 fb at 242 MeV for ^(53)Cr+***,these projected cross sections with excitation energy and beam energy will be useful in future Cr-induced fusion reaction investigations.

关键词： Fusion cross sections Compound nucleus formation probability Survival probability Evaporation residue cross sections

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Empirical model for fusion cross sections of Ca-induced reactions

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Chinese Physics C 2024年第3期48卷 126-132页

作者： Reddi Rani.L N.sowmya K.N Sridhar H C.Manjunatha M.M.Armstrong Arasu Department of Physics St.Joseph's College(Autonomous)Affiliated to Bharathidasan UniversityTiruchirappalli620002TNIndia Department of Physics Govt.First.Grade CollegeChikkaballapur-562101KarnatakaIndia Department of Physics Govt.First.Grade CollegeMalur-563160KarnatakaIndia Department of Physics Govt.First.Grade CollegeDevanahalli-562110KarnatakaIndia

A new empirical formula for the astrophysical S-factor has been suggested as a function of the Coulomb interaction parameter,center of mass energy,and barrier *** 22 fusion reactions with ^(40,48)Ca as projectiles were considered for different targets,leading to compound nuclei with atomic and mass numbers varying between 40≤Z≤≤Z≤112 and 88≤A≤27888≤A≤278,*** fusion cross-sections have been estimated using the geometric factor,the Gamow-Sommerfield factor,and the empirical formula for the *** study's findings showed better agreement with those of available experiments when compared to Wong's *** present work leads to a smaller standard deviation value than Wong's formula when used to correlate the experimental data of calcium-induced fusion ***'s formula provides a good approximation of fusion cross-sections when the center of mass energy is below the fusion barrier when compared to above the fusion barrier.

关键词： fusion cross-sections Wong formula Gamow-Sommerfield-factor Geometric-factor S-factor

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A novel diurnal and seasonal variation analysis of BTEX in Bengaluru urban area

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Research in Cold and Arid Regions 2024年第1期16卷 14-19页

作者： H.N.sowmya M.Dinamani G.P.Shivashankara H.K.Ramaraju B.S.Surendra Vijaya V.Shanbhag R.Prajwal Department of Civil Engineering Dayananda Sagar College of EngineeringBangalore 560078India Department of Chemistry Dayananda Sagar College of EngineeringBangalore 560078India Department of Physics GFGCVijayanagarBengaluru 560040India

In the urban atmosphere of Bengaluru, various volatile organic compounds(VOCs), particularly Benzene,Toluene, Ethylbenzene, and Xylene(BTEX), have shown an increasing trend in concentration. The present research was conducted during summer and monsoon seasons, focusing on Kadubeesanahalli, a high-traffic area within the Bengaluru Metropolitan City. Hourly sample data was collected using a BTEX analyzer(Model GC955-600) and subsequently transformed into daily, monthly, and seasonal values. The study revealed distinct patterns in benzene concentrations. Benzene levels were lowest during the early morning hours, specifically from 1:00 *** 7:00 a.m.. Concentrations then increased from 7:00 a.m. to 9:00 a.m. and again from 4:00 p.m. to 11:00 p.m.,corresponding to the morning and evening peak traffic hours. However, between 10:00 a.m. and 4:00 p.m., the concentration decreased due to reduced traffic levels. These diurnal variations in benzene concentration are influenced by meteorological parameters. Comparing the two seasons, higher concentrations of Benzene, EthylBenzene, and MP-xylene were observed during the summer season. This increase is attributed to the elevated temperatures during summer, which promote the vaporization of BTEX compounds. Conversely, lower BTEX concentrations were recorded during the monsoon season due to the wet deposition process. The observed positive correlation(r > 0.5) among BTEX parameters strongly suggests a common source, most likely originating from vehicular emissions.

关键词： BTEX Summer variation Meteorological parameters Correlation

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The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo Conan Juan Alec C.Bancroft Ji Hae Choi Chase A.Pagani Aysel A.Fernandes Michael Woodard Juhoon Lee sowmya Ramesh Aaron W.James David Hudson Kevin N.Dalby Lin Xu Robert J.Tower Benjamin Levi Center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical Biology and Medicinal Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and downstream processes of cell fate after musculoskeletal injury remains to be ***(HO)is a debilitating condition where abnormal bone formation occurs within extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to ***,we used a proven mouse injury-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the HO site,we found that collagen ECM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-CreER^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-CreER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPC *** results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

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Plasticized Polymer Electrolyte Membranes Based on PEO/PVdF-HFP for Use as an Effective Electrolyte in Lithium-ion Batteries

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Chinese Journal of Polymer Science 2017年第3期35卷 407-421页

作者： pradeepa prabakaran ramesh prabhu manimuthu sowmya gurusamy edwinraj sebasthiyan school of physics alagappa universityKaraikudi-630 004Tamil NaduIndia

Plasticized polymer electrolytes were prepared using poly（ethylene oxide）(PEO)/poly（vinylidene fluoridehexafluoro propylene）(PVd F-HFP) with lithium perchlorate（Li Cl O4） and different plasticizers. XRD and FTIR spectroscopic techniques were used to characterize the structure and the complexation of plasticizer with the host polymer matrix. The role of interaction between polymer hosts and plasticizer on conductivity is discussed using the results of alternating current（a.c.） impedance studies. TG-DTA and SEM were used for thermal and physical characterizations. Maximum ionic conductivity(3.26 × 10;S·cm;) has been observed for ethylene carbonate（EC）-based polymer electrolytes. Electrochemical performance of the plasticized polymer electrolyte is evaluated in LiFePO;/plasticized polymer electrolytes（PPEs）/Li coin cell. Good performance with low capacity fading on charge discharge cycling is demonstrated.

关键词： X-ray diffraction Impedance spectroscopy Atomic force microscopy Ionic conductivity Dielectrics

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Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success

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Cellular & Molecular Immunology 2023年第6期20卷 626-650页

作者： Grffn Copp Kevin P.Robb sowmya Viswanathan Osteoarthritis Research Program Division of Orthopedic SurgerySchroeder Arthritis InstituteUniversity Health NetworkTorontoONCanada Krembil Research Institute University Health NetworkTorontoONCanada institute of Biomedical Engineering University of TorontoTorontoONCanada Department of Medicine Division of HematologyUniversity of TorontoTorontoONCanada

Osteoarthritis(OA)is a degenerative multifactorial disease with concomitant structural,inflammatory,and metabolic changes that fluctuate in a temporal and patient-specific *** complexity has contributed to refractory responses to various *** have shown promise as multimodal therapeutics in mitigating OA symptoms and disease ***,we evaluated 15 randomized controlled clinical trials(RCTs)and 11 nonrandomized RCTs using culture-expanded MSCs in the treatment of knee OA,and we found net positive effects of MSCs on mitigating pain and symptoms(improving function in 12/15 RCTs relative to baseline and in 11/15 RCTs relative to control groups at study endpoints)and on cartilage protection and/or repair(18/21 clinical studies).We examined MsC dose,tissue of origin,and autologous *** origins as well as patient clinical phenotype,endotype,age,sex and level of OA severity as key parameters in parsing MSC clinical *** relatively small sample size of 610 patients limited the drawing of definitive ***,we noted trends toward moderate to higher doses of MsCs in select OA patient clinical phenotypes mitigating pain and leading to structural improvements or cartilage *** from preclinical studies is supportive of MsC anti-inflammatory and immunomodulatory effects,but additional investigations on immunomodulatory,chondroprotective and other clinical mechanisms of action are *** hypothesize that MsC basal immunomodulatory"fitness"correlates with OA treatment efficacy,but this hypothesis needs to be validated in future *** conclude with a roadmap articulating the need to match an OA patient subset defined by molecular endotype and clinical phenotype with basally immunomodulatory"ft"or engineered-to-be-fit-for-OA MsCs in well-designed,data-intensive clinical trials to advance the field.

关键词： MSC Osteoarthritis Cell therapy mesenchymal stromal cell RCT

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Effects of stretching/shrinking on the thermal performance of a fully wetted convective-radiative longitudinal fin of exponential profile

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Applied Mathematics and Mechanics(English Edition) 2022年第3期43卷 389-402页

作者： B.J.GIREESHA M.L.KEERTHI G.sowmya Department of PG Studies and Research in Mathematics Kuvempu UniversityShankaraghatta 577451India Department of PG Mathematics The National College(Auto)Bangalore 560070India

The present investigation focuses on the thermal performance of a fully wet stretching/shrinking longitudinal fin of exponential profile coated with a mechanism like a conveyer *** modeled equation is non-dimensionalized and solved by applying the Runge-Kutta-Fehlberg(RKF)*** effects of parameters such as the wet parameter,the fin shape parameter,and the stretching/shrinking parameter on the heat transfer and thermal characteristics of the fin are graphically analyzed and *** is inferred that the negative effects of motion and internal heat generation on the fin heat transfer rate can be lessened by setting a shrinking mechanism on the fin *** current examination is inclined towards practical applications and is beneficial to the design of fins.

关键词： fully wet longitudinal fin convection exponential profile internal heat generation moving fin

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Overcoming the challenges of conducting translational research in cell therapy

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Frontiers of Medicine 2011年第4期5卷 333-335页

作者： sowmya Viswanathan Armand Keating Cell Therapy Program Princess Margaret HospitalUniversity Health NetworkTorontoONM5G 2M9Canada Division of Hematology Department of MedicineUniversity of TorontoTorontoONM5G 2M9Canada

Cell therapy holds promise in addressing a number of unmet medical needs but despite its considerable impetus,faces numerous challenges including support for translational research in this ***,we examine the challenges confronting cell therapy research including the limited funding available for translational research partly due to the uncompetitive nature of required validation studies in cell therapy that of necessity are not *** issues include lack of standardization of definitions of cell products,uncertainty regarding optimum preclinical animal models,duplication of efforts to secure regulatory approval and a lack of uniformity of nomenclature for some cell ***,several initiatives to address all of these issues are underway.

关键词： stem cells clinical trials funding animal models standardization common definitions

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