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Noscapine shows antimalarial activity against Plasmodium falciparum 3D7,its clinical isolate Pf140/SS,and Plasmodium berghei ANKA

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 350-358页

作者： Swaraj Kumar Babu Sameer Maharana Satyaranjan Chhatria Dibya ranjan Sahoo Ashirbad Nanda Satish Kanhar Prativa KBehera Sanjib Mohanty Pradeep Kumar Naik Praveen Kishore sahu Centre of Excellence in Natural Products and Therapeutics Department of Biotechnology and BioinformaticsSambalpur UniversityJyoti ViharSambalpur OdishaIndia Department of Molecular Biology and Infectious Diseases Community Welfare Society HospitalRourkelaOdishaIndia Molecular&Immunology Laboratory Infectious Disease Biology UnitIspat General HospitalRourkelaOdishaIndia Department of Pharmacy Centurion University of Technology and ManagementBhubaneswarOdishaIndia

Objective:To evaluate the antimalarial activity of noscapine against Plasmodium falciparum 3D7 strain(Pf3D7),its clinical isolate(Pf140/SS),and Plasmodium berghei ANKA(PbA).Methods:Using ring-stage survival assay,phenotypic assessments,and SYBR-green-based fluorescence assay,the antimalarial activities of noscapine were assessed compared with dihydroartemisinin(DHA)in in vivo and in vitro *** addition,hemolysis and cytotoxicity tests were carried out to evaluate its ***-PCR assay was also conducted to determine the effect of noscapine on papain-like cysteine protease Plasmodium falciparum falcipain-2(PfFP-2).Results:The antimalarial efficacy of noscapine against Pf3D7 and Pf140/SS was comparable to DHA,with IC50 values of(7.68±0.88)and(5.57±0.74)nM/mL,respectively,and>95%inhibition of PbA infected *** also showed a safe profile,as evidenced by low hemolysis and cytotoxicity even at high ***,PfFP-2 expression was significantly inhibited in both noscapine-treated Pf3D7 and Pf140/SS(P<0.01).Conclusions:Noscapine has antimalarial properties comparable to standard antimalarial DHA with better safety profiles,which may be further explored as a therapeutic candidate for the treatment of malaria.

关键词： Malaria Plasmodium falciparum Plasmodium berghei Noscapine Antimalarial Dihydroartemisinin Cytotoxicity Falcipain-2

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A review on recent advancements in biodegradable Mg-Ca alloys

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Journal of Magnesium and Alloys 2022年第8期10卷 2094-2117页

作者： manas.ranjan sahu T.S.Sampath Kumar Uday Chakkingal Department of Metallurgical and Materials Engineering Indian Institute of Technology MadrasChennai 600036India

The binary Mg-Ca alloys are drawing increasing attention as temporary implant materials because of their excellent biocompatibility,biodegradability, and good mechanical properties. However, their applications are limited due to their high degradation rates in the human physiological environment, the consequent release of hydrogen gas, and rapid loss in mechanical properties. Furthermore, biocompatibility depends upon the degradability of the material. Various researchers have demonstrated that these issues can be addressed by control of Ca content, thermo-mechanical processing to obtain suitable microstructures, deposition of surface coatings, etc. In this manuscript, a detailed review of published literature on Mg-Ca alloys is presented. The challenges and future directions of research in this area are also described.

关键词： Mg-Ca alloy Degradation Temporary implant Biocompatibility

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Application of quasi-oppositional symbiotic organisms search based extreme learning machine for stock market prediction

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International Journal of Intelligent Computing and Cybernetics 2019年第2期12卷 175-193页

作者： Smita Rath Binod Kumar sahu Manoj ranjan Nayak Institute of Technical Education and Research Siksha O Anusandhan UniversityBhubaneswarIndia

Purpose–Forecasting of stock indices is a challenging issue because stock data are dynamic,non-linear and uncertain in *** of an accurate forecasting model is very much essential to predict the next-day closing prices of the stock *** purpose of this paper is to develop an efficient and accurate forecasting model to predict the next-day closing prices of seven stock ***/methodology/approach–A novel strategy called quasi-oppositional symbiotic organisms search-based extreme learning machine(QSOS-ELM)is proposed to forecast the next-day closing prices *** in the prediction of closing price depends on output weights which are dependent on input weights and *** paper mainly deals with the optimal design of input weights and biases of the ELM prediction model using QSOS and SOS optimization ***–Simulation is carried out on seven stock indices,and performance analysis of QSOS-ELM and SOS-ELM prediction models is done by taking various statistical measures such as mean square error,mean absolute percentage error,accuracy and paired sample *** performance analysis reveals that the QSOS-ELM model outperforms the SOS-ELM model in predicting the next-day closing prices more accurately for all the seven stock indices under ***/value–The QSOS-ELM prediction model and SOS-ELM are developed for the first time to predict the next-day closing prices of various stock *** paired t-test is also carried out for the first time in literature to hypothetically prove that there is a zero mean difference between the predicted and actual closing prices.

关键词： Extreme learning machine Symbiotic organisms search Quasi-oppositional-based learning,Paired sample t-test

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Effect of Exercise on NAFLD and Its Risk Factors:Comparison of Moderate versus Low Intensity Exercise

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Journal of Clinical and Translational Hepatology 2020年第2期8卷 120-126页

作者： Preetam Nath manas Kumar Panigrahi Manoj Kumar sahu Jimmy Narayan ranjan Kumar Sahoo Ananya Apurba Patra Satyaswarup Jena Arun Kumar Patnaik Anjan Jena Shivaram Prasad Singh Department of Gastroenterology&Hepatology Kalinga Institute of Medical SciencesBhubaneswarOdishaIndia Department of Gastroenterology All India Institute of Medical SciencesBhubaneswarOdishaIndia Department of Gastroenterology IMS and SUM HospitalBhubaneswarOdishaIndia Department of Radiodiagnosis&Imaging Kalinga Institute of Medical SciencesBhubaneswarOdishaIndia Department of Radiology IMS and SUM HospitalBhubaneswarOdishaIndia Dispensary Biju Patnaik State Police AcademyBhubaneswarOdishaIndia Department of Gastroenterology S.C.B.Medical College753007 CuttackOdishaIndia

Background and Aims: Lifestyle (exercise and dietary) modification is the mainstay of treatment for non-alcoholic fatty liver disease (NAFLD). However, there is paucity of data on effect of intensity of exercise in management of NAFLD, and we aimed to study the effect of variable intensities of exercise on NAFLD. Methods: The study was performed in the Department of Gastroenterology of the SCB Medical Col-lege, Cuttack and the Biju Patnaik State Police Academy, Bhu-baneswar. The subjects were police trainees [18 in a moderate intensity exercise group (MIG) and 19 in a low in-tensity exercise group (LIG)] recruited for a 6-month physical training course (261.8 Kcalorie, 3.6 metabolic equivalent in MIG and 153.6 Kcalorie, 2.1 metabolic equivalent in LIG). NAFLD was diagnosed by ultrasonography, with exclusion of all secondary causes of steatosis. All participants were eval-uated by anthropometry (weight, height, body mass index (BMI), waist circumference), assessed for blood pressure and biochemical parameters (blood glucose, liver function test, lipid profile, serum insulin), and subjected to transabdo-minal ultrasonography before and after 6 months of physical training, and the results were compared. Results: Both the groups had similar BMI, fasting plasma glucose, AST, gamma-glutamyl transpeptidase, insulin, and homeostatic model as-sessment-insulin resistance (known as HOMA-IR) (p>0.05). However, subjects in the LIG were older and had lower alanine transaminase, higher triglycerides and lower high-density lip-oproteins than MIG subjects. There was a significant reduc-tion in BMI (27.0±2.1 to 26.8±2.0;p=0.001), fasting blood glucose (106.7±21.6 to 85.8±19.0;p<0.001), serum trigly-cerides (167.5±56.7 to 124.6±63.5;p=0.017), total choles-terol (216.8±29.2 to 196.7±26.6;p=0.037), low-density lipoprotein cholesterol (134.6±21.4 to 130.5±21.9;p=0.010), serum aspartate transaminase (39.3±32.2 to 30.9±11.4;p<0.001), serum alanine transaminase (56.6 ±28.7 to 33.0±11.3;p<0.

关键词： Exercise NAFLD Intensity Physical activity

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Fatal intracranial bleedings in a viper bite:A case report

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Chinese Journal of Traumatology 2023年第2期26卷 121-124页

作者： Alagarasan Naveen manas.ranjan sahu Manoj Kumar Mohanty Kimi Soumya Padhi Ashis Patnaik Department of Forensic Medicine&Toxicology All India Institute of Medical Sciences(AMS)BhubaneswarOdishaIndia Department of Neurosurgery Al India Institute of Medical Sciences(AIIMS)BhubaneswarOdishaIndia

Viper bite envenomation represents a significant occupational hazard among agricultural workers in *** viper bite envenomation is usually suspected when a patient presents with predominant local symptoms at the bitten site,including pain,swelling,and ***,systemic findings such as diffuse intravascular coagulation,hypotension,and shock may alert physicians of viper bite envenomation rather than a neurotoxic snake ***,cerebral complications are rare in viper bites but may potentially *** nervous system involvement in a viper bite is either due to neurotoxins or hemorrhagins present in the venom,which may induce cerebral thrombosis,ischemia,infarction,and *** we present a case of a previously healthy adult male who succumbed to extensive subarachnoid,intracerebral,and intraventricular hemorrhages involving bilateral cerebral hemispheres following viper snake bite *** report highlights the importance of anticipating cerebral complications in viper bite envenomation,a rare *** also emphasizes the need for early antisnake venom administration to prevent and control systemic envenomation and its complications.

关键词： Snake bite Viper Intracerebral hemorrhage Subarachnoid hemorrhage Anti-snake venom

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Fracture Union in Closed Interlocking Nail in Humera Shaft Fractures

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Chinese Medical Journal 2015年第11期 1428-1432页

作者： Ramji Lal sahu Raini ranjan Ajay Lal Department of Orthopaedics SMS and RI Sharda University Greater Noida Uttar Pradesh India

Background： Fracture shaft humerus is a major cause of morbidity in patients with upper extremity injuries. The aim of this study was to evaluate the outcome of interlocking nail in humeral shaft fractures. Methods： This study was conducted in the Department of Orthopedic Surgery in SMS and R Sharda University from January 2010 to November 2013. Seventy-eight patients were recruited from emergency and out-patient department having a close fracture of humerus shaft. All patients were operated under general anesthesia and closed reamed interlocking nailing was done. All patients were followed for 9 months. Results： Out of 78 patients, 69 patients underwent union in 90-150 days with a mean of I 10.68 days. Complications found in four patients who had nonunion, and five patients had delayed union, which was treated with bone grafting. All the patients were assessed clinically and radiologically for fracture healing joint movements and implant thilure. The results were excellent in 88.46% and good in 6.41% patients. Complete subjective, functional, and clinical recovery had occurred in almost 100% of the patients. ConcLusions： The results of the present study indicates that in the presence of proper indications, reamed antegrade intramedullary interlocked nailing appears to be a method of choice for internal fixation ofosteoporotic and pathologic fractures.

关键词： Bone Grafting Close Reamed Interlocking Nail Humeral Shaft Fractures Union

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Graphene-induced Pd nanodendrites： A high performance hybrid nanoelectrocatalyst

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Nano Research 2013年第9期6卷 635-643页

作者： Subash Chandra sahu Aneeya K. Samantarat Ajit Dash R. R. Juluri ranjan K. sahu B. K. Mishra Bikash Kumar Jena (1~3) Colloids & Materials Chemistry CSIR-Institute of Minerals and Materials Technology Bhubaneswar-7S I013 India Institute of Physics Bhubaneswar-751005 India Materials Science and Technology Division National Metallurgical Laboratory Jamshedpur-831007 India

A facile and green approach has been developed for the in situ synthesis of hybrid nanomaterials based on dendrite-shaped Pd nanostructures supported on graphene （RG）. The as-synthesized hybrid nanomaterials （RG-PdnDs） have been thoroughly characterized by high resolution transmission electron microscopy, X-ray photoelectron spectroscop）~ atomic force microscop）~ Raman spectroscopy and electrochemical techniques. The mechanism of formation of such dendrite- shaped Pd nanostructures on the graphene support has been elucidated using transmission electron microscopy （TEM） measurements. The RG induces the formation of, and plays a decisive role in shaping, the dendrite morphology of Pd nanostructures on its surface. Cyclic voltammetry and chronoamperometry techniques have been employed to evaluate the electrochemical performance of RG-PdnDs towards oxidation of methanol. The electrochemical （EC） activities of RG-PdnDs are compared with graphene-supported spherical-shaped Pd nanostructures, Pd nanodendrites alone and a commercial available Pd/C counterpart. The combined effect of the graphene support and the dendrite morphology of RG-PdnDs triggers the high electrocatalytic activity and results in robust tolerance to CO poisoning.

关键词： nanodendrites reduced graphene methanol oxidation surface poisoning

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Fracture Union in Closed Interlocking Nail in Humeral Shaft Fractures

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中华医学杂志(英文版) 2015年第11期128卷 1428-1432页

作者： sahu Ramji Lal ranjan Rajni Lal Ajay Department of Orthopaedics SMS and RI Sharda University Greater Noida Uttar Pradesh India

Background: Fracture shaft humerus is a major cause of morbidity in patients with upper extremity injuries. The aim of this study was to evaluate the outcome of interlocking nail in humeral shaft ***: This study was conducted in the Department of Orthopedic Surgery in SMS and R Sharda University from January 2010 to November 2013. Seventy-eight patients were recruited from emergency and out-patient department having a close fracture of humerus shaft. All patients were operated under general anesthesia and closed reamed interlocking nailing was done. All patients were followed for 9 ***: Out of 78 patients, 69 patients underwent union in 90–150 days with a mean of 110.68 days. Complications found in four patients who had nonunion, and five patients had delayed union, which was treated with bone grafting. All the patients were assessed clinically and radiologically for fracture healing, joint movements and implant failure. The results were excellent in 88.46% and good in 6.41% patients. Complete subjective, functional, and clinical recovery had occurred in almost 100% of the ***: The results of the present study indicates that in the presence of proper indications, reamed antegrade intramedullary interlocked nailing appears to be a method of choice for internal fixation of osteoporotic and pathologic fractures.

关键词： Bone Grafting Close Reamed Interlocking Nail Humeral Shaft Fractures Union

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Pattern of injuries due to wild animal attack among patients presenting to the emergency department:A retrospective observational study

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Chinese Journal of Traumatology 2021年第6期24卷 383-388页

作者： Pradeep Kumar Singh S Manwar Ali Rakesh Vadakkethil Radhakrishnan Chitta ranjan Mohanty manas.ranjan sahu Bishnu Prasad Patro Ijas MS Susant Kumar Panda Department of General Surgery All India Institute of Medical SciencesBhubaneswar751019India College of Nursing All India Institute of Medical SciencesBhubaneswar751019India Department of Trauma and Emergency All India Institute of Medical SciencesBhubaneswar751019India Department of Forensic Medicine and Toxicology All India Institute of Medical SciencesBhubaneswar751019India Department of Orthopedics All India Institute of Medical SciencesBhubaneswar751019India Department of General Surgery District Head Quarter HospitalAngulOdish1759122India

Purpose:The human-wildlife conflicts(HWCs)causing nuisances and injuries are becoming a growing public health concern over recent years *** aimed to study the demographic profile,mode of injury,pattern of injury,and outcome of wild animal attack victims presented to the emergency ***:This retrospective cross-sectional study was conducted in the emergency department of a tertiary-care hospital in Eastern *** were retrieved from the medical records from May 2017 to May *** of all ages and genders attacked by wild animals and secondary injuries were included in this *** with incomplete data,injuries due to the attack of stray and domestic animals and trauma due to other causes were *** profile,mode of injury,the pattern of injury,injury severity score(ISS),radiological pattern,and outcome were *** analysis with R(version 3.6.1.)was ***:A total of 411 wild animal attack victims were studied,of which 374(90.9%)were snakebite injuries and 37(9.1%)were wild mammalian(WM)attack *** mean age of WM attack victims was 46 years,and the male-to-female ratio was 4:*** attack injury(40.5%)was the most common WM attack injury *** WM attacks(43.2%)occurred between 4:00 *** 8:00 *** median ISS was 18.5(13-28),where 54.2%of patients had polytrauma(ISS>15).Elephant attack was associated with a higher ISS,but the difference was not significant compared to other animal types(p=0.2).Blunt trauma was common pattern of injury in the elephant attack injury *** and soft tissue injuries were common patterns in other animal *** snakebites,neurotoxic was the most common type(55.4%),and lower extremity was the most common site ***:The young male population is the major victim of HWCs;and elephant is the most common animal *** is a need to design scientifically sound preventive strategies for HWCs and to strengthen t

关键词： Wild animal Injury severity score Elephant Wild boar Polytrauma

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Fracture union in percutaneous Kirschner wire fixation in paediatric tibial shaft fractures

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Chinese Journal of Traumatology 2016年第6期19卷 353-357页

作者： Ramji Lal sahu Rajni ranjan Department of Orthopaedics SMS&R Sharda University Creater Noida UP India

Purpose： To evaluate the efficacy of intramedullary Kirschner wires for the treatment of unstable tibial shaft fractures in children. Methods： This prospective study was conducted at the Department of Orthopaedic Surgery in Maharishi Markandeshwar Medical College from June 2005 to June 2010. Sixty-six children having closed fracture of the tibial shaft with a mean age of 7.7 years （range, 2-14 years） were recruited from emergency and outpatient department. They were treated with percutaneous intramedullary Kirschner wires. The clinical results of our study were rated on the basis of the criteria of union, nonunion, delayed union or malunion. All children were followed for one year. Results： Children achieved union in a mean time of 8 weeks （range, 6-10 weeks）. Postoperatively, three children （4.55%） had delayed union, one （1.52%） valgus deformity of lower leg, three （4.55%） post- operative knee pain and twelve （18.18%） skin irritation at pin site. Wires were removed after 8-22 weeks without any complications. No patient was lost to follow-up. The results were excellent in 95.45% and good in 4.55% children. Conclusion： This technique is cost-effective, simple, quick to perform, safe and reliable and avoids pro- longed hospitalization with good results.

关键词： Kirschner wires Tibial shaft fractures Children

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