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Comparative domain modeling of human EGF-like module EMr2 and study of interaction of the fourth domain of EGF with chondroitin 4-sulphate

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The Journal of Biomedical research 2011年第2期25卷 100-110页

作者： Mukta rani manas r.dikhit Ganesh C Sahoo Pradeep Das Biomedical Informatics Division Rajendra Memorial Research Institute of Medical SciencesAgam KuanPatna 800007India

EMr2 is an EGF-like module containing mucin-like hormone receptor-2 precursor, a G-protein coupled receptor （G-PCr）. Mutation in EMr2 causes complicated disorders like polycystic kidney disease （PKD）. The structure of EMr2 shows that the fifth domain is comprised of EGF-TM7 helices. Functional assignment of EMr2 by support vector machine （SVM） revealed that along with transporter activity, several novel functions are predicted. A twenty amino acid sequence ＂MGGrVFLVFLAFCVWLTLPG＂ acts as the signal peptide responsible for post- translational transport. Eight amino acids are involved in N-glycosylation sites and two cleavage sites are LeuS17 and SerS18 in EMr2. The residue Arg241 is responsible for interaction with glycosaminoglycan and chondroitin sulfate. On the basis of structure, function and ligand binding sites, competitive EMr2 inhibitors designed may decrease the rate of human diseases like Usher＇s syndrome, bilateral frontoparietal polymicrogyria and PKD.

关键词： EMr2 G-protein coupled receptor transmembrane homology modeling EGF-TM7

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A New Vaccine Strategy of Dendritic Cell Presented Kinetoplastid Membrane(KMP-11)as Immunogen for Control against Experimental Visceral Leishmaniasis

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Modern research in Inflammation 2017年第3期6卷 15-28页

作者： rajesh Chaudhary Ajay Amit Akhilesh Kumar manas r.dikhit Krishna Pandey Pradeep Das Sanjiva Bimal Department of Immunology Rajendra Memorial Research Institute of Medical Sciences(ICMR)AgamkuanIndia

Available reports suggest that, Leishmania donovani antigen KMP-11 may be significant in the modulation of immune responses in visceral leishmaniasis (VL). This study evaluated vaccine prospect of presentation of KMP-11 antigen through murine dendritic cells against VL in infected BALB/c mice. We report here that immunization with KMP-11 delivered through bone marrow derived dendritic cells can lead to killing of L. donovani in infected BALB/c mice. Furthermore, the strategy to use KMP-11 as vaccine delivered through DCs can stimulate the production of IFN-g, IL-12, IL-2r and TNF-α with concomitant down-regulation of IL-10 and IL-4. Furthermore, anti-leishmanial defence function (rOS) of splenocytes was observed increased in the presence of DC-delivered KMP-11 vaccination accompanied with an increased p38-MAPK signalling in vaccinated splenocytes. We summarized from our data that KMP-11 delivered through DCs has potential for eliciting protective immunity through pro-inflammatory cytokines (IFN-γ, IL-12, IL-2, TNF-α) following an up-regulation in signalling event of p38-MAPK. Therefore the study suggests a new control strategy against VL in future.

关键词： Visceral Leishmaniasis Kinetoplastid Membrane Protein 11 Soluble Leishmania Antigen Interferon-γ Interleukin-12 Interleukin-10 Dendritic Cell Primed KMP-11

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role of remote sensing, geographic bioinformatics system and bioinformatics in kala-azar epidemiology

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The Journal of Biomedical research 2011年第6期25卷 373-384页

作者： Gouri Sankar Bhunia manas ranjan dikhit Shreekant Kesari Ganesh Chandra Sahoo Pradeep Das rajendra Memorial research Institute of Medical Sciences (ICMr) Agamkuan Patna Bihar 800007 India

Visceral leishmaniasis or kala-azar is a potent parasitic infection causing death of thousands of people each year. Medicinal compounds currently available for the treatment of kala-azar have serious side effects and decreased efficacy owing to the emergence of resistant strains. The type of immune reaction is also to be considered in patients infected with Leishmania donovani （L. donovani）. For complete eradication of this disease, a high level modern research is currently being applied both at the molecular level as well as at the field level. The computational approaches like remote sensing, geographic information system （GIS） and bioinformatics are the key resources for the detection and distribution of vectors, patterns, ecological and environmental factors and genomic and proteomic analysis. Novel approaches like GIS and bioinformatics have been more appropriately utilized in determining the cause of visearal leishmaniasis and in designing strategies for preventing the disease from spreading from one region to another.

关键词： bioinformatics geographical bioinformatics systems (GIS) rK39 support vector machine (SVM)

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Corrigendum to "role of remote sensing,geographic bioinformatics system and bioinformatics in kala-azar epidemiology" [originally published as J Biomed res 2011,25(6):373-384;doi:10.1016/S1674-8301(11)60050-X]

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The Journal of Biomedical research 2012年第5期26卷 371-371页

作者： Gouri Sankar Bhunia manas ranjan dikhit Shreekant Kesari Ganesh Chandra Sahoo Pradeep Das rajendra Memorial research Institute of Medical Sciences(ICMr) AgamkuanPatnaBihar 800007India

The author would like to inform the readers that the correct form of title ＂role of remote sensing, geographic bioinformatics system and bioinformatics in kala-azar epidemiology＂ , content in ab-stract ＂The computational approaches like remote sensing, geographic information system （GIS） and bioinformatics are the key re-sources for the detection and distribution of vectors, patterns, ecologi- cal and environmental factors and genomic and proteomic analysis.＂, and keyword ＂geographical bioinformatics systems （GIS）＂ should be read as follows： title ＂role of remote sensing, geographical bioinformation system and bioinformatics in kala-azar epidemiology＂, content in abstract ＂The com-putational approaches like remote sensing, geographical information system （GIS） and bioinformat-ics are the key re-sources for the detection and distribution of vectors, patterns, ecological and envi-ronmental factors and genomic and proteomic analysis.＂, and keyword ＂geographical bioinformation system （GIS）＂.

关键词： originally published as J Biomed res 2011,25 GIS Corrigendum to role of remote sensing,geographic bioinformatics system and bioinformatics in kala-azar epidemiology

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