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Text-mining-based Fake News Detection Using Ensemble Methods

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international Journal of Automation and computing 2020年第2期17卷 210-221页

作者： Harita Reddy Namratha Raj manali Gala Annappa Basava Department of Computer Science and Engineering National Institute of Technology KarnatakaMangalore 575025India

Social media is a platform to express one′s views and opinions freely and has made communication easier than it was *** also opens up an opportunity for people to spread fake news *** ease of access to a variety of news sources on the web also brings the problem of people being exposed to fake news and possibly believing such *** makes it important for us to detect and flag such content on social *** the current rate of news generated on social media,it is difficult to differentiate between genuine news and hoaxes without knowing the source of the *** paper discusses approaches to detection of fake news using only the features of the text of the news,without using any other related *** observe that a combination of stylometric features and text-based word vector representations through ensemble methods can predict fake news with an accuracy of up to 95.49%.

关键词： Fake news social media stylometric features word vectors ensemble methods

Efficacy of germination and probiotic fermentation on underutilized cereal and millet grains

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Food Production, Processing and Nutrition 2020年第1期2卷 112-128页

作者： Savita Budhwar Kashika Sethi manali Chakraborty Department of Nutrition Biology School of Interdisciplinary and Applied Life SciencesCentral University of HaryanaMahendragarhHaryana 123031India

Cereals and millets have been known as poor man’s crops for a long time,and have good potential in the mercenary system of food and in research and development but these coarse grains have been leftover and underutilised since a long *** addition to nutritional properties,various elements of cereal grains contain phenolic compounds as well as various anti-nutritional *** improve the nutritional quality and availability of these grains,they are processed in several *** review discusses the effect of pre-processing techniques such as germination with a combination of probiotic fermentation on various components of underutilised coarse cereals and millets and advantages it brings into the final *** food mixture usually contains a significantly higher amount of thiamine,lysine and niacin *** combination of cereals with other methods results in better nutrient profile and an enhanced amino acid *** is said to be the most crucial and popular process which considerably lowers the antinutrients present in coarse cereals such as trypsin inhibitor,phytic acid and tannins and hence,enhance the overall nutritive value of coarse cereals and other food ***,germinated cereal-based food products have higher cell count and better growth of beneficial bacteria,thus,germination of cereals facilitates the probiotic fermentation of cereals.

关键词： Cereals Germination Probiotics Antinutrients Phenolic compounds

miRT:A Database of Validated Transcription Start Sites of Human MicroRNAs

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Genomics, Proteomics & Bioinformatics 2012年第5期10卷 310-316页

作者： Malay Bhattacharyya manali Das Sanghamitra Bandyopadhyay Machine intelligence Unit Indian Statistical Institute Department of Bioinformatics West Bengal University of Technology

MicroRNAs （miRNAs） are small endogenous non-coding RNAs of about 22 nt in length that take crucial roles in many biological pro cesses. These short RNAs regulate the expression of mRNAs by binding to their 3＇-UTRs or by translational repression. Many of the current studies focus on how mature miRNAs regulate mRNAs, however, very limited knowledge is available regarding their transcrip- tional loci. it is known that primary miRNAs （pri-miRs） are first transcribed from the DNA, followed by the formation of precursor miRNAs （pre-miRs） by endonuclease activity, which finally produces the mature miRNAs. Till date, many of the pre-miRs and mature miRNAs have been experimentally verified. But unfortunately, identification of the loci of pri-miRs, promoters and associated transcrip- tion start sites （TSSs） are still in progress. TSSs of only about 40% of the known mature miRNAs in human have been reported. This information, albeit limited, may be useful for further study of the regulation of miRNAs. in this paper, we provide a novel database of validated miRNA TSSs, miRT, by collecting data from several experimental studies that validate miRNA TSSs and are available for full download. We present miRT as a web server and it is also possible to convert the TSS loci between different genome built, miRT might be a valuable resource for advanced research on miRNA regulation, which is freely accessible at： http：//***/~bioinfo_miu/ miRT/***.

关键词： MicroRNA Transcription start site Primary transcript Transcriptional regulation Database

Data Mining Strategy for “Gene Prediction” with Special Reference to Cotton Genome

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棉花学报 2008年第S1期20卷 118-页

作者： KSHiRSAGAR manali BALASUBRAMANi G SiNGH Col Gurmit Yeshwantrao Chavan College of Engineering Hingna Road Wanadongri Nagpur Central institute of Cotton Research Wardha Road the Department of iT and Electronics AAiDU

This paper presents an integrated approach towards solving the problem of "Gene Prediction".The "Gene Prediction" problem solving undergoes well defined stages starting with a DNA

关键词： data mining codon DNA genome mRNA protein splicing transcription translation

Disruption of NAD^+ binding site in glyceraldehyde 3-phosphate dehydrogenase affects its intranuclear interactions

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World Journal of Biological Chemistry 2015年第4期6卷 366-378页

作者： manali Phadke Natalia Krynetskaia Anurag Mishra Carlos Barrero Salim Merali Scott A Gothe Evgeny Krynetskiy Temple University School of Pharmacy Jayne Haines Center for Pharmacogenomics and Drug Safety Temple University

AiM:To characterize phosphorylation of human glyceraldehyde 3-phosphate dehydrogenase(GAPDH),and mobility of GAPDH in cancer cells treated with chemotherapeutic agents. METHODS:We used proteomics analysis to detect and characterize phosphorylation sites within human GAPDH. Site-specific mutagenesis and alanine scanning was then performed to evaluate functional significance of phosphorylation sites in the GAPDH polypeptide chain. Enzymatic properties of mutated GAPDH variants were assessed using kinetic studies. intranuclear dynamics parameters(diffusion coefficient and the immobile fraction) were estimated using fluorescence recovery after photobleaching(FRAP) experiments and confocal microscopy. Molecular modeling experiments were performed to estimate the effects of mutations on NAD+ cofactor ***:Using MALDi-TOF analysis,we identified novel phosphorylation sites within the NAD+ binding center of GAPDH at Y94,S98,and T99. Using polyclonal antibody specific to phospho-T99-containing peptide within GAPDH,we demonstrated accumulation of phospho-T99-GAPDH inthe nuclear fractions of A549,HCT116,and SW48 cancer cel s after cytotoxic stress. We performed site-mutagenesis,and estimated enzymatic properties,intranuclear distribution,and intranuclear mobility of GAPDH mutated variants. Site-mutagenesis at positions S98 and T99 in the NAD+ binding center reduced enzymatic activity of GAPDH due to decreased affinity to NAD+(Km = 741 ± 257 μmol/L in T99 i vs 57 ± 11.1 μmol/L in wild type GAPDH. Molecular modeling experiments revealed the effect of mutations on NAD+ binding with GAPDH. FRAP(fluorescence recovery after photo bleaching) analysis showed that mutations in NAD+ binding center of GAPDH abrogated its intranuclear interactions. CONCLUSiON:Our results suggest an important functional role of phosphorylated amino acids in the NAD+ binding center in GAPDH interactions with its intranuclear partners.

关键词： NAD+ Binding site Fluorescence recovery after phot

Molecular Marker Development in Post-genomic Era:Leveraging Multiple Resources for Marker Development in Cotton and Other Crops

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棉花学报 2008年第S1期20卷 29-页

作者： KUMPATLA Siva P SHAH manali R MUKHOPADHYAY Snehasis THOMPSON Steven A GREENE Thomas W Department of Trait Genetics & Technologies Dow AgroSciences LLC 9330 Zionsville Road indianapolis iN 46268 Department of Computer and information Science indiana University Purdue University indianapolis

While the importance of molecular marker technology was realized more than two decades ago,high-throughput marker development came into vogue only after the availability of hundreds of thousands of sequences in public *** examples now exist where markers are being used routinely in breeding programs for marker-assisted selection(MAS) of traits of interest or marker assisted recovery of genome of *** analysis with thousands to tens of thousands of markers is now possible due to the...

关键词： SSR Molecular Marker Development in Post-genomic Era

C19MC miRNA-520G induces SP100 antiviral gene transcription and inhibits melanin production in skin cutaneous melanoma

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Genes & Diseases 2024年第1期11卷 60-63页

作者： Goodwin G.Jinesh Marian T.Smallin Nino Mtchedlidze isha Godwin Marco Napoli Nicole Hackel manali S.Phadke Avani A.Deshpande Xiaobo Li John H.Lockhart Jaden R.Baldwin Suehelay Acevedo-Acevedo Yifeng Gao Michelle A.Reiser Keiran S.M.Smalley Elsa R.Flores Andrew S.Brohl Department of Molecular Oncology H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Molecular Medicine Program H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Saveetha Medical College ChennaiTamil Nadu 602105India Tumor Biology Department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Sarcoma Department H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA

SP100 is an antiviral protein that restricts the productive stage of human papillomavirus(HPV)and multiple other viruses,and viruses in turn block sUMO-1-mediated stabilization of SP100 and promotes its degradation(Table S1).interferon(iFN)signaling could still produce more SP100 through transcription to counteract viruses.1 Viruses also disable the transcriptional up-regulation of SP100 to achieve persistent infection in hosts.

关键词： SP100 melanoma stabilization

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英语学习（新锐空间） 2009年第5期 57-57页

作者： manali Oak

Development of SSR Markers towards Genetic Mapping in Cotton(Gossypium hirsutum L. )

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棉花学报 2002年第S1期14卷 26-26页

作者： Siva P.KUMPATLA Erin C.HORNE manali R.SHAH Manju GUPTA Steven A.THOMPSON Department of Trait Development Dow AgroSciences LLC9330 Zionsville Road IndianapolisIN 46268USADepartment of Trait DevelopmentDow AgroSciences LLC9330 Zionsville Road IndianapolisIN 46268USADepartment of Trait DevelopmentDow AgroSciences LLC9330 Zionsville Road IndianapolisIN 46268USADepartment of Trait DevelopmentDow AgroSciences LLC9330 Zionsville Road IndianapolisIN 46268USADepartment of Trait DevelopmentDow AgroSciences LLC9330 Zionsville Road IndianapolisIN 46268USA

Availability of informative molecular markers isa prerequisite for genetic mapping and marker-assisted selection ***-satellites orSimple Sequence Repeat(SSR)markers arePCR-based and currently the most widely usedmarker system in the plant molecular geneticscommunity due to their high degree ofpolymorphism,random distribution throughoutthe genome and their suitability for highthroughput genotyping *** itsglobal economic importance,cotton has

关键词： Gossypium Cotton cotton Repeat prerequisite Mapping currently slower suitability informative