检索结果-南通市图书馆

Effect of Avocado （Persea Americana）, Cabbage （Brassica Oleracea） and Ginger （Zingiber Officinale） on Rat Liver and Thy.oid Injuries Induced by.CCI4 （Carbon Tetrachloride）

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmacy.and Pharmacology 2016年第3期4卷 108-118页

作者： Asmaa F. Hamouda manal y. sameeh Randa M. Shrourou Department of biochemistry University of A lexandria Alexandria 21111 Egypt Department of chemistry University of AI Leith- Umm Al-Qura Mecca 21955 Saudi Arabia Department of Food Nutrition University of King Abdul-Aziz Jeddah 21589 Saudi Arabia

Avocado, Cabbage, and Ginger are a part of a regular human diet and have antioxidant, and antitumor effects. The effect of AVOE （avocado）, GE （Ginger） and CE （Cabbage） extracts separately.on liver NO （nitric oxide）, MDA （malondialdehy.e）, as well as serum AST （aspartate aminotransferase）, ALT （alanine aminotransferase）, total bilirubin, TC （total cholesterol）, T.G （trigly.eride）, HDL cholesterol （high-density.lipoprotein）, LDL cholesterol （low-density.lipoprotein）, TSH （thy.oid-stimulating hormone）, T3 （Triiodothy.onine）, T4 （Thy.oxine） in rats treated and untreated with CC14 （carbon tetrachloride） was studied. The levels of NO, MDA, as well as serum AST, ALT, total bilirubin, TC, T.G, LDL, and TSH, showed an elevation while, HDL, T3 and T4 showed the decline in rats treated with CC14 as compared to control. Treatment of rats with AVOE and GE pre, during, and post CC14 administration improve NO, MDA, as well as serum AST, ALT, total bilirubin, TC, T.G, HDL, LDL, TSH, T3, T4 as compared to CC14. Treatment of rats with CE pre, during, and post CC14 administration did not improve in the thy.oid hormones and lipid profile levels as compared to CC14. These findings suggest that avocado and ginger treatment exerts a protective effect on metabolic disorders by.decreasing oxidative stress.

关键词： Liver injuries CC14 (carbon tetrachloride) avocado (Persea Americana) cabbage (Brassica Oleracea) and ginger(Zingiber Officinale) thy.oid function.

Complex Decision Modeling Framework with Fairly.Operators and Quaternion Numbers under Intuitionistic Fuzzy.Rough Context

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2024年第5期139卷 1893-1932页

作者： Nadeem Salamat Muhammad Kamran Shahzaib Ashraf manal Elzain Mohammed Abdulla Rashad Ismail Mohammed M.Al-Shamiri Institute of Mathematics Khwaja Fareed University of Engineering&Information TechnologyRahim Yar Khan64200Pakistan Department of Mathematics Thal University BhakkarPunjab30000Pakistan Department of Mathematics Faculty of Science and ArtsKing Khalid UniversityMuhayl Assir61913Saudi Arabia

The main goal of informal computing is to overcome the limitations of hy.ersensitivity.to defects and uncertainty.while maintaining a balance between high accuracy.accessibility.and *** paper investigates the potential applications of intuitionistic fuzzy.sets(IFS)with rough sets in the context of sparse *** it comes to capture uncertain information emanating fromboth upper and lower approximations,these intuitionistic fuzzy.rough numbers(IFRNs)are superior to intuitionistic fuzzy.sets and py.hagorean fuzzy.sets,*** use rough sets in conjunction with IFSs to develop several fairly.aggregation operators and analy.e their underly.ng *** present numerous impartial laws that incorporate the idea of proportionate dispersion in order to ensure that the membership and non-membership activities of IFRNs are treated equally.within these *** operations lead to the development of the intuitionistic fuzzy.rough weighted fairly.aggregation operator(IFRWFA)and intuitionistic fuzzy.rough ordered weighted fairly.aggregation operator(IFRFOWA).These operators successfully.adjust to membership and non-membership categories with fairness and *** highlight the unique qualities of these suggested aggregation operators and investigate their use in the multiattribute decision-making *** use the intuitionistic fuzzy.rough environment’s architecture to create a novel strategy.in situation involving several decision-makers and non-weighted ***,we developed a novel technique by.combining the IFSs with quaternion *** establish a unique connection between alternatives and qualities by.using intuitionistic fuzzy.quaternion numbers(IFQNs).With the help of this framework,we can simulate uncertainty.in real-world situations and address a number of decision-making *** the examples we have released,we offer a sophisticated and sy.tematically.constructed illustrative scenario that is intricately.wo

关键词： Intuitionistic fuzzy.set quaternion numbers fuzzy.logic decision-making rough set

Sepsis Prediction Using CNNBDLSTM and Temporal Derivatives Feature Extraction in the IoT Medical Environment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第4期79卷 1157-1185页

作者： Sapiah Sakri Shakila Basheer Zuhaira Muhammad Zain Nurul Halimatul Asmak Ismail Dua’Abdellatef Nassar manal Abdullah Alohali Mais Ay.an Alharaki Department of Information Sy.tems College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityRiyadh11671Kingdom of Saudi Arabia Department of Computer Science and Information Technology Applied CollegePrincess Nourah Bint Abdulrahman UniversityRiyadh11671Kingdom of Saudi Arabia

Background:Sepsis,a potentially.fatal inflammatory.disease triggered by.infection,carries significant healthimplications *** detection is crucial as sepsis can rapidly.escalate if left *** in deep learning(DL)offer powerful tools to address this ***:Thus,this study.proposeda hy.rid CNNBDLSTM,a combination of a convolutional neural network(CNN)with a bi-directional long shorttermmemory.BDLSTM)model to predict sepsis *** the proposed model provides a robustframework that capitalizes on the complementary.strengths of both architectures,resulting in more accurate andtimelier ***:The sepsis prediction method proposed here utilizes temporal feature extraction todelineate six distinct time frames before the onset of *** time frames adhere to the sepsis-3 standardrequirement,which incorporates 12-h observation windows preceding sepsis *** models were trained usingthe Medical Information Mart for Intensive Care III(MIMIC-III)dataset,which sourced 61,522 patients with 40clinical variables obtained from the IoT medical *** confusion matrix,the area under the receiveroperating characteristic curve(AUCROC)curve,the accuracy.the precision,the F1-score,and the recall weredeploy.d to evaluate ***:The CNNBDLSTMmodel demonstrated superior performance comparedto the benchmark and other models,achieving an AUCROC of 99.74%and an accuracy.of 99.15%one hour beforesepsis *** results indicate that the CNNBDLSTM model is highly.effective in predicting sepsis onset,particularly.within a close proximity.of one ***:The results could assist practitioners in increasingthe potential survival of the patient one hour before sepsis onset.

关键词： Temporal derivatives hy.rid deep learning predicting sepsis onset MIMIC III machine learning(ML) deep learning

Evolving strategies: Enhancements in managing eosinophilic esophagitis in pediatric patients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Pediatrics 2024年第1期13卷 14-22页

作者： Ahmed Elghoudi Doaa Zourob Eman Al Atrash Fatima Alshamsi manal Alkatheeri Hassib Narchi Rana Bitar Department of Pediatric Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates Division of Pediatric Gastroenterology Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates Pediatric Residency.Program Sheikh Khalifa Medical CityAbu DhabiUnited Arab Emirates College of Medicine and Health Sciences United Arab Emirates UniversityAlainAbu DhabiUnited Arab Emirates

Eosinophilic esophagitis is a newly.recognized disease first described about 50 y.ars *** definition,diagnosis,and management have evolved with new published consensus guidelines and newly.approved treatment available to pediatricians,enabling a better understanding of this disease and more targeted treatment for *** describe the definition,presentation,and diagnosis of eosinophilic esophagitis including management,challenges,and future directions in *** definition,diagnosis,and management of eosinophilic esophagitis have evolved over the last 50 *** guidelines and newly.approved biologic treatment have enabled pediatricians to better understand this disease and allow for more targeted treatment for *** describe the definition,presentation,diagnosis,management,and treatment in addition to the challenges and future directions of eosinophilic esophagitis management in children.

关键词： Eosinophilic esophagitis Esophagitis Gastroesophageal reflux disease Food allergy Dy.phagia

COVID-19 Vaccine Acceptance and Hesitancy.among Pregnant Women: A Knowledge, Attitude, and Perceived Risks Survey.in Lusaka, Zambia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pharmacology.& Pharmacy 2024年第5期15卷 147-166页

作者： Steward Mudenda Ruth Mbewe manal Hadi Ghaffoori Kanaan Shafiq Mohamed Department of Pharmacy School of Health Sciences University of Zambia Lusaka Zambia Department of Agriculture Technical Institute of Suwaria Middle Technical University Baghdad Iraq Medicines Management and Pharmacy.Services St. James University Hospital Leeds Teaching Hospitals NHS Trust Leeds United Kingdom

Introduction: The coronavirus disease 2019 (COVID-19) is an infectious disease of the respiratory.tract caused by.SARS-CoV-2. Since its emergence, there have been increased rates of transmission and spread, morbidity.and mortality.which led to the development of COVID-19 vaccines to address the pandemic. This study.assessed acceptance, knowledge, attitude, and perceived risks regarding COVID-19 vaccines among pregnant women attending antenatal care at two First-Level Hospitals in Lusaka, Zambia. Materials and Methods: This was a cross-sectional study.that was conducted among 241 pregnant women using a questionnaire from August 2023 to October 2023 in two First-Level Hospitals in Lusaka district, Zambia. The collected data were analy.ed using IBM Statistical Package for Social Sciences (SPSS) version 22.0. Statistical analy.is was performed using a Chi-square test. The statistical significance was set at a 95% confidence level. Results: Of the 241 participants, 107 (42.7%) were aged between 24 and 34 y.ars. Overall, 64.3% accepted the COVID-19 vaccines, of which 122 (50.6%) were already.vaccinated. Further, 203 (84.6%) of the pregnant women had good knowledge, and 199 (82.6%) had positive attitudes towards COVID-19 vaccines. However, 58.5% thought COVID-19 vaccines were not safe and could cause infertility. Alongside this, 70.1% thought that COVID-19 vaccines were harmful during pregnancy. Having good knowledge of COVID-19 vaccines was associated with age (p = 0.049), education status (p = 0.001), and employ.ent status (p = 0.001). Having a positive attitude towards COVID-19 vaccines was associated with education status (p = 0.001) and employ.ent status (p = 0.001). Conclusion: This study.found that most pregnant women had good knowledge, and positive attitudes, and the majority.accepted the COVID-19 vaccine. Encouragingly. most of the pregnant women who accepted the COVID-19 vaccines were already.vaccinated. Most pregnant women thought that COVID-19 vaccines had sid

关键词： COVID-19 Vaccines Pregnant Women Vaccine Acceptance Vaccine Hesitancy Zambia

Return to Dialy.is after Kidney.Graft Failure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Nephrology 2024年第2期14卷 240-252页

作者： Ikram Ftaimi Soukaina Sakab manal Chattahi Tarik Bouattar Loubna Benamar Rabia Bay.hia Naima Ouzeddoun Service de Nphrologie-Dialy.e-Transplantationrnale CHU Ibn Sina Rabat Universit Mohammed V Rabat Morocco

Introduction: The transition period from renal transplantation to dialy.is is associated with high morbidity.and mortality. The aim of this study.is to describe the clinical and paraclinical characteristics, therapeutic management and evolutionary.profile of patients returning to dialy.is after kidney.graft failure. Material and Methods: This was a retrospective, descriptive study.conducted in the Nephrology.Dialy.is-Renal Transplant Department at university.hospital IbnSina between January.1998 and December 2021. We included all renal transplant recipients who had experienced kidney.graft dy.function and returned to dialy.is. Patients with a follow-up after return to dialy.is of less than 1 y.ar were excluded. Results: Among 166 renal transplant recipients, 20 returned to dialy.is after a median renal graft life of 85.5 months [42 - 186], corresponding to a prevalence of 12%. The mean age of our patients was 38.7 ± 11.9 y.ars, with a M/F sex ratio of 2.3. Dialy.is was initiated urgently.in 10 patients (50%). Hemodialy.is was the most commonly.used modality.(75%). Central venous catheterization was used in 35% of cases, including tunneled catheters. General condition is impaired in all patients, with persistent hy.ertension in 70% of cases. Mean uremia was 2.35 ± 0.8 g/l, mean creatinine 116 ± 48.3 mg/l, giving a mean GFR of 5.1 ± 2.2 ml/min. Mean albuminemia was 32.9 ± 6 g/l and mean hemoglobinemia 8.6 ± 1.9 g/dl. During the first y.ar of follow-up, none of the patients died. However, 13 patients required hospitalization, with a mean length of stay.of 15 day.. Eight patients were hospitalized for infections and 5 for renal graft intolerance sy.drome. After a mean follow-up of 22 months, 6 patients were detransplanted following graft necrosis. Conclusion: Return to dialy.is after RT is fraught with a high rate of complications. The management of these patients must be optimized to improve their vital prognosis and quality.of life.

关键词： Kidney.Graft Failure Dialy.is Detransplantation Immunosuppression

Juvenile Xanthogranuloma: A Case Report with Literature Review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Pediatrics 2024年第3期14卷 531-535页

作者： Ay.d Ghanam manal Azizi Hind Zahiri Aziza El Ouali Abdeladim Babakhouy. Maria Rkain Department of Pediatrics Mohammed VI University Hospital Faculty of Medicine and Pharmacy Mohammed First University Oujda Morocco

Juvenile xanthogranuloma (XGJ) is the most common form of non-Langerhansian histiocy.osis. We report a pediatric case of multiple XGJ without visceral involvement in a 6-month-old female infant who was hospitalized with disseminated congenital skin nodules, of firm consistency. of variable diameter ranging from a few millimetres to 1 cm, involving the face, scalp, trunk and limbs. There was no mucosal localization. The remainder of the somatic examination was unremarkable. The diagnosis of disseminated XGJ was confirmed by.skin biopsy.without visceral or sy.temic involvement. Therapeutic abstention was recommended. This observation underlines the fact that XGJ is a rare clinical entity.that should not be overlooked when faced with congenital skin nodules.

关键词： Cutaneous Nodules Juvenile Xanthogranuloma Child

Insights into the anorexic mechanism of Khat:an integrated in vivo,ex vivo,and in silico investigations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Traditional Medicine Research 2024年第10期9卷 36-51页

作者： Ahmed Ali Jerah manal Mohamed Elhassan Taha Abdullah Farasani Sivakumar Sivagurunathan Moni Emad Say.d Shaheen Andleeb Khan Ibrahim Abdo Khardali Magbool Oraiby.Hey.m Mohamed Ali Sidahmed Siddig Ibrahim Abdelwahab Department of Medical Laboratory.Technology College of Applied Medical SciencesJazan UniversityJazan 45142Saudi Arabia Health Research Centre Jazan UniversityJazan 45142Saudi Arabia Department of Pharmaceutics College of PharmacyJazan UniversityJazan 45142Saudi Arabia Department of Biosciences Faculty of ScienceIntegral UniversityLucknow 226026India Poison Control and Medical Forensic Chemistry.Center General Directorate of Health AffairsJazan 45142Saudi Arabia Department of Pharmaceutical Chemistry Faculty of PharmacyAl-Neelain UniversityKhartoum 16458Sudan

Background:Chewing Khat(Catha edulis)releases cathine and cathinone,which may.reduce appetite via an unknown *** study.investigated the peripheral and central effects of fresh leaves and buds of Catha edulis water extract(CEWE)on appetite biomarkers,gene expression,and body.weight,using in vivo,ex vivo,and in silico ***:Rats of both sexes were orally.administered CEWE at different doses and durations in three different *** chromatography.mass spectroscopy.LC-MS)-MS was used to detect cathinone and cathine in the murine *** effect of Khat on serotonin receptors was studied in isolated rat fundus *** of the two Khat ligands was performed on G(The 5-hy.roxy.ry.tamine-ty.e 2C receptor(5-HT2C)in an agonist-bound active conformation)and H(5-HT2C in an antagonist-bound inactive conformation)proteins to determine which ligands are most likely.to act as agonists or ***:Significant differences(Py.weight were observed between the CEWE-treated groups and the controls over eight ***,the plasma leptin and ghrelin levels did not change significantly.P>0.05).The expression of the ghrelin and leptin genes was also unaffected,but the expression of the 5-hy.roxy.ry.tamine(5-HT)gene decreased(Py.suppress appetite by.antagonizing the 5-HT *** research is required to understand its mechanism and potential applications.

关键词： Catha edulis appetite leptin ghrelin 5-hy.roxy.ry.tamine molecular docking

Correlation between DKK-1 Level and Bone Density.Status in Children on Maintenance Haemodialy.is

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Nephrology 2024年第1期14卷 48-61页

作者： manal Abd El-Salam Marwa Mohamed Anwar Rasha Mahmoud Gouda Naglaa Abou El Fattah Nadia y.ussef Riad Department of Pediatrics Faculty of Medicine (For Girls) Al-Azhar University Cairo Egypt Department of Internal Medicine Faculty of Medicine (For Girls) Al-Azhar University Cairo Egypt Department of Clinical Pathology National Heart Institute Cairo Egypt

Background: Renal osteody.trophy.(ROD) is a bone disorder resulting from chronic kidney.disease (CKD) and related metabolic diseases. Dickkopf-related protein-1 (DKK-1) is critical in regulating bone biology. This study.aimed to evaluate the serum DKK-1 level as a bone marker in children with CKD who undergo regular hemodialy.is (HD). Subjects and Methods: This case-control study.involved 40 children with CKD on HD and 40 healthy.children as controls. The study.measured serum DKK-1 levels and performed a dual-energy.X-ray.absorptiometry.scan (DEXA) in line with routine laboratory.investigations. Results: There was a significant increase in the serum level of DKK-1 in the patient group compared to the control group. The DKK-1 levels were 2540.65 (2215.4 - 2909.2) pg/ml and 1110.45 (885.45 - 1527.65) pg/ml, respectively. with a p-value of less than 0.001. In the hemodialy.is group, 25 patients (62.5%) had low bone mineral density.(BMD) with a Z-score of under -2.0. Eighteen of these patients had low BMD in both the neck of the femur and lumbar spines. Additionally. there was a significant increase in serum DKK-1 level in patients with low BMD (2567.35 (2303.8 - 3108.1) pg/ml) compared to patients with normal BMD (2454 (1859 - 2820) pg/ml) (p = 0.041). There was also a significant positive correlation between DKK1 level and phosphorus, alkaline phosphatase, and Parathormone serum levels. In conclusion, the study.indicates a clear correlation between DKK-1 and BMD in children undergoing maintenance hemodialy.is. DKK1 is a promising biomarker for CKD-MBD.

关键词： DKK-1 Children Haemodialy.is Bone Density.Status