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Bibliometric mapping of solid lipid nanoparticles research(2012–2022)using VOSviewer

Medicine in Novel Technology and Devices 2023年第1期17卷 132-140页

作者： Siddig Ibrahim Abdelwahab manal mohamed elhas.an taha Sivakumar S.Moni Abdulrahman A.Alsayegh Medical Research Centre Jazan UniversityJazanP.O.Box 45142Saudi Arabia Department of Pharmaceutics College of PharmacyJazan UniversityJazan45142Saudi Arabia Department of Clinical Nutrition College of Applied Medical SciencesJazan UniversityJazan45142Saudi Arabia

Nanotechnology is a rapidly expanding discipline,and solid lipid nanoparticles(SLN)are at the forefront of this *** offer various possible clinical and pharmaceutical research applications and numerous other fields.A quantitative review technique called bibliometric analysis uses statistics,data mining,and mathematics to find emerging trends in a particular academic *** is currently more widely utilized and is employed in many academic *** a result,the current study looked through Scopus-indexed research documents on SLNs from 2012 to 2022 to assess the growth and expansion of this body of knowledge and predict its course in the *** VOSviewer package and Scopus Analytics were used to conduct the bibliometric *** offers two distinct viewing modes:network and overlay visualization.A total of 3768 journal articles(n=3709)and conference papers(n=59)were *** number of research documents published by 12,367 authors was steadily increasing *** therapy,development and detection methods,bioavailability,and controlled release have been important research ***,E.B.,of the University of Porto in Portugal,is considered the most prolific and frequently cited *** University(India)is the top-publishing *** is the leading country in the number of publications and research *** International Journal of Pharmaceutics is the top *** current results keep pace with global scientific efforts in nanotechnology and successfully integrate them into the pharmaceutical industry.

关键词： Solid lipid nanoparticles Bibliometric analysis Scientific mapping Knowledge structure Performance analysis

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Nurses’ Knowledge, Attitude, and Practice Regarding Personal Protective Equipment for the Prevention of COVID-19 in Public Hospitals Khartoum State Sudan 2022

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Open Journal of Nursing 2023年第3期13卷 181-195页

作者： manal Bilal mohamed Fatma Elamin Hamid mohamed Nazik mohamed Abdalla taha Faculty of Nursing Science Omdurman Islamic University Omdurman Sudan Department of Surgical Nursing Faculty of Nursing Science Omdurman Islamic University Omdurman Sudan Medical Nursing Faculty of Nursing Science Omdurman Islamic university Omdurman Sudan

Since December 2019, there had been a series of unexplained cases of pneumonia reported in Wuhan, China, and on 12 January 2020, the World Health Organization (WHO) named this new virus as the 2019 novel coronavirus (2019-nCoV). The Novel Coronavirus disease (COVID-19) is an emerging, rapidly changing global health challenge affecting all sectors, including the health sector. This study aimed to investigate nurses’ knowledge, attitudes, and practices regarding the prevention and control of COVID-19. Methods: This cross-sectional study was conducted among nurses in three public health hospitals in Khartoum state. A self-administered questionnaire was used. A total of 14 knowledge questions were adopted. There are 5 questions constructed for attitude. A total of 12 practice questions were used. Mean score of knowledge considers as follows when the mean more than 75% considers as good knowledge while this percent uses as good practice and poor practice respectively to analyze the mean score differences of knowledge, attitudes, and practices between the independent variables. Spearman correlation was used to assess the relationship between mean knowledge and attitude scores. Results: Of the 101 nurses approached, a total of 100 nurses responded (99.0% response rate). The mean age of the participants was 27.6 (SD 5.3) years, and the majority of the participants were male (293/434, 67.5%). The mean knowledge score was 1.01 (SD 0.100). The mean attitude score was 10.5 (SD 4.1), and 54.8% (238/434) of the participants had a good attitude toward COVID-19. The mean practice score was 1.4176 (SD 1.4176). There was a negative correlation between knowledge and attitude scores (P < -0.014) and between knowledge and practice scores (P < -0.081). Conclusions: The overall levels of knowledge and practice and attitude were good.

关键词： COVID-19 Knowledge Attitude Practice Nurses Public Hospitals Khartoum State Sudan

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Fifty-year of Global Research in Calendula Officinalis L.(1971−2021):A Bibliometric Study

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Clinical Complementary Medicine and Pharmacology 2022年第4期2卷 73-82页

作者： Siddig Ibrahim Abdelwahab manal mohamed elhas.an taha Sarah mohamed elhas.an taha Abdulrahman Ahmed Alsayegh Medical Research Centre Jazan UniversityJazan 46852Saudi Arabia Clinical Nutrition Department College of Applied Medical SciencesJazan UniversityJazan 46852Saudi Arabia

Background:Calendula officinalis L.(Compositae)is a Mediterranean annual plant widely used for its versatile biological ***:A bibliometric study of research data conducted from 1971 to 2021 was ***:Bibliographic data was retrieved from the Scopus database and analyzed using VOSviewer and MS *** regression was used to assess the annual production of research documents related to ***:A total of 1,252 journal articles and conference papers were published by 4,452 authors,originated from 98 countries and disseminated in 706 ***(n=131),Brazil(n=119),India(n=113),Poland(n=112),and Italy(n=72)are the top-publishing *** of Ethnopharmacology is the top-cited journal,while Italy is the top-cited *** growth was observed in the last fifty years,from 1971 to *** anti-inflammatory,wound-healing,and anti-microbial properties are among the most prolific studies that have been conducted on this *** research has been carried out on antioxidant compounds,terpenes,and volatile *** care and wound healing are the most common clinical ***-citation analysis,keywords co-occurrence,and bibliographic coupling revealed diverse knowledge structures and intellectual ***:This comprehensive bibliometric study indicates that Calendula officinalis received significant *** structured information may help understand research trends and locate this plant’s research hot spots and gaps.

关键词： Calendula officinalis L. Bibliometric study VOSviewer Scopus

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Insights into the anorexic mechanism of Khat:an integrated in vivo,ex vivo,and in silico investigations

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Traditional Medicine Research 2024年第10期9卷 36-51页

作者： Ahmed Ali Jerah manal mohamed elhas.an taha Abdullah Farasani Sivakumar Sivagurunathan Moni Emad Sayed Shaheen Andleeb Khan Ibrahim Abdo Khardali Magbool Oraiby Heyam mohamed Ali Sidahmed Siddig Ibrahim Abdelwahab Department of Medical Laboratory Technology College of Applied Medical SciencesJazan UniversityJazan 45142Saudi Arabia Health Research Centre Jazan UniversityJazan 45142Saudi Arabia Department of Pharmaceutics College of PharmacyJazan UniversityJazan 45142Saudi Arabia Department of Biosciences Faculty of ScienceIntegral UniversityLucknow 226026India Poison Control and Medical Forensic Chemistry Center General Directorate of Health AffairsJazan 45142Saudi Arabia Department of Pharmaceutical Chemistry Faculty of PharmacyAl-Neelain UniversityKhartoum 16458Sudan

Background:Chewing Khat(Catha edulis)releases cathine and cathinone,which may reduce appetite via an unknown *** study investigated the peripheral and central effects of fresh leaves and buds of Catha edulis water extract(CEWE)on appetite biomarkers,gene expression,and body weight,using in vivo,ex vivo,and in silico ***:Rats of both sexes were orally administered CEWE at different doses and durations in three different *** chromatography-mass spectroscopy(LC-MS)-MS was used to detect cathinone and cathine in the murine *** effect of Khat on serotonin receptors was studied in isolated rat fundus *** of the two Khat ligands was performed on G(The 5-hydroxytryptamine-type 2C receptor(5-HT2C)in an agonist-bound active conformation)and H(5-HT2C in an antagonist-bound inactive conformation)proteins to determine which ligands are most likely to act as agonists or ***:Significant differences(P0.05).The expression of the ghrelin and leptin genes was also unaffected,but the expression of the 5-hydroxytryptamine(5-HT)gene decreased(P<0.05)with CEWE *** antagonizes 5-HT receptors in isolated rat fundus *** findings indicated that the khat ligands bound to 5-HT2C *** and cathinone levels in rat plasma were ***:Khat extract may suppress appetite by antagonizing the 5-HT *** research is required to understand its mechanism and potential applications.

关键词： Catha edulis appetite leptin ghrelin 5-hydroxytryptamine molecular docking

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Molecular docking of amphetamine,cathine and cathinone with dihydrofolate reductase:a computational analysis of inhibition of dihydrofolate reductase by khat alkaloids

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Toxicology Communications 2022年第2期4卷 23-28页

作者： Siddig Ibrahim Abdelwahab Abdullah Farasani Ahmed Jerah manal mohamed elhas.an taha Anil Bidwai Medical Research Centre Jazan UniversityJazan 45142Saudi Arabia College of Applied Medical Sciences Jazan UniversityJazan 45142Kingdom of Saudi Arabia Substance Abuse Research Center Jazan UniversityJazan 45142Saudi Arabia

Interaction of amphetamine,cathine and cathinone with the enzyme dihydrofolate reductase was studied by molecular docking using AutoDock 4.2 as the docking software *** 4.2 software serves as a valid and acceptable docking application to study the interactions of small compounds with *** of amphetamine,cathine and cathinone with dihydrofolate reductase were compared to those of methotrexate,a known inhibitor of the *** calculated free energy of binding(ΔG binding)shows that the three ligands(ΔG=-6.87 to-7.21 kcal/mol;Ki=9.15 to 5.18μM)bind with affinity slightly lower than methotrexate(ΔG=-8.78 kcal/mol;Ki=363 nM).Binding interactions of the three ligands with active site residues of the enzyme are also *** the ligands appear to bind in a similar conformation making extensive VDW contacts in the active site of the *** bonding and pi-pi interaction with key active site residues is also ***,a probable inhibition of dihydrofolate reductase by khat alkaloids can be explained on the basis of this in silico binding and khat alkaloids can be considered as potential lead compounds in the development of new inhibitors of dihydrofolate reductase which is a potential target of anti-cancer *** results of these studies can serve as a starting point for further computational and experimental studies.

关键词： amphetamine cathine cathinone methotrexate docking AutoDock DHFR khat alkaloids

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