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Assessment of maintenance oral Etoposide following induction chemotherapy with gemcitabine and cisplating in chemonaive extensive small cell lung cancer

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The Chinese-German Journal of Clinical Oncology 2010年第10期9卷 569-573页

作者： Lobna R Ezz Elarab manal m abdel wahab menha Swellam Zakaria mostafa Radiation Oncology&Nuclear medicine Faculty of MedicineAin Shams University Biochemistry Department Genetic Engineering and Biotechnology Research DivisionNational Research Center Abbasia Chest Hospital

Objective： The aim of our study was to evaluate the response and tolerability to treatment when using gemcitabine-cisplatin combination （GC）, followed by maintenance therapy of oral etoposide for non-progressive patients in trial to improve progression free survival and overall survival. methods： Thirty nine patients with extensive small cell lung cancer （SCLC） and ECOG ≤ 2 received 4 cycles of chemotherapy consisting of gemcitabine 1000 mg/m^2 （day 1 and 8） cisplating 75 mgim2 （day 1） every three weeks. Twenty seven non-progressive patients after 4 cycles of chemotherapy were randomized either to receive oral etoposide 50 mg/m^2 for consecutive 15 days every 3 weeks vs no therapy for three months or progression. Results： Thirty nine eligible patients treated with GC, 27 non progressive patients were subsequently randomized to oral etoposide or observation. median follow-up was 18 months. The overall response rate to GC was 59% and toxicity to oral etoposide was mild. There was improvement in median progression-free survival （PFS） favoring the maintenance arm of 10.5 months vs 7 months （P 〈 0.05）. median overall survival （OS） had improved towards the maintenance arm （13 vs 11.5 months）. One year survival （60% vs 24%）, 18 months survival （20% vs 5%） favoring the maintenance. multivariate analysis revealed that age, performance status, maintenance therapy, and response to treatment were independent prognostic factors for OS. Age, maintenance therapy, and response to treatment were highly significant factors for PFS. Conclusion： Gemcitabine-cisplatin is an effective and tolerable regiment for extensive disease of SCLC. The addition of 3 months of oral etoposide in non progressing patients was associated with a significant improvement of PFS and longer OS.

关键词： gemcitabine cisplatin small cell lung cancer

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Skeletal events of Anastrozole versus Tamoxifen on bone mineral density and bone biomarker osteocalcin in postmenopausal women with early breast cancer

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The Chinese-German Journal of Clinical Oncology 2010年第10期9卷 574-578页

作者： Lobna R Ezz Elarab menha Swellam manal m abdel wahab Karima m maher Radiation Oncology & Nuclear medicine Faculty of MedicineAin Shams University Biochemistry Department Genetic Engineering and Biotechnology Research DivisionNational Research Center Radiology Department Faculty of MedicineAin Shams University

Objective： Postmenopausal women with breast cancer are at increased risk of bone loss because of age related estrogen deficiency face which accelerated with the use of aromatase inhibitors （AIs）. We aimed to study the effect on bone mineral density （BmD） and bone formation biomarker osteocalcin level in postmenopausal breast cancer patients, for the first three years of adjuvant hormonal treatment of both groups Tamoxifen versus Anastrozol. methods： One-hundered postmenopausal breast cancers were prospectively randomized to receive either Tamoxifen 20 rag/day （n = 50） or Anastrozole 10 mg （n = 50）. Both BmD and osteocalcin were assessed initially before treatment and then at regular intervals for both groups. Results： Use of Tamoxifen was associated with significant annual decrease in osteocalcin （P = 0.001）, whereas Anastrozole group had gradual increase of the annual levels （P 〈 0.01）. BmD decreased significantly in Anastrozole versus Tamoxifen groups （2.6% vs. 0.4%, P 〈 0.001）. Osteoporosis T 〈 -2.5 was reported significantly higher in Anastrozole group （P 〈 0.01）. Women with initial osteopenia in Anastrozole group showed significant decrease in BmD （P 〈 0.05）. The addition of bisphosphonate for patients with early osteoporosis markedly improved both osteocalcin level and BmD. Conclusion： Tamoxifen preserves BmD in postmenopausal breast cancer patients, whereas Anastrozole accelerates age associated fall in BmD especially in the first year of therapy, moreover, the addition of bisphosphonate can help to decrease the skeletal related events associated with treatment to ensure better quality of life with treatment.

关键词： Anastrozole Tamoxifen, bone mineral density (BmD) breast cancer osteocalcin

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Capecitabine plus cisplatin treatment in patients with advanced hepatocellular carcinoma

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The Chinese-German Journal of Clinical Oncology 2010年第12期9卷 718-723页

作者： manal m abdel wahab Lobna R Ezz Elarab mohamed A Ezz Elarab Radiation Oncology and Nuclear medicine Department Faculty of MedicineAin Shams University National Hepatology and Tropical medicine Research Institute

Objective： Hepatocellular carcinoma （HCC） is the sixth most common cancer in the world and the third leading cause of cancer related death globally. Parentral treatment of Egyptian patients of bilharziasis contributed to the high incidence of viral hepatitis, and subsequently liver cirrhosis and HCC. CapecJtabJne plus cJsplatJn protocol was evaluated regarding the efficacy and safety in patients with advanced HCC as first line chemotherapy. methods： One hundred patients with advanced HCC were randomized to receive either capecitabine （1000 mg/m2） twice daily for fourteen days plus intravenous cisplatin （60 mg/m2） on day one to be repeated every three weeks with a maximum of six cycles or placebo （phase III trial）. Results： Baseline characteristics were comparable in both groups. According to Barcelona Clinic Liver Cancer Staging System, stage C was the most predominant （82% vs. 75%） in both groups. median OS was 12 months versus 10 months in favor of the treated group （P value 〈 0.05）. median TTP was significantly higher in the chemotherapy group （7 months vs. 4.5 months） as well as disease control rate （40% vs. 29%）, no patient had achieved complete response. Grade 3 toxicity was more pronounced in the treatment group, as regards vomiting and diarrhea （10% vs. 2%）, neurotoxicity （6% vs. 2%）, elevation of aminotransferase and bilirubin （9.8% vs. 4.9%）, hand and foot syndrome reaction was recorded only in chemotherapy group. Conclusion： Capecitabine plus cisplatin regimen showed modest antitumor activity with tolerable toxicity in patients with advanced HCC. moreover, because of the significantly prolonged time to progression, we demand further attention to this convenient, outpatient, and economic profile based chemotherapy protocol.

关键词： capecitabine cisplatin hepatocellular carcinoma (HCC) bilharziasis liver cirrhosis

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Effect of fatigue load on the bending tribo-corrosion-fatigue behaviors between the main cable wires

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Friction 2024年第7期12卷 1512-1531页

作者： Bo WANG Dagang WANG Jihong YE Liang TANG Hailang CHONG Wei XU Xinxin ZHANG Jianhao CHEN Haiyan DENG Jie ZHANG Guowen YAO magd abdel wahab School of mechatronic Engineering China University of Mining and TechnologyXuzhou 221116China Xuzhou Key Laboratory for Fire Safety of Engineering Structures China University of Mining and TechnologyXuzhou 221116China National Wire Rope Quality Inspection Center Nantong Product Quality Supervision and Inspection InstituteNantong 226011China Jiangsu Langshan Wire Rope Co. Ltd.Nantong 226003China School of mechatronic Engineering Southwest Petroleum UniversityChengdu 610500China School of Civil Engineering Chongqing Jiaotong UniversityChongqing 400074China Soete Laboratory Faculty of Engineering and ArchitectureGhent UniversityZwijnaarde B-9052Belgium

The main cable bent around the saddle of the suspension bridge is subjected to the wind,the vehicle,the bridge’s own weight and the corrosive *** coupling of the three loads and the environments causes the friction,the corrosion,and the fatigue(tribo-corrosion-fatigue)among the wires inside the main *** this paper,a wire bending tribo-corrosion-fatigue test rig was designed and *** effect of fatigue load on the bending friction behaviors between the cable wires in ultrapure water and 3.5%NaCl solution was *** tribological properties and electrochemical corrosion behaviors under different fatigue loading ranges were *** tribo-corrosion-fatigue interaction between the cable wires was quantitatively characterized,and the mechanism of the interaction was *** results demonstrate that the increasing fatigue load exacerbates the coupling damage of the cable wires attributed to the enhanced *** findings carry theoretical importance when assessing the main cable’s deterioration and the load-bearing safety of a suspension bridge.

关键词： bending tribo-corrosion-fatigue interaction parallel steel wires fatigue load

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Intelligent Smart Grid Stability Predictive model for Cyber-Physical Energy Systems

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Computer Systems Science & Engineering 2023年第2期44卷 1219-1231页

作者： Ashit Kumar Dutta manal Al Faraj Yasser Albagory mohammad zeid m Alzamil Abdul Rahaman wahab Sait Department of Computer Science and Information Systems College of Applied SciencesAlMaarefa UniversityAd DiriyahRiyadh13713Kingdom of Saudi Arabia Department of Computer Engineering College of Computers and Information TechnologyTaif UniversityTaif21944Kingdom of Saudi Arabia Department of Archives and Communication King Faisal UniversityAl AhsaHofuf31982Kingdom of Saudi Arabia

A cyber physical energy system(CPES)involves a combination of pro-cessing,network,and physical *** smart grid plays a vital role in the CPES model where information technology(IT)can be related to the physical *** the same time,the machine learning(mL)modelsﬁnd useful for the smart grids integrated into the CPES for effective decision ***,the smart grids using mL and deep learning(DL)models are anticipated to lessen the requirement of placing many power plants for electricity *** this aspect,this study designs optimal multi-head attention based bidirectional long short term memory(OmHA-mBLSTm)technique for smart grid stability predic-tion in *** proposed OmHA-mBLSTm technique involves three subpro-cesses such as pre-processing,prediction,and hyperparameter *** OmHA-mBLSTm technique employs min-max normalization as a pre-proces-sing ***,the mBLSTm model is applied for the prediction of stability level of the smart grids in *** the same time,the moth swarm algorithm(mHA)is utilized for optimally modifying the hyperparameters involved in the mBLSTm *** ensure the enhanced outcomes of the OmHA-mBLSTm technique,a series of simulations were carried out and the results are inspected under several *** experimental results pointed out the better outcomes of the OmHA-mBLSTm technique over the recent models.

关键词： Stability prediction smart grid cyber physical energy systems deep learning data analytics moth swarm algorithm

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Optimal Sparse Autoencoder Based Sleep Stage Classification Using Biomedical Signals

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Computer Systems Science & Engineering 2023年第2期44卷 1517-1529页

作者： Ashit Kumar Dutta Yasser Albagory manal Al Faraj Yasir A.m.Eltahir Abdul Rahaman wahab Sait Department of Computer Science and Information Systems College of Applied SciencesAlMaarefa UniversityAd DiriyahRiyadh13713Kingdom of Saudi Arabia Department of Computer Engineering College of Computers and Information TechnologyTaif UniversityTaif21944Kingdom of Saudi Arabia Department of Respiratory Care College of Applied SciencesAlMaarefa UniversityAd DiriyahRiyadh13713Kingdom of Saudi Arabia Department of Archives and Communication King Faisal UniversityAl AhsaHofuf31982Kingdom of Saudi Arabia

The recently developed machine learning(mL)models have the ability to obtain high detection rate using biomedical ***,this article develops an Optimal Sparse Autoencoder based Sleep Stage Classiﬁcation model on Electroencephalography(EEG)Biomedical Signals,named OSAE-SSCEEG *** major intention of the OSAE-SSCEEG technique is toﬁnd the sleep stage disorders using the EEG biomedical *** OSAE-SSCEEG technique primarily undergoes preprocessing using min-max data normalization ***,the classiﬁcation of sleep stages takes place using the Sparse Autoencoder with Smoothed Regularization(SAE-SR)with softmax(Sm)***,the parameter optimization of the SAE-SR technique is carried out by the use of Coyote Optimization Algorithm(COA)and it leads to boosted classiﬁcation efﬁ*** order to ensure the enhanced performance of the OSAE-SSCEEG technique,a wide ranging simulation analysis is performed and the obtained results demonstrate the betterment of the OSAE-SSCEEG tech-nique over the recent methods.

关键词： Biomedical signals EEG sleep stage classiﬁcation machine learning autoencoder softmax parameter tuning

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Optical properties and radiative rates of Nd^(3+) doped zinc-sodium phosphate glasses

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Journal of Rare Earths 2019年第3期37卷 253-259页

作者： A.A.El-maaref Shimaa Badr Kh.S.Shaaban E.A.abdel wahab m.m.ElOkr Physics Department Faculty of Science Al-Azhar University modern Academy for Engineering & Technology Chemistry Department Faculty of Science Al-Azhar University

Preparation using melt quenching technique and optical characterizations of Nd^(3+) doped Zn-Na phosphate glasses are presented. The structure of the present glasses was studied using X-ray diffraction and FT-IR spectroscopy. UV-vis spectra of the present glasses were analyzed at different concentrations of Nd_2 O_3. The effect of neodymium concentration on the density and energy band gap was investigated. The density of the present glasses slightly increases with the increasing of Nd_2 O_3. A small variation of energy band gap with the increasing of neodymium content is observed as well, while E_g values decrease with the increase of Nd_2 O_3 content. The E_g values lie between 4.36 and 4.69 eV. Based on the measured optical spectra, Judd-Ofelt theory was used to determine the optical parameters such as line strengths, optical intensity parameters(Ω_t), transition probabilities, and transition lifetimes. Hypersensitive transitions were identified in the absorption spectrum, the greatest line strengths are recorded at the transitions^2 G_(7/2)+ ~4 G_(5/2), ~4 S_(3/2) + ~4 F_(7/2) and ~4 D_(1/2) + ~4 D_(3/2)+ ~4 D_(5/2) + ~2 I_(11/2) with wavelengths of 580, 475 and 355 nm,respectively. Lifetimes of the important ~4 F_(3/2) laser-level were determined; which show decreasing trend with the increasing of Nd_2 O_3 content and are found to be between 0.838 and 1.595 ms. The uncertainty of the present results was estimated. The RmS deviations were determined, which show lower values than those in the literature.

关键词： Phosphate glass UV-vis spectroscopy Judd-Ofelt Radiative rates Rear earth ions

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Determination of the Normal Contact Stiffness and Integration Time Step for the Finite Element modeling of Bristle-Surface Interaction

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Computers, materials & Continua 2018年第7期56卷 169-184页

作者： Libardo V.Vanegas-Useche magd m.abdel-wahab Graham A.Parker Facultad de Ingeniería mecánica Universidad Tecnológica de Pereira.Pereira 660003Colombia Division of Computational mechanics Ton Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Civil Engineering Ton Duc Thang UniversityHo Chi Minh CityVietnam Soete Laboratory Faculty of Engineering and ArchitectureGhent UniversityTechnologiepark Zwijnaarde 903Zwijnaarde B-9052Belgium Faculty of Engineering and Physical Sciences University of Surrey.GuildfordUK

In finite element modeling of impact,it is necessary to define appropriate values of the normal contact stiffness,Kn,and the Integration Time Step(ITS).Because impacts are usually of very short duration,very small ITSs are ***,the selection of a suitable value of Kn is a critical issue,as the impact behavior depends dramatically on this *** this work,a number of experimental tests and finite element analyses have been performed in order to obtain an appropriate value of Kn for the interaction between a bristle of a gutter brush for road sweeping and a concrete ***,a suitable ITS is *** experiments consist of releasing a steel bristle that is placed vertically at a certain distance from a concrete surface and tracking the ***,in the finite element analyses,a beam is modeled in free fall and impacting a surface;contact and target elements are attached to the beam and the surface,*** results of the experiments and the modeling are integrated through the principle of conservation of energy,the principle of linear impulse and momentum,and Newton’s second *** results demonstrate that,for the case studied,Kn and the impact time tend to be independent of the velocity just before impact and that Kn has a very large variation,as concrete is a composite material with a rough ***,the ratio between the largest height of the bristle after impact and the initial height tends to be constant.

关键词： Brush street sweeping finite element modeling contact mechanics

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Numerical Analysis of Tilted Cutting and F128 Brushes

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Computer modeling in Engineering & Sciences 2019年第10期121卷 23-47页

作者： Libardo V.Vanegas-Useche magd m.abdel-wahab Graham A.Parker Facultad de Ingeniería mecánica Universidad Tecnológica de PereiraLa JulitaPereira 660003Colombia Division of Computational mechanics Ton Duc Thang UniversityHo Chi Minh CityViet Nam Faculty of Civil Engineering Ton Duc Thang UniversityHo Chi Minh CityViet Nam Soete Laboratory Faculty of Engineering and ArchitectureGhent UniversityTechnologiepark Zwijnaarde 46B-9052 ZwijnaardeBelgium Faculty of Engineering and Physical Sciences University of Surrey.Guildford GU27XHUK.

Road sweeping is an essential service that has to be conducted for public health,as well as aesthetic *** many countries,sweeping vehicles are used for this *** usually comprise a gutter brush that sweeps the debris that is located in the road *** work studies the performance of two kinds of gutter brushes:a cutting brush and a flicking(F128)*** is carried out by means of a 3-D dynamic,nonlinear Finite Element(FE)brush model developed by the *** this model,inertia forces are applied to the bristle,and its clamped end is ***,the surface(road)is rotated,translated,and ***-road interaction is modelled as flexible-to-rigid *** particular,the aim of this article is to compare the performance of a conventional brush and a brush rotating at variable *** brushes normally work tilted,FE analyses are carried out for tilted cutting and F128 brushes,rotating at speeds that fluctuate at different *** is concluded that brush oscillations have a significant effect on bristle tip velocities and bristle-road ***,at certain frequencies,oscillations seem to improve sweeping performance of the F128 ***,they do not appear to improve significantly the performance of the cutting brush.

关键词： Gutter brushes cutting brush flicking brush FEm variable speed brushing

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Removal of arsenite by reductive precipitation in dithionite solution activated by UV light

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Journal of Environmental Sciences 2018年第12期30卷 168-176页

作者： Bahngmi Jung Aya Safan Yuhang Duan Vishakha Kaushik Bill Batchelor Ahmed abdel-wahab Chemical Engineering Program Texas A&M University at Qatar Education City Zachry Department of Civil Engineering Texas A&M University College Station

This study investigates the removal of arsenite（As（III）） from water using dithionite activated by UV light. This work evaluated the removal kinetics of As（III） under UV light irradiation as affected by dithionite dose and light intensity, and characterized the nature of the precipitated solids using XPS and SEm-EDS. Photolysis of dithionite was observed by measuring dithionite concentration using UV absorbance at 315 nm. This study also investigated the effect of UV light path length on soluble As concentrations to understand resolubilization mechanisms. Total soluble As concentrations were observed to decrease with reaction time due to reduction of arsenite to form solids having a yellow-orange *** removal mechanism was found to be reductive precipitation that formed solids of elemental arsenic or arsenic sulfide. However, these solids were observed to resolubilize at later times after dithionite had been consumed. Resolubilization of As was prevented and additional As removal was obtained by frequent dosing of dithionite throughout the experiment. As（III） removal is attributed to photolysis of dithionite by UV light and production of reactive radicals that reduce As（III） and convert it to solid forms.

关键词： Arsenite Sodium dithionite Reductive precipitation and Ultraviolet light

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