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Occult hepatitis b virus infection among Egyptian blood donors

World Journal of Hepatology 2013年第2期5卷 64-73页

作者： Zeinab N Said manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah manal b azzab Heidi Goubran Amal bassili Gamal E Esmat Microbiology and Immunology Department Faculty of Medicine(for Girls)AlAzhar University11511 CairoEgypt Pediatric Department Hematology/Oncology DivisionFaculty of MedicineAin Shams University11511 CairoEgypt Community Medicine Department National Research Center12411 GizaEgypt Ain-Shams Maternity and Women's University Hospital 11511 CairoEgypt Community Enviromental and Occupational Medicine DepartmentFaculty of MedicineAin Shams University11511 CairoEgypt National blood Transfusion Center 11511 CairoEgypt Tb Surveillance officer STB/WHO/EMRO.Focal pointTropical Disease Research11511 CairoEgypt Tropical Medicine Department Faculty of Medicine-Cairo University11511 CairoEgypt

AIM:To identify blood donors with occult hepatitis b virus(HbV) infection(ObI) to promote safe blood ***:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis b surface antigen(HbsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus *** were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HbV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis b core(Anti-Hbc) Plus-bio-Rad] and(ARC-Hbc total-AbbOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis b surface(anti-Hbs)(ETI-Ab-AUK-3,Dia Sorin-Italy).Serum anti-Hbs titers > 10 IU/L was considered *** HbV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-Hbs and also for 32 whose anti-Hbs serum titers were > 1000 IU/***,265 recipients were included,34 of whom were followed up for 3-6 *** were investigated for ALT and AST,HbV serological markers:HbsAg(ETI-MAK-4,Dia Sorin-Italy),anti-Hbc,quantitative detection of anti-Hbs and ***:525/3167(16.6%) of blood units were positive for total anti-Hbc,64% of those were antiHbs *** by ARCHITECT anti-Hbc assay were carried out for 498/525 anti-Hbc positive samples,where 451(90.6%) confirmed *** for anti-Hbc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total *** DNA was quantified by real time PCR in 52/303(17.2%) of anti-Hbc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHbc was the only marker in 68.6% of *** and multivariate logistic analysis for identifying risk factors associated with anti-Hbc and HbV-DNA positivity a

关键词： Hepatitis b virus Total anti-Hbc Occult hepatitis b virus infection Hepatitis b surface antigen Hepatitis b virus-DNA

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