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Management of gastric and duodenal neuroendocrine tumors

World Journal of Gastroenterology 2016年第30期22卷 6817-6828页

作者： Yuichi Sato Satoru Hashimoto Ken-ichi Mizuno manabu takeuchi Shuji Terai Department of Gastroenterology Niigata University Graduate School of Medical and Dental Sciences Division of Endoscopy Niigata University Medical and Dental Hospital

Gastrointestinal neuroendocrine tumors (GI-NETs) are rare neoplasms, like all NETs. However, the incidence of GI-NETS has been increasing in recent years. Gastric NETs (G-NETs) and duodenal NETs (D-NETs) are the common types of upper GI-NETs based on tumor location. G-NETs are classified into three distinct subgroups: type I, II, and III. Type I G-NETs, which are the most common subtype (70%-80% of all G-NETs), are associated with chronic atrophic gastritis, including autoimmune gastritis and Helicobacter pylori associated atrophic gastritis. Type II G-NETs (5%-6%) are associated with multiple endocrine neoplasia type 1 and Zollinger-Ellison syndrome (MEN1-ZES). Both type I and II G-NETs are related to hypergastrinemia, are small in size, occur in multiple numbers, and are generally benign. In contrast, type III G-NETs (10%-15%) are not associated with hypergastrinemia, are large-sized single tumors, and are usually malignant. Therefore, surgical resection and chemotherapy are generally necessary for type III G-NETs, while endoscopic resection and follow-up, which are acceptable for the treatment of most type I and II G-NETs, are only acceptable for small and well differentiated type III G-NETs. D-NETs include gastrinomas (50%-60%), somatostatin-producing tumors (15%), nonfunctional serotonin-containing tumors (20%), poorly differentiated neuroendocrine carcinomas (< 3%), and gangliocytic paragangliomas (< 2%). Most D-NETs are located in the first or second part of the duodenum, with 20% occurring in the periampullary region. Therapy for D-NETs is based on tumor size, location, histological grade, stage, and tumor type. While endoscopic resection may be considered for small nonfunctional D-NETs (G1) located in the higher papilla region, surgical resection is necessary for most other D-NETs. However, there is no consensus regarding the ideal treatment of D-NETs.

关键词： Gastric neuroendocrine tumors Duodenal neuroendocrine tumors Classification Endoscopic treatment Endoscopic submucosal dissection

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Adhesion Force Measurements of Polymer Particles by Detachment Field Method

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仪器仪表学报 2004年第S3期 62-66页

作者： Masashi Nagayama ,Nobuyasu Sakurai,Tatsuaki Wada,manabu takeuchi Department of Electrical and Electronic Engineering Ibaraki University Hitachi 316-8511 Japan Department of Electrical and Electronic Engineering Ibaraki University Hitachi 316-8511 Japan Department of Electrical and Electronic Engineering Ibaraki University Hitachi 316-8511 Japan Department of Electrical and Electronic Engineering Ibaraki University Hitachi 316-8511 Japan

The adhesion force distributions of polymer particles to aluminum substrates were measured by the detachment field method. Polymer particles with conducting surface treatment were used for the measurements. Further the conventional detachment field method was modified to be applicable to the adhesion force measurements of a single particle. The adhesion force of the polymer particles increased with an increase in relative humidity. The surface roughness of the substrate influenced the adhesion forces of particles significantly. The influence of the CF4 plasma treatment of the polymer particles and thin layer coating of the substrate surface on the adhesion forces of the polymer particles was also studied, and factors affecting adhesion forces of polymer particles are discussed.

关键词： Toner Adhesion force van der Waals force

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Esophageal diverticulum: New perspectives in the era of minimally invasive endoscopic treatment

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World Journal of Gastroenterology 2019年第12期25卷 1457-1464页

作者： Hiroki Sato manabu takeuchi Satoru Hashimoto Ken-ichi Mizuno Koichi Furukawa Akito Sato Junji Yokoyama Shuji Terai Division of Gastroenterology Niigata University Medical and Dental Hospital Division of Gastroenterology Nagaoka Red Cross Hospital Division of Gastroenterology Niigata City General Hospital Division of Gastroenterology Nagaoka Chuo General Hospital

Esophageal diverticula are rare conditions that cause esophageal symptoms, such as dysphagia, regurgitation, and chest pain. They are classified according to their location and characteristic pathophysiology into three types: epiphrenic diverticulum, Zenker's diverticulum, and Rokitansky diverticulum. The former two disorders take the form of protrusions, and symptomatic cases require interventional treatment. However, the esophageal anatomy presents distinct challenges to surgical resection of the diverticulum, particularly when it is located closer to the oral orifice. Since the condition itself is not malignant,minimally invasive endoscopic approaches have been developed with a focus on alleviation of symptoms. Several types of endoscopic devices and techniques are currently employed, including peroral endoscopic myotomy(POEM). However,the use of minimally invasive endoscopic approaches, like POEM, has allowed the development of new disorder called iatrogenic esophageal diverticula. In this paper, we review the pathophysiology of each type of diverticulum and the current state-of-the-art treatment based on our experience.

关键词： Diverticulum Esophagus Epiphrenic diverticulum Zenker's diverticulum Rokitansky diverticulum Iatrogenic disease Esophageal achalasia Peroral endoscopic myotomy Diverticulectomy

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Case of severe alcoholic hepatitis treated with granulocytapheresis

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World Journal of Clinical Cases 2016年第11期4卷 369-374页

作者： Yukari Watanabe Kenya Kamimura Tomohiro Iwasaki Hiroyuki Abe Shunsaku Takahashi Ken-ichi Mizuno manabu takeuchi Atsushi Eino Ichiei Narita Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata University Japan Labor Health and Welfare Organization Tsubame Rosai Hospital Division of Clinical Nephrology and Rheumatology Graduate School of Medical and Dental SciencesNiigata University

Severe alcoholic hepatitis(AH) has a high mortality,and it is associated with encephalopathy,acute renal failure,sepsis,gastrointestinal bleeding,and *** 28-d mortality remains poor(34%-40%),because no effective treatment has been ***,corticosteroids(CS) have been considered effective for significantly improving the prognosis of those with AH,as it prevents the production of pro-inflammatory ***,CS are not always appropriate as an initial therapeutic option,such as in cases with an infection or resistance to *** describe a patient with severe AH complicated by a severe infection caused by the multidrug resistance bacteria(Pseudomonas aeruginosa),and was successfully treated with granulocytapheresis monotherapy without using *** experience of this case will provide understanding of the disease and information treating cases without using CS.

关键词： Apheresis Hepatitis Alcoholic Alcoholic hepatitis Case reports

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The deep-space multi-object orbit determination system and its application to Hayabusa2’s asteroid proximity operations

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Astrodynamics 2020年第4期4卷 377-392页

作者： Hiroshi takeuchi Kent Yoshikawa Yuto Takei Yusuke Oki Shota Kikuchi Hitoshi Ikeda Stefania Soldini Naoko Ogawa Yuya Mimasu Go Ono Fuyuto Terui Naoya Sakatani manabu Yamada Toru Kouyama Shingo Kameda Takanao Saiki Yuichi Tsuda Institute of Space and A stronautical Science Japan A erospace Exploration AgencySagamihara 252-5210Japan The Graduate University for Aduanced Studies Hayama 240-0193Japan Research and Development Directorate Japan Aerospace Exploration AgencySagamihara 252-5210Japan University of Liverpool Liverpool L693BXUK Chiba Institute of Technology Narashino 275-0016Japan National Institute of Aduanced Industrial Science and Technology Koto-ku 135-0064Japan Rikkyo University Toshima-ku 171-8501Japan

The deep-space multi-object orbit determination system(DMOODS)and its application in the asteroid proximity operation of the Hayabusa2 mission are *** was developed by the Japan Aerospace Exploration Agency(JAXA)for the primary purpose of determining the trajectory of deep-space spacecraft for JAXA’s planetary *** weighted least-squares batch filter is used for the orbit estimator of *** orbit estimator supports more than 10 data types,some of which are used for relative trajectory measurements between multiple space objects including natural satellites and small *** system consists of a set of computer programs running on Linux-based consumer PCs on the ground,which are used for orbit determination and the generation of radiometric tracking data,such as delta differential one-way ranging and doppler tracking *** the asteroid proximity phase of Hayabusa2,this system played an essential role in operations that had very strict navigation requirements or operations in which few optical data were obtained owing to special constraints on the spacecraft attitude or distance from the *** example is orbit determination during the solar conjunction phase,in which the navigation accuracy is degraded by the effect of the solar *** large range bias caused by the solar corona was accurately estimated with DMOODS by combining light detection and ranging(LIDAR)and ranging measurements in the superior solar conjunction phase of *** the orbiting operations of target markers and the MINERVA-II2 rover,the simultaneous estimation of six trajectories of four artificial objects and a natural object was made by *** type of simultaneous orbit determination of multi-artificial objects in deep-space has never been accomplished before.

关键词： orbit determination optical navigation gravity measurements superior solar conjunction delta differential one-way ranging(delta-DOR)

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Orbit insertion strategy of Hayabusa2’s rover with large release uncertainty around the asteroid Ryugu

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Astrodynamics 2020年第4期4卷 309-329页

作者： Yusuke Oki Kent Yoshikawa Hiroshi takeuchi Shota Kikuchi Hitosi Ikeda Daniel JScheeres Jay WMcMahon Junichiro Kawaguchi Yuto Takei Yuya Mimasu Naoko Ogawa Go Ono Fuyuto Terui manabu Yamada Toru Kouyama Shingo K ameda Kazuya Yoshida Kenji Nagaoka Tetsuo Yoshimitsu Takanao Saiki Yuichi Tsuda Japan A erospace Exploration Agency T'sukuba 305-8505Japan Japan Aerospace Exploration Agency Sagamihara 252-5210Japan University of Colorado BoulderCO 80309USA Planetary Exploration Research Center Chiba Institute of TechnologyNarashino 275-0016Japan National Institute of Aduanced Industrial Science and Technology Koto-ku 135-0064Japan Rikkyo University Toshima-ku 171-8501Japan Department of A erospace Engineering Tohoku UniversitySendai 980-8579Japan Kyushu Institute of Technology Kitakyusyu 804-8550Japan

This paper describes the orbit design of the deployable payload Rover 2 of MINERVA-II,installed on the Hayabusa2 *** Rover 2 did not have surface exploration capabilities,the operation team decided to experiment with a new strategy for its deployment to the *** rover was ejected at a high altitude and made a semi-hard landing on the surface of the asteroid Ryugu after several *** on the orbital analysis around Ryugu,the expected collision speed was tolerable for the rover to function *** the rover could not control its position,its motion was entirely governed by the initial ***,the largest challenge was to insert the rover into a stable orbit(despite its large release uncertainty),and avoid its escape from Ryugu due to an environment strongly perturbed by solar radiation pressure and gravitational *** study investigates the solution space of the orbit around Ryugu and evaluates the orbit’s robustness by utilizing Monte Carlo simulations to determine the orbit insertion *** analyzing the flight data of the rover operation,we verified that the rover orbited Ryugu for more than one period and established the possibility of a novel method for estimating the gravity of an asteroid.

关键词： solar radiation pressure augmented elliptic Hill three-body problem gravitational irregularity

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Neck neuromuscular treatment for depressive disorders with cervical muscular tension or chronic neck pain—A pilot study

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Open Journal of Psychiatry 2012年第1期2卷 61-67页

作者： Takayoshi Matsui Toshiro Fujimoto Yuzo Endo Syuntaro Hojo manabu Sakuda Syuji Kamano Kenichi Hirao Kayoko Matsumura Masaki Matsui Kouzou takeuchi Katsumi Nakamura 不详

BACKGROUND: An intimate relationship between depressive disorders and chronic pain is well known but often neglected. We studied patients with depressive disorders accompanying cervical muscular tension or neck pain. They also complaints of various physical, psychosomatic, and psychiatric signs such as anxiety and non-specific complaints related to autonomic imbalance. These complaints or symptoms are commonly resistant to pharmacological treatment, and thus we tried to treat these conditions by reducing their cervical muscular tension or pain. METHODS: We evaluated 30 complaints of 138 patients suffering from depressive disorders with cervical muscular abnormality (52 men and 86 women). The presence of the 30 complaints was evaluated as ‘positive’ or ‘negative’ before and during treatment. The necks of all patients were treated using low-frequency stimulation, micro-wave therapies, electric needle application, and acupuncture. RESULTS: Reducing cervical muscular tension remitted or cured the 30 complaints including depressive mood. The reduction of cervical muscle pain or tension initially ameliorated the depressive symptoms and anxiety, and subsequently improved their autonomic imbalances. Discriminant analysis of the first and second examinations correctly classified 95.3% of original grouped cases. CONCLUSION: Reducing cervical muscular tension is an effective treatment for patients suffering from depressive disorders with cervical neuromuscular pain or rigidity.

关键词： Depressive Disorders Autonomic Nerve Cervical Muscular Tension Neck Pain Anxiety

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Motion reconstruction of the small carry-on impactor aboard Hayabusa2

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Astrodynamics 2020年第4期4卷 289-308页

作者： Takanao Saiki Yuya Mimasu Yuto Takei manabu Yamada Hirotaka Sawada K azunori Ogawa Naoko Ogawa Hiroshi takeuchi Akira Miura Yuri Shimaki Koji Wada Rie Honda Yasuhiro Yokota Kei Shirai Naruhisa Sano Hirohito Ohtsuka Go Ono Kent Yoshikawa Shota Kikuchi Chikako Hirose Yukio Yamamoto Takahiro Iwata Masahiko Arakawa Seiji Sugita Satoshi Tanaka Fuyuto Terui Makoto Yoshikawa Satoru Nakazawa Sei-ichiro Watanabe Yuichi Tsuda Japan Aerospace Exploration Agency Sagamihara 252-5210Japan Chiba Institute of Technology Narashino 275-0016Japan Kobe University K obe 657-8501Japan The Graduate University for Aduanced Studies Sagamihara 252-5210Japan Kochi University Kochi 780-8520Japan IHI Aerospace Co. LtdTomioka 370-2398Japan The University of Tokyo Tokyo 113-0033Japan Nagoya University Nagoya 464-8601Japan

Subsurface exploration is one of the most ambitious scientific objectives of the Hayabusa2 mission.A small device called small carry-on impactor(SCI)was developed to create an artificial crater on the surface of asteroid *** enables us to sample subsurface materials,which will provide a window to the *** physical properties of the resulting crater are also useful for understanding the internal structure of *** understanding of the crater and ejecta properties,including the depth of excavation of subsurface materials,requires accurate information on impact *** particular,the impact angle is a critical factor because it greatly influences the size and shape of the *** April 5,2019,the Hayabusa2 spacecraft deployed the SCI at 500 m of altitude above the asteroid *** SCI gradually reduced its altitude,and it shot a 2 kg copper projectile into the asteroid 40 min after *** the position of the released SCI is essential for determining the impact *** study describes the motion reconstruction of the SCI based on the actual operation *** results indicate that the SCI was released with high accuracy.

关键词： small body exploration Hayabusa2 kinetic impact artificial crater motion reconstruction

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Correction to: Orbit insertion strategy of Hayabusa2’s rover with large release uncertainty around the asteroid Ryugu

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Astrodynamics 2021年第2期5卷 183-183页

作者： Yusuke Oki Kent Yoshikawa Hiroshi takeuchi Shota Kikuchi Hitosi Ikeda Daniel J.Scheeres Jay W.McMahon Junichiro Kawaguchi Yuto Takei Yuya Mimasu Naoko Ogawa Go Ono Fuyuto Terui manabu Yamada Toru Kouyama Shingo Kameda Kazuya Yoshida Kenji Nagaoka Tetsuo Yoshimitsu Takanao Saiki Yuichi Tsuda Japan Aerospace Exploration Agency Tsukuba305-8505Japan Japan Aerospace Exploration Agency Sagamihara252-5210Japan University of Colorado BoulderCO80309USA Planetary Exploration Research Center Chiba Institute of TechnologyNarashino275-0016Japan National Institute of Advanced Industrial Science and Technology Koto-ku135-0064Japan Rikkyo University Toshima-ku171-8501Japan Department of Aerospace Engineering Tohoku UniversitySendai980-8579Japan Kyushu Institute of Technology Kitakyusyu804-8550Japan

Correction to:Oki,Y.,Yoshikawa,K.,takeuchi,*** *** insertion strategy of Hayabusa2's rover with large release uncertainty around the asteroid *** 2020,4(4):309-329 https://***/10.1007/s42064-020-0080-y The article“Orbit insertion strategy of Hayabusa2’s rover with large release uncertainty around the asteroid Ryugu”written by Yusuke Oki,Kent Yoshikawa,Hiroshi takeuchi et al.,was originally published electronically on the publisher’s internet portal(currently SpringerLink)on 05 November 2020 without open *** publication in Volume 4,Issue 4,page 309–329,the author(s)decided to opt for Open Choice and to make the article an open access publication.

关键词： asteroid insertion release

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