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Endocytoscopic visualization of squamous cell islands within Barrett's epithelium

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World Journal of Gastrointestinal Endoscopy 2013年第4期5卷 174-179页

作者： Nicholas Eleftheriadis Haruhiro Inoue Haruo Ikeda manabu Onimaru Akira Yoshida Toshihisa Hosoya Roberta Maselli Shin-ei Kudo Digestive Disease Center Showa University Northern Yokohama Hospital

AIM: To study the endocytoscopic visualization of squamous cell islands within Barrett's epithelium. METHODS: Endocytoscopy (ECS) has been studied in the surveillance of Barrett's esophagus, with controversial results. In initial studies, however, a soft catheter type endocytoscope was used, while only methylene blue dye was used for the staining of Barrett's mucosa. Integrated type endocytoscopes (GIF-Q260 EC, Olympus Corp, Tokyo, Japan) have been recently developed, with the incorporation of a high-power magnifying endocytoscope into a standard endoscope together with narrow-band imaging (NBI). Moreover, double staining with a mixture of 0.05% crystal violet and 0.1% of methylene blue (CM) during ECS enables higher quality images comparable to conventional hematoxylin eosin histopathological ***: In vivo endocytoscopic visualization of papillary squamous cell islands within glandular Barrett's epithelium in a patient with long-segment Barrett's esophagus is reported. Conventional white light endoscopy showed typical long-segment Barrett's esophagus, with small squamous cell islands within normal Barrett's mucosa, which were better visualized by NBI endoscopy. ECS after double CM staining showed regular Barrett's esophagus, while higher magnification (×480) revealed the orifices of glandular structures better. Furthermore, typical squamous cell papillary protrusion, classified as endocytoscopic atypia classification (ECA) 2 according to ECA, was identified within regular glandular Barrett's mucosa. Histological examination of biopsies taken from the same area showed squamous epithelium within glandular Barrett's mucosa, corresponding well to endocytoscopic findings. CONCLUSION: To our knowledge, this is the first report of in vivo visualization of esophageal papillary squamous cell islands surrounded by glandular Barrett's epithelium.

关键词： Endocytoscopy Barrett’s esophagus Surveillance Endocytoscopic atypia classification Crystal violet Methylene blue Hematoxylin eosin stain

基于传统煎药工艺的蒲公英饮片标准汤剂制备及质量评价方法研究

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中华中医药学刊 2020年第9期38卷 249-254页

作者：孙博李西文朱广伟张鹏李琦杉田亨友田健久万林春中国中医科学院中药研究所北京100700 哈尔滨商业大学黑龙江哈尔滨150076 上海市药材有限公司上海200002 日本国株式会社津村东京107-8521 江西省药品检验检测研究院江西南昌330029

目的建立不同产地13批次蒲公英饮片标准汤剂质量评价方法,并以出膏率、指标成分量及转移率、指纹图谱为指征进行研究。方法以水为溶剂,参照传统煎药工艺制备标准汤剂,采用UPLC-DAD法测定咖啡酸量,计算转移率、出膏率,采用UPLC-ESI-MS/M... 详细信息

目的建立不同产地13批次蒲公英饮片标准汤剂质量评价方法,并以出膏率、指标成分量及转移率、指纹图谱为指征进行研究。方法以水为溶剂,参照传统煎药工艺制备标准汤剂,采用UPLC-DAD法测定咖啡酸量,计算转移率、出膏率,采用UPLC-ESI-MS/MS法进行指纹图谱研究并确认共有峰。结果13批蒲公英样品制成的标准汤剂中咖啡酸含量为1.9~11.34μg/mL,咖啡酸转移率在4.78%~29.29%,平均转移率为10.65%,标准偏差(RE)为7.06%。出膏率为17.68%~34.25%,平均出膏率为23.36%,标准偏差(RE)为4.99%。指纹图谱共有峰11个,确认6个,分别为绿原酸、咖啡酸、菊苣酸、金丝桃苷、单咖啡酰酒石酸、木犀草苷。结论13批次蒲公英饮片标准汤剂制备工艺符合传统汤剂制法,样品来源具有代表性,样品批次符合指纹图谱研究要求,质量评价内容涵盖面广,所得数据具有代表性,可用于蒲公英饮片标准汤剂的制备及质量评价,可以为配方颗粒标准的制定及工业化生产提供基础数据支撑。

关键词：蒲公英标准汤剂配方颗粒指纹图谱 UPLC-ESI-MS/MS

基于最大可传递转矩估计的主动稳定性控制(英文)

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汽车安全与节能学报 2011年第1期2卷 34-38页

作者：殷德军大前学清水浩堀洋一庆应义塾大学政策与传媒研究科东京大学工学系研究科

直接横摆力矩控制(DYC)可增强车辆二维运动的稳定性。该文建立了一个两轮的车辆模型作为控制参考模型,以便提高对电动汽车轮毂电机的二维运动控制的稳定性和实用性。基于最大可传递转矩估计(MTTE)的牵引力控制,可用于抑制打滑现象以增... 详细信息

直接横摆力矩控制(DYC)可增强车辆二维运动的稳定性。该文建立了一个两轮的车辆模型作为控制参考模型,以便提高对电动汽车轮毂电机的二维运动控制的稳定性和实用性。基于最大可传递转矩估计(MTTE)的牵引力控制,可用于抑制打滑现象以增强纵向和横向摩擦力,并可提供关于轮胎与路面间的额外信息。提出了一种新的基于MTTE的DYC策略。经过完整控制系统的MTTE增强型DYC与常规DYC的数值仿真对比,结果验证了这种控制策略的优越性。

关键词：电动汽车直接横摆力矩控制(DYC) 最大可传递转矩估计(MTTE) 稳定性控制轮毂电机

Detection of active bleeding from gastric antral vascular ectasia by capsule endoscopy

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World Journal of Gastrointestinal Endoscopy 2013年第3期5卷 138-140页

作者： Tetsuya Ohira Akira Hokama Nagisa Kinjo manabu Nakamoto Chiharu Kobashigawa Yuya Kise Satoshi Yamashiro Fukunori Kinjo Yukio Kuniyoshi Jiro Fujita Department of Endoscopy University Hospital of the RyukyusOkinawa 903-0125Japan Department of Infectious Respiratory and Digestive MedicineGraduate School of MedicineUniversity of the RyukyusOkinawa 903-0125Japan Division of Thoracic and Cardiovascular Surgery Graduate School of MedicineUniversity of the RyukyusOkinawa 903-0125Japan

Gastric antral vascular ectasia(GAVE) has been recognized as one of the important causes of occult and obscure gastrointestinal *** diagnosis is typically made based on the characteristic endoscopic features,including longitudinal row of flat,reddish stripes radiating from the pylorus into the antrum that resemble the stripes on a *** appearances,however,can easily be misinterpreted as moderate to severe *** it is believed that capsule endoscopy(CE) is not helpful for the study of the stomach with its large lumen,GAVE can be more likely to be detected at CE rather than conventional *** can be regarded as "physiologic" endoscopy,without the need for gastric inflation and subsequent compression of the *** blood flow of the ecstatic vessels may be diminished in an inflated ***,GAVE may be prominent in *** herein describe a case of active bleeding from GAVE detected by CE and would like to emphasize a possibility that CE can improve diagnostic yields for GAVE.

关键词： Gastrointestinal bleeding Gastrointestinal endoscopy Capsule endoscopy Gastric antral vascular ectasia Argon plasma coagulation

Mesenteric paraganglioma: Report of a case

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World Journal of Gastrointestinal Surgery 2013年第3期5卷 62-67页

作者： Takeshi Fujita Kinji Kamiya Yoshiaki Takahashi Shinichiro Miyazaki Ichirota Iino Hirotoshi Kikuchi Yoshihiro Hiramatsu manabu Ohta Satoshi Baba Hiroyuki Konno Second Department of Surgery Hamamatsu University School of Medicine Department of Diagnostic Pathology Hamamatsu University School of Medicine

We report a rare case of paraganglioma that developed in the mesentery of terminal ileum. A 78-year-old woman complained of right-sided abdominal pain. Abdominal computed tomography revealed a solid heterogeneously enhanced mass in the right lower abdomen. The tumor was laparoscopically excised. The mesenteric tumor was well circumscribed, ovoid, and encapsulated and measured 3 cm × 1.5 cm × 1.5 cm. Histological examination showed a cellular neoplasm comprised of nests and groups of tumor cells separated by fibrovascular connective tissue, giving a characteristic nested Zellballen pattern. Immunohistochemically, the tumor cells were positive for chromogranin, synaptophysin, CD56, and vimentin and negative for cytokeratins, SMA, CD34, CD117/c-kit and S100. On the basis of histologic and immunohistochemical features, a diagnosis of mesenteric paraganglioma was made. The operative and postoperative courses were unremarkable, and the patient was discharged on postoperative day 7. She was doing well 1 year after the surgery with no signs of recurrence. Extra-adrenal paragangliomas most commonly develop adjacent to the aorta, particularly the area corresponding to the organ of Zuckerkandl. Mesenteric paraganglioma, as in our case, is extremely rare; only 11 cases have been reported in the literature. We herein discuss the clinical findings of these cases.

关键词： Mesenteric tumor Extra-adrenal paraganglioma Pheochromocytoma Surgical management Preoperative diagnosis

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赤芍饮片标准汤剂制备及质量标准研究

世界科学技术-中医药现代化 2016年第12期18卷 2062-2069页

作者：朱广伟李西文邬兰杉田享友田健久李琦中国中医科学院中药研究所北京100700 日本国株式会社津村东京107-8521 上海市药材有限公司上海200002

目的:制备赤芍饮片标准汤剂,并进行质量标准研究。方法:以水为溶剂,标准化工艺制备标准汤剂,采用UPLC-DAD法测定芍药苷含量,并进行转移率、出膏率计算及指纹图谱研究。结果:15批次赤芍样品制成的标准汤剂中芍药苷含量范围为3.79-5.68 mg... 详细信息

目的:制备赤芍饮片标准汤剂,并进行质量标准研究。方法:以水为溶剂,标准化工艺制备标准汤剂,采用UPLC-DAD法测定芍药苷含量,并进行转移率、出膏率计算及指纹图谱研究。结果:15批次赤芍样品制成的标准汤剂中芍药苷含量范围为3.79-5.68 mg·m L^(-1),芍药苷转移率范围为56.58%-90.14%,平均转移率为73.97%,标准偏差为10.91%。出膏率范围为16.74%-29.24%,平均出膏率为21.82%,标准偏差为3.55%。指纹图谱共有峰11个,确认4个,分别是:氧化芍药苷(RT=4.489),芍药内酯苷(RT=7.752),芍药苷(RT=8.192),苯甲酰芍药苷(RT=26.212)。结论:本研究中的样品处理方法简单易行、重复性好,可用于赤芍标准汤剂的制备及质量标准研究。

关键词：赤芍标准汤剂标准煎液配方颗粒指纹图谱

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慢性光化性皮炎与成人T细胞白血病

世界核心医学期刊文摘（皮肤病学分册） 2005年第6期1卷 16-16页

作者： sugita K. Shimauchi T. Tokura Y. 冯义国 Dr.Depart-ment of Dermatology School of Medicine Univ.Occup. Environ.Hlth.Japan 1-1 Iseigaoka Yahatanishi-ku Kitakyushu 807- 8555 Japan

We describe a patient with chronic actinic dermatitis that occurred with the progress of adult T-cell leukemia. Immunohistochemically, CD8+ T cells, but not CD4+ cells, predominantly infiltrated the lichenoid lesional skin, indicating that the eruption was induced by reactive, normal CD8+ T cells but not adult T-cell leukemia cells. Our patient suggests that chronic actinic dermatitis may occur in association with the advanced human T-lymphotrophic virus- I infectious disorder.

关键词：慢性光化性皮炎白血病细胞反应性增生免疫组织化学

Neck neuromuscular treatment for depressive disorders with cervical muscular tension or chronic neck pain—A pilot study

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应用多排探测器的螺旋CT动脉双期扫描检出富血供的肝细胞癌

Open Journal of Psychiatry（精神病学期刊） 2012年第1期

作者： Takayoshi Matsui Toshiro Fujimoto Yuzo Endo Syuntaro Hojo manabu Sakuda Syuji Kamano Kenichi Hirao Kayoko Matsumura Masaki Matsui Kouzou Takeuchi Katsumi Nakamura

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放射学实践 2001年第6期16卷 359-359页

作者： Takamichi Murakami Tonsok Kim manabu Takamura 张淑倩河北省人民医院医学影像中心

目的:评价应用多排探测器螺旋CT的动脉双期扫描技术能否提高对富血供肝细胞癌(HCC)的检出率.方法:作者对共有96个HCC病灶的51例患者进行全肝的对比剂增强动脉双期成像.以5ml/s的流量静脉内注射对比剂约2ml/kg体重.

关键词：富血供肝细胞癌 HCC 多排探测器螺旋CT 动脉双期成像诊断