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World Journal of Gastroenterology 2007年第2期13卷 280-284页

作者： Hidenari Nagai Masahiro Kanayama Katsuya Higami Kouichi Momiyama Akiko Ikoma Naoki Okano Katsuhiko Matsumaru manabu Watanabe Koji Ishii Yasukiyo Sumino Kazumasa Miki Division of Gastroenterology and Hepatology Toho University Medical Center Omori Hospital 6-11-1 Omorinishi Ota-ku Tokyo 143-8541 Japan

AIM: To evaluate the time dependence of intra-arterial 5-fluorouracil (5-FU) therapy for advanced hepatocellular carcinoma (aHCC). METHODS: Thirty-seven adult Japanese patients who had aHCC and liver cirrhosis were treated with combined intra-arterial 5-FU, cisplatin (CDDP), and leucovorin (LV). The Japan Integrated Staging score (JIS score) of each patient was 3 or more. The patients were divided into two groups, after which the 15 patients in group S were treated with 6-h infusion chemotherapy (LV at 12 mg/h, CDDP at 10 mg/h, and 5-FU at 250 mg/m2 per 4 h) and the 22 patients in group L were treated with 24-h infusion chemotherapy (LV at 12 mg/h, CDDP at 10 mg/h, and 5-FU at 250 mg/m2 per 22 h). Continuous infusion chemotherapy was performed via the proper hepatic artery every 5 d for 4 wk using an implanted drug reservoir. RESULTS: The percentages of patients with a partial response after 4 wk of chemotherapy were 6.7% in group S and 31.8% in group L. The survival of group L was significantly better than that of group S, with the median survival time being 496 d in group L and 226 d in group S (P < 0.05). CONCLUSION: Continuous 24-h intra-arterial infusion is more effective for aHCC and can markedly prolong survival time as compared to 6-h infusion.

关键词：肝癌化学治疗肿瘤亚叶酸氟尿嘧啶抗癌药

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不断向前的美丽女神

国际服装技术 2006年第3期 108-111页

作者： Tomoko Sazuki Gokon（翻译） manabu Mizuta（neat）（摄影）

以动人心魄的美丽气质迷倒众人的长谷川京子小姐。最近，肢体愈发柔美，难道是因为衣服的原因？就让我们近距离接触一下越来越有女人味的长谷川小姐！

关键词：美丽近距离女人

Microvasculature of the esophagus and gastroesophageal junction: Lesson learned from submucosal endoscopy

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World Journal of Gastrointestinal Endoscopy 2016年第19期8卷 690-696页

作者： Roberta Maselli Haruhiro Inoue Haruo Ikeda manabu Onimaru Akira Yoshida Esperanza Grace Santi Hiroki Sato Bu'Hussain Hayee Shin-Ei Kudo Digestive Disease Center Showa University Northern Yokohama Hospital Department of "Paride Stefanini" Surgical Umberto I° General HospitalSapienza University of Rome King's College Hospital NHSFT

Advanced therapeutic endoscopy,in particular endoscopic mucosal resection,endoscopic submucosal dissection,per-oral endoscopic myotomy,submucosal endoscopic tumor resection opened a new era where direct esophageal visualization is *** these information with advanced diagnostic endoscopy,the esophagus is organized,from the luminal side to outside,into five layers(epithelium,lamina propria with lamina muscularis mucosa,submucosa,muscle layer,adventitia).A specific vascular system belonging to each layer is thus visible: Mucosa with the intra papillary capillary loop in the epithelium and the sub-epithelial capillary network in the lamina propria and,at the lower esophageal sphincter(LES) level with the palisade vessels; submucosa with the drainage vessels and the spindle veins at LES level; muscle layer with the perforating vessels; periesophageal veins in *** structures are particularly important to define endoscopic landmark for the gastro-esophageal junction,helpful in performing submucosal therapeutic endoscopy.

关键词：微脉管系统食道的解剖 Submucosal 内视镜检查法每口头的内视镜的肌切开术先进成像

Hepatitis C virus G1b infection decreases the number of small low-density lipoprotein particles

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World Journal of Gastroenterology 2016年第29期22卷 6716-6725页

作者： Chika Kinoshita Tomohisa Nagano Nobuyoshi Seki Yoichi Tomita Tomonori sugita Yuta Aida Munenori Itagaki Kenichi Satoh Satoshi Sutoh Hiroshi Abe Akihito Tsubota Yoshio Aizawa Department of Gastroenterology and Hepatology Internal Medicine of Jikei University Katsushika Medical Center Tokyo 125-8506 Japan Core Research Facilities for Basic Science Research Center for Medical Science Jikei University School of Medicine Tokyo 105-8461 Japan

AIM: To investigate how hepatitis C virus(HCV) G1 b infection influences the particle number of ***: The numbers of lipoprotein particles in fasting sera from 173 Japanese subjects, 82 with active HCV G1 b infection(active HCV group) and 91 with cleared HCV infection(SVR group), were examined. Serum lipoprotein was fractionated by high-performance liquid chromatography into twenty fractions. The cholesterol and triglyceride concentrations in each fraction were measured using Lipo SEARCH. The number of lipoprotein particles in each fraction was calculated using a newly developed algorithm, and the relationship between chronic HCV G1 b infection and the lipoprotein particle number was determined by multiple linear regression ***: The median number of low-density lipoprotein(LDL) particles was significantly lower in the active HCV group [1182 nmol/L, interquartile range(IQR): 444 nmol/L] than in the SVR group(1363 nmol/L, IQR: 472 nmol/L, P < 0.001), as was that of highdensity lipoprotein(HDL) particles(14168 nmol/L vs 15054 nmol/L, IQR: 4114 nmol/L vs 3385 nmol/L, P = 0.042). The number of very low-density lipoprotein(VLDL) particles was similar between the two groups. Among the four LDL sub-fractions, the number of large LDL particles was similar between the two groups. However, the numbers of medium(median: 533.0 nmol/L, IQR: 214.7 nmol/L vs median: 633.5 nmol/L, IQR: 229.6 nmol/L, P < 0.001), small(median: 190.9 nmol/L, IQR: 152.4 nmol/L vs median: 263.2 nmol/L, IQR: 159.9 nmol/L; P < 0.001), and very small LDL particles(median: 103.5 nmol/L, IQR: 66.8 nmol/L vs median: 139.3 nmol/L, IQR: 67.3 nmol/L, P < 0.001) were significantly lower in the active HCV group than in the SVR group, respectively. Multiple linear regression analysis indicated an association between HCV G1 b infection and the decreased numbers of medium, small, and very small LDL particles. However, active HCV infection did not affect the number of large LDL particles or

关键词： Chronic hepatitis C Lipoprotein particles Low-density lipoproteins Very low-density lipoproteins Tri

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民族艺术的系谱

内蒙古艺术学院学报 2022年第1期19卷 46-50页

作者： [日本]杉田繁治王天歌(译) 张思宇(校) 日本国立民俗学博物馆日本大阪市565-85112 中国艺术研究院北京100029 日本关西学院大学日本兵库县662-8501

一、民族艺术中所见的核心--技术与冗长度就像对“文化”概念的判断一样,“艺术”一词也经常被模糊地使用,它在未来会成为难以理解内容的代表吗?更进一步讲,如果说“民族学”的同义词是“文化人类学”的话,那么“民族艺术”便是“文化... 详细信息

一、民族艺术中所见的核心--技术与冗长度就像对“文化”概念的判断一样,“艺术”一词也经常被模糊地使用,它在未来会成为难以理解内容的代表吗?更进一步讲,如果说“民族学”的同义词是“文化人类学”的话,那么“民族艺术”便是“文化”和“艺术”这两个暧昧概念的结合。这可能会让“民族艺术”的概念越来越复杂,甚至会让人觉得这是一个莫名其妙的研究对象。一般而言,从事美术和工艺领域相关工作的人在日常生活中存在甚广,但像“艺术”这样指向性非常明确的词汇出现在日常生活中时,这种概念在日常生活中被无限制地使用真的可以吗?

关键词：民族艺术学冗长度意外性人工度

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全球化与哲学的可能性

浙江树人大学学报（人文社会科学版） 2007年第1期7卷 60-63页

作者：杉田正树关东学院大学

笔者认为哲学必须要“解决时代提出的问题”,“阐明事物的本质”,哲学具有完成这一任务的“可能性”。在全球化时代,哲学尤其要解决由“市场竞争”导致的精神问题以及其它全球性问题。现代已经成为最需要哲学的时代。

关键词：哲学事物本质贫困精神

Effects of Povidone-Iodine or Ethanol Exposure on Bone Formation at the Osteotomy Site of the Proximal Tibia in Rats

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Open Journal of Orthopedics 2019年第12期9卷 265-272页

作者： Itsuki Nagahata Naohisa Miyakoshi Yuji Kasukawa Hiroyuki Tsuchie Yusuke Yuasa manabu Akagawa Yuichi Ono Chiaki Sato Koji Nozaka Michio Hongo Yoichi Shimada Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan

Background: Povidone-iodine (PVI) irrigation is currently used to decrease the frequency of postoperative surgical site infections. Ethanol (EtOH) is sometimes applied to prevent local recurrence after curettage of benign bone tumors. However, the effects of PVI and EtOH on surrounding soft tissue and on bone union are unclear. The purpose of this study was to determine whether PVI or EtOH adversely affects the cancellous bone healing of the osteotomy site at the proximal tibia in rats. Methods: A cancellous bone osteotomy was performed at the right proximal tibia in 4-month-old, female, Sprague Dawley rats. Vehicle, 10% PVI, or 95% EtOH-soaked gauze was inserted into the osteotomy site and maintained for 6 minutes. The rats were euthanized 2 or 4 weeks after the osteotomy. Results: Two weeks after treatment, the bone union rate was significantly higher in the vehicle group than in the PVI group and the EtOH group (p < 0.001). However, the bone union rate was not significantly different between the PVI and EtOH groups. There was no significant difference among the three groups in the bone union rate 4 weeks after treatment. Conclusion: PVI or EtOH delayed bone union of the cancellous bone osteotomy site of the proximal tibia in the early phase (2 weeks), but not at 4 weeks, in rats.

关键词： Cancellous Bone Union Povidone-Iodine Ethanol

Neck neuromuscular treatment for depressive disorders with cervical muscular tension or chronic neck pain—A pilot study

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Open Journal of Psychiatry 2012年第1期2卷 61-67页

作者： Takayoshi Matsui Toshiro Fujimoto Yuzo Endo Syuntaro Hojo manabu Sakuda Syuji Kamano Kenichi Hirao Kayoko Matsumura Masaki Matsui Kouzou Takeuchi Katsumi Nakamura 不详

BACKGROUND: An intimate relationship between depressive disorders and chronic pain is well known but often neglected. We studied patients with depressive disorders accompanying cervical muscular tension or neck pain. They also complaints of various physical, psychosomatic, and psychiatric signs such as anxiety and non-specific complaints related to autonomic imbalance. These complaints or symptoms are commonly resistant to pharmacological treatment, and thus we tried to treat these conditions by reducing their cervical muscular tension or pain. METHODS: We evaluated 30 complaints of 138 patients suffering from depressive disorders with cervical muscular abnormality (52 men and 86 women). The presence of the 30 complaints was evaluated as ‘positive’ or ‘negative’ before and during treatment. The necks of all patients were treated using low-frequency stimulation, micro-wave therapies, electric needle application, and acupuncture. RESULTS: Reducing cervical muscular tension remitted or cured the 30 complaints including depressive mood. The reduction of cervical muscle pain or tension initially ameliorated the depressive symptoms and anxiety, and subsequently improved their autonomic imbalances. Discriminant analysis of the first and second examinations correctly classified 95.3% of original grouped cases. CONCLUSION: Reducing cervical muscular tension is an effective treatment for patients suffering from depressive disorders with cervical neuromuscular pain or rigidity.

关键词： Depressive Disorders Autonomic Nerve Cervical Muscular Tension Neck Pain Anxiety

Nodular fasciitis in the mesentery, a differential diagnosis of peritoneal carcinomatosis

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World Journal of Gastroenterology 2014年第5期20卷 1361-1364页

作者： Mai Shiga Ken Okamoto manabu Matsumoto Hiromichi Maeda Ken Dabanaka Tsutomu Namikawa Sunao Uemura Masaya Munekage Michiya Kobayashi Kazuhiro Hanazaki Department of Surgery Kochi Medical School Cancer Treatment Center Kochi Medical School Laboratory of Diagnostic Pathology Kochi Medical School Hospital

Nodular fasciitis is a benign proliferative lesion composed of fibroblast-like cells that affects various sites in the *** describe a patient with nodular fasciitis in the mesentery,encountered during laparotomy for the treatment of ascending colon *** nodular fasciitis in our patient resembled peritoneal dissemination of malignancy on macroscopic *** the treatment options change with concomitant peritoneal dissemination of gastrointestinal tract malignancy,recognition of this rare condition and preparation for unexpected nodular lesions are crucial.

关键词： Colon cancer Digestive system cancer Laparoscopic