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Swimmer with submerged SiO_(2)/Al/LiNbO_(3) surface acoustic wave propulsion system

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Biomimetic Intelligence & Robotics 2024年第2期4卷 71-77页

作者： Deqing Kong Ryo Tanimura Fang Wang Kailiang Zhang Minoru Kuribayashi Kurosawa manabu Aoyagi Department of Engineering Muroran Institute of TechnologyMuroran 050-8585Japan Tianjin Key Laboratory of Film Electronic and Communication Devices School of Integrated Circuit Science and EngineeringTianjin University of TechnologyTianjin 300384China School of Engineering Tokyo Institute of TechnologyYokohama 226-8501Japan

Acoustic propulsion system presents a novel underwater propulsion approach in small scale *** study introduces a submerged surface acoustic wave(SAW)propulsion system based on the SiO_(2)/Al/LiNbO_(3) *** 19.25 MHz,the SAW propulsion system is proposed and investigated by the propulsion force calculation,PIV measurements and propulsion measurements.3.3 mN propulsion force is measured at 27.6 V_(pp).To evaluate the miniature swimmer,the SAW propulsion systems with multiple frequencies are *** 2.2 W,the submerged SAW propulsion system at 38.45 MHz demonstrates 0.83 mN/mm^(2) propulsion *** 96.13 MHz and 24 V_(pp),the movements of miniature swimmer with a fully submerged SAW propulsion system are recorded and analyzed to a maximum of 177 mm/*** of miniaturization,high power density,and simple structure,the SAW propulsion system can be expected for some microrobot applications,such as underwater drone,pipelinerobotand intravascularrobot.

关键词： Acoustofluidics Surface acoustic wave Swimmer Underwater propulsion system

Neck neuromuscular treatment for depressive disorders with cervical muscular tension or chronic neck pain—A pilot study

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Open Journal of Psychiatry 2012年第1期2卷 61-67页

作者： Takayoshi Matsui Toshiro Fujimoto Yuzo Endo Syuntaro Hojo manabu sakuda Syuji Kamano Kenichi Hirao Kayoko Matsumura Masaki Matsui Kouzou Takeuchi Katsumi Nakamura 不详

BACKGROUND: An intimate relationship between depressive disorders and chronic pain is well known but often neglected. We studied patients with depressive disorders accompanying cervical muscular tension or neck pain. They also complaints of various physical, psychosomatic, and psychiatric signs such as anxiety and non-specific complaints related to autonomic imbalance. These complaints or symptoms are commonly resistant to pharmacological treatment, and thus we tried to treat these conditions by reducing their cervical muscular tension or pain. METHODS: We evaluated 30 complaints of 138 patients suffering from depressive disorders with cervical muscular abnormality (52 men and 86 women). The presence of the 30 complaints was evaluated as ‘positive’ or ‘negative’ before and during treatment. The necks of all patients were treated using low-frequency stimulation, micro-wave therapies, electric needle application, and acupuncture. RESULTS: Reducing cervical muscular tension remitted or cured the 30 complaints including depressive mood. The reduction of cervical muscle pain or tension initially ameliorated the depressive symptoms and anxiety, and subsequently improved their autonomic imbalances. Discriminant analysis of the first and second examinations correctly classified 95.3% of original grouped cases. CONCLUSION: Reducing cervical muscular tension is an effective treatment for patients suffering from depressive disorders with cervical neuromuscular pain or rigidity.

关键词： Depressive Disorders Autonomic Nerve Cervical Muscular Tension Neck Pain Anxiety

Current perspectives of viral

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World Journal of Gastroenterology 2024年第18期30卷 2402-2417页

作者： Daisuke Usuda Yuki Kaneoka Rikuo Ono Masashi Kato Yuto Sugawara Runa Shimizu Tomotari Inami Eri Nakajima Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Shintaro Shimozawa Yuta Hotchi Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima 177-8521TokyoJapan Department of Sports Medicine Faculty of MedicineJuntendo UniversityBunkyo 113-8421TokyoJapan

Viral hepatitis represents a major danger to public health,and is a globally leading cause of *** five liver-specific viruses:Hepatitis A virus,hepatitis B virus,hepatitis C virus,hepatitis D virus,and hepatitis E virus,each have their own unique epidemiology,structural biology,transmission,endemic patterns,risk of liver complications,and response to antiviral *** remain few options for treatment,in spite of the increasing prevalence of viral-hepatitiscaused liver ***,chronic viral hepatitis is a leading worldwide cause of both liver-related morbidity and mortality,even though effective treatments are available that could reduce or prevent most patients’*** 2016,the World Health Organization released its plan to eliminate viral hepatitis as a public health threat by the year 2030,along with a discussion of current gaps and prospects for both regional and global eradication of viral ***,treatment is sufficiently able to prevent the disease from reaching advanced ***,future therapies must be extremely safe,and should ideally limit the period of treatment necessary.A better understanding of pathogenesis will prove beneficial in the development of potential treatment strategies targeting infections by viral *** review aims to summarize the current state of knowledge on each type of viral hepatitis,together with major innovations.

关键词： Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus Current perspectives

Goblet cell carcinoid of the appendix:Six case reports

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World Journal of Clinical Cases 2024年第22期12卷 5217-5224页

作者： Toshiaki Toshima Ryo Inada Shinya Sakamoto Eri Takeda Takahiro Yoshioka Kento Kumon Naoki Mimura Nobuo Takata Motoyasu Tabuchi Kazuyuki Oishi Takuji Sato Kenta Sui Takehiro Okabayashi Kazuhide Ozaki Toshio Nakamura Yuichi Shibuya manabu Matsumoto Jun Iwata Department of Gastroenterological Surgery Kochi Health Sciences CenterKochi 781-8555Japan Department of Diagnostic Pathology Kochi Health Sciences CenterKochi 781-8555Japan

BACKGROUND Goblet cell carcinoid(GCC)of the appendix is a rare tumor characterized by neuroendocrine and adenocarcinoma *** preoperative diagnosis is very difficult,with most patients complaining mainly of abdominal *** tomography shows swelling of the appendix,so diagnosis is usually made incidentally after appendectomy based on a preoperative diagnosis of *** if a patient undergoes preoperative colonoscopy,accurate endoscopic diagnosis is very difficult because GCC shows a submucosal growth pattern with invasion of the appendiceal *** SUMMARY Between 2017 and 2022,6 patients with GCC were treated in our *** presenting complaint for 5 of these 6 patients was abdominal *** 5 patients underwent appendectomy,including 4 for a preoperative diagnosis of appendicitis and the other for diagnosis and treatment of an appendiceal *** sixth patient presented with vomiting and underwent ileocecal resection for GCC diagnosed from preoperative *** 2 patients with GCC underwent colonoscopy,no neoplastic changes were *** of the six patients showed lymph node metastasis on pathological *** of the last followup(median:15 mo),all cases remained alive without *** As preoperative diagnosis of GCC is difficult,this possibility must be considered during surgical treatments for presumptive appendicitis.

关键词： Goblet cell carcinoid Appendix Preoperative diagnosis Endoscopic diagnosis Surgical treatment Case report

Mechanical properties and failure mechanisms of Mg-Zn-Y alloys with different extrusion ratio and LPSO volume fraction

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Journal of Magnesium and Alloys 2022年第8期10卷 2158-2172页

作者： Wujun Yin Fabien Briffod Takayuki Shiraiwa manabu Enoki Department of Materials Engineering The University of Tokyo7-3-1 HongoBunkyo-kuTokyo113–8656Japan

In long period stacking ordered(LPSO)phase containing Mg-Zn-Y alloys,high elastic modulus and deformation kinks of LPSO phase considerably enhance the tensile yield strength,with slight detriment of or benefit to the ductility depending on its volume *** present work,uniaxial tensile tests and fracture toughness tests are carried out using Mg99.2Zn0.2Y0.6,Mg97Zn1Y2,Mg89Zn4Y7 and Mg85Zn6Y9(at%)materials with different extrusion *** processing enhances both strength and ductility due to the recrystallization of Mg *** plastic deformation mechanisms are activated depending on volume fraction of Mg and LPSO phase as well as their relative size during bending.{1012¯}tensile twins in Mg grains and deformation kinks in LPSO phase are observed,which dissipate large amount of deformation energy favoring for ***,inherently brittle LPSO phase is detrimental to ***-motivated empirical models for yield strength and fracture toughness prediction based on rule of mixtures are calibrated by experimental *** release rates of individual mechanisms are estimated,which quantitatively indicate strong Mg/LPSO interaction.

关键词： Mg-Zn-Y alloys LPSO Phase Fracture toughness Rule of mixtures

Deoxynortryptoquivaline:A unique antiprostate cancer agent

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肿瘤学研究(英文) 2023年第6期31卷 845-853页

作者： YOHKO YAMAZAKI manabu KAWADA ISAO MOMOSE Institute of Microbial Chemistry(BIKAKEN) Numazu BranchMicrobial Chemistry Research FoundationNumazu410-0301Japan Institute of Microbial Chemistry(BIKAKEN) Laboratory of OncologyMicrobial Chemistry Research FoundationShinagawa-ku141-0021Japan

The androgen receptor (AR) is a critical target in all the clinical stages of prostate cancer. To identify a new ARinhibitor, we constructed a new screening system using the androgen-dependent growth of prostate cancer cell lines as ascreening indicator. We screened 50,000 culture broths of microorganisms using this screening system and found that thefermentation broth produced by a fungus inhibited androgen-dependent growth of human prostate cancer LNCaP cellswithout cytotoxicity. Purification of this culture medium was performed, and this resulted in deoxynortryptoquivaline(DNT) being identified as a novel inhibitor of AR function. DNT showed potent inhibition of androgen-dependentgrowth of human prostate cancer LNCaP cells. The AR competitor assay was performed, and DNT did not act as anAR antagonist. However, DNT inhibited AR-dependent transcriptional activity and AR nuclear translocation, itsuggested that the suppression of AR function leads to inhibition activity against androgen-dependent growth.

关键词： Anticancer antibiotics Prostate cancer Androgen receptor Androgen dependency

Data-driven soft sensors in blast furnace ironmaking:a survey

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Frontiers of Information Technology & Electronic Engineering 2023年第3期24卷 327-354页

作者： Yueyang LUO Xinmin ZHANG manabu KANO Long DENG Chunjie YANG Zhihuan SONG State Key Laboratory of Industrial Control Technology College of Control Science and EngineeringZhejiang UniversityHangzhou 310027China Department of Systems Science Kyoto UniversityKyoto 606-8501Japan Research Institute Baoshan Iron&Steel Co.Ltd.Shanghai 201900China

The blast furnace is a highly energy-intensive,highly polluting,and extremely complex reactor in the ironmaking *** sensors are a key technology for predicting molten iron quality indices reﬂecting blast furnace energy consumption and operation stability,and play an important role in saving energy,reducing emissions,improving product quality,and producing economic *** the advancement of the Internet of Things,big data,and artificial intelligence,data-driven soft sensors in blast furnace ironmaking processes have attracted increasing attention from researchers,but there has been no systematic review of the data-driven soft sensors in the blast furnace ironmaking *** review covers the state-of-the-art studies of data-driven soft sensors technologies in the blast furnace ironmaking ***,wefirst conduct a comprehensive overview of various data-driven soft sensor modeling methods(multiscale methods,adaptive methods,deep learning,etc.)used in blast furnace ***,the important applications of data-driven soft sensors in blast furnace ironmaking(silicon content,molten iron temperature,gas utilization rate,etc.)are ***,the potential challenges and future development trends of data-driven soft sensors in blast furnace ironmaking applications are discussed,including digital twin,multi-source data fusion,and carbon peaking and carbon neutrality.

关键词： Soft sensors Data-driven modeling Machine learning Deep learning Blast furnace Ironmaking

On fluorescence imaging:The diffusion equation model and recovery of the absorption coefficient of fluorophores

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Science China Mathematics 2022年第6期65卷 1179-1198页

作者： Jijun Liu manabu Machida Gen Nakamura Goro Nishimura Chunlong Sun School of Mathematics Southeast UniversityNanjing 210096China Institute for Medical Photonics Research Hamamatsu University School of MedicineHamamatsu 431-3192Japan Department of Mathematics Hokkaido UniversitySapporo 060-0810Japan Research Institute for Electronic Science Hokkaido UniversitySapporo 060-0810Japan

To quantify fluorescence imaging of biological tissues,we need to solve an inverse problem for the coupled radiative transfer equations which describe the excitation and emission fields in biological *** begin by giving a concise mathematical argument to derive coupled diffusion equations with the Robin boundary condition as an approximation of the radiative transfer *** by using this coupled system of equations as a model for the fluorescence imaging,we have a nonlinear inverse problem to identify the absorption coefficient in this *** associated linearized inverse problem is to ignore the absorbing effect on the excitation *** firstly establish the estimates of errors on the excitation field and the solution to the inverse problem,which ensures the reasonability of the model approximation *** numerical verification is presented to show the validity of such a linearizing process ***,based on the analytic expressions of excitation and emission fields,the identifiability of the absorption coefficient from the linearized inverse problem is rigorously analyzed for the absorption coefficient in the special form,revealing the physical difficulty of the3-dimensional imaging model by the back scattering diffusive system.

关键词： fluorescence imaging diffusion equation inverse problem linearization error estimates identifiability

The effect of the 18R-LPSO phase on the fatigue behavior of extruded Mg/LPSO two-phase alloy through a comparative experimental-numerical study

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Journal of Magnesium and Alloys 2021年第1期9卷 130-143页

作者： Fabien Briffod Takayuki Shiraiwa manabu Enoki Department of Materials Engineering The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan

The fatigue behavior of four extruded Mg-Y-Zn alloys containing different volume fractions of long-period stacking ordered(LPSO)grains was investigated through a comparative study combining experiments and crystal plasticity finite element *** controlled low-cycle fatigue experiments were conducted at different strain amplitudes and revealed a limited cyclic hardening in Mg_(89)Zn_(4)Y_(7)alloy or softening in Mg_(99.2)Zn_(0.2)Y_(0.6)and Mg_(97)Zn_(1)Y_(2)alloys.A decrease in the fatigue life against the plastic strain with the increase in LPSO phase volume fraction was observed and was related the limited ductility of extruded LPSO ***-strain hysteresis curves were used to calibrate and validate a crystal plasticity model taking into account twinning and *** interaction of the different phases on the distribution of local micro-mechanical fields at the grain scale was then analyzed on synthetic microstructures under strain-controlled *** twinning activity was predicted in coarse unrecrystallized grains and tended to disappear with the increase in the LPSO phase volume ***-like facets observed in LPSO grains were related to high tensile stress,especially at the Mg/LPSO interface,due to the limited number of deformation mechanisms in LPSO crystal to accommodate out-of-basal plane *** increase of the fatigue limit with the increase in LPSO phase volume fraction was finally associated with the decreasing presence of coarse unrecrystallizedα-Mg grains due to a higher dynamic recrystallization activity during the extrusion process.

关键词： Magnesium alloy Fatigue Long-period stacking ordered phase Crystal plasticity Finite element method