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Intranasal administration of stem cell-derived exosomes for central nervous system diseases

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Neural Regeneration Research 2024年第6期19卷 1249-1255页

作者： Shuho gotoh Masahito Kawabori Miki Fujimura Department of Neurosurgery Hokkaido University Graduate School of MedicineHokkaidoJapan

Exosomes,lipid bilayer-enclosed small cellular vesicles,are actively secreted by various cells and play crucial roles in intercellular *** nanosized vesicles transport internalized proteins,mRNA,miRNA,and other bioactive *** findings have provided compelling evidence that exosomes derived from stem cells hold great promise as a therapeutic modality for central nervous system *** exosomes exhibit multifaceted properties including antiapoptotic,anti-inflammatory,neurogenic,and vasculogenic ***,exosomes offer several advantages over stem cell therapy,such as high preservation capacity,low immunogenicity,the ability to traverse the blood-brain barrier,and the potential for drug ***,researchers have turned their attention to exosomes as a novel therapeutic ***,akin to the limitations of stem cell treatment,the limited accumulation of exosomes in the injured brain poses a challenge to their clinical *** overcome this hurdle,intranasal administration has emerged as a non-invasive and efficacious route for delivering drugs to the central nervous *** exploiting the olfactory and trigeminal nerve axons,this approach enables the direct transport of therapeutics to the brain while bypassing the blood-brain ***,exosomes,owing to their small size,can readily access the nerve pathways using this *** a result,intranasal administration has gained increasing recognition as an optimal therapeutic strategy for exosomebased *** this comprehensive review,we aim to provide an overview of both basic and clinical research studies investigating the intranasal administration of exosomes for the treatment of central nervous system ***,we elucidate the underlying therapeutic mechanisms and offer insights into the prospect of this approach.

关键词： central nervous system disease exosome extracellular vesicle intranasal administration stem cell

On systematic development of FSI solvers in the context of particle methods

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Journal of Hydrodynamics 2022年第3期34卷 395-407页

作者： Abbas Khayyer Hitoshi gotoh Yuma Shimizu Department of Civil and Earth Resources Engineering Kyoto UniversityKyotoJapan

This paper presents a review on state-of-the-art of developments corresponding to fluid-structure interaction(FSI)solvers developed within the context of particle *** paper reviews and highlights the potential robustness of entirely Lagrangian meshfree FSI solvers in reproducing FSI corresponding to extreme events and portrays the future perspectives for systematic developments towards reliable engineering applications with respect to rapid advances in technology and emergence of so-called advanced materials that can result in complex and highly non-linear structural ***,the paper highlights the necessity for reproduction of comprehensive structural responses,including viscoelastic,elastoplastic and progressive damages/failures,by the advanced FSI solvers developed within the context of particle *** this regard,extensions of the structure model are suggested to be conducted in a variationally consistent framework to ensure stability,accuracy and physical reliability including thermodynamic *** paper reviews basics of mathematical and numerical modelling for entirely Lagrangian meshfree hydroelastic FSI solvers and presents a brief background on extensions of such solvers towards reproducing viscoelastic structural *** preliminary numerical results on structural viscoelasticity achieved by an extended Hamiltonian SPH(HSPH)model are *** vision paper also concisely portrays the future perspectives for systematic development of particle-based FSI solvers.

关键词： Fluid-structure interaction(FSI) entirely Lagrangian meshfree smoothed particle hydrodynamics(SPH) Hamiltonian SPH(HSPH) viscoelasticity

Three-dimensional machining of insulating ceramics materials with electrical discharge machining

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中国有色金属学会会刊：英文版 2009年第B09期19卷 150-156页

作者： Yasushi FUKUZAWA Naotake MOHRI Hiromitsu gotoh Takayuki TANI Department of Mechanical Engineering Nagaoka University of Technology Department of Precision Engineering The University of Tokyo Department of Industrial Information Tsuku ba University of Technology

The insulating ceramics were processed with sinking and wire cut electrical discharge machining(EDM). The new technology was named as the assisting electrode method. In the machining, the electrical conductive material was adhered on the surface of insulating workpiece as the starting point of electrical discharge. As the processing operated in oil, the electrical conductive product composed of decomposition carbon element from working oil adhered on the workpiece during discharge. The discharges generated continuously with the formation of the electrical conductive layer. So, the insulating ceramics turn to the machinable material by EDM. We introduced the mechanism and the application of the machining of insulating ceramics such as Si3N4 and ZrO2.

关键词：绝缘陶瓷放电加工三维加工陶瓷材料工件表面导电材料机械加工分解过程

Towards development of enhanced fully-Lagrangian mesh-free computational methods for fluid-structure interaction

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Journal of Hydrodynamics 2018年第1期30卷 49-61页

作者： Abbas Khayyer Hitoshi gotoh Hosein Falahaty Yuma Shimizu Department of Civil and Earth Resources Engineering Kyoto UniversityKatsura Campus

Simulation of incompressible fluid flow-elastic structure interactions is targeted by using fully-Lagrangian mesh-free computational methods. A projection-based fluid model（moving particle semi-implicit（MPS）） is coupled with either a Newtonian or a Hamiltonian Lagrangian structure model（MPS or HMPS） in a mathematically-physically consistent manner. The fluid model is founded on the solution of Navier-Stokes and continuity equations. The structure models are configured either in the framework of Newtonian mechanics on the basis of conservation of linear and angular momenta, or Hamiltonian mechanics on the basis of variational principle for incompressible elastodynamics. A set of enhanced schemes are incorporated for projection-based fluid model（Enhanced MPS）, thus, the developed coupled solvers for fluid structure interaction（FSI） are referred to as Enhanced MPS-MPS and Enhanced MPS-HMPS. Besides, two smoothed particle hydrodynamics（SPH）-based FSI solvers, being developed by the authors, are considered and their potential applicability and comparable performance are briefly discussed in comparison with MPS-based FSI solvers. The SPH-based FSI solvers are established through coupling of projection-based incompressible SPH（ISPH） fluid model and SPH-based Newtonian/Hamiltonian structure models, leading to Enhanced ISPH-SPH and Enhanced ISPH-HSPH. A comparative study is carried out on the performances of the FSI solvers through a set of benchmark tests, including hydrostatic water column on an elastic plate,high speed impact of an elastic aluminum beam, hydroelastic slamming of a marine panel and dam break with elastic gate.

关键词： Fluid structure interaction(FSI) projection-based method moving particle semi-implicit incompressible smoothed particle hydrodynamics(ISPH) Hamiltonian MPS(HMPS) Hamiltonian SPH(HSPH)

Incompressible SPH simulation of solitary wave propagation on permeable beaches

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Journal of Hydrodynamics 2020年第4期32卷 664-671页

作者： Chiaki Tsurudome Dongfang Liang Yuma Shimizu Abbas Khayyer Hitoshi gotoh Department of Engineering University of CambridgeTrumpington StreetCambridgeUK Graduate School of Engineering Kyoto UniversityKyotoJapan

Wave propagation on uniformly sloped beaches is a canonical coastal engineering topic that has been studied extensively in the past few ***,most of these studies treat beaches as solid boundaries even though they are often made of porous materials,such as sediment and *** beaches struck by tsunami-like waves have not been adequately *** is expected that the degree of penneability plays a crucial role in mitigating the impact of the *** study examines solitary wave run-ups on sandy beaches using an incompressible smoothed particle hydrodynamics(ISPH)*** permeability of the beach is considered to be directly related to the diameter of its constituent sand *** obtain a satisfactory pressure field,which cannot be achieved using the original ISPH algorithm,the source term of the pressure Poisson equation has been modified based on a higher-order source-term *** within the porous medium are computed in the same framework as those outside the porous *** the current model,no transition zone is needed at the boundary of the porous *** wave-attenuation effect of the porous medium is discussed,with a particular focus on the relationship between the mn-up height and grainsize.

关键词： Solitary wave porosity incompressible smoothed particle hydrodynamics(ISPH) run-up

Endoscopic diagnosis of Barrett's esophagus

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World Journal of Gastroenterology 2012年第26期18卷 3477-3478页

作者： Tomoyuki Akiyama Yusuke Sekino Hiroshi Iida Shigeru Koyama Eiji gotoh Shin Maeda Atsushi Nakajima Masahiko Inamori Department of Gastroenterology Tokyo Metropolitan Hiroo HospitalTokyo 150-0013Japan Gastroenterology Division Yokohama City University HospitalYokohama 2360004Japan Department of Medical Education Yokohama City University School of MedicineYokohama 2360004Japan Office of Postgraduate Medical Education Yokohama City University HospitalYokohama 2360004Japan

The Prague C and M Criteria have been developed for the objective endoscopic diagnosis of Barrett's esophagus(BE).BE arises between the squamocolumnar junction and the gastroesophageal junction at the proximal margin of the gastric *** this study,we reported that 43.0% of the subjects examined were diagnosed with BE based on the Prague C and M *** criticism by John Dent proposed that our data should be considered invalid because the prevalence of BE reported in our study was extraordinarily high and discordant with previous *** predicted that the position of the gastroesophageal junction in our study was judged to be lower than the actual position due to the effacement of the proximal ends of the gastric folds because of the routine use of a high degree of air distension during typical Japanese endoscopic *** endoscopic evaluation of the superior gastric folds is certainly influenced by the degree of air distension of the ***,in our study,the proximal limit of the gastric mucosal folds was prospectively imaged while the oesophagus was minimally ***,under a high level of air distension,the distal ends of the palisade-shaped longitudinal vessels were imaged because they are more easily observed when *** the majority of patients,the distal ends of the palisade-shaped longitudinal vessels correspond to the proximal limit of the gastric mucosal *** endoscopic evaluation was appropriately performed according to the Prague C and M *** suspect that the high prevalence of BE in our study may be due to the inclusion of ultrashort-segment BE,which defines BE with an affected mucosal length under 5 mm,in our positive results.

关键词： Barrett's esophagus Gastroesophagealjunction Squamocolumnar junction Digital endoscopicimages Endoscopy

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超声波在纺织品水溶液洗涤中的应用

中国洗涤用品工业 2013年第7期 54-59页

作者： Keiko gotoh KokoroHarayama 杨杰

本论文探讨了超声波作为机械去污应用在纺织品的清洗。本实验将被炭黑或油酸污染的涤纶布(后面文章中称之为脏织物)与没有被污染的涤纶布(后面文章中称之为原织物)在有碱或者表面活性剂的水溶液中和没有碱或者表面活性剂的水溶液中一起... 详细信息

本论文探讨了超声波作为机械去污应用在纺织品的清洗。本实验将被炭黑或油酸污染的涤纶布(后面文章中称之为脏织物)与没有被污染的涤纶布(后面文章中称之为原织物)在有碱或者表面活性剂的水溶液中和没有碱或者表面活性剂的水溶液中一起用超声波、震荡和搅拌等三种去污方式来洗涤。三种去污方式的清洁度和污垢再沉积的现象用脏织物和原织物的表面折射率的变化来进行评价。实验发现超声波和震荡、搅拌相比能在较短的时间内和较低的浴比下有效地去除颗粒和油污。随着超声功率的增加,超声波去污的效果更好,超过了常用的Wascator洗衣机(一种横轴滚筒式洗衣机)。实验中还使用三种标准织物确定洗涤中机械作用对织物造成的损伤大小,结果显示超声波对织物几乎没有造成损伤。然而,超声波清洗中污垢再沉积的现象经常被观察到,尤其是在低浴比条件下。

关键词：超声波清洗水溶液纺织品洗涤应用滚筒式洗衣机表面活性剂机械作用

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压控充钠热管炉温度稳定性及复现性（节译）

计量与测试技术 1994年第1期21卷 41-44页

作者： gotoh,M 邓萍贵州省计量测试技术研究所

压控充钠热管炉温度稳定性及复现性（节译）Ｍ·Ｇｏｔｏｈ日本东京大学Ｋ．Ｄ．Ｈｉｌｌ加拿大国家研究院ＩＴＳ—９０温标，使铂电阻温度计上限温度值从ＩＰＴＳ—６８温标规定为６３０．７４Ｃ延伸到９６１．７８Ｃ，尽管为开发固／... 详细信息

压控充钠热管炉温度稳定性及复现性（节译）Ｍ·Ｇｏｔｏｈ日本东京大学Ｋ．Ｄ．Ｈｉｌｌ加拿大国家研究院ＩＴＳ—９０温标，使铂电阻温度计上限温度值从ＩＰＴＳ—６８温标规定为６３０．７４Ｃ延伸到９６１．７８Ｃ，尽管为开发固／液相转变铜银共熔体做了许多努力，在...

关键词：温度稳定性热管炉

Effect of Microstructure of Cementite on Interphase Stress State in Carbon Steel

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Journal of Iron and Steel Research International 2007年第4期14卷 31-38页

作者： CHE Lei gotoh Masahide HORIMOTO Yoshiaki HIROSE Yukio Graduate School Kanazawa University Kanazawa 920-1192 Japan Department of Materials Science and Engineering Kanazawa University Kanazawa 920-1192 Japan

The experiments related to stress states of ferrite and cementite in carbon steels were carried out including in situ four-point bending and tensile test by X-ray diffraction technique. Stresses in the cementite phase can be measured by conventional X-ray diffraction instrument after a specific treatment on the specimen surface. In order to estimate the stress states in two phases, the X-ray elastic constants of two phases in single-phase state （PXEC） are determined by the experimental X-ray elastic constants of them in composite state （CXEC）. The effects of volume fraction and particle size of spheroidal cementite on the interphase stress state are estimated. The experimental results are in good agreement with the theoretical relationships reported in the previous studies.

关键词： multi-phase material surface treatment plastic deformation residual stress X-ray diffraction