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Open Journal of Orthopedics 2019年第12期9卷 265-272页

作者： Itsuki Nagahata Naohisa Miyakoshi Yuji Kasukawa Hiroyuki Tsuchie Yusuke Yuasa manabu akagawa Yuichi Ono Chiaki Sato Koji Nozaka Michio Hongo Yoichi Shimada Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan

Background: Povidone-iodine (PVI) irrigation is currently used to decrease the frequency of postoperative surgical site infections. Ethanol (EtOH) is sometimes applied to prevent local recurrence after curettage of benign bone tumors. However, the effects of PVI and EtOH on surrounding soft tissue and on bone union are unclear. The purpose of this study was to determine whether PVI or EtOH adversely affects the cancellous bone healing of the osteotomy site at the proximal tibia in rats. Methods: A cancellous bone osteotomy was performed at the right proximal tibia in 4-month-old, female, Sprague Dawley rats. Vehicle, 10% PVI, or 95% EtOH-soaked gauze was inserted into the osteotomy site and maintained for 6 minutes. The rats were euthanized 2 or 4 weeks after the osteotomy. Results: Two weeks after treatment, the bone union rate was significantly higher in the vehicle group than in the PVI group and the EtOH group (p < 0.001). However, the bone union rate was not significantly different between the PVI and EtOH groups. There was no significant difference among the three groups in the bone union rate 4 weeks after treatment. Conclusion: PVI or EtOH delayed bone union of the cancellous bone osteotomy site of the proximal tibia in the early phase (2 weeks), but not at 4 weeks, in rats.

关键词： Cancellous Bone Union Povidone-Iodine Ethanol

Effect of Fluidic Diode on Performance of Unidirectional Impulse Turbine

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Journal of Thermal Science 2024年第3期33卷 807-814页

作者： DODDAMANI Hithaish ABDUS Samad manabu Takao SHINYA Okuhara M M ASHRAFUL Alam Department of Ocean Engineering Indian Institute of Technology MadrasChennai600036India Department of Mechanical Engineering National Institute of TechnologyMatsue CollegeShimane6908518Japan Center of Support Practical Education National Institute of TechnologyMatsue CollegeShimane6908518Japan Department of Transportation Engineering Osaka Sangyo UniversityDaito5748530Japan

A pair of unidirectional turbines(UT)can operate in oscillatory airflow without additional ***,this arrangement suffers from poor flow rectification.A fluidic diode(FD)offers variable hydrodynamic resistance based on the flow direction,and this can be coupled with UT to improve flow *** this work,a numerical investigation on the effect of FD with UT is presented using the commercial fluid dynamics software ANSYS Fluent 16.1 with k-ωSST turbulence closure *** domains of UT and FD are numerically validated individually with experimental ***,both are coupled to obtain the combined effect,and these results are compared with the analytical *** was observed that coupling FD with UT improved the unit's performance at the lower flow coefficient(<1),but its performance decreased as the flow coefficient *** to the diode's presence,fluid leaving the turbine experiences higher resistance at a higher flow coefficient,which decreases the overall performance of the combined unit.

关键词： wave energy oscillating water column unidirectional impulse turbine fluidic diode flow rectification

Swimmer with submerged SiO_(2)/Al/LiNbO_(3) surface acoustic wave propulsion system

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Biomimetic Intelligence & Robotics 2024年第2期4卷 71-77页

作者： Deqing Kong Ryo Tanimura Fang Wang Kailiang Zhang Minoru Kuribayashi Kurosawa manabu Aoyagi Department of Engineering Muroran Institute of TechnologyMuroran 050-8585Japan Tianjin Key Laboratory of Film Electronic and Communication Devices School of Integrated Circuit Science and EngineeringTianjin University of TechnologyTianjin 300384China School of Engineering Tokyo Institute of TechnologyYokohama 226-8501Japan

Acoustic propulsion system presents a novel underwater propulsion approach in small scale *** study introduces a submerged surface acoustic wave(SAW)propulsion system based on the SiO_(2)/Al/LiNbO_(3) *** 19.25 MHz,the SAW propulsion system is proposed and investigated by the propulsion force calculation,PIV measurements and propulsion measurements.3.3 mN propulsion force is measured at 27.6 V_(pp).To evaluate the miniature swimmer,the SAW propulsion systems with multiple frequencies are *** 2.2 W,the submerged SAW propulsion system at 38.45 MHz demonstrates 0.83 mN/mm^(2) propulsion *** 96.13 MHz and 24 V_(pp),the movements of miniature swimmer with a fully submerged SAW propulsion system are recorded and analyzed to a maximum of 177 mm/*** of miniaturization,high power density,and simple structure,the SAW propulsion system can be expected for some microrobot applications,such as underwater drone,pipelinerobotand intravascularrobot.

关键词： Acoustofluidics Surface acoustic wave Swimmer Underwater propulsion system

Artificially frozen ground and related engineering technology in Japan

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Research in Cold and Arid Regions 2021年第2期13卷 77-86页

作者： Satoshi akagawa Cryosphere Engineering Laboratory TokyoJapan

Since the 1970's, frozen ground has been developing near the Tokyo Bay area around liquefied natural gas(LNG) inground storage tanks. For disaster prevention purposes, the tanks are constructed below the ground surface. Since the temperature of the liquid stored in the tanks is -162℃ the soil surrounding the tanks freezes. Since this frozen ground has existed for almost half a century, we have permafrost near Tokyo. The development of artificial frozen ground may cause frost heaving, resulting in frost heave forces that may cause structural damage of adjacent LNG in-ground storage ***, the demand for frozen ground engineering increased and consequently we now have advanced technology in this area. Fortunately, we use this engineering technology and artificial ground freezing for civil engineering, especially in big and crowded cities like Tokyo. This paper provides a summary of the testing apparatus, test methods, and assessment methods for frost heaving.

关键词： artificial ground freezing frost heave frozen ground engineering

Current perspectives of viral

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World Journal of Gastroenterology 2024年第18期30卷 2402-2417页

作者： Daisuke Usuda Yuki Kaneoka Rikuo Ono Masashi Kato Yuto Sugawara Runa Shimizu Tomotari Inami Eri Nakajima Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Shintaro Shimozawa Yuta Hotchi Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura manabu Sugita Department of Emergency and Critical Care Medicine Juntendo University Nerima HospitalNerima 177-8521TokyoJapan Department of Sports Medicine Faculty of MedicineJuntendo UniversityBunkyo 113-8421TokyoJapan

Viral hepatitis represents a major danger to public health,and is a globally leading cause of *** five liver-specific viruses:Hepatitis A virus,hepatitis B virus,hepatitis C virus,hepatitis D virus,and hepatitis E virus,each have their own unique epidemiology,structural biology,transmission,endemic patterns,risk of liver complications,and response to antiviral *** remain few options for treatment,in spite of the increasing prevalence of viral-hepatitiscaused liver ***,chronic viral hepatitis is a leading worldwide cause of both liver-related morbidity and mortality,even though effective treatments are available that could reduce or prevent most patients’*** 2016,the World Health Organization released its plan to eliminate viral hepatitis as a public health threat by the year 2030,along with a discussion of current gaps and prospects for both regional and global eradication of viral ***,treatment is sufficiently able to prevent the disease from reaching advanced ***,future therapies must be extremely safe,and should ideally limit the period of treatment necessary.A better understanding of pathogenesis will prove beneficial in the development of potential treatment strategies targeting infections by viral *** review aims to summarize the current state of knowledge on each type of viral hepatitis,together with major innovations.

关键词： Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus Current perspectives

The effect of the 18R-LPSO phase on the fatigue behavior of extruded Mg/LPSO two-phase alloy through a comparative experimental-numerical study

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Journal of Magnesium and Alloys 2021年第1期9卷 130-143页

作者： Fabien Briffod Takayuki Shiraiwa manabu Enoki Department of Materials Engineering The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan

The fatigue behavior of four extruded Mg-Y-Zn alloys containing different volume fractions of long-period stacking ordered(LPSO)grains was investigated through a comparative study combining experiments and crystal plasticity finite element *** controlled low-cycle fatigue experiments were conducted at different strain amplitudes and revealed a limited cyclic hardening in Mg_(89)Zn_(4)Y_(7)alloy or softening in Mg_(99.2)Zn_(0.2)Y_(0.6)and Mg_(97)Zn_(1)Y_(2)alloys.A decrease in the fatigue life against the plastic strain with the increase in LPSO phase volume fraction was observed and was related the limited ductility of extruded LPSO ***-strain hysteresis curves were used to calibrate and validate a crystal plasticity model taking into account twinning and *** interaction of the different phases on the distribution of local micro-mechanical fields at the grain scale was then analyzed on synthetic microstructures under strain-controlled *** twinning activity was predicted in coarse unrecrystallized grains and tended to disappear with the increase in the LPSO phase volume ***-like facets observed in LPSO grains were related to high tensile stress,especially at the Mg/LPSO interface,due to the limited number of deformation mechanisms in LPSO crystal to accommodate out-of-basal plane *** increase of the fatigue limit with the increase in LPSO phase volume fraction was finally associated with the decreasing presence of coarse unrecrystallizedα-Mg grains due to a higher dynamic recrystallization activity during the extrusion process.

关键词： Magnesium alloy Fatigue Long-period stacking ordered phase Crystal plasticity Finite element method

Frost heaving in ballast railway tracks

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Research in Cold and Arid Regions 2015年第5期7卷 632-636页

作者： Satoshi akagawa Michiaki Hori Cryosphere Engineering Laboratory Hokkaido Railway Campany

Frost heaving is a well-known phenomenon in cold regions, which may occur in wet clayey grounds during winter. Railway track upheaval occurring in cold regions during the winter is generally understood as frost heaving in the subgrade layer. However, it has been confirmed that upheaval due to frost heaving sometimes occurs in the ballast layer. This un- derstanding has been observed in active railways in northern Japan. The samples collected from ballast and subgrade layers have been examined for frost heave susceptibilities and confirmed that ballast layers which contain fines may heave.

关键词： frost heaving ballast layer subgrade layer railway track

Effect of End Plates on the Performence of a Wells Turbine for Wave Energy Conversion

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Journal of Thermal Science 2006年第4期15卷 319-323页

作者： manabu Takao Toshiaki Setoguchi YoichiKinoue KenjiKaneko Department of Mechanical Engineering Matsue National College of Technology 14-4 Nishiikuma-choMatsue-shiShimane 690-8518Japan Institute of Ocean Energy Saga University1 Honjo-machiSaga-shiSaga 840-8502Japan Department of Mechanical Engineering Saga University1 Honjo-machiSaga-shiSaga 840-8502Japan

In order to improve the performance of the Wells turbine for wave energy conversion, the effect of end plates on the turbine characteristics has been investigated experimentally by model testing under steady flow conditions. The end plate attached to the tip of the original rotor blade is slightly larger than the original blade profile. The characteristics of the Wells turbine with end plates have been compared with those of the original Wells turbine, i.e., the turbine without end plate. As a result, it has been concluded that the characteristics of the Wells turbine with end plates are superior to those of the original Wells turbine and the characteristics are dependent on the size and position of end plate. Furthermore, the effect of annular plate on the turbine performance, which encircles the turbine and is attached to the tip, was investigated as an additional experiment. However, its device was not effective in improving the turbine characteristics.

关键词： fluid machinery natural energy Wells turbine end plate wave energy conversion ocean energy.

Impact of Temperature in Summer on Emergency Transportation for Heat-Related Diseases in Japan

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Chinese Medical Journal 2018年第5期131卷 574-582页

作者： Yukie IIo manabu Akahane Tomoaki Imamura Department of Public Health Health Management and Policy Faculty of Medicine Nara Medical University Kashihara Nara Japan

Background： In Japan, the demand for emergency transportation for people with heat-related illness has recently increased. The purpose of this study was to investigate the relationship between incidents of heat-related illness and the daily maximum temperature. Methods： The daily maximum temperatures in Japan＇s 11 districts over the past 10 years were classified into four categories, with cutoff points at the 50th, 75th, 95th, and higher than 95th percentiles. We then conducted a logistic regression analysis of einergency transportation demand in each temperature category by age group, using the 50th percentile as tile reference category for each area. Results： There were 42,931 cases of emelgency transportation due to heat-related diseases during the study period. Classified by age. 12.5%, 43.4%, and 44.1% of cases involved children, adults, and elderly people, respectively. The analysis showed that the number of cases of emergency transportation for people with heat-related diseases （per 100,000 people; corresponding to a 1.0~C increase in the daily maximum temperature） was 0.016-0.106 among children （24.9-169.9 children required emergency transportation for heat-related diseases）, from 0.013 to 0.059 among adults （19.8 98.2 adults required emergency transportation）, and from 0.045 to 0.159 among elderly persons （30.0 145.4 elderly people required emergency transportation）. The risk was highest for elderly persons, followed by children and finally adults. Cases of emergency transportation due to heat-related illness increased by 2.4-8.9 times when the daily maximum temperature was approximately 1.5℃ above the mean daily maximum temperature. In fact, the daily maximum temperature had a larger effect than the daily relative humidity level oil emergency transportation for people with heat-related diseases. Conclusion： Public health organizations and health-care services should support elderly people and children, two high-risk groups for heat-related diseases.

关键词： Emergency Transportation Heat-Related Diseases Temperature

Steroid-sparing strategies in the management of ulcerative colitis:Efficacy of leukocytapheresis

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World Journal of Gastroenterology 2012年第41期18卷 5833-5838页

作者： manabu Shiraki Takayuki Yamamoto Inflammatory Bowel Disease Center Yokkaichi Social Insurance Hospital Yokkaichi Mie 510-0016 Japan

Active ulcerative colitis （UC） is frequently associated with infiltration of a large number of leukocytes into the bowel mucosa. Leukocytapheresis is a novel nonphar- macologic approach for active UC, in which leukocytes are mechanically removed from the circulatory system. Current data indicate that leukocytapheresis is effica- cious in improving response and remission rates with excellent tolerability and safety in patients with UC. Corticosteroid therapy remains a mainstay in the treat- ment of active UC, however, long-term, high doses of corticosteroids usually produce predictable and po- tentially serious side effects. If leukocytapheresis can spare patients from exposure to corticosteroids, the risk of steroid-induced adverse events should be mini- mized. This may be of great benefit to patients because severe side effects of steroids seriously impair health- related quality of life. In this article, we reviewed cur- rent evidence on whether leukocytapheresis can avoid or reduce the use of corticosteroids in the manage- ment of patients with UC. Several studies have shown that leukocytapheresis was effective for steroid-nafve patients with active UC. Furthermore, both short-term and long-term studies have demonstrated the steroid- sparing effects of leukocytapheresis therapy in patients with UC. Although the evidence level is not striking, theavailable data suggest that leukocytapheresis can avoid or reduce the use of corticosteroids in the management of UC. Large, well-designed clinical trials are necessary to more accurately evaluate the steroid-sparing effects of leukocytapheresis in the management of UC.

关键词： Corticosteroid Granulocyte and monocyteadsorptive apheresis Leukocytapheresis Steroid-naivepatients Steroid-sparing effect Ulcerative colitis