检索结果-南通市图书馆

Guided chemotherapy based on patient-derived mini-xenograft models improves survival of gallbladder carcinoma patients

引用

Cancer Communications 2018年第1期38卷 511-519页

作者： Ming Zhan Rui-meng Yang Hui Wang Min He Wei Chen Sun-wang Xu Lin-hua Yang Qiang Liu man-mei long Jian Wang Department of Biliary-Pancreatic Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong University160 Pujian RoadShanghai 200127P.R.China Department of Pathology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127P.R.China Department of Pathology Shanghai Ninth People’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200011P.R.China

Background:Gallbladder carcinoma is highly aggressive and resistant to chemotherapy,with no consistent strategy to guide first line ***,patient-derived xenograft(PDX)model has been increasingly used as an effective model for in preclinical study of ***:Mini-PDX model was established using freshly resected primary lesions from 12 patients with gallblad-der to examine the sensitivity with five of the most commonly used chemotherapeutic agents,namely gemcitabine,oxaliplatin,5-fluorouracil,nanoparticle albumin-bound(nab)-paclitaxel,and *** results were used to guide the selection of chemotherapeutic agents for adjunctive treatment after the ***-meier method was used to compare overall survival(OS)and disease free survival(DFS)with 45 patients who received conventional chemo-therapy with gemcitabine and ***:Cell viability assays based on mini-PDX model revealed significant heterogeneities in drug ***-meier analysis showed that patients in the PDX-guided chemotherapy group had significantly longer median OS(18.6 months;95%CI 15.9-21.3 months)than patients in the conventional chemotherapy group(13.9 months;95%CI 11.7-16.2 months)(P=0.030;HR 3.18;95%CI 1.47-6.91).Patients in the PDX-guided chemotherapy group also had significantly longer median DFS(17.6 months;95%CI 14.5-20.6 months)than patients in the conventional chemotherapy group(12.0 months;95%CI 9.7-14.4 months)(P=0.014;HR 3.37;95%CI 1.67-6.79).Conclusion:The use of mini-PDX model to guide selection of chemotherapeutic regimens could improve the out-come in patients with gallbladder carcinoma.

关键词： Gallbladder cancer Mini-PDX Chemosensitivity Overall survival Personalized therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Calibration of the Solar X-ray Detector on-board the Macao Science Satellite-1B for Soft X-ray Detection

引用

Science China Earth Sciences 2025年第1期68卷 11-26页

作者： man-Hei NG Xiaoping ZHANG Jianwu CHEN Yongqiang SHI Fuchang ZUO Wenxi PENG Weichun FU Liansheng LI Pengwei LUO Chi-long TANG Guozheng ZHANG Zhiwu mei Li WANG Cunhui LI Jiaming OU Yanyan XU State Key Laboratory of Lunar and Planetary Sciences Macau University of Science and Technology China National Space Administration (CNSA) Macau Center for Space Exploration and Science Space Optoelectronic Measurement and Perception Laboratory Beijing Institute of Control Engineering Institute of High Energy Physics Chinese Academy of Sciences Science and Technology on Vacuum Technology and Physics Laboratory Lanzhou Institute of Physics

The Solar X-ray Detector(SXD) on-board the Macao Science Satellite-1B(MSS-1B) was successfully launched via the Chinese long March-2C rocket on 21 May 2023, and commenced operations in early June of the same year. The MSS-1B/Soft X-ray Detection Units(SXDUs) employ two silicon drift detectors(SDDs), providing a wide range of energy spectra spanning from 0.7 to 24 keV. Notably, the SXDUs deliver a high-resolution capability of 0.14 keV@5.9 keV and operate with a time cadence of 1 second. Here, we perform thorough calibrations of the MSS-1B/SXDUs, employing a combination of ground experiments and simulations. In addition, quantitative analysis comparing the flux measurements obtained by the MSS-1B/SXDUs to the data collected by the Geostationary Operational Environmental Satellite(GOES), provides compelling evidence of their consistency. Furthermore, the preliminary spectral analysis results showcase the robustness and expected performance of the MSS-1B/SXDUs, unlocking their potential for facilitating the study of dynamic evolution of solar flares. Moreover, the innovative MSS-1B/Solar X-ray Detector facilitates concurrent observations of solar soft and hard X-rays, thereby making valuable contributions to the advancements in solar research.

关键词： Macao Science Satellite-1B (MSS-1B) Calibration Solar X-Ray Detector Spectrometer Soft X-rays Solar flares Solar abundances

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

引用

Neural Regeneration Research 2025年第1期20卷 159-173页

作者： man Han Deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mini患者来源异种移植模型指导化疗可延长胆囊癌患者的生存期

引用

癌症 2019年第4期38卷 177-186页

作者： Ming Zhan Rui-meng Yang Hui Wang Min He Wei Chen Sun-wang Xu Lin-hua Yang Qiang Liu man-mei long Jian Wang 上海交通大学医学院附属仁济医院胆胰外科上海200127 上海交通大学医学院附属仁济医院病理科上海200127 上海交通大学医学院附属第九人民医院病理科上海200011

背景与目的胆囊癌具有高度侵袭性和化疗抵抗性,目前缺少一致的治疗策略来指导一线化疗。然而,患者来源异种移植(patient-derived xenograft,PDX)模型作为一种有效模型,已越来越多地用于化疗敏感性的临床前研究。方法采用来自12例胆囊患... 详细信息

背景与目的胆囊癌具有高度侵袭性和化疗抵抗性,目前缺少一致的治疗策略来指导一线化疗。然而,患者来源异种移植(patient-derived xenograft,PDX)模型作为一种有效模型,已越来越多地用于化疗敏感性的临床前研究。方法采用来自12例胆囊患者的新切除的原发病灶建立mini-PDX模型,检测5种最常用化疗药物的敏感性,包括吉西他滨、奥沙利铂、5-氟尿嘧啶、纳米颗粒白蛋白结合(nanoparticle albumin-bound,nab)–紫杉醇和伊立替康。基于此检测结果指导术后辅助化疗药物的选择。采用Kaplanmeier方法比较45例接受吉西他滨和奥沙利铂常规化疗患者的总生存(overallsur vival,OS)和无病生存(disease free survival,DFS)。结果 Mini-PDX模型的细胞活力检测结果显示出药物反应的显著异质性。Kaplan-meier分析结果表明,PDX指导化疗组患者的中位OS(18.6个月;95%CI:15.9–21.3个月)显著高于常规化疗组(13.9个月;95%CI:11.7–16.2个月)(P=0.030;HR=3.18;95%CI:1.47–6.91)。PDX指导化疗组患者的中位DFS(17.6个月;95%CI:14.5–20.6个月)也显著高于常规化疗组(12.0个月;95%CI:9.7–14.4个月)(P=0.014;HR=3.37;95%CI:1.67–6.79)。结论使用mini-PDX模型指导化疗方案的选择可以改善胆囊癌患者的预后。

关键词：胆囊癌 Mini-PDX 化疗敏感性总生存个体化治疗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

一种新型的Cu^(2+)荧光分子探针的合成及性能研究

引用

化工新型材料 2017年第10期45卷 118-120页

作者：张曼龙梅刘艳红冯爱民赤峰学院化学化工学院赤峰024000

设计合成了一种新型的铜离子(Cu^(2+))罗丹明酰肼对二苯甲醛荧光分子探针(R)。检测了分子荧光探针对几种金属离子响应的紫外吸收光谱和荧光光谱。研究了它的光谱性能和对Cu^(2+)的识别作用,探针R加入Cu^(2+)时荧光加强,R加入Cu^(2+)之后... 详细信息

设计合成了一种新型的铜离子(Cu^(2+))罗丹明酰肼对二苯甲醛荧光分子探针(R)。检测了分子荧光探针对几种金属离子响应的紫外吸收光谱和荧光光谱。研究了它的光谱性能和对Cu^(2+)的识别作用,探针R加入Cu^(2+)时荧光加强,R加入Cu^(2+)之后,溶液由无色变为紫红色,探针R对Cu^(2+)具有专一的选择性。通过实验,考察和确定了荧光分子探针与Cu^(2+)响应的最佳pH和时间,在此基础上进行了定量检测,为了探究探针R和Cu^(2+)的实际配比,通过Job's plot的绘制实验方法,确定了Cu^(2+)与探针的物质的量比是1∶1,推测出了荧光探针R与Cu^(2+)络合物模型。

关键词：罗丹明B衍生物荧光探针 Cu2+

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

MixerKT:A Knowledge Tracing Model Based on Pure MLP Architecture

引用

Computers, Materials & Continua 2025年第1期82卷 485-498页

作者： Jun Wang Mingjie Wang Zijie Li Ken Chen Jiatian mei Shu Zhang Key Laboratory of Education Informatization for Nationalities Ministry of EducationYunnan Normal UniversityKunming650000China Yunnan Key Laboratory of Smart Education Yunnan Normal UniversityKunming650000China

In the field of intelligent education,the integration of artificial intelligence,especially deep learning technologies,has garnered significant *** tracing(KT)plays a pivotal role in this field by predicting students’future performance through the analysis of historical interaction data,thereby assisting educators in evaluating knowledgemastery and tailoring instructional *** knowledge tracingmethods,largely based on Recurrent Neural Networks(RNNs)and Transformer models,primarily focus on capturing long-term interaction patterns in sequential ***,these models may neglect crucial short-term dynamics and other relevant *** paper introduces a novel approach to knowledge tracing by leveraging a pure Multilayer Perceptron(MLP)*** proposeMixerKT,a knowledge tracing model based on theHyperMixer framework,which uniquely integrates global and localMixer feature *** architecture enables more effective extraction of both long-terminteraction trends and recent learning behaviors,addressing limitations in currentmodels thatmay overlook these key *** evaluations on twowidely-used datasets,ASSIS Tments2009 and Algebra2005,demonstrate that MixerKT consistently outperforms several state-of-the-art models,including DKT,SAKT,and Separated Self-Attentive Neural Knowledge Tracing(SAINT).Specifically,MixerKT achieves higher prediction accuracy,highlighting its effectiveness in capturing the nuances of learners’knowledge *** results indicate that our model provides a more comprehensive representation of student learning patterns,enhancing the ability to predict future performance with greater precision.

关键词： Knowledge tracing multilayer perceptron channel mixer sequence mixer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An Improved Repetitive-Control System Using a Complex-Coefficient Filter

引用

IEEE/CAA Journal of Automatica Sinica 2025年第1期 282-284页

作者： Qicheng mei Jinhua She Fei long Yanjun Shen the College of Electrical Engineering and New Energy China Three Gorges University the Hubei Provincial Key Laboratory for Operation and Control of Cascaded Hydropower Station the School of Engineering Tokyo University of Technology

Dear Editor,This letter presents an improved repetitive controller(IRC) that uses a complex-coefficient filter to enhance the tracking performance of a system for periodic signals. Compared with the low-pass filter used in the conventional repetitive controller(CRC), the complex-coefficient filter causes less change in the phase and amplitude of a signal at the frequencies of the periodic signal, especially at the fundamental frequency, when the two filters have the same cutofffrequency.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Palladium installed copper-organic framework for C–C coupling reactions

引用

Science China Chemistry 2025年

作者： Yu-mei Wang mei-Xia Tao Kai-Ming Mo Xu Chen Shu-Hua Zhong Elena S Shubina Guo-Hong Ning Dan Li College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Supramolecular Coordination ChemistryJinan University A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences

The formation of C–C bonds is a crucial aspect of organic synthesis. Synthesists' long-term objective is to identify novel catalysts to optimize reaction systems based on traditional transition metal catalysis. This study explores the synthesis and catalytic potential of palladium-installed covalent metal-organic frameworks(CMOFs) based on copper cyclic trinuclear units(Cu-CTUs). By incorporating palladium ions into the imine-based framework JNM-7 through a straightforward immersion method, we achieved a notable enhancement in catalytic activity for critical C–C coupling reactions, including C–H arylation and Sonogashira cross-coupling. The resulting JNM-7-Pd demonstrated remarkable stability and recyclability, maintaining its efficiency over at least three cycles without any decline in efficiency.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Recent progress in metal-organic frameworks(Part II—material application)

引用

Science China Chemistry 2025年

作者： Jiandong Pang Wentao Jiang Xue-Wen Zhang Hao-long Zhou Yuxiu Sun Wei Gong Bin Wang Fuyin Ma Linwei He long Chen Qiang Chen He-Qi Zheng Yuanjing Cui Wen-Jie Shi Chao Zhang mei Wang Yue-Biao Zhang Jie-Peng Zhang Chongli Zhong Yong Cui Shuao Wang Jian-Rong Li Guodong Qian Tong-Bu Lu Huan Pang Xian-He Bu Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology School of Chemistry and Chemical Engineering Yangzhou University School of Materials Science and Engineering Nankai University School of Physical Science and Technology ShanghaiTech University MOE Key Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular Engineering School of Chemistry IGCMESun Yat-sen University Department of Chemistry Shantou University School of Chemical Engineering and Technology Tiangong University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences Soochow University College of Materials Science & Engineering Beijing University of Technology State Key Laboratory of Silicon and Advanced Semiconductor Materials Cyrus Tang Center for Sensor Materials and ApplicationsSchool of Materials Science & Engineering Zhejiang University

As a class of functional crystalline porous materials, metal-organic frameworks(MOFs) gained rapid development in the past three decades and a large number of MOFs with ordered structures, high surface areas, and functionalized channels have been investigated. MOFs and MOF-derived/composite materials show great potential in many application fields. In this review, we discussed the main applications of MOFs and MOF-derived/composite materials in small molecule storage, separation, luminescence, sensing, multitype catalysis, and energy storage. In addition, challenges and problems in the future research of MOFsrelated fields are also discussed.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Conceiving Yin and Yang:Harmony and You

引用

Chinese Journal of Integrative Medicine 2011年第9期17卷 650-654页

作者： man Fong mei The Chinese Medical Institute and Register(CMIR).101-105 Camden High Street London NW1 7JNUK

We all know that＂it takes two to tango＂.A man and a woman dancing in unison is a simple way to perceive the idea of yin（阴） and yang（阳）.At the same time,when the male partner moves his right foot forward,the fe... 详细信息

关键词： Conceiving Yin and Yang

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：