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Distinctive Genes Involved in Steroidogenesis Associated with Follicular Abnormal Development in Polycystic Ovary Syndrome Model

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Reproductive and Developmental Medicine 2019年第3期3卷 141-147,I0002,I0003页

作者： Kai-Lun Yu Xiu-Li Zhang Xue-Mei Tan Meng-Meng Ji Yao Chen man-man liu Zeng-Li Yu Department of Nutrition and Food Hygiene Public Health College of Zhengzhou UniversityZhengzhou 450001China Department of Surgery The First Affiliated Medical College of Zhengzhou UniversityZhengzhou 450052China Department of Epidemiology Public Health College of Southeast UniversityNanjing 210009China

Objective:Polycystic ovary syndrome(PCOS),a heterogeneous endocrine disorder,affects female reproductive function,but its etiology has not been *** this study,we analyzed the differential genes related to ovarian steroid biosynthesis in patients with PCOS,to explore the mechanism of ***:The GSE59456 data were downloaded from the Gene Expression Omnibus *** identified differentially expressed genes(DEGs)in ovaries between the female Sprague-Dawley rats those implanted with 5α-dehydrotestestrone(DHT)and those in control(CTL,implanted with empty capsule).Gene ontology,pathway enrichment analysis,and protein-protein interaction(PPI)network construction were subsequently ***:In total,530 upregulated DEGs and 522 downregulated DEGs were *** identified DEGs were mostly associated with steroid *** the PPI network,the module M1 was mainly related to steroid biosynthesis,and five genes(Hsd17b7,Tm7sf2,Idi1,Msmo1,and Sqle)of the module M1 were from the aforementioned group of upregulated ***,the 19 DEGs(Idi1,Cga,C1qb,Thy1,Gpx1,Ctss,Lpl,A2m,Cited2,Plppr4,Prkar2b,Slc44a1,Inha,Rbp4,Pla2g2a,Gata4,Fabp3,Cpa2,and Cpa1)between DHT and CTL groups were associated with the process of the transformation of primordial follicles to primary ***:These DEGs,such as Hsd17b7,Tm7sf2,Idi1,Msmo1,Sqle,Rbp4,Gata4,Inha,and Cited2,may be used to elucidate the etiology of PCOS,which may provide new insights into the exploration of pathological mechanism and biomarkers for polycystic ovary.

关键词： Anovulation Differentially Expressed Genes Gene Ontology Polycystic Ovary Syndrome

Differentially Expressed Genes Associated with Primordial Follicle Formation and Transformation to Primary Follicles

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Reproductive and Developmental Medicine 2018年第3期2卷 142-149页

作者： Xue‑Mei Tan Xiu‑Li Zhang Meng‑Meng Ji Kai‑Lun Yu man-man liu Yu-Chang Tao Zeng‑Li Yu Department of Nutrition and Food Hygiene Public Health College of Zhengzhou UniversityZhengzhou 450001China

Objective: Primordial follicle assembly and the transition from primordial follicle to primary follicle are critical processes in ovarian *** processes determine the size of the primordial follicle pool, which may limit the reproductive lifespan of a female. When the follicle pool is depleted, reproduction ceases and females enter menopause. In this study, we aimed to explore the role of differentially expressed genes(DEGs) in the processes of primordial follicle assembly and the transformation from primordial to primary ***: The gene chip GSE9300 was downloaded from the Gene Expression Omnibus database. DEGs between ovaries on postnatal day0 and ovaries on postnatal day 4, as well as ovaries on postnatal day 4 and ovaries cultured for 7 days from postnatal day 0 were *** ontology(GO), pathway enrichment analysis, and protein-protein interaction network construction were ***: In total, 99 upregulated genes and 123 downregulated genes were identified in the process of primordial follicle assembly, and 101 upregulated genes and 98 downregulated genes were identified in the process of transformation from primordial to primary follicle. The GO analysis showed that response to estradiol was associated with two of the processes of assembly and subsequent development of primordial follicle, but the genes involved in response to estradiol between the two processes were significantly different. Furthermore, the two groups of DEGs were all associated with metabolic ***: DEGs may provide new insights into the exploration of mechanisms related to primordial follicle assembly and subsequent development.

关键词： Differentially Expressed Genes Estradiol Gene Ontology Primordial Follicle

Asymptotic false discovery control of the Benjamini-Hochberg procedure for pairwise comparisons

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Science China Mathematics 2025年第1期 223-252页

作者： Weidong liu Dennis Leung Qi-man Shao School of Mathematical Sciences Shanghai Jiao Tong University School of Mathematics and Statistics University of Melbourne Department of Statistics and Data Science SICMSouthern University of Science and Technology

In a one-way analysis-of-variance(ANOVA) model,the number of pairwise comparisons can become large even with a moderate number of *** by this,we consider a regime with a growing number of groups and prove that,when testing pairwise comparisons,the Benjamini-Hochberg(BH) procedure can asymptotically control false discoveries,despite the fact that the involved t-statistics do not exhibit the wellknown positive dependence structure required for exact false discovery rate(FDR) *** Tukey's perspective that the difference between the means of any two groups cannot be exactly zero,our main result provides control over the directional false discovery rate and directional false discovery proportion.A key technical contribution of our work is demonstrating that the dependence among the t-statistics is sufficiently weak to establish the convergence result typically required for asymptotic FDR *** analysis does not rely on conventional assumptions such as normality,variance homogeneity,or a balanced design,thereby offering a theoretical foundation for applications in more general settings.

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组蛋白去乙酰化酶抑制剂伏立诺他抗小鼠骨髓瘤效应的实验研究

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中国实验血液学杂志 2018年第2期26卷 470-476页

作者：霍磊张宸瑜党艺方张婉君刘缦缦刘禄社朱尊民房娜季少平孙恺郑州大学人民医院血液科河南郑州450003 河南大学基础医学院河南开封475000 锦州医科大学辽宁锦州121001 郑州大学人民医院血液病研究所河南郑州450003

目的:观察组蛋白去乙酰化酶抑制剂伏立诺他(suberoylanilide hydroxamic acid,SAHA)对小鼠骨髓瘤细胞SP2/0增殖的影响并探讨其作用机制。方法:用不同浓度SAHA处理SP2/0细胞24及48 h,CCK-8法检测细胞增殖抑制率;流式细胞术分析细胞周期... 详细信息

目的:观察组蛋白去乙酰化酶抑制剂伏立诺他(suberoylanilide hydroxamic acid,SAHA)对小鼠骨髓瘤细胞SP2/0增殖的影响并探讨其作用机制。方法:用不同浓度SAHA处理SP2/0细胞24及48 h,CCK-8法检测细胞增殖抑制率;流式细胞术分析细胞周期和细胞凋亡的变化;Western blot法检测不同浓度SAHA处理SP2/0细胞48 h后Caspase-3和p53蛋白表达水平变化。分别以尾静脉途径和皮下途径注射SP2/0细胞,建立非侵袭性和侵袭性荷瘤模型。建模后d 3开始,治疗组经腹腔注射SAHA,剂量为60 mg/(kg·d)(每周5次,连续3周),对照组腹腔注射SAHA溶剂。通过外周血涂片观察有无骨髓瘤细胞存在;每2 d观察皮下荷瘤小鼠局部肿瘤体积变化;计算抑瘤率,记录小鼠生存期。结果:不同浓度的SAHA处理SP2/0细胞24或48 h后的结果显示,SAHA对SP2/0细胞的增殖抑制作用呈剂量依赖性关系(r_(24h)=0.959;r_(48h)=0.985)。在SAHA体外作用下,SP2/0细胞周期分布结果显示G2期细胞比例明显升高,S期细胞比例明显降低。浓度分别为0.8、1.2、1.6、2.0、2.4μmol/L的SAHA作用48 h后,SP2/0细胞早期凋亡率分别为8.14%±0.50%、21.08%±0.94%、27.30%±0.63%、55.58%±0.65%、72.22%±0.88%。Western blot检测显示,SP2/0细胞Caspase-3、p53蛋白表达水平随SAHA浓度增加而升高(r_(Caspase-3)=0.968;r_(p53)=0.984)。经尾静脉注射SP2/0细胞(1×106)的荷瘤方式,仅诱导出非侵袭性荷瘤小鼠模型;而同样数量的SP2/0细胞皮下注射则诱导出了侵袭性荷瘤小鼠模型。与对照组相比,SAHA治疗后,非侵袭性荷瘤小鼠外周血循环中的骨髓瘤细胞消失,侵袭性荷瘤小鼠瘤体生长速度缓慢,小鼠生存期延长。结论:SAHA显著抑制了小鼠骨髓瘤细胞增殖,其抑制效应与诱导骨髓瘤细胞周期阻滞及凋亡相关联,而其机制与SAHA能够上调Caspase-3和p53蛋白表达水平有关。

关键词：多发性骨髓瘤伏立诺他动物模型细胞凋亡细胞周期

Adaptive control of nonlinear systems with severe uncertainties in the input powers

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Science China(Information Sciences) 2021年第1期64卷 227-238页

作者： Linzhen YU Yungang liu Yongchao man School of Control Science and Engineering Shandong University

In this study, we discuss global adaptive stabilization for a class of uncertain nonlinear *** input powers of the system are unknown, and the upper bound and the nonzero lower bound are not known in advance. This suggests that the system suffers from severe uncertainties with respect to the input powers when compared with the related literature, which would considerably challenge the control design. The switching-based strategy can compensate for severe system uncertainties, especially new types of uncertainties, including those associated with the input powers. Herein, a switching adaptive controller is successfully designed to ensure that the resulting closed-loop system states are globally bounded and ultimately converge to the origin(the equilibrium point). The proposed controller is extended to the systems with unknown control directions by redefining the involved switching sequences. A simulation example demonstrates the effectiveness of the proposed switching adaptive controller.

关键词： nonlinear systems severe uncertainties global stabilization unknown input powers switching adaptive control

Global adaptive stabilization for planar nonlinear systems with unknown input powers

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Science China(Information Sciences) 2021年第9期64卷 261-263页

作者： Yongchao man Yungang liu School of Control Science and Engineering Shandong University

Dear editor,Despite the development of extensive strategies [1,2], adaptive control still requires thorough investigations to improve its capability and cover more uncertain systems. This study aims to demonstrate the powerful ability of adaptive control in compensating multiple serious uncertainties, particularly those in input powers,

关键词： Nonlinear systems multiple serious uncertainties unknown input powers adaptive control global stabilization

Littlewood–Paley Operators on Spaces with Variable Exponent on Homogeneous Groups

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Acta Mathematica Sinica,English Series 2020年第5期36卷 535-558页

作者： Dong Li liu Ji man ZHAO Key Laboratory of Mathematics and Complex Systems Ministry of Education Institution of Mathematics and Mathematical Education School of Mathematical SciencesBeijing Normal UniversityBeijing 100875P.R.China

In this paper,on homogeneous groups,we study the Littlewood–Paley operators in variable exponent ***,we prove that the weighted Littlewood–Paley operators are controlled by the weighted Hardy–Littlewood maximal function,and obtain the vector-valued inequalities of the Littlewood–Paley operators,including the Lusin function,Littlewood–Paley g function and gλ* ***,we prove the boundedness of multilinear Littlewood–Paley gψ,λ* function.

关键词： Littlewood–Paley operators variable Lebesgue spaces homogeneous groups

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果蔗新品种桂果蔗1号高产栽培技术

中国糖料 2017年第6期39卷 54-56,59页

作者：何毅波李松刘俊仙余坤兴刘红坚刘丽敏卢曼曼刘欣广西农业科学院甘蔗研究所/广西蔗糖产业协同创新中心/农业部广西甘蔗生物技术与遗传改良重点实验室广西甘蔗遗传改良重点实验室南宁530007

为了进一步规范果蔗新品种桂果蔗1号的高产栽培技术,做到良种良法配套,因地制宜地加快该品种的推广,达到果蔗高产、稳产和优质,通过对其高产栽培技术试验和大面积生产示范,分析其主要特征特性、产量结构、品质、适应范围和利用前景,明... 详细信息

为了进一步规范果蔗新品种桂果蔗1号的高产栽培技术,做到良种良法配套,因地制宜地加快该品种的推广,达到果蔗高产、稳产和优质,通过对其高产栽培技术试验和大面积生产示范,分析其主要特征特性、产量结构、品质、适应范围和利用前景,明确了该品种高产栽培的产量构成及种茎处理、整地、施肥、播种、田间管理等技术,适用于广西、广东等果蔗产区中高产肥力田地种植。

关键词：桂果蔗1号产量构成田间管理栽培技术

Anisotropy of multi-layered structure with sliding and bonded interlayer conditions

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Frontiers of Structural and Civil Engineering 2020年第3期14卷 632-645页

作者： Lingyun YOU Kezhen YAN Jianhong man Nengyuan liu College of Civil Engineering Hunan UniversityChangsha 410082China Department of Civil and Environmental Engineering Michigan Technological UniversityHoughtonMI 49931USA

A better understanding of the mechanical behavior of the multilayered structure under extermal loading is the most important item for the structural design and the risk *** objective of this study are to propose and develop an analytical solution for the mechanical behaviors of multi-layered structure generated by axisy mmetric loading,and to investigate the impact of anisotropic layers and interlayer conditions on the multi-layered *** reach these objectives,first,according to the goveming equations,the analytical solution for a single layer was formulated by adopting the spatial Hankel *** the global matrix technique is applied to achieve the analytical solution of multi-layered structure in Hankel *** sliding and bonded interlayer conditions were considered in this ***,the numerical inversion of integral transform was used to solve the components of displacement and stress in real ***-Lcgendre quadrature is a key scheme in the numerical inversion ***,following by the verification of the proposed analytical solution,one typical three-layered flexible pavement was applied as the computing carrier of numerical analysis for the multi-layered *** results have shown that the anisotropic layers and the interlayer conditions significantly affect the mechanical behaviors of the proposed structure.

关键词： multi-layered structure Hankel transformation anisotropic transversely isotropic interlayer condition Gauss-Legendre quadrature