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Activation of Akt and cardioprotection against reperfusion injury are maximal with only five minutes of sevoflurane postconditioning in isolated rat hearts

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第6期14卷 511-517页

作者： Yuan-yuan YAO man-hua zhu Feng-jiang ZHANG Chuan-yun WEN Lei-lei MA Wen-na WANG Can-can WANG Xian-bao LIU Li-na YU Ling-bo QIAN Jian-an WANG Min YAN Department of Anesthesiology the Second Affiliated HospitalSchool of MedicineZhejiang University Jiangsu Province Key Laboratory of Anesthesiology Xuzhou Medical College Department of Cardiology the Second Affiliated HospitalSchool of MedicineZhejiang University Department of Physiology Zhejiang Medical College

It had been proved that administration of sevoflurane for the first two minutes of reperfusion effectively protects the heart against reperfusion injury in rats in *** aim was to investigate the duration of effective sevoflurane administration and its underlying mechanism in isolated rat hearts exposed to global ischemia/reperfusion(I/R) *** male Sprague-Dawley rats were randomly divided into six groups(n=12):a sham-operation group,an I/R group,and four sevoflurane postconditioning groups(S2,S5,S10,and S15).In the S2,S5,S10,and S15 groups,the duration times of sevoflurane administration were 2,5,10,and 15 min after the onset of reperfusion,*** isolated rat hearts were mounted on the Langendorff system,and after a period of equilibrium were subjected to 40 min global ischemia and 120 min *** ventricular(LV) hemodynamic parameters were monitored throughout each experiment and the data at 30 min of equilibrium and 30,60,90,and 120 min of reperfusion were *** infarct size at the end of reperfusion(n=7 in each group) and the expression of myocardial phosphorylated Akt(p-Akt) after 15-min reperfusion were determined in a duplicate set of six groups of rat hearts(n=5 in each group).Compared with the I/R group,the S5,S10,and S15 groups had significantly improved left ventricular end-diastolic pressure(LVEDP),left ventricular developed pressure(LVDP),and the maximal rate of rise or fall of the LV pressure(±dP/dtmax),and decreased myocardial infarct size(P<0.05),but not the S2 *** 15 min of reperfusion,the expression of p-Akt was markedly up-regulated in the S5,S10,and S15 groups compared with that in the I/R group(P<0.05),but not in the S2 *** postconditioning for 5 min was sufficient to activate Akt and exert maximal cardioprotection against I/R injury in isolated rat hearts.

关键词： Sevoflurane postconditioning Ischemia/reperfusion(I/R) injury Cardioprotection Duration of administration Akt

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Novel Action of 3,4-DAA ameliorating Acute Liver Allograft Injury

Novel Action of 3,4-DAA ameliorating Acute Liver Allograft I...

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2012年浙江省医学会肝病、感染病学学术年会暨浙江省感染科医师学术年会

作者： Qing-Feng Sun Ji-Guang Ding Ji-Fang Sheng man-hua zhu Jun-Jie Li Zi-Ke Sheng Xiao-Feng Tang Department of Infectious Diseases the Third Affiliated Hospital to Wenzhou Medical College Department of infectious diseases The First Affiliated Hospital to Medical College of Zhejiang University Department of Surgery The First Affiliated Hospital to Medical College of Zhejiang University

The anti-allergic drug,N-(3,4-dimethoxycinnamonyl) anthranilic acid(3,4-DAA),is a synthetic anthranilic acid derivative that has been used therapeutically in Japan for many *** this study,to investigate the effects of 3,4-DAA in allograft immunorejection model,liver orthotopic transplants were performed using inbred male Dark Agouti donors and Lewis rat recipients(allografts).The levels of indoleamine 2,3-dioxygenases (IDO) enzymic activities in four groups,allografts(control),DMSO-treated group(vehicle control),200 mg/kg/day 3,4-DAA-treated group and 200 mg/kg/day 3,4-DAA+5mg/ml 1-Methyl-D-tryptophan(1-MT)-treated group were confirmed by determination of L-kynurenine(L-Kyn) *** serum alanine aminotransferase(ALT) levels in 3,4-DAA-treated rats significantly decreased compared with those in mock and control group while treatment of 1-MT in allografts led to the opposite *** of 3,4-DAA reduced histological severity of allograft immunorejection,decreased serum levels of cytokines tumor necrosis factor-alpha(TNF-α) and interferon-gamma(IFN-γ),and raised serum levels of interleukin-10(IL-10), suggesting 3,4-DAA has both anti-inflammatory and anti-immunorejection properties through IDO in immune regulation,and may therefore be useful in filling an unmet need,in the treatment of allograft immunorejection.

关键词： DAA Action Novel Action of 3,4-DAA ameliorating Acute Liver Allograft Injury

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Deciphering Water Oxidation Catalysts: The Dominant Role of Surface Chemistry over Reconstruction Degree in Activity Promotion

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NANO-MICRO LETTERS 2025年第1期17卷 1-15页

作者： An, Li Li, Jianyi Sun, Yuanmiao zhu, Jiamin Seow, Justin zhu Yeow Zhang, Hong Zhang, Nan Xi, Pinxian Xu, Zhichuan J. Yan, Chun-hua Lanzhou Univ Frontiers Sci Ctr Rare Isotopes Key Lab Nonferrous Met Chem & Resources Utilizat G State Key Lab Appl Organ ChemColl Chem & Chem Eng Lanzhou 730000 Peoples R China Nanyang Technol Univ Sch Mat Sci & Engn Singapore 639798 Singapore Chinese Acad Sci Fac Mat Sci & Energy Engn Shenzhen Inst Adv Technol Inst Technol Carbon Neutral Shenzhen 518055 Peoples R China Yunnan Univ Natl Ctr Int Res Photoelect & Energy Mat Electron Microscopy Ctr Sch Mat & EnergyKey Lab Electromagnet Mat & Devic Kunming 650091 Peoples R China Baotou Res Inst Rare Earths State Key Lab Baiyunobo Rare Earth Resource Res & Baotou 014030 Peoples R China Peking Univ Beijing Natl Lab Mol Sci State Key Lab Rare Earth Mat Chem & Applicat PKU HKU Joint Lab Rare Earth Mat & Bioinorgan Chem Beijing 100871 Peoples R China

Demonstrate that the key factor to determine the activity of reconstructed surfaces is the surface chemistry, instead of reconstruction degree using the popular perovskite LaNi1-xFexO3 oxides as model *** content can influence both the surface reconstruction degree, the activation degree, and the activity of reconstructed *** oxygen evolution reaction activity of reconstructed catalysts is primarily governed by the chemistry of the reconstructed surface species. Water splitting hinges crucially on the availability of electrocatalysts for the oxygen evolution reaction. The surface reconstruction has been widely observed in perovskite catalysts, and the reconstruction degree has been often correlated with the activity enhancement. Here, a systematic study on the roles of Fe substitution in activation of perovskite LaNiO3 is reported. The substituting Fe content influences both current change tendency and surface reconstruction degree. LaNi0.9Fe0.1O3 is found exhibiting a volcano-peak intrinsic activity in both pristine and reconstructed among all substituted perovskites in the LaNi1-xFexO3 (x = 0.00, 0.10, 0.25, 0.50, 0.75, 1.00) series. The reconstructed LaNi0.9Fe0.1O3 shows a higher intrinsic activity than most reported NiFe-based catalysts. Besides, density functional theory calculations reveal that Fe substitution can lower the O 2p level, which thus stabilize lattice oxygen in LaNi0.9Fe0.1O3 and ensure its long-term stability. Furthermore, it is vital interesting that activity of the reconstructed catalysts relied more on the surface chemistry rather than the reconstruction degree. The effect of Fe on the degree of surface reconstruction of the perovskite is decoupled from that on its activity enhancement after surface reconstruction. This finding showcases the importance to customize the surface chemistry of reconstructed catalysts for water oxidation.

关键词： Oxygen evolution reaction Perovskite oxides Doping Activation and reconstruction

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New insight into the origin and evolution of the flora and fauna of Hainan Island, China

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Science China Earth Sciences 2025年第1期 52-61页

作者： hua zhu Center for Integrative Conservation Xishuangbanna Tropical Botanical Garden Chinese Academy of Sciences Yunnan International Joint Laboratory of Southeast Asia Biodiversity Conservation Yunnan Key Laboratory for the Conservation of Tropical Rainforests and Asian Elephants

The origin of the biota of Hainan Island, China, remains a fundamental scientific problem. Comparative studies on the biota, geological tectonics, and paleomagnetism proposed that during the Eocene, Hainan Island connected Vietnam and Guangxi, and then moved to the southeast to reach its present location. This review mainly discusses its biota origin from molecular phylogeny and palaeobotanical research. The formation and evolution of the biological groups of Hainan Island were identified via research on their genomes, phylogeny, and molecular biogeography. This research showed that the genera and species that appeared and diverged early in their evolution(i.e., before the Miocene) can be explained by the land connection between Hainan Island, Vietnam, and Guangxi during the Eocene-Oligocene. According to Southeast Asian tectonic theory, in the Middle Miocene(at about 15 million years ago), Hainan Island had moved to its present position. The population and genetic divergence of species with late divergence times(after 15 Ma) can be reasonably explained by the close proximity(or land connection) between Hainan Island and the Leizhou Peninsula, enabling genetic communication between Hainan Island and the Chinese mainland, but have exceptional cases. Conclusions have been obtained through palaeobotanical studies, showing that in the Eocene-Oligocene period, southwest China and Hainan Island had subtropical vegetation and flora. However, the fossil group in southeast China(in Maoming, near present-day Hainan Island) in the Late Eocene indicated a tropical rainforest vegetation and flora. This suggests that in the Paleogene, Hainan Island may have been located near or on the southwest border of Guangxi and northern Vietnam, rather than in its present location. The floristic division of the flora of Hainan Island basically presents a northeast-southwest inclined distribution pattern. This pattern can be explained by the counterclockwise rotation of Hainan Island during i

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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu zhu Ying Wang Zhihui huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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The rise of two-dimensional tellurium for next-generation electronics and optoelectronics

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Frontiers of physics 2023年第3期18卷 27-50页

作者： Tao zhu Yao Zhang Xin Wei man Jiang hua Xu State Key Laboratory of Photon-Technology in Western China Energy International Collaborative Center on Photoelectric Technology and Nano Functional MaterialsInstitute of Photonics&Photon TechnologySchool of PhysicsNorthwest UniversityXi’an 710069China Key Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education Shaanxi Key Laboratory for Advanced Energy DevicesSchool of Materials Science and EngineeringShaanxi Normal UniversityXi’an 710119China

Single-element two-dimensional(2D)tellurium(Te)which possesses an unusual quasi-one-dimensional atomic chain structure is a new member in 2D materials family.2D Te possesses high carrier mobility,wide tunable bandgap,strong light-matter interaction,better environmental stability,and strong anisotropy,making Te exhibit tremendous application potential in next-generation electronic and optoelectronic ***,as an emerging 2D material,the research on fundamental property and device application of Te is still in its ***,this review summarizes the most recent research progresses about the new star 2D Te and discusses its future development ***,the structural features,basic physical properties,and various preparation methods of 2D Te are systemically ***,we emphatically summarize the booming development of 2D Te-based electronic and optoelectronic devices including field effect transistors,photodetectors and van der Waals heterostructure ***,the future challenges,opportunities,and development directions of 2D Te-based electronic and optoelectronic devices are prospected.

关键词： two-dimensional materials tellurium van der Waals heterostructure electronic optoelectronic

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Design and Synthesis of Lipids Bearing Nucleosides as Gene Vectors

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Chinese Chemical Letters 2001年第9期12卷 779-782页

作者： man Zhou zhu Qi hua WU Qing Xiang GUO Department of Chemistry University of Science and Technology of ChinaHefei 230026

Some novel lipids bearing nucleosides were designed and synthesized as gene vectors, and the structures of these compounds were characterized by UV, IR, 1HNMR, 13CNMR and elemental analysis.

关键词： Gene vector lipid nucleoside synthesis

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Multiple olfactory pathways contribute to the lure process of Caenorhabditis elegans by pathogenic bacteria

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Science China(Life Sciences) 2021年第8期64卷 1346-1354页

作者： man zhu Yao Chen Ninghui Zhao hua Bai Keqin Zhang Xiaowei huang State Key Lab for Conservation and Utilization of Bio-Resources and College of Life ScienceYunnan UniversityKunming 650091China Neurosurgery of the Second Hospital Affiliated with Kunming Medical University Kunming 650101China College of Public Health Kunming Medical UniversityKunming 650500China

Chemosensation is indispensable for the survival of Caenorhabditis elegans to discriminate food and pathogenic bacteria in their living environment. Food-like odors emitted by the pathogen Bacillus nematocida B16 for trapping its hosts and an olfactory signaling pathway responsible to sense the attractant 2-heptanone were identified in our previous study. Here, we further explore how the worms recognize the attractive molecules indole and 2-ethyl hexanol, which have different chemical properties and modest nematode-luring ability. We show that the chemotaxis toward indole and 2-ethyl hexanol requires the G protein-coupled receptors encoded by str-193 on AWC and str-7 on AWA. In a further genetic screen for downstream effectors in olfactory signaling cascades, the Gα subunit GSA-1, guanylyl cyclase ODR-1 and DAF-11 and the c GMP-gated channel TAX-2/TAX-4 were found to be necessary for indole sensation, whereas the TRPV channels OSM-9/OCR-2 and the PLC pathway activated by GPA-6 are responsible for the detection of 2-ethyl hexanol. Altogether, our current work further clarifies the distinct olfactory signaling pathways through which C. elegans senses different chemicals and is lured by B. nematocida B16, improving our comprehensive understanding of the mechanisms by which bacterial pathogens effectively infect their hosts.

关键词： attractive trapping process

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Deep Audio-visual Learning:A Survey

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International Journal of Automation and computing 2021年第3期18卷 351-376页

作者： Hao zhu man-Di Luo Rui Wang Ai-hua Zheng Ran He Anhui Provincial Key Laboratory of Multimodal Cognitive Computation School of Computer Science and TechnologyAnhui UniversityHefei 230601China Center for Research on Intelligent Perception and Computing(CRIPAC)and National Laboratory of Pattern Recognition(NLPR) Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of the Chinese Academy of SciencesBeijing 100049China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China

Audio-visual learning,aimed at exploiting the relationship between audio and visual modalities,has drawn considerable attention since deep learning started to be used *** tend to leverage these two modalities to improve the performance of previously considered single-modality tasks or address new challenging *** this paper,we provide a comprehensive survey of recent audio-visual learning *** divide the current audio-visual learning tasks into four different subfields:audiovisual separation and localization,audio-visual correspondence learning,audio-visual generation,and audio-visual representation ***-of-the-art methods,as well as the remaining challenges of each subfield,are further ***,we summarize the commonly used datasets and challenges.

关键词： Deep audio-visual learning audio-visual separation and localization correspondence learning generative models representation learning

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Generation of Entangled Coherent States in Raman-Coupled Bose-Einstein Condensates

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Chinese Physics Letters 2004年第6期21卷 999-1002页

作者： KUANGLe-man ZENGAi-hua KUANGZhen-hua DepartmentofPhysics HunanNormalUniversityChangsha410081 DepartmentofPhysics ShaoyangUniversityShaoyang422000

A method for producing entangled coherent states (ECSs) for atomic Bose-Einstein condensates (BECs) is presented. The proposed method involves a BEC with three internal states and two classical laser beams in a three-level Lambda configuration. We show how to generate multi-state ECSs through properly manipulating strengths of these interactions and laser detunings. A maximally entangled coherent state is obtained explicitly.

关键词： Quantum gases liquids and solids Computational physics Optics quantum optics and lasers Quantum information and quantum mechanics

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