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Novel lactylation-related signature to predict prognosis for pancreatic adenocarcinoma

World Journal of Gastroenterology 2024年第19期30卷 2575-2602页

作者： Tian Peng Fang Sun Jia-Chun Yang Mei-Hong Cai man-xiu huai Jia-Xing Pan Fei-Yu Zhang Lei-Ming Xu Department of Gastroenterology Xinhua Hospital Affiliated to Shanghai Jiao Tong UniversityShanghai 200092China

BACKGROUND Lactate,previously considered a metabolic byproduct,is pivotal in cancer progression and maintaining the immunosuppressive tumor *** investigations confirmed that lactate is a primary regulator,introducing recently described post-translational modifications of histone and non-histone proteins,termed lysine *** adenocarcinomas are characterized by increased glycolysis and lactate ***,our understanding of lactylation-related genes in pancreatic adenocarcinomas remains *** To construct a novel lactylation-related gene signature to predict the survival of patients with pancreatic *** RNA-seq and clinical data of pancreatic adenocarcinoma(PDAC)were obtained from the GTEx(Genotype-Tissue Expression)and TCGA(The Cancer Genome Atlas)databases via Xena Explorer,and GSE62452 datasets from *** on lactylation-related genes were obtained from publicly available *** expressed genes(DEGs)were acquired by using R package“DESeq2”in *** COX regression analysis,LASSO Cox and multivariate Cox regressions were produced to construct the lactylation-related prognostic *** analyses,including functional enrichment,ESTIMATE,and CIBERSORT,were performed to analyze immune status and treatment responses in patients with pancreatic *** and normal human cell lines were subjected to western blot analysis under lactic acid intervention;two PDAC cell lines with the most pronounced lactylation were ***,RT-PCR was employed to assess the expression of LRGs genes;SLC16A1,which showed the highest expression,was selected for further ***16A1-mediated lactylation was analyzed by immunofluorescence,lactate production analysis,colony formation,transwell,and wound healing assays to investigate its role in promoting the proliferation and migration of PDAC *** vivo validation was performed using an established tumor *** In this stud

关键词： Pancreatic adenocarcinoma Lactylation Prognosis Immunotherapy Tumor microenvironment

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Feasibility and efficacy of endoscopic purse-string suture-assisted closure for mucosal defects induced by endoscopic manipulations

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World Journal of Gastroenterology 2023年第4期29卷 731-743页

作者： Ming-Ming Li Yi Zhang Fang Sun man-xiu huai Fei-Yu Zhang Chun-Ying Qu Feng Shen Zheng-Hong Li Lei-Ming Xu Department of Gastroenterology Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 200092China

BACKGROUND Large or transmural defects induced by gastrointestinal endoscopic manipulations are difficult to close,although complete closure is recommended for better *** purse-string assisted suturing(EPSS)has been used in clinical practice and has proven to be an effective and safe technique for the closure of large mucosal ***,details regarding the efficacy of endoscopic pre-purse-string suture(P-EPSS)are unknown,especially that it offers several advantages over conventional EPSS(C-EPSS).AIM To elucidate the outcomes of EPSS-assisted closure in different clinical situations,and evaluate the efficacy of *** This retrospective observational study included a total of 180 patients who underwent closure assisted by P-EPSS(n=63)or C-EPSS(n=117)between July 2014 and June *** P-EPSS and C-EPSS groups were compared and the intergroup differences in aspects such as the lesion size,location,and morphology,incidence of complete closure,intraoperative perforation,and delayed adverse events were *** on the features and clinical course of cases with adverse events were collected for further *** Patients with lesion size larger than 3 cm,lesions located at the fundus of stomach,or submucosal tumors originating from the deep mucosa were more likely to undergo P-EPSS-assisted *** P-EPSS group showed a significantly higher proportion of intraoperative perforation(56%vs 17%)and a much shorter procedure time(9.06±6.14 min vs 14.84±7.25 min).Among adverse events,the incidence of delayed perforation(5%vs 4%;P=0.82)and delayed bleeding(3%vs 4%;P=0.96)did not differ significantly between the *** analysis revealed that lesions with incomplete closure[odds ratio(OR)=21.33;95%confidence interval(CI):5.45-83.45;P<0.01]or size greater than 3 cm(OR=3.14;95%CI:1.08-9.18;P=0.039)showed a statistical tendency to result in an increase in delayed adverse *** The present study revealed that EPSS

关键词： Endoscopic purse-string suture Mucosal defect Endoscopic full-thickness resection Endoscopic submucosal dissection

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Tanshinone ⅡA improves Alzheimer’s disease via RNA nuclearenriched abundant transcript 1/microRNA-291a-3p/member RAS oncogene family Rab22a axis

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World Journal of Psychiatry 2024年第4期14卷 563-581页

作者： Long-xiu Yang man Luo Sheng-Yu Li Department of Neurology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530000Guangxi Zhuang Autonomous RegionChina Department of Neurology Wuming Hospital of Guangxi Medical UniversityNanning 530199Guangxi Zhuang Autonomous RegionChina

BACKGROUND Alzheimer’s disease(AD)is a neurodegenerative condition characterized by oxidative stress and *** ⅡA(Tan-ⅡA),a bioactive compound isolated from Salvia miltiorrhiza plants,has shown potential neuroprotective effects;however,the mechanisms underlying such a function remain *** To investigate potential Tan-ⅡA neuroprotective effects in AD and to elucidate their underlying *** Hematoxylin and eosin staining was utilized to analyze structural brain tissue *** assess changes in oxidative stress and neuroinflammation,we performed enzyme-linked immunosorbent assay and western ***,the effect of Tan-ⅡA on AD cell models was evaluated in vitro using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** changes related to the long non-coding RNA(lncRNA)nuclear-enriched abundant transcript 1(NEAT1)/microRNA(miRNA,miR)-291a-3p/member RAS oncogene family Rab22a axis were assessed through reverse transcription quantitative polymerase chain *** In vivo,Tan-ⅡA treatment improved neuronal morphology and attenuated oxidative stress and neuroinflammation in the brain tissue of AD *** vitro experiments showed that Tan-ⅡA dose-dependently ameliorated the amyloid-beta 1-42-induced reduction of neural stem cell viability,apoptosis,oxidative stress,and *** this process,the lncRNA NEAT1-a potential therapeutic target-is highly expressed in AD mice and downregulated via Tan-ⅡA ***,NEAT1 promotes the transcription and translation of Rab22a via miR-291a-3p,which activates nuclear factor kappa-B(NF-κB)signaling,leading to activation of the pro-apoptotic B-cell lymphoma 2-associated X protein and inhibition of the anti-apoptotic B-cell lymphoma 2 protein,which exacerbates ***-ⅡA intervention effectively blocked this process by inhibiting the NEAT1/miR-291a-3p/Rab22a axis and NF-κB *** This study demonstrates that

关键词： TanshinoneⅡA Alzheimer’s disease Nuclear-enriched abundant transcript 1 Member of RAS oncogene family Rab22a Reactive oxygen species

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Combining protein arginine methyltransferase inhibitor and antiprogrammed death-ligand-1 inhibits pancreatic cancer progression

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World Journal of Gastroenterology 2020年第26期26卷 3737-3749页

作者： Nan-Nan Zheng Min Zhou Fang Sun man-xiu huai Yi Zhang Chun-Ying Qu Feng Shen Lei-Ming Xu Department of Gastroenterology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China

BACKGROUND Immunotherapy targeting programmed death-1(PD-1)or programmed deathligand-1(PD-L1)has been shown to be effective in a variety of malignancies but has poor efficacy in pancreatic ductal adenocarcinoma(PDAC).Studies have shown that PD-L1 expression in tumors is an important indicator of the efficacy of *** cells usually evade chemotherapy and host immune surveillance by epigenetic *** arginine methylation is a common posttranslational *** arginine methyltransferase(PRMT)1 is deregulated in a wide variety of cancer types,whose biological role in tumor immunity is *** To investigate the combined effects and underlying mechanisms of anti-PD-L1 and type I PRMT inhibitor in pancreatic cancer in *** PT1001B is a novel type I PRMT inhibitor with strong activity and good selectivity.A mouse model of subcutaneous Panc02-derived tumors was used to evaluate drug efficacy,toxic and side effects,and tumor growth in *** flow cytometry,we determined the expression of key immune checkpoint proteins,detected the apoptosis in tumor tissues,and analyzed the immune *** staining for cellular proliferation-associated nuclear protein Ki67,TUNEL assay,and PRMT1/PD-L1 immunofluorescence were used to elucidate the underlying molecular mechanism of the antitumor *** Cultured Panc02 cells did not express PD-L1 in vitro,but tumor cells derived from Panc02 transplanted tumors expressed *** therapeutic efficacy of anti-PD-L1 mAb was significantly enhanced by the addition of PT1001B as measured by tumor volume(1054.00±61.37 mm3 vs 555.80±74.42 mm3,P<0.01)and tumor weight(0.83±0.06 g vs 0.38±0.02 g,P<0.05).PT1001B improved antitumor immunity by inhibiting PD-L1 expression on tumor cells(32.74%±5.89%vs 17.95%±1.92%,P<0.05).The combination therapy upregulated tumorinfiltrating CD8+T lymphocytes(23.75%±3.20%vs 73.34%±4.35%,P<0.01)and decreased PD-1+leukocytes(35.77%±3.30%vs 6.48%±1.08%,

关键词： Protein arginine methyltransferase Programmed death-ligand-1 blockade Pancreatic cancer Combination therapy Tumor microenvironment Pancreatic ductal adenocarcinoma

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Millisecond dynamics of colloidal suspension studied by X-ray photon correlation spectroscopy at the Shanghai Synchrotron Radiation Facility

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Nuclear Science and Techniques 2024年第1期35卷 1-9页

作者： Chen-Hui Cui Zi-Mu Zhou Lin-Feng Wei Song-Lin Li Feng Tian xiu-Hong Li Zhi Guo Yi-Hui Xu huai-Dong Jiang Ren-Zhong Tai Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Center for Transformative Science ShanghaiTech UniversityShanghai 201210China

X-ray photon correlation spectroscopy(XPCS)has emerged as a powerful tool for probing the nanoscale dynamics of soft condensed matter and strongly correlated materials owing to its high spatial resolution and penetration *** technique requires high brilliance and beam coherence,which are not directly available at modern synchrotron beamlines in *** facilitate future XPCS experiments,we modified the optical setup of the newly commissioned BL10U1 USAXS beamline at the Shanghai Synchrotron Radiation Facility(SSRF).Subsequently,we performed XPCS measurements on silica suspensions in glycerol,which were opaque owing to their high *** were collected using a high frame rate area detector.A comprehensive analysis was performed,yielding correlation functions and several key dynamic *** the results were consistent with the theory of Brownian motion and demonstrated the feasibility of XPCS at ***,by carefully optimizing the setup and analyzing the algorithms,we achieved a time resolution of 2 ms,which enabled the characterization of millisecond dynamics in opaque systems.

关键词： XPCS SSRF Silica suspension Glycerol Brownian motion Millisecond dynamics

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Periorbital purpura can be the only initial symptom of primary light chain amyloidosis:A case report

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World Journal of Clinical Cases 2024年第26期12卷 5946-5951页

作者： xiu-Feng Wang Ting Li man Yang Yan Huang Department of Hematology The First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100Henan ProvinceChina Department of Blood Purification The First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100Henan ProvinceChina

BACKGROUND Primary light chain amyloidosis is a rare and complex disease with complex clinical features and is highly susceptible to misdiagnosis and underdiagnosis in the early *** SUMMARY We report a case of a 47-year-old female patient whose only initial symptom was periorbital purpura,which was not taken seriously *** the disease progressed,pleural effusion gradually appeared,and after systematic diagnosis and treatment,she was diagnosed with“primary light chain amyloidosis”.She achieved rapid hematological remission after treatment with a daratumumab+bortezomib+cyclophosphamide+dexamethasone *** Periorbital purpura can be the only initial symptom of primary light chain amyloidosis;we should pay attention to the cases where the initial clinical symptoms are only periorbital purpura.

关键词： Primary light chain amyloidosis Periorbital purpura Initial symptom Literature review Case report

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复杂协同攻击下一类非线性系统的分布式一致性滤波器设计

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控制与决策 2024年第1期39卷 189-195页

作者：高霞吴怀宇郑秀娟武汉科技大学机器人与智能系统研究院武汉430081 武汉科技大学冶金自动化与检测技术教育部工程研究中心武汉430081

针对复杂协同攻击下一类非线性系统的状态估计问题,提出一种分布式一致性递推滤波算法.首先,将拒绝服务攻击(denial of service, DoS)和虚假数据注入攻击(false data injection, FDI)现象描述为两个随机Bernoulli序列,并利用统一的框架... 详细信息

针对复杂协同攻击下一类非线性系统的状态估计问题,提出一种分布式一致性递推滤波算法.首先,将拒绝服务攻击(denial of service, DoS)和虚假数据注入攻击(false data injection, FDI)现象描述为两个随机Bernoulli序列,并利用统一的框架建立包含DoS和FDI的复杂协同攻击模型;然后,基于一致性理论设计具有分布式结构的递推滤波器,计算最优滤波器增益,并推导该滤波器估计误差满足均方有界的充分必要条件;最后,利用室内机器人的定位问题进行验证,仿真结果验证了所提出滤波器算法的有效性.

关键词：一致性滤波器状态估计 FDI攻击 DoS攻击室内机器人定位

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国家形象建构视域下的对外话语翻译策略研究——以《人民网》日文版习近平对外话语的日译为例

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上海翻译（中英文） 2024年第4期 35-39页

作者：刘曼杨怀明上海理工大学上海200093

国家形象体现了一个国家的综合实力和影响力,是国家软实力的重要组成部分。中国国家形象长期以西方媒体他塑为主导,为改变这一局面,党和国家非常重视对国家形象的自塑。近年来,以习近平为代表的党和国家领导人在各大国际场合发表重要讲... 详细信息

国家形象体现了一个国家的综合实力和影响力,是国家软实力的重要组成部分。中国国家形象长期以西方媒体他塑为主导,为改变这一局面,党和国家非常重视对国家形象的自塑。近年来,以习近平为代表的党和国家领导人在各大国际场合发表重要讲话,这些内涵丰富的对外话语是当今中国国家形象建构的重要自塑路径。为提升中国国家形象的建构效果,做好对外话语的翻译工作尤为重要。本文以《人民网》日文版习近平对外话语的日译文本为研究语料,探究习近平对外话语中呈现的国家形象及其日译策略。研究发现,习近平对外话语充分展现了可信、可爱、可敬的中国国家形象,这些对外话语的日译文本主要运用了直译、意译、增译、减译以及多策略并用的翻译策略,确保再现对外话语中呈现的中国国家形象。

关键词：中国国家形象自塑路径习近平对外话语日译策略

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基于时空多头图注意力网络的交通流预测

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电子学报 2024年第2期52卷 500-509页

作者：梁秀霞夏曼曼何月阳梁涛河北工业大学人工智能与数据科学学院天津300132

针对当前路网交通流量预测方法中存在的挖掘复杂的动态时空特性和长距离的空间依赖性能力不足等问题,基于多头自注意力网络构建一种新型的交通流预测模型.考虑到交通流在不同周期尺度下呈现出的高度相似性,以及静态时空特征,引入日和周... 详细信息

针对当前路网交通流量预测方法中存在的挖掘复杂的动态时空特性和长距离的空间依赖性能力不足等问题,基于多头自注意力网络构建一种新型的交通流预测模型.考虑到交通流在不同周期尺度下呈现出的高度相似性,以及静态时空特征,引入日和周这2种周期尺度下的数据张量作为模型输入,来表达交通流数据的时间相似性,并通过输入数据的时空位置编码获取其静态时空特征.考虑到交通流的动态时空特性和长距离的空间依赖性,主体模型基于多头自注意力机制分别设计时间多头注意力模块和空间多头注意力模块.时间多头注意力模块利用一个图掩码矩阵获得局部注意力,并将其融合到一个多头自注意力中,以提取交通流的动态时间特征.空间多头注意力模块利用两个图掩码矩阵获得局部注意力和全局注意力,并将其融合到一个多头自注意力中,以提取路网节点的动态空间特征和长距离的空间依赖性.最后,设计一个门控融合模块自适应地融合交通流数据的时空相关性特征.在三个真实交通流基准数据集PEMS04,PEMS07和PEMS08上进行模型的有效性验证,结果表明,所建模型在3个数据集上的3个预测精度指标与其他精度最高模型相比,平均提高了4.437%,2.930%,4.275%.

关键词：智能交通多头图注意力网络图掩码机制特征融合时空数据位置嵌入

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A polarization sensitive interferometer:Delta interferometer

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Chinese Physics B 2024年第3期33卷 369-377页

作者：卫超奇刘建彬董翼飞孙雨农周宇郑淮斌刘严严闫秀生李福利徐卓 Key Laboratory of Multifunctional Materials and Structures Ministry of Education & International Center for Dielectric ResearchSchool of Electronic Science and EngineeringXi'an Jiaotong UniversityXi'an 710049China MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter Department of Applied PhysicsXi'an Jiaotong UniversityXi'an 710049China Science and Technology on Electro-Optical Information Security Control Laboratory Tianjin 300308China

A new type of polarization sensitive interferometer is proposed,named the Delta interferometer,inspired by its geometry resembling the Greek letter *** main difference between the Delta interferometer and other existing interferometers,such as Michelson,Mach-Zehnder and Young's double-slit interferometers,is that the two interfering paths are asymmetrical in the Delta *** visibility of the first-order interference pattern observed in the Delta interferometer is dependent on the polarization of the incidental *** coherence theory is employed to interpret this phenomenon and single-mode continuous-wave laser light is employed to verify the theoretical *** theoretical and experimental results are *** Delta interferometer is a perfect tool to study the reflection of electromagnetic fields in different polarizations and may find applications in polarization-sensitive scenarios.

关键词： phase sensitive interferometer Fresnel formula first-order interference

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