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燕赵医学古籍文献数据库构建研究

中国数字医学 2024年第3期19卷 99-104页

作者：于淼刘丽红齐晓凡满伟周计春河北中医药大学基础医学院石家庄050091 中国中医科学院中医药信息研究所

为深入挖掘和传承燕赵中医药精华,河北中医药大学开发建设了燕赵医学古籍文献数据库。项目搜集整理14部代表性的燕赵医学著作,导入数据库进行核心病、证、症、治、方、药等实体及实体间语义关系标注,在此基础上实现数据库的检索统计分... 详细信息

为深入挖掘和传承燕赵中医药精华,河北中医药大学开发建设了燕赵医学古籍文献数据库。项目搜集整理14部代表性的燕赵医学著作,导入数据库进行核心病、证、症、治、方、药等实体及实体间语义关系标注,在此基础上实现数据库的检索统计分析功能,构建完成具有中医文献标注与检索分析功能的数据库。该数据库可检索燕赵医学相关古籍,统计分析古籍核心信息,并以可视化方式展示结果,便于用户探寻燕赵医家学派的用药规律、学术特色以及各类疾病的证治特点,可为燕赵医学古籍的研读、燕赵医家学术思想的研究提供帮助。

关键词：中医古籍文献标注数据库

Emission spectra produced by pulsed laser ablation of metal Al at different ambient pressures

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Chinese Science Bulletin 1997年第13期42卷 1139-1143页

作者： man, BY miao, Y Guo, XX Wang, GT Hu, XR Wang, XT Infrared and Remote Sensing Lab. Shandong University Jinan 250100 China Department of Physics Shandong Normal University Jinan 250014 China

INTERACTION between laser and material is closely related to background besides properties oflaser and material. The interaction process can be influenced to a great extent by ambient at-mosphere and pressures. In the present work, a time and space resolved diagnostic tech-nique was used to study the emission spectrum from the plume produced by a pulsed laser on

关键词： laser ablation time-resolved spectrum plasma.

从地中海到青海——都兰热水墓出土“半人半鱼”图像考

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南京艺术学院学报（美术与设计） 2024年第2期 16-22,I0002页

作者：苗亚婻杜建录宁夏大学民族与历史学院宁夏银川750021

青海都兰热水墓出土了3件半人半鱼图像金饰片,母型是来自古希腊海神特里同的另一种形象肯陶洛斯—特里同,主要流行于希腊化时期至罗马帝国时期,伴随亚历山大东征,传到中亚与西北印度,继而进入都兰。其在墓葬中既象征王权,又护佑死者灵... 详细信息

青海都兰热水墓出土了3件半人半鱼图像金饰片,母型是来自古希腊海神特里同的另一种形象肯陶洛斯—特里同,主要流行于希腊化时期至罗马帝国时期,伴随亚历山大东征,传到中亚与西北印度,继而进入都兰。其在墓葬中既象征王权,又护佑死者灵魂进入极乐冥界,同时直观反映了丝绸之路青海道上多民族多元文化的交流交融。

关键词：半人半鱼图像都兰热水墓特里同丝绸之路青海道

银杏叶提取物激活Nrf2/ARE通路改善慢性间歇性低氧诱导大鼠血管内皮功能障碍

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中国药理学通报 2024年第10期40卷 1837-1844页

作者：司胜勇李虹漫缪思斯韩肖李治菁韦朝俊刘大男贵州医科大学附属医院高血压科贵州贵阳550004

目的探讨银杏叶提取物(Ginkgo biloba extract,GBE)对慢性间歇性低氧(chronic intermittent hypoxia,CIH)诱导大鼠血管内皮功能障碍的影响及相关机制。方法构建CIH大鼠模型,并用50、100 mg·kg^(-1)的GBE灌胃,检测各组大鼠尾动脉收缩压(... 详细信息

目的探讨银杏叶提取物(Ginkgo biloba extract,GBE)对慢性间歇性低氧(chronic intermittent hypoxia,CIH)诱导大鼠血管内皮功能障碍的影响及相关机制。方法构建CIH大鼠模型,并用50、100 mg·kg^(-1)的GBE灌胃,检测各组大鼠尾动脉收缩压(systolic blood pressure,SBP);HE染色检测主动脉组织形态;DAF-FM DA染色和硝酸还原酶法检测NO水平;ELISA法检测血清ET-1、TNF-α、IL-6水平;DHE染色检测主动脉组织活性氧水平;试剂盒检测血清MDA、SOD、GSH-Px水平;Western blot检测主动脉组织VCAM-1、ICAM-1、细胞核Nrf2、HO-1、NQO1水平。结果GBE明显降低CIH大鼠的尾动脉SBP、ET-1、活性氧、MDA、VCAM-1、ICAM-1、TNF-α、IL-6水平,明显增加NO、SOD、GSH-Px、细胞核Nrf2、HO-1、NQO1水平。GBE明显改善CIH大鼠主动脉组织形态学。结论GBE可改善CIH模型大鼠血管内皮功能障碍,降低血压,其机制可能与激活Nrf2/ARE通路、抑制氧化应激与炎症反应有关。

关键词：银杏叶提取物 Nrf2/ARE通路慢性间歇性低氧血管内皮功能障碍高血压氧化应激

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白术多糖对Cr(Ⅵ)诱导PK-15细胞凋亡和小鼠肾损伤的影响

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动物医学进展 2024年第3期45卷 59-66页

作者：吕昌洋范汝鹏赵茜曼高忆凡蒋猛林李林珏郑丕苗刘建柱赵晓娜山东农业大学动物科技学院山东泰安271018

为探讨白术多糖(RAMPS_(t))对Cr(Ⅵ)致PK-15细胞凋亡和小鼠肾损伤的保护作用,为临床中药多糖缓解重金属中毒导致肾损伤提供理论依据。采用RAMPS_(t)干预Cr(Ⅵ)所致PK-15细胞损伤,检测细胞存活率、ROS水平、线粒体膜电位、细胞凋亡率及Ba... 详细信息

为探讨白术多糖(RAMPS_(t))对Cr(Ⅵ)致PK-15细胞凋亡和小鼠肾损伤的保护作用,为临床中药多糖缓解重金属中毒导致肾损伤提供理论依据。采用RAMPS_(t)干预Cr(Ⅵ)所致PK-15细胞损伤,检测细胞存活率、ROS水平、线粒体膜电位、细胞凋亡率及Bax、Bcl-2蛋白表达水平,测定MDA、SOD和GSH含量。为了进一步验证RAMPS_(t)对Cr(Ⅵ)致小鼠肾氧化应激及凋亡的保护作用,检测肾组织中ROS、MDA、SOD、GSH的变化及Bcl-2、Bax的表达水平。结果显示,RAMPS_(t)缓解Cr(Ⅵ)引起细胞内ROS水平升高,线粒体膜电位下降,MDA水平升高及SOD、GSH水平降低,且减少细胞凋亡率。同时,RAMPS_(t)增强Bcl-2蛋白表达水平,降低Bax蛋白表达水平。RAMPS_(t)干预可抑制Cr(Ⅵ)致小鼠ROS、MDA水平升高和SOD、GSH水平下降;并且降低Bax蛋白表达水平,增加Bcl-2蛋白的表达水平,减轻Cr(Ⅵ)诱导的小鼠肾脏细胞凋亡。因此,RAMPS_(t)通过降低ROS水平,阻断氧化应激介导的线粒体凋亡途径,从而拮抗Cr(Ⅵ)致PK-15细胞和小鼠肾氧化应激及凋亡的作用。

关键词：白术多糖 Cr(Ⅵ) 氧化应激细胞凋亡 PK-15细胞

Dynamic protein-protein interaction subnetworks of lung cancer in cases with smoking history

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Chinese Journal of Cancer 2013年第2期32卷 84-90页

作者： Wei Yu Li-Ran He Yan-Chao Zhao man-Him Chan Meng Zhang miao He School of Life Sciences Sun Yat-sen University College of Software Technology South China Agricultural University Department of Architecture Cardiff University

Smoking is the primary cause of lung cancer and is linked to 85% of lung cancer ***,how lung cancer develops in patients with smoking history remains *** approaches that combine human protein-protein interaction (PPI) networks and gene expression data are superior to traditional *** performed these systems to determine the role that smoking plays in lung cancer development and used the support vector machine (SVM) model to predict *** defining expression variance (EV),we found 520 dynamic proteins (EV>0.4) using data from the Human Protein Reference Database and Gene Expression Omnibus Database,and built 7 dynamic PPI subnetworks of lung cancer in patients with smoking *** also determined the primary functions of each subnetwork:signal transduction,apoptosis,and cell migration and adhesion for subnetwork A;cell-sustained angiogenesis for subnetwork B;apoptosis for subnetwork C;and,finally,signal transduction and cell replication and proliferation for subnetworks *** probability distribution of the degree of dynamic protein and static protein differed,clearly showing that the dynamic proteins were not the core proteins which widely connected with their neighbor *** were high correlations among the dynamic proteins,suggesting that the dynamic proteins tend to form specific dynamic *** also found that the dynamic proteins were only correlated with the expression of selected proteins but not all neighbor proteins when cancer occurred.

关键词：蛋白质相互作用肺癌子网吸烟病例基因表达数据人类蛋白质细胞凋亡

水中苯并三唑类紫外吸收剂的分散固相萃取-高效液相色谱测定法

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环境与健康杂志 2024年第5期41卷 425-428页

作者：李欣欣贾叶青李淼王曼曼王茜郝玉兰华北理工大学公共卫生学院河北唐山063210 河北省煤矿卫生与安全重点实验室天津市疾病预防控制中心卫生检验检测所理化科

目的建立水环境中4种苯并三唑类紫外吸收剂的高效液相色谱测定法。方法取35 ml水样,调节水样pH值为6,采用40 mg Ce/MOF-801固相萃取柱富集5 min,1 ml乙腈洗脱待测物,经C18色谱柱(4.6 mm×250 mm,5μm)分离,以乙腈∶水(体积比为52∶48)... 详细信息

目的建立水环境中4种苯并三唑类紫外吸收剂的高效液相色谱测定法。方法取35 ml水样,调节水样pH值为6,采用40 mg Ce/MOF-801固相萃取柱富集5 min,1 ml乙腈洗脱待测物,经C18色谱柱(4.6 mm×250 mm,5μm)分离,以乙腈∶水(体积比为52∶48)为流动相进行等度洗脱,柱温25℃。采用紫外检测器(200 nm)测定4种苯并三唑类紫外吸收剂,外标法定量。结果在0.02~1.00μg/ml的范围内,4种苯并三唑类紫外吸收剂所得回归方程的线性关系良好,r≥0.9992。该方法的检出限为0.057~0.117μg/L,定量下限为0.171~0.351μg/L;平均回收率为79.3%~107.2%,RSD为0.51%~4.47%。吸附剂可重复使用至少8次,富集因子可以达到56.6~73.9。结论该方法具有灵敏、简便且快速等优点,适用于水环境中痕量4种紫外吸收剂的检测。

关键词：水苯并三唑类金属有机骨架分散固相萃取色谱法,高效液相

A Potential Alternative to Polystyrene: Ring-opening Terpolymerization of Different Epoxides with Phthalic Anhydride Using Metal-free Dual Catalysts

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Chinese Journal of Polymer Science 2021年第3期39卷 337-343,I0006页

作者： Li-miao Lin Yong-Hang Xu man Shen Jia-Xin Liang Shuan-Jin Wang Min Xiao Yue-Zhong Meng The Key Laboratory of Low-carbon Chemistry&Energy Conservation of Guangdong Province/State Key Laboratory of Optoelectronic Materials and Technologies School of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou 510275China School of Environmental and Chemical Engineering Foshan UniversityFoshan 528000China School of Materials Science&Energy Engineering Foshan UniversityFoshan 528000China

A series of semi-aromatic polyesters named as Poly(PO-CHO-PA) were facilely synthesized via ring-opening terpolymerization of biobased cyclohexane oxide(CHO)/propylene oxide(PO)/phthalic anhydride(PA) using economical U1/PPNCl as dual catalyst. The proportion of CHO-PA and PO-PA segments in polymer can be readily altered by changing the feed ratio of CHO/PO because the reactivity ratios of CHO and PO with PA calculated by Fineman-Ross method are comparable. All synthesized amorphous polyesters with various compositions show one Tg ranging from 62 ℃ to 133 ℃. Significantly, the mechanical, thermal and barrier properties of these amorphous semi-aromatic polyesters are also adjustable and investigated for the first time. The results indicate the semi-polyesters exhibit superior thermostability(T5% ranging from 306 ℃ to323 ℃) and high tensile strength(40.21-55.7 MPa) that is comparable with polystyrene(PS). Furthermore, Poly(PO-CHO-PA) films possess a promising prospect as packaging materials because of its colorless and highly transparent nature, along with low oxygen and water vapor transmission rate. All above performances may guarantee its potential alternative to commercial PS.

关键词： Aromatic polyester Ring-opening polymerization Metal-free catalyst Polystyrene Barrier properties

EFFECT OF ESCAPE DEVICE FOR SUBMERGED FLOATING TUNNEL (SFT) ON HYDRODYNAMIC LOADS APPLIED TO SFT

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Journal of Hydrodynamics 2012年第4期24卷 609-616页

作者： DONG man-sheng miao Guo-ping YONG Long-chang NIU Zhong-rong PANG Huan-ping HOU Chao-qun School of Civil Engineering Hefei University of Technology Hefei 230009 China State Key Laboratory of Ocean Engineering -Shanghai JiaoTong Universityl Shanghai 200030 China School of Transportation Engineering Hefei University of Technology'Hefei 230009 China

This paper presents a potential approach to settle the problem of surviving major safety accidents in Submerged Floating Tunnel （SFT） that detachable emergency escape devices are set up outside SFT. The Computational Fluid Dynamics （CFD） technology is used to investigate the effect of emergency escape devices on the hydrodynamic load acting on SFT in uniform and oscillatory flows and water waves by numerical test. The governing equations, i.e., the Reynolds-Averaged Navier-Stokes （RANS） equations and k - ε standard turbulence equations, are solved by the Finite Volume Method （FVM）. Analytic solutions for the Airy wave are applied to set boundary conditions to generate water wave. The VOF method is used to trace the free surface. In uniform flow, hydrodynamic loads, applied to SFT with emergency escape device, reduce obviously. But, in oscillatory flow, it has little influence on hydrodynamic loads acting on SFT. Horizontal and vertical wave loads of SFT magnify to some extend due to emergency escape devices so that the influence of emergency escape devices on hydrodynamic loads of SFT should be taken into consideration when designed.

关键词： Submerged Floating Tunnel (SFT) conceptual design flow Airy wave escape device hydrodynamic load