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Food Science and Human Wellness 2024年

作者： miao Zheng Ming Ma Ruxue Fang Yilin Sun Xinyan yang Chaoxin man Qianyu Zhao Yujun Jiang Key Lab of Dairy Science， Ministry of Education， College of Food Science， Northeast Agricultural University

Food allergy (FA) is an aberrant immune response triggered by the ingestion of a food antigen. Ovalbumin (OVA)-sensitized and challenged BALB/c mice were orally administered heat-killed (HK)-L. paracasei JY56. In this work， HK-L. paracasei JY56 alleviated the FA-induced decrease in body weight and rectal temperature and reduced the allergy score. Serum analysis showed that HK-L. paracasei JY56 reduced the levels of specific antibodies (OVA-sIgE and OVA-sIgG) and allergic mediators (histamine and mast cell protease) in FA mice. In addition， HK-L. paracasei JY56 also could alleviate OVA-induced FA by suppressing Th2 and Th17-type immune responses， which was evidenced by the regulation of splenic lymphocyte subpopulations and associated cytokine secretion. Moreover， jejunal histological analysis and intestinal barrier function related gene expression measurement were performed to verify the intestinal barrier repair of HK-L. paracasei JY56. Meanwhile， the TLR4/NF-κB inflammatory pathway activation was inhibited by HK-L. paracasei JY56 at gene and protein levels. Finally， HK-L. paracasei JY56 was performed to modulate the gut microbiota structure and increase the levels of short-chain fatty acids. In conclusion， HK-L. paracasei JY56 could alleviate OVA-induced FA in multiple ways， and this study provides a theoretical basis for the application of inactivated probiotics in functional foods for FA.

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Inflammatory and Immunomodulatory Effects of Tripterygium wilfordii Multiglycoside in Mouse Models of Psoriasis Keratinocytes

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Chinese Journal of Integrative Medicine 2024年第3期30卷 222-229页

作者： ZHANG Shuo LI Hong-jin yang Chun-mei LIU Liu SUN Xiao-ying WANG Jiao CHEN Si-ting LU Yi HU man-qi YAN Ge ZHOU Ya-qiong miao Xiao LI Xin LI Bin Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai200437China Institute of Dermatology Shanghai Academy of Traditional Chinese MedicineShanghai201203China Department of Integrated Traditional Chinese and Western Medicine Shanghai Skin Disease HospitalTongji University School of MedicineShanghai200443China

Objective:To determine the role of Tripterygium wilfordii multiglycoside(TGW) in the treatment of psoriatic dermatitis from a cellular immunological ***:Mouse models of psoriatic dermatitis were established by imiquimod(IMQ).Twelve male BALB/c mice were assigned to MQ or IMQ+TGW groups according to a random number *** changes in vivo were assessed by hematoxylin and eosin *** of immune cells and cytokines in mice,as well as PAM212 cell proliferation in vitro were assessed by flow ***-inflammatory cytokine expression was determined using reverse transcription quantitative polymerase chain ***:TGW significantly ameliorated the severity of IMQ-induced psoriasis-like mouse skin lesions and restrained the activation of CD45^(+)cells,neutrophils and T lymphocytes(all P<0.01).Moreover,TGW significantly attenuated keratinocytes(KCs) proliferation and downregulated the mRNA levels of inflammatory cytokines including interleukin(IL)-17A,IL-23,tumor necrosis factor α,and chemokine(C-X-C motif) ligand 1(P<0.01 or P<0.05).Furthermore,it reduced the number of γδ T17 cells in skin lesion of mice and draining lymph nodes(P<0.01).Conclusions:TGW improved psoriasis-like inflammation by inhibiting KCs proliferation,as well as the associated immune cells and cytokine *** inhibited IL-17 secretion from γδ T cells,which improved the immune-inflammatory microenvironment of psoriasis.

关键词： psoriasis Tripterygium wilfordii multiglycoside γδT cells inflammation Chinese medicine

Proteomic analysis of "Oriental Beauty" oolong tea leaves with different degrees of leafhopper infestation

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Proteomic analysis of "Oriental Beauty" oolong tea leaves wi...

Changes of mitochondrial dynamics during the progression of non-alcoholic fatty liver disease: a review

2018年中国质谱学术大会（CMSC2018）

作者： Han-Ju Chien Pei-Chien Sung Chia-Chang Wu man-miao yang Chien-Chen Lai Institute of Molecular Biology Chung Hsing University

Oriental Beauty, a variety of oolong tea native to Taiwan, is highly prized by connoisseurs for its unique fruity aroma and sweet taste. Oriental Beauty owes its unique quality to the tea green leafhopper(Jacobiasca formosana), an insect of the Cicadelleidae family that feeds on the tea leaves.1 Leaves of Oriental Beauty vary in appearance, aroma and taste depending on the degree of leafhopper infestation. However, no studies have looked at differences in the proteome in leaves of Oriental Beauty with different degrees of tea green leafhopper infestation. In this study, we used a gel-based proteomic approach to investigate the differential expression of proteins in tea leaves with different degrees of leafhopper infestation. A total of 65 protein spots with at least two-fold differences in expression among leaves with low, medium and high degrees of infestation were excised from the gels and 157 proteins were identified by nano-liquid chromatography-electrospray/tandem mass spectrometry(nanoLC-ESIMS/MS). In gene ontology analysis, it showed that the majority of those proteins participated in biosynthesis, carbohydrate metabolism, transport, response to stress, and amino acid metabolism. Our results indicate that the unique aroma and taste of Oriental Beauty Tea might be influenced by the protein expression profiles besides other factors as a defense response to tea green leafhopper saliva. Those proteins may produce or alter metabolites which are actually the molecules responsible for the aroma.

关键词： Proteomics Oriental Beauty Leafhopper 2-DE Oolong tea

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Biomedical Engineering Communications 2024年第1期3卷 15-20页

作者： man-Na Li Ling yang Huan-Tian Cui Jia-Bao Liao Ning Wang Jing miao Ying Zhang Hai-Di Wang School of Nursing Yunnan University of Chinese MedicineKunming 650500China The First Clinical Medical College of Yunnan University of Chinese Medicine Kunming 650500China Department of Chinese Medicine Tianjin Second People's HospitalTianjin 30012China

Non-alcoholic fatty liver disease(NAFLD)is a chronic liver disease closely related to metabolic disorders that pose a serious threat to human ***,no specific drugs are available for treating the aetiology of NAFLD in clinical *** have various biological functions inside the *** have found that mitochondrial fission and fusion are closely related to ***,identifying therapeutic targets for NAFLD through mitochondrial fission and fusion is *** in the field of traditional Chinese medicine,good therapeutic effects have been achieved in the treatment of NAFLD by protecting mitochondrial fusion and ***,this article reviews the relationship between mitochondrial dynamics and NAFLD as well as the treatment of NAFLD through the regulation of mitochondrial fission and fusion with traditional Chinese medicine to provide a reference for the clinical application of traditional Chinese medicine in regulating mitochondrial fission and fusion functions to treat NAFLD.

关键词： mitochondrial dynamics NAFLD traditional Chinese medicine

Erratum to “Lipidome Atlas of the Developing Heart Uncovers Dynamic Membrane Lipid Attributes Underlying Cardiac Structural and Metabolic Maturation”

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Research 2024年第1期6卷 825-826页

作者： Huan miao Bowen Li Zehua Wang Jinming Mu Yanlin Tian Binhua Jiang Shaohua Zhang Xia Gong Guanghou Shui Sin man Lam State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China LipidALL Technologies Company Limited Changzhou 213022Jiangsu ProvinceChina

Main Text In the Research Article“Lipidome Atlas of the Developing Heart Uncovers Dynamic Membrane Lipid Attributes Underlying Cardiac Structural and Metabolic Maturation”[1],there was an error in *** authors mistakenly repeated the chord diagram designated for P7 with that from *** figure amendment did not affect the in-text discussion of the figure,which was focused on changes between P0 and P21,and did not alter the *** 2B has now been corrected in the PDF and HTML(full text).

关键词： Atlas Dynamic HTML

Treatment of anastomotic stricture after rectal cancer operation by magnetic compression technique:A case report

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1443-1448页

作者： miao-miao Zhang Huan-Chen Sha Hai-Rong Xue Yuan-Fa Qin Fang-Fang Dong Li Zhang Yi Lyu Xiao-Peng Yan Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Shaanxi Provincial Key Laboratory of Magnetic Medicine The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUNDThe treatment of postoperative anastomotic stenosis(AS)after resection of colorectalcancer is *** balloon dilation is used to treat stenosisin such cases,but some patients do not show improvement even after multipleballoon *** compression technique(MCT)has been used for gastrointestinalanastomosis,but its use for the treatment of postoperative AS aftercolorectal cancer surgery has rarely been *** SUMMARYWe report a 72-year-old man who underwent radical resection of colorectal cancerand ileostomy one year *** ileostomy closure was prepared six months ago,but colonoscopy revealed a narrowing of the rectal *** balloondilation was performed three times,but colonoscopy showed no significantimprovement in *** AS was successfully treated using *** is a minimally invasive method that can be used for the treatment of postoperativeAS after colorectal cancer surgery.

关键词： Rectostenosis Magnetic surgery Magnetic Surgery Clinic Rectal cancer Magnetic compression technique Case report

倾听的艺术与回应的章法——儿童哲学实践的瓶颈及突破

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湖北师范大学学报（哲学社会科学版） 2024年第3期44卷 105-112页

作者：苗曼江苏师范大学教育科学学院江苏徐州221116

如何去倾听儿童发出的哲学之声以及如何对其做出有价值的回应,已成为当下制约儿童哲学实践发展的严重瓶颈。“哲学之听”不是简单的耳朵之听见,也不仅是直接的语义信息之听取,而是需要对语言背后的思想乃至其逻辑纹理予以心领神会。“... 详细信息

如何去倾听儿童发出的哲学之声以及如何对其做出有价值的回应,已成为当下制约儿童哲学实践发展的严重瓶颈。“哲学之听”不是简单的耳朵之听见,也不仅是直接的语义信息之听取,而是需要对语言背后的思想乃至其逻辑纹理予以心领神会。“哲学之听”比其他倾听具有更高的难度。儿童哲学表达方式的多样性以及儿童哲学思考方式的独特性,使“儿童哲学之倾听”比发生在成人间的哲学之倾听具有更大挑战性。儿童尤其是低龄儿童哲学之倾听,亟需提升至“艺术”境界或至少提升为一种专业性“技艺”。“解析式倾听”“追问式倾听”“把捉式倾听”等应成为儿童哲学倾听者的基本技艺;从倾听出发,助力儿童哲学自由绽放的“生产性回应”,应成为儿童哲学活动中教师回应的基本章法。

关键词：儿童哲学倾听回应

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降尿酸乳酸菌菌株的筛选及其全基因组分析

中国食品学报 2024年第7期24卷 88-99页

作者：苗超张宇杨鑫焱姜毓君满朝新赵倩玉东北农业大学食品学院乳品科学教育部重点实验室哈尔滨150030

高尿酸血症是痛风发病的生化基础,严重威胁人体健康。通过测定35株乳酸菌对鸟苷和肌苷的降解能力,筛选出4株具有较高降解能力的乳酸菌,对这4株菌的菌悬液、细胞内容物及代谢物进行黄嘌呤氧化酶活性抑制试验,选取其中抑制能力最强的菌株... 详细信息

高尿酸血症是痛风发病的生化基础,严重威胁人体健康。通过测定35株乳酸菌对鸟苷和肌苷的降解能力,筛选出4株具有较高降解能力的乳酸菌,对这4株菌的菌悬液、细胞内容物及代谢物进行黄嘌呤氧化酶活性抑制试验,选取其中抑制能力最强的菌株进行全基因组测序和安全性验证。结果表明,鼠李糖乳酪杆菌JY027对鸟苷和肌苷的降解率分别达80.27%和87.33%,且该菌株的菌悬液、细胞内容物及代谢物对黄嘌呤氧化酶的抑制率分别为85.71%,78.34%,84.05%,说明其具有较强的降尿酸能力。此外,通过对鼠李糖乳酪杆菌JY027的全基因组编码基因的预测,发现该菌株具有次黄嘌呤磷酸核糖基转移酶、次黄嘌呤核苷酸脱氢酶等多个尿酸代谢相关基因。经过吲哚、溶血等试验验证了该菌株的安全性。本研究为鼠李糖乳酪杆菌JY027用于缓解高尿酸血症提供了理论基础。

关键词：乳酸菌高尿酸血症鼠李糖乳酪杆菌全基因组安全性

Magnetic compression anastomosis to restore biliary tract continuity after obstruction following major abdominal trauma:A case report

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1933-1938页

作者： miao-miao Zhang Jie Tao Huan-Chen Sha Yun Li Xiao-Gang Song Oliver J Muensterer Fang-Fang Dong Li Zhang Yi Lyu Xiao-Peng Yan Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Shaanxi Provincial Key Laboratory of Magnetic Medicine The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina National Local Joint Engineering Research Center for Precision Surgery&Regenerative Medicine The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of Pediatric Surgery Dr.von Hauner Children’s HospitalLudwig-Maximilians-University Medical CenterMunich 80337Germany

BACKGROUND The combination of magnetic compression anastomosis(MCA)and endoscopy has been used to treat biliary stricture after liver ***,its use for the treatment of complex biliary obstruction after major abdominal trauma has not been *** case report describes the successful use of MCA for the treatment of biliary obstruction resulting from major abdominal trauma.A 23-year-old man underwent major abdominal surgery(repair of liver rupture,right half colon resection,and ileostomy)following a car accident one year *** abdominal drainage tube,positioned at the Winslow foramen,was draining approximately 600-800 mL of bile per *** the two endoscopic retrograde cholangiopancreatography procedures,the guide wire was unable to enter the common bile duct,which prevented placement of a biliary *** combined with endoscopy was used to successfully achieve magnetic anastomosis of the peritoneal sinus tract and duodenum,and then a choledochoduodenal stent was ***,the external biliary drainage tube was *** patient achieved internal biliary drainage leading to the removal of the external biliary drainage tube,which improved the quality of *** Magnetic compression technique can be used for the treatment of complex biliary obstruction with minimal operative trauma.

关键词： Magnetic compression anastomosis Magnetosurgery Endoscopy Magnetic Surgery Clinic Biliary obstruction Case report

Novel magnetic compression technique for the treatment of postoperative anastomotic stenosis in rectal cancer:A case report

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1926-1932页

作者： miao-miao Zhang Huan-Chen Sha Hai-Rong Xue Yuan-Fa Qin Xiao-Gang Song Yun Li Yu Li Zheng-Wu Deng Yu-Lin Gao Fang-Fang Dong Yi Lyu Xiao-Peng Yan Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Shaanxi Provincial Key Laboratory of Magnetic Medicine The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of National Local Joint Engineering Research Center for Precision Surgery&Regenerative Medicine The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina

BACKGROUND The treatment of postoperative anastomotic stenosis after excision of rectal cancer is *** balloon dilation and radial incision are not effective in all *** present a new endoscopy-assisted magnetic compression technique(MCT)for the treatment of rectal anastomotic *** successfully applied this MCT to a patient who developed an anastomotic stricture after radical resection of rectal cancer.A 50-year-old man had undergone laparoscopic radical rectal cancer surgery at a local hospital 5 months ago.A colonoscopy performed 2 months ago indicated that the rectal anastomosis was narrow due to which ileostomy closure could not be *** patient came to the Magnetic Surgery Clinic of the First Affiliated Hospital of Xi'an Jiaotong University after learning that we had successfully treated patients with colorectal stenosis using *** performed endoscopy-assisted magnetic compression surgery for rectal *** magnets were removed 16 d later.A follow-up colonoscopy performed after 4 months showed good anastomotic patency,following which,ileostomy closure surgery was *** MCT is a simple,non-invasive technique for the treatment of anastomotic stricture after radical resection of rectal *** technique can be widely used in clinical settings.

关键词： Rectal cancer Magnetic compression technique Magnetosurgery Anastomotic stricture Magnetic surgery clinic Case report