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Epstein-Barr virus in hepatocellular carcinogenesis

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World Journal of Gastroenterology 2004年第23期10卷 3409-3413页

作者： WeiLi bao-AnWu Yong-MingZeng Guang-CanChen Xin-XinLi Jun-TianChen Yu-WenGuo man-HongLi YiZeng DepartmentofGeneralSurgery theFirstAffiliatedHospitalofShantouUniversityMedicalCollegeShantou515041GuangdongProvinceChina DepartmentofPathology theFirstAffiliatedHospitalofShantouUniversityMedicalCollegeShantou515041GuangdiongProvinceChina OncogenicVirusLaboratory InstituteforViralDiseasePreventionandControlChineseCenterforDiseaseControlandPrevention(ChinaCDC)Beijing100052China

AIM: In recent years, studies have suggested that EpsteinBarr virus (EBV) is associated with HCC. The present study was to determine the prevalence of EBV in HCC patients,and whether EBV acted synergistically with hepatitis viruses in HCC ***: Liver tissue 115 HCC patients and 26 noncarcinoma patients were studied, Polymerase chain reaction (PCR) was performed to detect EBV BarnHI W DNA, EBV LMP1 DNA, HI3V X DNA, and HBV S DNA, Reverse transcription PCR (RT-PCR) was performed to detect HCV RNA and HDV RNA, Immunohistochemistry was performed to detect LMP1,HBsAg, HBcAg and HCV, The positive ratios were compared between HCC group and control group by X^2 test,RESULTS: Totally, 78 HCC samples whose 13-globulin DNA was positively detected by amplified PCR were selected,PCR was performed in all cases for EI3V DNA and HBV DNA,RT-PCR was performed in 18 cases for HCV RNA and HDV RNA. EBV BarnHI W and EBV LMP1 were positive in 18 and 6 cases, respectively. HBV X gene and HBV S gene were positive in 42 and 27 cases respectively. HCV was positive in one of the 18 cases, and none was positive for HDV. The positive rates were 28.2% (22 of 78) for EBV DNA (BarnHI W and/or LMP1) and 56.4% (44 of 78) for HBV DNA (X gene and/or S gene) respectively. In addition, 12 cases were positive for both EBV DNA and HBV DNA. Among the 26 cases in the control group, 2 cases were positive for EBV BarnHI W, 4 positive for HBV X gene and 3 positive for HBV S gene. The positive rates were 8.0% (2 of 26) and 23.1% (6 of 26),respectively, for EBV DNA and HBV DNA. The result of DNA sequencing of BamHI W was 100% homologous with the corresponding sequence of B95-8. There was significant difference in EBV infection rate between HCC patients and controls (X^2 = 4.622, P0.05). LMP1, HBV (HBsAg, HI3cAg) an

关键词： EBV 爱泼斯坦-巴尔病毒肝细胞致癌作用肿瘤肝癌

Role of graphene in improving catalytic behaviors of AuNPs/MoS_(2)/Gr/Ni-F structure in hydrogen evolution reaction

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Chinese Physics B 2021年第8期30卷 551-557页

作者： Xian-Wu Xiu Wen-Cheng Zhang Shu-Ting Hou Zhen Li Feng-Cai Lei Shi-Cai Xu Chong-Hui Li bao-Yuan man Jing Yu Chao Zhang School of Physics and Electronics Collaborative Innovation Center of Light Manipulations and ApplicationsInstitute of Materials and Clean EnergyShandong Normal UniversityJinan 250014China College of Chemistry Chemical Engineering and Materials ScienceInstitute of Biomedical SciencesShandong Normal UniversityJinan 250014China Shandong Key Laboratory of Biophysics Institute of BiophysicsDezhou UniversityDezhou 253023China Institute for Integrative Nanosciences IFW DresdenDresden01069Germany

The efficient production of hydrogen through electrocatalytic decomposition of water has broad prospects in modern energy ***,the catalytic efficiency and durability of hydrogen evolution catalyst are still very deficient,which need to be further *** in this work,we prove that introducing a graphene layer(Gr)between the molybdenum disulfide and nickel foam(Ni-F)substrate can greatly improve the catalytic performance of the *** to the excitation of local surface plasmon resonance(LSPR)of gold nanoparticles(NPs),the electrocatalytic hydrogen releasing activity of the MoS_(2)/Gr/Ni-F heterostructure is greatly *** results in a significant increase in the current density of AuNPs/MoS_(2)/Gr/Ni-F composite material under light irradiation and in the dark at 0.2 V(versus reversible hydrogen electrode(RHE)),which is much better than in MoS_(2)/Gr/Ni-F composite *** enhancement of hydrogen release can be attributed to the injection of hot electrons into MoS_(2)/Gr/Ni-F by AuNPs,which will improve the electron density of MoS_(2)/Gr/Ni-F,promote the reduction of H_(2)O,and further reduce the activation energy of the electrocatalyst hydrogen evolution reaction(HER).We also prove that the introduction of graphene can improve its stability in acidic catalytic *** work provides a new way of designing efficient water splitting system.

关键词： hydrogen evolution reaction catalytic graphene plasmon resonance

Clival metastasis of renal clear cell carcinoma: Case report and literature review

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World Journal of Clinical Cases 2018年第9期6卷 301-307页

作者： Wei-Qi Zhang Yue bao Bo Qiu Yong Wang Zhi-Peng Li Yi-bao Wang Department of Neurosurgery First Affiliated Hospital of China Medical University

The clivus is an atypical metastatic site for renal clear cell carcinoma(RCCC). Here we report a 54 year old man with acute cavernous sinus syndrome. Brain magnetic resonance imaging identified a clival-based lesion with associated bony erosion. The patient underwent endoscopic endonasal biopsy and partial resection of the clival mass. Because histologic examination of the resected specimen resulted in a diagnosis of RCCC, contrast-enhanced computed tomography scan of the abdomen was performed and showed an enhanced left renal mass. The patient subsequently underwent laparoscopic left radical nephrectomy and gamma knife was planned for the residual clival lesion. We also retrospectively reviewed available published reports on clival metastases, specifically those from RCCC, since 1990.

关键词： Clival metastases Endoscopic skull base surgery Renal clear cell carcinoma Renal Carcinoma

Subcapsular hepatic haematoma after endoscopic retrograde cholangiopancrea-tography: An unusual case

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World Journal of Gastroenterology 2013年第9期19卷 1502-1504页

作者： bao-Ying Fei Cai-Hong Li Department of Gastroenterology Zhejiang Provincial People's Hospital

Subcapsular hepatic haematoma is a rare complication of endoscopic retrograde cholangiopancrea-tography (ERCP), and there are few reports about this unusual complication worldwide. The primary symptom of most cases reported in the literature is abdominal pain. We report an unusual case with the primary symptom of fever. A 56-year-old man who had a six-month history of recurrent episodes of upper abdominal pain was diagnosed with a common bile duct stone by magnetic resonance cholangiopancrea-tography. Endoscopic biliary sphincterotomy was performed, and stones from the common bile duct were successfully extracted with a basket. The patient had a persistent fever after ERCP, and treatment with intravenous antibiotics was unsuccessful. Computed tomography showed a 13 cm × 6 cm subcapsular hepatic haematoma filled with air and liquid on the surface of the right hepatic lobe. The patient was successfully treated with peritoneal drainage under B-ultra guidance. Subcapsular liver haematoma should be considered when hard-toexplain symptoms persist in the early period after ERCP. Percutaneous drainage is an effective treatment.

关键词： Endoscopic retrograde cholangiopancreatography Hepatic Hematoma Complication Treatment

从“传统福利”到“积极福利”:我国困境儿童家庭支持福利体系构建研究

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东北大学学报（社会科学版） 2016年第2期18卷 173-178页

作者：满小欧王作宝东北大学文法学院辽宁沈阳110819

社会转型与变迁使传统补缺型儿童救助政策已无法承载当前的困境儿童问题。与传统儿童福利制度相比,家庭支持福利制度既包括来自政府及福利机构提供的福利津贴也包括一系列支持性服务项目,体现了理念上的革新,注重以预防策略为主的积极... 详细信息

社会转型与变迁使传统补缺型儿童救助政策已无法承载当前的困境儿童问题。与传统儿童福利制度相比,家庭支持福利制度既包括来自政府及福利机构提供的福利津贴也包括一系列支持性服务项目,体现了理念上的革新,注重以预防策略为主的积极性政策及专业社工服务的提供。构建我国困境儿童家庭支持福利制度即是在肯定"家庭"作为儿童福利制度设计核心要素的同时,从社会投资与能力建设视角出发,为家庭提供包括多层次津贴、专业社工服务及以社区为依托的支持性服务在内的综合福利体系。

关键词：困境儿童家庭支持儿童福利积极福利

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珙桐种质资源保存样本策略的研究

植物生态学报 2005年第3期29卷 422-428页

作者：宋丛文包满珠华中农业大学湖北省林业科学研究院武汉430079

珙桐(Davidiainvolucrata)是我国特有的珙桐科单型属植物,起源古老,是第三纪热带植物区系的孑遗种,被列为国家一级保护植物。利用RAPD技术,通过11个多态引物对5个天然珙桐种群的遗传多样性、种群内和种群间的遗传变异进行了研究。结果表... 详细信息

珙桐(Davidiainvolucrata)是我国特有的珙桐科单型属植物,起源古老,是第三纪热带植物区系的孑遗种,被列为国家一级保护植物。利用RAPD技术,通过11个多态引物对5个天然珙桐种群的遗传多样性、种群内和种群间的遗传变异进行了研究。结果表明:珙桐天然种群具有丰富的遗传多样性,但群体间的差异明显,2 6 %的遗传变异存在于群体间。研究将珙桐划分为东南部和西北部两大种源区。通过对珙桐群体间及群体内的聚类分析,结合遗传标记的捕获曲线研究提出了珙桐种质资源保存的样本策略。原地保存可以选择甘肃文县、四川峨眉山和贵州梵净山3个种群作为保存对象,每个群体保存面积3hm2 以上;异地保存应抽取甘肃文县、四川峨眉山、湖北神农架、贵州梵净山等4个群体,每个群体抽样30个以上个体,株间最小间距30m以上,共计保存15 0个个体,分别在东南部和西北部建立一个异地保存点。

关键词：珙桐种质资源保存样本策略 RAPD 遗传多样性遗传变异原地保存异地保存

Atherosclerosis related receptor LPAR1

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Atherosclerosis related receptor LPAR1

第五届泛环渤海生物化学与分子生物学会学术交流会

作者： ZHAI man-jue WU Shuang ALATAN Gaole bao Liang Department of Biochemistry and Molecular Biology College of Life ScienceInner Mongolia University Institute of Biochemistry Vocational College of Huhhot

The migration and proliferation of vascular smooth muscle cells(SMCs) is a hallmark of the pathogenesis of atherosclerosis. We previously showed that Plasma low-density lipoprotein(LDL) induced the migration of human coronary artery SMCs(CASMCs). Among bioactive lipids postulated to be present in LDL, lysophosphatidic acid(LPA),amount of which is higher than others, mimicked the LDL action. In this work, we tested the effects of LPA on human artery smooth muscle cells(HASMCs)and found that LPA induced migrat ion and proliferat ion of HASMCs. This effect was markedly inhibited by Ki-16425, an antagonist of LPA1/3 receptor, and a small interfering RNA(si RNA) targeted for LPAR1 receptors. LPA can also induce extracellular signal-regulated kinase(ERK1/2) activation. Both of si RNA targeting LPAR1 receptor and PTX,an inhibitor of Gi protein,inhibit ed LPA induced ERK activat ion and HASMCs proliferat ion. Due to these results, we suppose that LPA can promote proliferation and migrat ion of SMCs and final induced the atherosclerosis through LPAR1. To confirm this hypothesis,the atherosclerosis disease animal model was studied. As the experimental group, ten rabbits were feed with high-lipid forage for 70 days and the another ten were feed with normal forage for a contrast. The atherosclerotic plaques were occurred in aorta of the experimental group of which atherosclerosis index(AI) was higher than control group. Our data indicate that the lpr1 gene expression was obviously increased in atherosclerotic plaque. Taken together, these data indicate that the G protein coupled receptor LPAR1 is an atherosclerosis related receptor.

关键词： CASMCs LPAR1 atherosclerosis

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美罗培南导致伪膜性肠炎的1例病例分析

中国临床药理学杂志 2017年第3期33卷 255-257页

作者：刘家宝朱曼天津市南开医院药学部天津300100 解放军总医院药品保障中心北京100853

目的探讨临床药师参与1例患者应用美罗培南后导致严重伪膜性肠炎药物治疗的作用。方法临床药师详细了解患者的症状、体征及各项检查结果,结合病情对药物治疗方案进行分析及建议,并进行药学监护。结果与结论患者抗感染的治疗过程中导致... 详细信息

目的探讨临床药师参与1例患者应用美罗培南后导致严重伪膜性肠炎药物治疗的作用。方法临床药师详细了解患者的症状、体征及各项检查结果,结合病情对药物治疗方案进行分析及建议,并进行药学监护。结果与结论患者抗感染的治疗过程中导致了伪膜性肠炎,药师可以配合医师,积极对症处理,根据病情优化方案,保障用药的安全性及有效性。

关键词：美罗培南伪膜性肠炎病例分析

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东乡语情态词初探

中央民族大学学报（哲学社会科学版） 2016年第2期43卷 115-119页

作者：包满亮中央民族大学蒙古语言文学系北京100081

情态是叙述者对所述行为或事物所持的态度和看法。东乡语情态词按其含义可分为推断、肯定、显然、必须、强调、允许、可能等。情态的表现手段可有多种。从语义学和类型学角度对一个语言的情态词、情态意义及其表现手段等进行梳理,有助... 详细信息

情态是叙述者对所述行为或事物所持的态度和看法。东乡语情态词按其含义可分为推断、肯定、显然、必须、强调、允许、可能等。情态的表现手段可有多种。从语义学和类型学角度对一个语言的情态词、情态意义及其表现手段等进行梳理,有助于了解和揭示该语言情态范畴系统及其表现规律。

关键词：东乡语情态词情态意义