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Crosstalk between degradation and bioenergetics: how autophagy and endolysosomal processes regulate energy production

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Neural Regeneration Research 2025年第3期20卷 671-681页

作者： Angelid Pabon Jagannatham Naidu Bhupana ching-On wong Department of Biological Sciences Rutgers UniversityNewarkNJUSA

Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy production, and metabolic reprogramming stipulates a shift in such balance to optimize both bioenergetic efficiency and anabolic requirements. Failure in switching bioenergetic dependence can lead to maladaptation and pathogenesis. While cellular degradation is known to recycle precursor molecules for anabolism, its potential role in regulating energy production remains less explored. The bioenergetic switch between glycolysis and mitochondrial respiration involves transcription factors and organelle homeostasis, which are both regulated by the cellular degradation pathways. A growing body of studies has demonstrated that both stem cells and differentiated cells exhibit bioenergetic switch upon perturbations of autophagic activity or endolysosomal processes. Here, we highlighted the current understanding of the interplay between degradation processes, specifically autophagy and endolysosomes, transcription factors, endolysosomal signaling, and mitochondrial homeostasis in shaping cellular bioenergetics. This review aims to summarize the relationship between degradation processes and bioenergetics, providing a foundation for future research to unveil deeper mechanistic insights into bioenergetic regulation.

关键词： autophagy bioenergetics endolysosome energy production glycolysis metabolic reprogramming mitochondria

Ignition Pattern Analysis for Automotive Engine Trouble Diagnosis Using Wavelet Packet Transform and Support Vector Machines

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chinese Journal of Mechanical Engineering 2011年第5期24卷 870-878页

作者： VONG chi-man wong Pak-kin TAM Lap-mou ZHANG Zaiyong Department of Computer and Information Science Faculty of Science and Technology University of Macao Macao China Department of Electromechanical Engineering Faculty of Science and Technology University of Macao Macao China

Engine spark ignition is an important source for diagnosis of engine *** on the waveform of the ignition pattern,a mechanic can guess what may be the potential malfunctioning parts of an engine with his/her experience and ***,this manual diagnostic method is imprecise because many spark ignition patterns are very ***,a diagnosis needs many trials to identify the malfunctioning *** the mechanic needs to disassemble and assemble the engine parts for *** tackle this problem,an intelligent diagnosis system was established based on ignition ***,the captured patterns were normalized and *** wavelet packet transform（WPT） was employed to extract the representative features of the ignition ***,a classification system was constructed by using multi-class support vector machines（SVM） and the extracted *** classification system can intelligently classify the most likely engine fault so as to reduce the number of diagnosis *** results show that SVM produces higher diagnosis accuracy than the traditional multilayer feedforward neural *** is the first trial on the combination of WPT and SVM to analyze ignition patterns and diagnose automotive engines.

关键词： automotive engine ignition pattern diagnosis pattern classification wavelet packet transform support vector machines.

Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： Bin Xie Yuanhui Guo Yun Chen Hao Zhang Jiawei Xiao Maoxiang Hou Huilong Liu Li Ma Xin Chen chingping wong State Key Laboratory of Precision Electronic manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

A landscape of β-Ga_(2)O_(3) Schottky power diodes

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Journal of Semiconductors 2023年第9期44卷 47-56页

作者： man Hoi wong Department of Electronic and Computer Engineering Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

β-Ga_(2)O_(3) Schottky barrier diodes have undergone rapid progress in research and development for power electronic *** paper reviews state-of-the-art β-Ga_(2)O_(3) rectifier technologies,including advanced diode architectures that have enabled lower reverse leakage current via the reduced-surface-field *** device properties including onresistance,breakdown voltage,rectification ratio,dynamic switching,and nonideal effects are summarized for the different *** results on the high-temperature resilience of β-Ga_(2)O_(3) Schottky diodes,together with the enabling thermal packaging solutions,are also presented.

关键词： β-Ga_(2)O_(3) Schottky diodes power device edge termination nickel oxide

Nanoimprint lithography-assisted block copolymer self-assembly for hyperfine fabrication of magnetic patterns based on L10-FePt nanoparticles

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Science china Chemistry 2025年

作者： Jie Zhang Yi Chen Guijun Li Zelin Sun Zhengong Meng Wai-Yeung wong Department of Applied Biology and Chemical Technology and Research Institute for Smart Energy The Hong Kong Polytechnic University The Hong Kong Polytechnic University Shenzhen Research Institute Division of Integrative Systems and Design and Department of Electronic and Computer Engineering The Hong Kong University of Science and Technology School of Flexible Electronics (Future Technology) and Institute of Advanced Materials (IAM) Nanjing Tech University

L10-FePt-type bit-patterned media has provided a promising alternative for ultrahigh-density magnetic recording systems in the current digital era, but rapid fabrication of magnetic patterns with hyperfine bit islands is still challenging, especially with the target for miniaturization and scalable production simultaneously. Herein, Fe,Pt-containing block copolymers were utilized as single-source precursors for solution-processable patterning and subsequent generation of the demanding magnetic FePt dots by in situ pyrolysis. High-throughput nanoimprint lithography was initially employed to fabricate the predefined bit cells precisely,and then the intrinsic self-assembly of phase-separated block copolymers further drove the formation of accurate bit *** from the synergistic effect of top-down lithographic approach and bottom-up self-assembly, the customizable patterns could be achieved for large-scale mass production in targeted areas, but high-density isolated dots could also be accurately aligned along the patterned features after subsequent self-assembly. This reliable strategy would provide a good avenue to precisely construct ultrahigh-density magnetic data storage devices.

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MHC class I-LILRB3 delivers a punch to eliminate precancerous cells

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Cellular & Molecular Immunology 2022年第6期19卷 655-656页

作者： chi Chun wong Jun Yu Institute of Digestive Disease Department of Medicine and TherapeuticsState Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong SARChina

In the study by Ayukawa et al.[1],the authors presented an innate defense mechanism whereby normal epithelial cells actively remove precancerous cells from the epithelium via mechanical extrusion(Fig.1).

关键词： precancerous epithelium

Low-temperature metal–oxide thin-film transistor technologies for implementing flexible electronic circuits and systems

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Journal of Semiconductors 2023年第9期44卷 3-10页

作者： Runxiao Shi Tengteng Lei Zhihe Xia man wong State Key Laboratory of Advanced Displays and Optoelectronics and Technologies Department of Electronic and Computer EngineeringThe Hong Kong University of Science and TechnologyHong KongChina

Here we review two 300℃metal–oxide(MO)thin-film transistor(TFT)technologies for the implementation of flexible electronic circuits and ***-enhanced TFTs for suppressing the variation and shift of turn-on voltage(VON),and dual-gate TFTs for acquiring sensor signals and modulating VON have been deployed to improve the robustness and performance of the systems in which they are *** circuit building blocks based on fluorinated TFTs have been designed,fabricated,and characterized,which demonstrate the utility of the proposed low-temperature TFT technologies for implementing flexible electronic *** construction and characterization of an analog front-end system for the acquisition of bio-potential signals and an active-matrix sensor array for the acquisition of tactile images have been reported recently.

关键词： flexible electronics metal-oxide semiconductor thin-film transistor dual gate fluorination analog front-end system sensors

Development of An ICR Mouse Bioassay for Toxicity Evaluation in Neurotoxic Poisoning Toxins-Contaminated Shellfish

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Biomedical and Environmental Sciences 2013年第5期26卷 346-364页

作者： wong Chun Kwan HUNG Patricia KAM Kai man Biotoxin Laboratory Microbiology DivisionPublic Health Laboratory Services BranchCentre for Health ProtectionDepartment of HealthShek Kip MeiKowloon

Objective To develop an ICR （female） mouse bioassay （MBA） for toxicity confirmation and evaluation of neurotoxins （brevetoxins）-contaminated shellfish. Methods Brevetoxins （BTX-B） as a causative agent of neurotoxic shellfish poisoning （NSP） under different shellfish matrices were intraperitoneally injected at different doses into mice to study their toxic effects and to differentiate the range of lethal and sublethal dosages. Their sensitivity and specificity were analyzed with 2 competitive ELISA kits for quantitative determination of standard BTX-B and dihydroBTX-B under different shellfish matrix-diluent combinations. Detection rates of MBA and two antibody-based assays for BTX-B from field NSP-positive shellfish samples were compared. Results BTX-B could be detected in shellfish tissues at concentration of 50-400 μg/100 g under shellfish matrix-Tween-saline media, which were appropriate to identify toxic shellfish at or above the regulatory limit （80 μg/100 g shellfish tissues）. The LD 50 identified was 455 g/kg for BTX-B under general shellfish matrices （excluding oyster matrices） dissolved in Tween-saline. The presence of shellfish matrices, of oyster matrices in particular, retarded the occurrence of death and toxicity presentation in mice. Two antibody-based assays, even in the presence of different shellfish matrix-diluent combinations, showed acceptable results in quantifying BTX-B and dihydroBTX-B well below the regulatory limit. Conclusion The two ELISA analyses agree favorably （correlation coefficient, r 0.96; Student＇s t-tests, P〉0.05） with the developed bioassay.

关键词： Antibody-based assay Brevetoxin ICR female mice LD 50 Mouse bioassay Neurotoxic shellfish poisoning

Synthesis and enhanced piezoelectric response of CVD-grown SnSe layered nanosheets for flexible nanogenerators

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Nano Research 2023年第9期16卷 11839-11845页

作者： Fumei Yang man-Chung wong Jianfeng Mao Zehan Wu Jianhua Hao Department of Applied Physics the Hong Kong Polytechnic UniversityHong Kong 999077China

Piezoelectricity is the electric charge which accumulates in certain materials in response to mechanical stimuli,while piezoelectric nanogenerators(PENGs)converting mechanical energy into electricity can be widely used for energy harvesting and self-powered *** group IV-VI monochalcogenides may exhibit strong piezoelectricity because of their puckered C_(2v)symmetry and electronic structure,making them promising for flexible ***,we investigated the synthesis and piezoelectric properties of multilayer SnSe nanosheets grown by chemical vapor deposition(CVD).The SnSe nanosheets exhibited high single-crystallinity,large area,and good *** strong layer-dependent in-plane piezoelectric coefficient of SnSe nanosheets showed a saturated trend to be~110 pm/V,which overcomes the weak piezoelectric response or odd-even effects in other layered nanosheets.A high energy conversion efficiency of 9.3%and a maximum power density of 538 mW/cm^(2)at 1.03%strain have been demonstrated in a SnSe-based *** on the enhanced piezoelectricity of SnSe and attractive output performance of the nanogenerator,a self-powered sensor for human motion monitoring is further *** results demonstrate the strong piezoelectricity in high quality CVD-grown SnSe nanosheets,allowing for application in flexible smart piezoelectric sensors and advanced microelectromechanical devices.

关键词： SnSe piezotronics piezoresponse force microscope piezoelectric nanogenerator self-powered device