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Resident and migratory adipose immune cells control systemic metabolism and thermogenesis

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Cellular & Molecular Immunology 2022年第3期19卷 421-431页

作者： Kevin man Axel Kallies Ajithkumar Vasanthakumar Peter Doherty Institute for Infection and Immunity MelbourneVICAustralia Department of Microbiology and Immunology University of MelbourneMelbourneVICAustralia Olivia Newton-John Cancer Research Institute MelbourneVICAustralia

Glucose is a vital source of energy for all *** balance between glucose uptake,metabolism and storage determines the energy status of an individual,and perturbations in this balance can lead to metabolic *** maintenance of organismal glucose metabolism is a complex process that involves multiple tissues,including adipose tissue,which is an endocrine and energy storage organ that is critical for the regulation of systemic *** tissue consists of an array of different cell types,including specialized adipocytes and stromal and endothelial *** addition,adipose tissue harbors a wide range of immune cells that play vital roles in adipose tissue homeostasis and *** cells contribute to the regulation of systemic metabolism by modulating the inflammatory tone of adipose tissue,which is directly linked to insulin sensitivity and ***,these cells affect the control of *** lean adipose tissue is rich in type 2 and anti-inflammatory cytokines such as IL-10,obesity tips the balance in favor of a proinflammatory milieu,leading to the development of insulin resistance and the dysregulation of systemic ***,anti-inflammatory immune cells,including regulatory T cells and innate lymphocytes,protect against insulin resistance and have the characteristics of tissue-resident cells,while proinflammatory immune cells are recruited from the circulation to obese adipose ***,we review the key findings that have shaped our understanding of how immune cells regulate adipose tissue homeostasis to control organismal metabolism.

关键词： adipose tissue immune cells metabolism

Prothrombin kringle-2, a mediator of microglial activation: new insight in Alzheimer’s disease pathogenesis

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Neural Regeneration Research 2022年第12期17卷 2675-2676页

作者： Jae man Lee sang Ryong Kim Department of Biochemistry and Cell Biology Cell and Matrix Research InstituteSchool of MedicineKyungpook National UniversityDaeguKorea Brain science and Engineering Institute Kyungpook National UniversityDaeguKorea school of Life sciences BK21 FOUR KNU Creative BioResearch GroupInstitute of Life Science and BiotechnologyKyungpook National UniversityDaeguKorea

Microglial activation in Alzheimer’s disease(AD):In 1907,*** Alzheimer,a Bavarian-born German psychiatrist and neuropathologist,published an article describing the clinical and neuropathological features of an unclassified psychiatric *** disorder was later named AD and is currently the most common brain disorder(Takata et al.,2021).AD involves the accumulation of amyloid-β(Aβ)and hyperphosphorylated tau proteins in the brain,which are associated with senile plaques and neurofibrillary tangles,respectively(Vergara et al.,2019;Takata et al.,2021).AD is characterized by cognitive impairment and memory loss with hippocampal neurodegeneration(Kim et al.,2021).

关键词： Alzheimer Aβ tau

Analytical solutions for Predicting Tensile and shear Moduli of Triaxial Weave Fabric Composites

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Acta Mechanica solida sinica 2016年第1期29卷 59-77页

作者： Jiangbo Bai Junjiang Xiong Meng Liu Ziyu man school of Transportation science and Engineering Beihang University Beijing 100083 China

Novel micromechanical curved beam models were presented for predicting the ten- sile and shear moduli of triaxial weave fabric （TWF） composites by considering the interactions between the triaxial yarns of 0° and ±60° The triaxial yarns in micromechanieal representative unit cell （RUC） were idealized as curved beams with a path depicted using the sinusoidal shape functions, and the tensile and shear moduli of TWF composites were derived by means of the strain energy approach founded on micromechanics. In order to validate the new models, the predictions were compared with the experimental data from literature. It was shown that the predictions from the new model agree well with the experimental results. Using these models, the tensile and shear properties of TWF composites could be predicted based only on the properties of basic woven fabric.

关键词： triaxial weave fabric (TWF) composite elastic properties tension modulus shearmodulus

Optimized use of MgO flux in the agglomeration of high-chromium vanadium–titanium magnetite

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International Journal of Minerals,Metallurgy and Materials 2015年第4期22卷 371-380页

作者： Jue Tang man-sheng Chu Xiang-xin Xue school of Material and Metallurgy Northeastern University

The optimized use of MgO flux in the agglomeration of high-chromium vanadium-titanium magnetite was investigated system- atically through sinter and pellet experiments. MgO was added in the form of magnesite. When the content of MgO in the sinter was in- creased from 1.95wt% to 2.63wt%, the low-temperature reduction degradation index increased from 80.57% to 82.71%. When the content of MgO in the pellet was increased from 1.14wt% to 2.40wt%, the reduction swelling index decreased from 15.2% to 8.6%; however, the com- pressive strength of the oxidized pellet decreased dramatically and it was 1985 N with an MgO content of 1.14wt%. This compressive strength does not satisfy the requirements for blast-furnace production. When all of the aforementioned results were taken into account, the sinter with a high MgO content （2.63wt%） matching the pellet with a low MgO content （less than 1.14wt%） was the rational burden structure for smelting high-chromium vanadium-titanium magnetite in blast furnaces.

关键词： magnetite ore pellets magnesia agglomeration burden sintering

Interplay of laser power and pore characteristics in selective laser melting of ZK60 magnesium alloys:A study based on in-situ monitoring and image analysis

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Journal of Magnesium and Alloys 2024年第4期12卷 1346-1366页

作者： Weijie Xie Hau-Chung man Chi-Wai Chan Department of Industrial and systems Engineering The Hong Kong Polytechnic UniversityHong KongChina school of Mechanical and Aerospace Engineering Queen’s UniversityBelfast BT95AHUK Research Institute for Advanced manufacturing The Hong Kong Polytechnic UniversityHong KongChina

This study offers significant insights into the multi-physics phenomena of the sLM process and the subsequent porosity characteristics of ZK60 Magnesium(Mg)***-speed in-situ monitoring was employed to visualise process signals in real-time,elucidating the dynamics of melt pools and vapour plumes under varying laser power conditions specifically between 40 W and 60 *** morphological analysis was performed using scanning-Electron Microscopy(sEM),demonstrating a critical correlation between laser power and pore *** laser power led to increased pore coverage,whereas a denser structure was observed at higher laser *** laser power influence on porosity was further confirmed via Optical Microscopy(OM)conducted on both top and cross-sectional surfaces of the *** increase in laser power resulted in a decrease in pore coverage and pore size,potentially leading to a denser printed part of Mg alloy.X-ray Computed Tomography(XCT)augmented these findings by providing a 3D volumetric representation of the sample internal structure,revealing an inverse relationship between laser power and overall pore *** laser power appeared to favour the formation of interconnected pores,while a reduction in interconnected pores and an increase in isolated pores were observed at higher *** interplay between melt pool size,vapour plume effects,and laser power was found to significantly influence the resulting porosity,indicating a need for effective management of these factors to optimise the sLM process of Mg alloys.

关键词： selective laser melting(sLM) Magnesium(Mg)alloys Biodegradable implants Porosity In-situ monitoring

Research progress of quantum dot photolithography patterning and direct photolithography application

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Nano Research 2024年第12期17卷 10386-10411页

作者： Zhong Chen Yu Li Zhongwei man Aiwei Tang Key Laboratory of Luminescence and Optical Information Ministry of Education School of Physical Science and EngineeringBeijing Jiaotong UniversityBeijing 100044China

For the new display technology based on quantum dots(QDs),realizing high-precision arrays of red,green,and blue(RGB)pixels has been a significant research focus at present,aimed at achieving high-quality and high-resolution image ***,challenges such as material stability and the variability of process environments complicate the assurance of quality in high-precision *** novel optical patterning technology,exemplified by direct photolithography,is considered a highly promising approach for achieving submicron-level,hyperfine *** the technological level,this method produces patterned quantum dot light-emitting films through a photochemical ***,we provide a comprehensive review of various methods of QD photolithography patterning,including traditional photolithography,lift off,and direct photolithography,which mainly focused on direct *** review covers the classification of direct photolithography technologies,summarizes the latest research progress,and discusses future perspectives on the advancement of photolithography technology de-masking.

关键词： display quantum dots patterning photolithography photochemistry

FeP nanoparticles derived from metal-organic frameworks/GO as high-performance anode material for lithium ion batteries

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science China Chemistry 2018年第9期61卷 1151-1158页

作者： man Gao Xiaowu Liu Hai Yang Yan Yu Key Laboratory of Materials for Energy Conversion Chinese Academy of Sciences(CAS) Department of Materials Science and EngineeringUniversity of Science and Technology of China

Double carbon coated Fe P composite(Fe P@NC@r GO)was in situ fabricated via the phosphorization process of the as-prepared Prussian blue@graphene oxide(PB@GO)*** Fe P nanocrystals were successfully embedded in the nitrogen-doped porous carbon *** used as the anode for lithium ion batteries(LIBs),the Fe P@NC@r GO anode shows superior lithium storage properties,delivering a high specific capacity of 830 m A h g^(-1)after 100 cycles at 100 m A g^(-1)and excellent rate capability of 359 m A h g^(-1)at 5 A g^(-1).The outstanding performance mainly ascribes to the synergistic effect of the double carbon coating and porous structure *** introduction of porous carbon and graphene coating on Fe P nanoparticles greatly enhance the electronic conductivity of the active material and well accommodates the large volume variation of Fe P during the cycling process.

关键词： FeP Prussian blue reduced graphene oxide anode lithium ion battery

The Heat Transfer Coefficients of the Heating surface of 300 MWe CFB Boiler

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Journal of Thermal science 2012年第4期21卷 368-376页

作者： WU Haibo ZHANG man LU Qinggang sUN Yunkai Institute of Engineering Thermophysics Chinese Academy of Sciences Beijing 100190China . Graduate University of Chinese Academy of sciences Beijing 100049China

A study of the heat transfer about the heating surface of three commercial 300 MWe CFB boilers was conducted in this work. The heat transfer coefficients of the platen heating surface, the external heat exchanger (EHE) and cyclone separator were calculated according to the relative operation data at different boiler loads. Moreover, the heat transfer coefficient of the waterwall was calculated by heat balance of the hot circuit of the CFB boiler. With the boiler capacity increasing, the heat transfer coefficients of these heating surface increases, and the heat transfer coefficient of the water wall is higher than that of the platen heating surface. The heat transfer coefficient of the EHE is the highest in high boiler load, the heat transfer coefficient of the cyclone separator is the lowest. Because the fired coal is different from the design coal in No.1 boiler, the ash content of the fired coal is much lower than that of the design coal. The heat transfer coefficients which calculated with the operation data are lower than the previous design value and that is the reason why the bed temperature is rather high during the boiler operation in No.1 boiler.

关键词： CFB boiler heating surface heat transfer coefficient calculation

CFD study of NO_x Emissions in a Model Commercial Aircraft Engine Combustor

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Chinese Journal of Aeronautics 2012年第6期25卷 854-863页

作者： ZHANG man FU Zhenbo LIN Yuzhen LI Jibao AVIC Commercial Aircraft Engine Co. Ltd. Shanghai 200241 China National Key Laboratory of science and Technology on Aero-Engine Aero-thermodynamics Beihang University Beijing 100191 China

Air worthiness requirements of the aircraft engine emission bring new challenges to the combustor research and design. With the motivation to design high performance and clean combustor, computational fluid dynamics （CFD） is utilized as the powerful design approach. In this paper, Reynolds averaged Navier-stokes （RANs） equations of reactive two-phase flow in an experimental low emission combustor is performed. The numerical approach uses an implicit compressible gas solver together with a Lagrangian liquid-phase tracking method and the extended coherent flamelet model for turbulence-combustion interaction. The NOx formation is modeled by the concept of post-processing, which resolves the NOx transport equation with the assumption of frozen temperature distribution. Both turbulence-combustion interaction model and NOx formation model are firstly evaluated by the comparison of experimental data published in open literature of a lean direct injection （LDI） combustor. The test rig studied in this paper is called low emission stirred swirl （LEss） combustor, which is a two-stage model combustor, fueled with liquid kerosene （RP-3） and designed by Beihang University （BUAA）. The main stage of LEss combustor employs the principle of lean prevaporized and premixed （LPP） concept to reduce pollutant, and the pilot stage depends on a diffusion flame for flame stabili-zation. Detailed numerical results including species distribution, turbulence performance and burning performance are qualita-tively and quantitatively evaluated. Numerical prediction of NOx emission shows a good agreement with test data at both idle condition and full power condition of LEss combustor. Preliminary results of the flame structure are shown in this paper. The flame stabilization mechanism and NOx reduction effort are also discussed with in-depth analysis.

关键词： air worthiness computational fluid dynamics low emission combustor lean prevaporized and premixed NOx reduction