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高原急性低氧对大鼠食欲及下丘脑神经肽Y表达的影响

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营养学报 2006年第2期28卷 113-115,119页

作者：田秀灵糜漫天第三军医大学预防系营养卫生学教研室重庆400038

目的:探讨不同海拔高度急性低氧对大鼠食欲及其下丘脑神经肽Y(neuropeptideY,NPY)表达的影响。方法:Wistar大鼠随机分为平原对照组、3000、4000、5000和6000m低氧组,各低氧组缺氧时间分别为1、2、3d。观察低氧环境下大鼠食欲的变化;应... 详细信息

目的:探讨不同海拔高度急性低氧对大鼠食欲及其下丘脑神经肽Y(neuropeptideY,NPY)表达的影响。方法:Wistar大鼠随机分为平原对照组、3000、4000、5000和6000m低氧组,各低氧组缺氧时间分别为1、2、3d。观察低氧环境下大鼠食欲的变化;应用免疫组化法,研究大鼠下丘脑NPY的分布和表达。结果:(1)高原急性低氧后,大鼠食欲减退。(2)对照组和低氧组下丘脑NPY免疫阳性神经元在弓状核(ARC)、室旁核(PVN)和背中核(DMN)均有分布。低氧组NPY免疫阳性神经元数随海拔高度的上升和缺氧时间的延长逐渐减少。结论:高原急性低氧对大鼠食欲有抑制作用;急性低氧后下丘脑NPY表达降低,可能是大鼠食欲减退的重要原因之一。

关键词：急性低氧食欲下丘脑神经肽Y 免疫组织化学染色

Transformer and GAN-Based Super-Resolution Reconstruction Network for Medical Images

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Tsinghua Science and Technology 2024年第1期29卷 197-206页

作者： Weizhi Du Shihao tian Arts&Sciences College Washington University in St.LouisSt.LouisMO 63130USA Department of Electric and Computing Engineering Cornell UniversityIthacaNY 14850USA

Super-resolution reconstruction in medical imaging has become more demanding due to the necessity of obtaining high-quality images with minimal radiation dose,such as in low-field magnetic resonance imaging(MRI).However,image super-resolution reconstruction remains a difficult task because of the complexity and high textual requirements for diagnosis *** this paper,we offer a deep learning based strategy for reconstructing medical images from low resolutions utilizing Transformer and generative adversarial networks(T-GANs).The integrated system can extract more precise texture information and focus more on important locations through global image matching after successfully inserting Transformer into the generative adversarial network for picture ***,we weighted the combination of content loss,adversarial loss,and adversarial feature loss as the final multi-task loss function during the training of our proposed model *** comparison to established measures like peak signal-to-noise ratio(PSNR)and structural similarity index measure(SSIM),our suggested T-GAN achieves optimal performance and recovers more texture features in super-resolution reconstruction of MRI scanned images of the knees and belly.

关键词： super-resolution image reconstruction Transformer generative adversarial network(GAN)

Robust adaptive radar beamforming based on iterative training sample selection using kurtosis of generalized inner product statistics

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Journal of Systems Engineering and Electronics 2024年第1期35卷 24-30页

作者： tian Jing ZHANG Wei School of Information and Electronics Beijing Institute of TechnologyBeijing 100081China National Key Laboratory of Electromagnetic Space Security Chengdu 610036China

In engineering application,there is only one adaptive weights estimated by most of traditional early warning radars for adaptive interference suppression in a pulse reputation interval(PRI).Therefore,if the training samples used to calculate the weight vector does not contain the jamming,then the jamming cannot be removed by adaptive spatial *** the weight vector is constantly updated in the range dimension,the training data may contain target echo signals,resulting in signal cancellation *** cope with the situation that the training samples are contaminated by target signal,an iterative training sample selection method based on non-homogeneous detector(NHD)is proposed in this paper for updating the weight vector in entire range *** principle is presented,and the validity is proven by simulation results.

关键词： adaptive radar beamforming training sample selection non-homogeneous detector electronic jamming jamming suppression

从行业层面探讨影响我国出口国内分布的各种因素

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华东经济管理 2011年第3期25卷 57-60页

作者：薛漫天东南大学经济管理学院江苏南京210096

文章依据全国各省分行业出口额的数据,研究了地理距离等因素对各行业出口在国内分布的影响。经分析发现,在样本期间,产生决定性影响的因素为:交易成本,包括地理距离(体现在各省至出海口距离和沿途运输基础设施指数)和本省中间品供给;管... 详细信息

文章依据全国各省分行业出口额的数据,研究了地理距离等因素对各行业出口在国内分布的影响。经分析发现,在样本期间,产生决定性影响的因素为:交易成本,包括地理距离(体现在各省至出海口距离和沿途运输基础设施指数)和本省中间品供给;管理成本,体现在各省至服务业中心城市的直线距离。上述因素对不同行业的影响有一定差别。其它因素没有产生明显影响。

关键词：出口地理距离交易成本管理成本

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股权分置改革中内幕交易和市场操纵行为研究

审计与经济研究 2007年第4期22卷 103-107页

作者：田满文广东技术师范学院广东广州510400

通过运用事件研究方法,对样本股权分置改革前后的累积超常收益率(CAR)、超常换手率(AAT)的变化趋势进行比较研究。研究发现,在股权分置改革中存在较为严重的信息泄漏从而导致内幕交易和市场操纵的行为。这种行为严重损害了证券市场的"三... 详细信息

通过运用事件研究方法,对样本股权分置改革前后的累积超常收益率(CAR)、超常换手率(AAT)的变化趋势进行比较研究。研究发现,在股权分置改革中存在较为严重的信息泄漏从而导致内幕交易和市场操纵的行为。这种行为严重损害了证券市场的"三公"原则,削弱了资本市场效率。因此,必须强化信息披露与监管,促进股权分置改革的顺利完成。

关键词：股权分置改革内幕交易事件研究法

Relationships between the severity of ciliated respiratory epithelium abnormalities and cell-mediated immune response in Mycoplasma pneumoniae pneumonia

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Relationships between the severity of ciliated respiratory e...

中华医学会第十三届全国儿科呼吸学术会议

作者： Lulu Qian Wujun Jiang Hui Liang man tian Feng Liu Deyu Zhao Department of Respiratory Medicine the Affiliated Nanjing Children’s Hospital of Nanjing Medical University Department of Respiratory Medicine Suzhou Childrens HospitalSuzhou University

Objective No studies have investigated whether ciliated respiratory epithelium(CRE) abnormalities are secondary phenomenon of cell-mediated immunity reaction in *** pneumonia(MP).We designed the study to search for an association between the ciliated respiratory epithelium abnormalities and the host cell-mediated immunity in patients with MP. Methods The participants included 19 patients with MP and 4 controls who underwent fiber-optic

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覆土厚度对受损河滩草地群落特征的影响

草业科学 2019年第9期36卷 2193-2200页

作者：田曼严成周静中国科学院新疆生态与地理研究所/荒漠与绿洲生态国家重点实验室新疆乌鲁木齐830011 中国科学院大学北京100049 中国科学院新疆生态与地理研究所莫索湾沙漠研究站新疆石河子832000

为修复新疆天山天池自然保护区三工河天池南段河道受损草地,对裸露河滩实施覆土,覆土厚度分别为0、8、12和16 cm,均匀撒播豆禾科混合草种。针对恢复6年的草地,进行群落盖度、高度、地上生物量和物种多样性调查,分析不同覆土厚度对草地... 详细信息

为修复新疆天山天池自然保护区三工河天池南段河道受损草地,对裸露河滩实施覆土,覆土厚度分别为0、8、12和16 cm,均匀撒播豆禾科混合草种。针对恢复6年的草地,进行群落盖度、高度、地上生物量和物种多样性调查,分析不同覆土厚度对草地群落特征的影响。结果表明:1)随着覆土厚度的增加,草地植物群落的盖度、植物高度和地上生物量呈逐渐增加趋势,覆土0和8 cm草地植物群落的盖度、高度、地上生物量显著低于12和16 cm样地(P覆土12 cm>覆土8 cm>覆土0 cm,Pielou均匀度指数为覆土16cm>覆土8 cm>覆土12 cm>覆土0 cm,Margalef丰富度指数为覆土12 cm>覆土16 cm>覆土8 cm>覆土0 cm,覆土8、12、16 cm草地植被群落的物种多样性指数均不存在显著差异(P> 0.05)。3)不同覆土厚度样地群落地上生物量与Shannon-Wiener多样性指数显著正相关(P <0.01)。研究表明,相同补播条件下,覆土措施能够促进草地植被群落恢复,覆土16 cm是天池海南受损河滩区草地植被恢复的适宜土壤厚度。

关键词：三工河覆土厚度盖度物种多样性地上生物量

Novel lactylation-related signature to predict prognosis for pancreatic adenocarcinoma

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World Journal of Gastroenterology 2024年第19期30卷 2575-2602页

作者： tian Peng Fang Sun Jia-Chun Yang Mei-Hong Cai man-Xiu Huai Jia-Xing Pan Fei-Yu Zhang Lei-Ming Xu Department of Gastroenterology Xinhua Hospital Affiliated to Shanghai Jiao Tong UniversityShanghai 200092China

BACKGROUND Lactate,previously considered a metabolic byproduct,is pivotal in cancer progression and maintaining the immunosuppressive tumor *** investigations confirmed that lactate is a primary regulator,introducing recently described post-translational modifications of histone and non-histone proteins,termed lysine *** adenocarcinomas are characterized by increased glycolysis and lactate ***,our understanding of lactylation-related genes in pancreatic adenocarcinomas remains *** To construct a novel lactylation-related gene signature to predict the survival of patients with pancreatic *** RNA-seq and clinical data of pancreatic adenocarcinoma(PDAC)were obtained from the GTEx(Genotype-Tissue Expression)and TCGA(The Cancer Genome Atlas)databases via Xena Explorer,and GSE62452 datasets from *** on lactylation-related genes were obtained from publicly available *** expressed genes(DEGs)were acquired by using R package“DESeq2”in *** COX regression analysis,LASSO Cox and multivariate Cox regressions were produced to construct the lactylation-related prognostic *** analyses,including functional enrichment,ESTIMATE,and CIBERSORT,were performed to analyze immune status and treatment responses in patients with pancreatic *** and normal human cell lines were subjected to western blot analysis under lactic acid intervention;two PDAC cell lines with the most pronounced lactylation were ***,RT-PCR was employed to assess the expression of LRGs genes;SLC16A1,which showed the highest expression,was selected for further ***16A1-mediated lactylation was analyzed by immunofluorescence,lactate production analysis,colony formation,transwell,and wound healing assays to investigate its role in promoting the proliferation and migration of PDAC *** vivo validation was performed using an established tumor *** In this stud

关键词： Pancreatic adenocarcinoma Lactylation Prognosis Immunotherapy Tumor microenvironment

CCL9/CCR1 axis-driven chemotactic nanovesicles for attenuating metastasis of SMAD4-deficient colorectal cancer by trapping TGF-β

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3711-3729页

作者： Boning Niu tianyi tian Lu Wang Yinmei tian tian tian Yuanyuan Guo Hu Zhou Zhiping Zhang Tongji School of Pharmacy Huazhong University of Science and TechnologyWuhan 430030China Department of Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pharmacy Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Pharmaceutical Sciences Fujian Provincial Key Laboratory of Innovative Drug Target ResearchHigh Throughput Drug Screening PlatformXiamen UniversityXiamen 361102China National Engineering Research Center for Nanomedicine Huazhong University of Science and TechnologyWuhan 430030China Hubei Engineering Research Centre for Novel Drug Delivery System Huazhong University of Science and TechnologyWuhan 430030China

SMAD4 deficiency in colorectal cancer(CRC)is highly correlated with liver metastasis and high mortality,yet there are few effective precision therapies ***,we show that CCR1^(+)-granulocytic myeloid-derived suppressor cells(G-MDSCs)are highly infiltrated in SMAD4-deficient CRC via CCL15/CCR1 and CCL9/CCR1 axis in clinical specimens and mouse models,*** excessive TGF-β,secreted by tumor-infiltrated CCR1^(+)-G-MDSCs,suppresses the immune response of cytotoxic T lymphocytes(CTLs),thus facilitating ***,we develop engineered nanovesicles displaying CCR1 and TGFBR2 molecules(C/T-NVs)to chemotactically target the tumor driven by CCL9/CCR1 axis and trap TGF-βthrough TGF-β-TGFBR2 specific *** C/T-NVs counteract CCR1^(+)-G-MDSC infiltration through competitive responding CCL9/CCR1 axis.C/T-NVs-induced intratumoral TGF-βexhaustion alleviates the TGF-β-suppressed immune response of ***,C/T-NVs attenuate liver metastasis of SMAD4-deficient *** further exploration,high expression of programmed cell death ligand-1(PD-L1)is observed in clinical specimens of SMAD4-deficient *** C/T-NVs with anti-PD-L1 antibody(aPD-L1)induces tertiary lymphoid structure formation with sustained activation of CTLs,CXCL13^(+)-CD4^(+)T,CXCR5^(+)-CD20^(+)B cells,and enhanced secretion of cytotoxic cytokine interleukin-21 and IFN-γaround tumors,thus eradicating metastatic *** strategy elicits pleiotropic antimetastatic immunity,paving the way for nanovesicle-mediated precision immunotherapy in SMAD4-deficient CRC.

关键词： SMAD4-deficient CRC Metastasis G-MDSCs TGF-β CCR1 TGFBR2