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A macro-mesoscopic constitutive model for porous and cracked rock under true triaxial conditions

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 3080-3098页

作者： Li Qian Zuguo mo Jianhai Zhang Xianglin Xing Ru Zhang Tianzhi Yao Yunpeng Gao State Key Laboratory of Hydraulics and mountain River Engineering College of Water Resources and HydropowerSichuan UniversityChengdu610065China Power China Chengdu Engineering Corporation Limited Chengdu610072China

The complex mechanical and damage mechanisms of rocks are intricately tied to their diverse mineral compositions and the formation of pores and cracks under external *** rock tests reveal a complex interplay between the closure of porous defects and the propagation of induced cracks,presenting challenges in accurately representing their mechanical properties,especially under true triaxial stress *** paper proposes a conceptualization of rock at the mesoscopic level as a two-phase composite,consisting of a bonded medium matrix and frictional medium *** bonded medium is characterized as a mesoscopic elastic material,encompassing various minerals surrounding porous *** mechanical properties are determined using the mixed multi-inclusion *** of the bonded medium into the frictional medium occurs through crack extension,with its elastoplastic properties defined by the DruckerePrager yield criterion,accounting for hardening,softening,and *** and Eshelby’s equivalent inclusion methods are applied to the bonded and frictional media,*** macroscopic mechanical properties of the rock are derived from these mesoscopic ***,a True Triaxial Macro-Mesoscopic(TTMM)constitutive model is *** model effectively captures the competitive effect and accurately describes the stress-deformation characteristics of *** the TTMM model,the strains resulting from porous defect closure and induced crack extension are differentiated,enabling quantitative determination of the associated damage evolution.

关键词： Micromechanics Macroemesoscopic Homogenization Constitutive model Competitive effect

Transplantation of fibrin-thrombin encapsulated human induced neural stem cells promotes functional recovery of spinal cord injury rats through modulation of the microenvironment

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Neural Regeneration Research 2024年第2期19卷 440-446页

作者： Sumei Liu Baoguo Liu Qian Li Tianqi Zheng Bochao Liu mo Li Zhiguo Chen Cell Therapy Center Beijing Institute of GeriatricsXuanwu HospitalCapital Medical UniversityNational Clinical Research Center for Geriatric Diseasesand Key Laboratory of Neurodegenerative DiseasesMinistry of EducationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Center of Parkinson’s Disease Beijing Institute for Brain DisordersBeijingChina

Recent studies have mostly focused on engraftment of cells at the lesioned spinal cord,with the expectation that differentiated neurons facilitate *** a few studies have attempted to use transplanted cells and/or biomaterials as major modulators of the spinal cord injury ***,we aimed to investigate the role of microenvironment modulation by cell graft on functional recovery after spinal cord *** neural stem cells reprogrammed from human peripheral blood mononuclear cells,and/or thrombin plus fibrinogen,were transplanted into the lesion site of an immunosuppressed rat spinal cord injury ***,Beattie and Bresnahan score,electrophysiological function,and immunofluorescence/histological analyses showed that transplantation facilitates motor and electrophysiological function,reduces lesion volume,and promotes axonal neurofilament expression at the lesion *** of the graft and niche components revealed that although the graft only survived for a relatively short period(up to 15 days),it still had a crucial impact on the ***,induced neural stem cells and human fibrin reduced the number of infiltrated immune cells,biased microglia towards a regenerative M2 phenotype,and changed the cytokine expression profile at the lesion ***-induced changes of the microenvironment during the acute and subacute stages might have disrupted the inflammatory cascade chain reactions,which may have exerted a long-term impact on the functional recovery of spinal cord injury rats.

关键词： biomaterial fibrinogen functional recovery induced neural stem cell transplantation microenvironment microglia spinal cord injury thrombin

补肾活血汤加减配合LCP治疗四肢长骨骨干骨折不愈合的临床观察

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中国实验方剂学杂志 2021年第7期27卷 80-85页

作者：范荣刘玉金白曼莫李畅黄健三亚市中医院海南三亚572220 海口市中医医院海口570216

目的:探讨补肾活血汤加减配合自体骨植骨术联合加压锁定钢板内固定(LCP)治疗四肢长骨骨干骨折不愈合的临床疗效及对微循环、成骨分化因子和骨代谢指标的影响作用。方法:按随机数字表法将70例患者随机分为对照组和观察组各35例。两组患... 详细信息

目的:探讨补肾活血汤加减配合自体骨植骨术联合加压锁定钢板内固定(LCP)治疗四肢长骨骨干骨折不愈合的临床疗效及对微循环、成骨分化因子和骨代谢指标的影响作用。方法:按随机数字表法将70例患者随机分为对照组和观察组各35例。两组患者均采用LCP治疗。对照组口服跌打生骨颗粒,10 g/次,1次/d;观察组口服补肾活血汤,1剂/d。疗程均为治疗3个月并随访3个月。每周进行疼痛、压痛、纵向叩击痛、肿胀等症状、体征检查,比较主要症状、体征消失时间;每月进行1次X射线检查,检查骨痂形成及骨折线情况,记录骨折愈合时间;进行治疗前后Fugl-Meyer(FMA)评分;检测治疗前后纤维蛋白原(FIB),全血黏度(BV)(高切、低切)、血浆黏度(PV),血小板聚集率(PAR),D-二聚体(D-D),骨形成蛋白-2(BMP-2),BMP-7,胰岛素样生长因子-1(IGF-1),血管内皮细胞生长因子(VEGF),转化生长因子-β1(TGF-β1),骨钙素(BGP),骨保护素(OPG),血清Ⅰ型原胶原氨基端前肽(PINP),I型胶原交联C末端肽(S-CTX)和血清抗酒石酸酸性磷酸酶(TRACP)水平;进行安全性评价。结果:观察组疼痛、压痛、纵向叩击痛、肿胀消失时间和骨折愈合时间均短于对照组(P<0.01);治疗后3个月、随访3个月观察组骨痂评分和FMA评分(上肢、下肢)均高于同期对照组(P<0.01);观察组D-D,FIB,PAR,BV(高切、低切),PV水平均低于对照组(P<0.01);观察组BMP-2,BMP-7,IGF-1,VEGF和TGF-β1水平均高于对照组(P<0.01);观察组BGP,OPG,PINP水平均高于对照组(P<0.01),S-CTX和TRACP水平均低于对照组(P<0.01);观察组骨折愈合疗效优于对照组(Z=1.977,P<0.05);观察组肢体功能恢复情况优于对照组(Z=1.970,P<0.05)。未发现服用补肾活血汤后有不良反应。结论:在自体骨植骨联合LCP的基础上,内服补肾活血汤加减用于四肢长骨骨干骨折不愈合患者,可促进骨折愈合,缩短了病程,促进了肢体功能恢复,有着较好的临床疗效,并能改善微循环、促进成骨分化因子的表达、调节骨代谢,起到促进骨折愈合的作用,临床使用安全。

关键词：骨折不愈合肾虚血瘀补肾活血汤微循环成骨分化因子骨代谢

Revisiting the sodium-ion storage capability of hard carbon in carbonate-based electrolytes via a sodium-metal-free protocol

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Science China Chemistry 2024年第7期67卷 2240-2247页

作者： Gaopan Liu Yanbing mo Jiawei Chen Yu Peng Xiao Zhu Fei Wang Xiaoli Dong Yongyao Xia Department of Chemistry and Shanghai Key Laboratory of molecular Catalysis and Innovative Materials Institute of New EnergyLaboratory of Advanced MaterialsFudan UniversityShanghai 200438China

Common evaluation methodology of sodium(Na)-containing two-electrode or three-electrode configurations overlooks the interference from highly reactive Na metal,leading to the underestimation or inconsistent performance of low-potential hard carbon(HC)***,the trap of Na metal was systematically investigated with or without applied current,uncovering its inadequacy as the reference or counter electrode in different configurations.A Na-metal-free three-electrode protocol is proposed for evaluating the actual Na^(+)-storage capability of the typical low-potential HC *** avoiding Na crosstalk and precisely controlling the working electrode's potential,the actual electrochemical performance of HC in the carbonate esterbased electrolyte can be recognized with high capacity of 222 mAh g^(-1)at 2 C and 113 mAh g^(-1)at 5 C,correcting the misunderstanding of the inferior performance of HC in coin-type half cells(68%and 50%undervaluation at 2 C and 5 C,respectively).The advanced protocol is expected to reduce misunderstandings or underestimation due to evaluation methods and to guide the development of high-performance battery materials.

关键词： highly reactive sodium potential drift carbonate ester sodium-metal-free protocol sodium storage capability

Coupled CFD-DEM Numerical Simulation of the Interaction of a Flow-Transported Rag with a Solid Cylinder

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Fluid Dynamics & Materials Processing 2024年第7期20卷 1593-1609页

作者： Yun Ren Lianzheng Zhao Xiaofan mo Shuihua Zheng Youdong Yang Zhijiang College Zhejiang University of TechnologyShaoxing312030China College of Mechanical Engineering Zhejiang University of TechnologyHangzhou310032China

A coupled Computational Fluid Dynamics-Discrete Element Method(CFD-DEM)approach is used to calculate the interaction of a flexible rag transported by a fluid current with a fixed solid *** specifically a hybrid Eulerian-Lagrangian approach is used with the rag being modeled as a set of interconnected *** influence of various parameters is considered,namely the inlet velocity(1.5,2.0,and 2.5 m/s,respectively),the angle formed by the initially straight rag with the flow direction(45°,60°and 90°,respectively),and the inlet position(90,100,and 110 mm,respectively).The results show that the flow rate has a significant impact on the permeability of the *** higher the flow rate,the higher the permeability and the rag speed *** angle has a minor effect on rag permeability,with 45°being the most favorable angle for *** inlet position has a small impact on rag permeability,while reducing the initial distance between the rag an the cylinder makes it easier for rags to pass through.

关键词： Rag flow around cylinder flow characteristics numerical simulation

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聚甘油脂肪酸酯QSPR的研究

计算机与应用化学 2012年第5期29卷 615-619页

作者：田静莫蛮刘学民曹秋雨江南大学化学与材料工程学院江苏无锡214122

采用量子化学moPAC-AM1和单点能方法计算聚甘油脂肪酸酯的分子结构参数,然后用逐步线性回归方法建立聚甘油脂肪酸酯HLB值的定量结构性质(QSPR)模型,所得的预测模型中包含4个参数[单位质量分子所含氧原子数Xo、生成热fHm、电子能Ee和水合... 详细信息

采用量子化学moPAC-AM1和单点能方法计算聚甘油脂肪酸酯的分子结构参数,然后用逐步线性回归方法建立聚甘油脂肪酸酯HLB值的定量结构性质(QSPR)模型,所得的预测模型中包含4个参数[单位质量分子所含氧原子数Xo、生成热fHm、电子能Ee和水合能Eh,预测值及外部检验的复相关系数(R2)和标准偏差(SD)分别为0.9553、0.73722和0.9678、6.34426。结果表明,量子化学方法计算简单,对聚甘油脂肪酸酯结构的表征能力较强,所建定量结构性质模型具有能较好的预测能力和较强的稳健性,并在一定程度上阐明了聚甘油脂肪酸酯HLB值与其分子结构之间的关系。

关键词：量子化学参数定量结构性质关系(QSPR) 聚甘油脂肪酸酯亲水亲油平衡(HLB)

Impact of oxaliplatin and trastuzumab combination therapy on tumor markers and T lymphocyte subsets for advanced gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3905-3912页

作者： Cheng-Wan Zheng Yun-mo Yang Hui Yang Department of Thyroid Surgery The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina

BACKGROUND Advanced gastric cancer(AGC)remains a challenging malignancy with poor *** combination of oxaliplatin and trastuzumab has shown promising results in AGC *** study aimed to investigate the effects of oxaliplatin and trastuzumab combination therapy on serum tumor markers and T lymphocyte subsets in patients with AGC and to explore their potential as predictive biomarkers for treatment *** To investigate the impact of oxaliplatin and trastuzumab combination therapy on serum markers and T cell subsets in patients with *** This prospective study enrolled 60 patients with *** patients received oxaliplatin(130 mg/m^(2),every 3 weeks)and trastuzumab(8 mg/kg loading dose,followed by 6 mg/kg every 3 weeks)for six *** carcinoembryonic antigen(CEA),cancer antigen 19-9(CA19-9),and cancer antigen 72-4(CA72-4)were measured before and after treatment.T-lymphocyte subsets,including CD3+,CD4+,CD8+,and CD4+/CD8+ratios,were also *** clinical response was assessed using the Response Evaluation Criteria in Solid Tumors version *** After six cycles of treatment,the CEA,CA19-9,and CA72-4 serum levels significantly decreased compared to baseline levels(Pmor markers(≥50%reduction)and a higher increase in CD4+/CD8+ratio(≥1.5-fold)showed better clinical response rates(Pmor marker levels and modulated T lymphocyte subsets in patients with *** therapy not only has a direct antitumor effect,but also enhances the immune response in patients with *** tumor markers and T lymphocyte subsets may serve as potential predictive biomarkers for treatment respon

关键词： Advanced gastric cancer Oxaliplatin Trastuzumab Serum tumor markers T lymphocyte subsets Predictive biomarkers

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World Journal of Gastroenterology 2024年第26期30卷 3206-3209页

作者： mo-Wei Kong Xin-Rui Li Yu Gao Ting-Fang Yang Department of Cardiology Guiqian International General HospitalGuiyang 550018Guizhou ProvinceChina Department of Endocrinology The Affiliated Hospital of Chengde Medical CollegeChengde 067000Hebei ProvinceChina Department of Oncology Guiqian International General HospitalGuiyang 550018Guizhou ProvinceChina

In this editorial,we review the work of Razali et al published in World J Gas-troenterology,with a particular focus on the effect of rs10889677 variation in the phosphatidylinositol 3-kinase(PI3K)pathway and buparlisib on colitis-associated *** role of PI3K in promoting cancer progression has been widely recognized,as it is involved in regulating the survival,differentiation,and prolif-eration of cancer *** complement Clq/TNF-related protein 6(CTRP6)is a newer tumor-associated *** studies have revealed the pro-tumor effect of CTRP6 in gastric cancer,hepatocellular carcinoma,colorectal cancer,and other gastrointestinal tumors through the PI3K *** article attempts to reveal the mechanism through which the CTRP6 affects the development of digestive system tumors through the PI3K pathway by summarizing recent research.

关键词： Phosphatidylinositol 3-kinase Complement Clq/TNF-related protein 6 Gastric cancer Colorectal cancer Tumor-related factor

Prox1 Suppresses Proliferation and Drug Resistance of Retinoblastoma Cells via Targeting Notch1

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Current Medical Science 2024年第1期44卷 223-231页

作者： Hong-li ZHANG Na LI Lin DONG Hong-xia MA mo-chi YANG Department of Ophthalmology General Hospital of Ningxia Medical UniversityYinchuan 750004China

Objective Retinoblastoma(RB)is a prevalent type of eye cancer in *** homeobox 1(Prox1)is a homeobox transcriptional repressor and downstream target of the proneural gene that is relevant in lymphatic,hepatocyte,pancreatic,heart,lens,retinal,and cancer *** goal of this study was to investigate the role of Prox1 in RB cell proliferation and drug resistance,as well as to explore the underlying Notch1 *** Human RB cell lines(SO-RB50 and Y79)and a primary human retinal microvascular endothelial cell line(ACBRI-181)were used in this *** expression of Prox1 and Notch1 mRNA and protein in RB cells was detected using quantitative real time-polymerase chain reaction(RT-qPCR)and Western *** proliferation was assessed after Prox1 overexpression using the Cell Counting Kit-8 and the MTS ***-resistant cell lines(SO-RB50/vincristine)were generated and treated with Prox1 to investigate the role of Prox1 in drug *** employed pcDNA-Notch1 to overexpress Notch1 to confirm the role of Notch1 in the protective function of ***,a xenograft model was constructed to assess the effect of Prox1 on RB in *** Prox1 was significantly downregulated in RB *** of Prox1 effectively decreased RB cell growth while increasing the sensitivity of drug-resistant cells to ***1 was involved in Prox1’s regulatory ***1 was identified as a target gene of Prox1,which was found to be upregulated in RB cells and repressed by increased Prox1 *** pcDNA-Notch1 was transfected,the effect of Prox1 overexpression on RB was ***,by downregulating Notch1,Prox1 overexpression slowed tumor development and increased vincristine sensitivity in *** These data show that Prox1 decreased RB cell proliferation and drug resistance by targeting Notch1,implying that Prox1 could be a potential therapeutic target for RB.

关键词： Proxl Notch1 retinoblastoma cells proliferation drug resistance