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Association of total bilirubin with depression risk in adults with diabetes:A cross-sectional study

World Journal of Clinical Cases 2024年第18期12卷 3428-3437页

作者： man-Li ye Jie-Ke Wang Department of Laboratory Medicine The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Department of Hand and Plastic Surgery The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Individuals with diabetes mellitus are more likely to experience depression,although most patients remain undiagnosed.The relation between total bilirubin and depression has been increasingly discussed,but limited studies have examined the association of total bilirubin with depression risk in adults with diabetes,which warrants attention.AIM To investigate the association between total bilirubin levels and the risk of depression in adults with diabetes.METHODS The study included adults with diabetes from the National Health and Nutrition Examination Survey 2007-2018.Depression was determined using the Patient Health Questionnaire-9.Multivariable logistic regression,propensity scorematched analysis and restricted cubic spline models were utilized to investigate the association between total bilirubin levels and depression risk in adults with diabetes.RESULTS The study included 4758 adults with diabetes,of whom 602(12.7%)were diagnosed with depression.After adjusting for covariates,we found that diabetic adults with lower total bilirubin levels had a higher risk of depression(OR=1.230,95%CI:1.006-1.503,P=0.043).This association was further confirmed after propensity score matching(OR=1.303,95%CI:1.034-1.641,P=0.025).Subgroup analyses showed no significant dependence of age,body mass index,sex,race or hypertension on this association.Restricted cubic spline models displayed an inverted U-shaped association of total bilirubin levels with depression risk within the lower range of total bilirubin levels.The depression risk heightened with the increasing levels of total bilirubin,reaching the highest risk at 6.81μmol/L and decreasing thereafter.CONCLUSION In adults with diabetes,those with lower levels of total bilirubin were more likely to have depressive symptoms.Serum total bilirubin levels may be used as an additional indicator to assess depression risk in adults with diabetes.

关键词： Depression Total bilirubin Diabetes National health and nutrition examination survey Mental health Patient health questionnaire-9

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LIFU-responsive nanomedicine enables acoustic droplet vaporization-induced apoptosis of macrophages for stabilizing vulnerable atherosclerotic plaques

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Bioactive Materials 2022年第10期7卷 120-133页

作者： Jingxin Hou Jun Zhou Meiqi Chang Guangcheng Bao Jie Xu man ye Yixin Zhong Shuling Liu Junrui Wang Wei Zhang Haitao Ran Zhigang Wang Yu Chen Dajing Guo Department of Radiology Second Affiliated Hospital of Chongqing Medical UniversityChongqing400010PR China Materdicine Lab School of Life SciencesShanghai UniversityShanghai200444PR China Chongqing Key Laboratory of Ultrasound Molecular Imaging&Department of Ultrasound Second Affiliated Hospital of Chongqing Medical UniversityChongqing400010PR China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050PR China Department of Radiology Children’s Hospital of Chongqing Medical UniversityChongqing400014PR China

Due to the high risk of tearing and rupture,vulnerable atherosclerotic plaques would induce serious cardiovascular and cerebrovascular diseases.Despite the available clinical methods can evaluate the vulnerability of plaques and specifically treat vulnerable plaques before a cardiovascular event,but the efficiency is still low and undesirable.Herein,we rationally design and engineer the low-intensity focused ultrasound(LIFU)-responsive FPD@CD nanomedicine for the highly efficient treatment of vulnerable plaques by facilely loading phase transition agent perfluorohexane(PFH)into biocompatible PLGA-PEG-PLGA nanoparticles(PPP NPs)and then attaching dextran sulphate(DS)onto the surface of PPP NPs for targeting delivery.DS,as a typical macrophages-targeted molecule,can achieve the precise vaporization of NPs and subsequently controllable apoptosis of RAW 264.7 macrophages as induced by acoustic droplet vaporization(ADV)effect.In addition,the introduction of DiR and Fe3O4 endows nanomedicine with near-infrared fluorescence(NIRF)and magnetic resonance(MR)imaging capabilities.The engineered FPD@CD nanomedicine that uses macrophages as therapeutic targets achieve the conspicuous therapeutic effect of shrinking vulnerable plaques based on in vivo and in vitro evaluation outcomes.A reduction of 49.4%of vascular stenosis degree in gross pathology specimens were achieved throughout the treatment period.This specific,efficient and biosafe treatment modality potentiates the biomedical application in patients with cardiovascular and cerebrovascular diseases based on the relief of the plaque rupture concerns.

关键词： Vulnerable plaques Acoustic droplet vaporization Macrophages Apoptosis Nanomedicine

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符号消费视域下虚拟偶像综艺节目的破圈传播研究

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艺术科技 2024年第3期37卷 50-52页

作者：叶曼南京林业大学人文社会科学学院江苏南京210037

目的:在消费文化盛行的社会环境中,虚拟偶像因具有丰富的符号消费意涵而受到众人的追捧。在当下综艺节目多元化、智能化的背景下,众多头部企业开始打造全新的虚拟偶像综艺节目形式,广泛引起人们的注意。文章以虚拟偶像综艺节目为研究对... 详细信息

目的:在消费文化盛行的社会环境中,虚拟偶像因具有丰富的符号消费意涵而受到众人的追捧。在当下综艺节目多元化、智能化的背景下,众多头部企业开始打造全新的虚拟偶像综艺节目形式,广泛引起人们的注意。文章以虚拟偶像综艺节目为研究对象,基于符号消费理论视角,研究虚拟偶像综艺节目本身具有的文化内涵,探究其破圈路径,旨在为虚拟偶像综艺节目未来的科学发展提供重要启示。方法:文章从符号建构理论出发,从人物、场景、仪式符号这三个方面剖析虚拟偶像综艺节目,分析其创新之处。同时文章基于符号消费理论分析虚拟偶像的粉丝群体如何完成自我投射与认同,提升综艺节目的粉丝经济价值。结果:虚拟偶像综艺节目推陈出新,契合当下大众的文化娱乐心态,由此实现破圈传播,为综艺节目的发展提供了更多可能。结论:国内虚拟偶像综艺节目从内容、技术、媒介、受众这四个层面出发,力求通过内容建设实现价值引领、技术赋能丰富展演空间、媒介融合蓄力加速破圈、受众互动建立情感联结,最终不断突破传统的圈层壁垒,逐渐被更多观众喜爱。

关键词：虚拟偶像综艺节目符号消费台网联动传播

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高频燃烧-红外吸收光谱法测定土壤和水系沉积物中总有机碳和有机质的含量

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理化检验（化学分册） 2024年第5期60卷 449-454页

作者：耶曼李田义李小桂李湘西安西北有色地质研究院有限公司西安710054

传统重铬酸钾容量法已难以满足测定批量土壤样品中总有机碳和有机质的绿色环保要求,为有效提高检测效率,达到少用或不用有毒、有害试剂的目标,提出了题示方法。取0.050 0 g样品(已于105℃烘2 h)于陶瓷坩埚(已于1 000℃灼烧4 h)中,置于8... 详细信息

传统重铬酸钾容量法已难以满足测定批量土壤样品中总有机碳和有机质的绿色环保要求,为有效提高检测效率,达到少用或不用有毒、有害试剂的目标,提出了题示方法。取0.050 0 g样品(已于105℃烘2 h)于陶瓷坩埚(已于1 000℃灼烧4 h)中,置于85℃恒温电热板上,滴加体积比1∶5的盐酸-水混合溶液,直至溶液停止冒泡,蒸干后于105℃恒温干燥箱中烘烤2~3 h,取出,加入0.4 g纯铁助熔剂和1.5 g纯钨助熔剂,选择高碳池分析气路,分析时间为30 s,采用高频燃烧-红外吸收光谱法测定其中总有机碳和有机质的含量。结果表明,总有机碳的检出限(3s)为0.012%,有机质的检出限(3s)为0.021%。测定了6种标准物质中总有机碳,测定值的相对标准偏差(n=12)小于5.0%,与认定值基本一致。方法用于分析20个实际样品,测定结果与NY/T 1121.6-2006中传统重铬酸钾容量法进行对比,结果表明两种方法的测定结果具有较好的一致性。

关键词：总有机碳有机质高频燃烧-红外吸收光谱法土壤水系沉积物

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Clinical Effect of an Improved Post-Operative Feeding Protocol“in Transition”Infants of Congenital Heart Disease with Pulmonary Hypertension

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Congenital Heart Disease 2021年第6期16卷 655-673页

作者： Huaying He Zhiyong Lin Yuelan Weng Jianjie Zhou man ye Xiaowei Luo Qifeng Zhao The Children’s Department of Cardiovascular and Thoracic Surgery Children’s Heart CenterThe Second Affiliated Hospital&Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou325027China Institute of Cardiovascular Development And Translational Medicine the Second School of MedicineWenzhou Medical UniversityWenzhou325027China

Background:To achieve successful management of infants with congenital heart disease(CHD)together with pulmonary hypertension(PH),postoperative care,especially feeding care is vital in addition to surgery.Postoperative feeding is comprised of three stages:feeding in the intensive care unit,feeding in the general ward and family feeding,in which the general ward is considered as the“transitional stage”.At present,there is little research on the optimal mode of feeding care for the transitional stage,and there is no universally recognized and accepted protocol.Methods:We retrospectively analyzed 114 CHD infants with PH who underwent family-centered(FC)feeding care from July 2017 to December 2018,and prospectively studied 122 CHD infants with the same baseline level who adopted the improved mode,nurse-parent-driven(NPD)feeding mode from January 2019 to June 2020.The feasibility and efficacy of NPD as a“transitional”feeding nursing mode in CHD infants with PH were compared with the FC cohort by observing and analyzing the stress of family caregivers,feedingrelated complications,the proportion of breastfeeding,improvement of nutritional status,acquisition of knowledge and skills of feeding care,inpatient’s satisfaction rating and prognosis.Results:When compared with the FC feeding care,the NPD mode significantly reduced the burden of family caregivers,improved the rate of feeding care knowledge and skills and inpatient’s satisfaction rating,reduced the incidence of improper feeding-related complications,and enhanced the proportion of breastfeeding and nutritional status of infants at the“transitional stage”(all P<0.05).The self-assessment score of care ability of family caregivers and weight gain of children in the NPD group were significantly higher than those in the FC group(all P<0.05)during the follow-up.Conclusions:As a transitional mode of feeding in CHD infants with PH,NPD feeding care is superior to the conventional FC mode,which therefore can be adopted as a standard protocol in clinical practice.

关键词： Congenital heart disease pulmonary hypertension postoperative feeding care infant

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土壤缓效钾测定数据的技术提升措施

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当代化工研究 2024年第1期 167-169页

作者：柯艳耶曼李小桂西安西北有色地质研究院有限公司陕西710054

土壤中蕴含丰富的钾元素,其中缓效钾是非常重要的组成部分,可以使土壤中的钾元素得到补充,起到重要的缓冲作用。本文研究的主要目的,是探讨现阶段在开展土壤缓效钾测定时,如何不断提高技术水平,提高钾元素的分析速度,降低成本,为我国农... 详细信息

土壤中蕴含丰富的钾元素,其中缓效钾是非常重要的组成部分,可以使土壤中的钾元素得到补充,起到重要的缓冲作用。本文研究的主要目的,是探讨现阶段在开展土壤缓效钾测定时,如何不断提高技术水平,提高钾元素的分析速度,降低成本,为我国农业领域的进一步快速发展提供技术支持。

关键词：土壤缓效钾电感耦合等离子发射光谱仪全钾速效钾

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工程教育专业认证下的课程建设实践探索——以“现代交流传动及其控制系统”为例

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教育教学论坛 2024年第6期 96-99页

作者：章勇高刘鹏叶满园曾建军华东交通大学电气与自动化工程学院江西南昌330013

课程建设是工程教育专业认证体系中的重要指标,通过“现代交流传动及其控制系统”课程建设,探索工程专业的课程建设模式。围绕专业培养目标和毕业要求,制定了课程教学大纲,确定了课程教学目标及与毕业要求的对应关系,讨论了课堂教学模... 详细信息

课程建设是工程教育专业认证体系中的重要指标,通过“现代交流传动及其控制系统”课程建设,探索工程专业的课程建设模式。围绕专业培养目标和毕业要求,制定了课程教学大纲,确定了课程教学目标及与毕业要求的对应关系,讨论了课堂教学模式和教学方式的组织形式,设计了课程考核方式及考核指标的标准,最后提出课程教学改进措施。从大纲制定、课堂教学组织、课程考核、考核评估及改进措施五个方面说明课程建设如何实现课程目标及与毕业要求的对应关系,满足工程教育专业认证要求,提升课程教学质量。

关键词：工程教育专业认证课程教学现代交流传动及其控制系统

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Construction of Circular Economy Industrial System

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Chinese Journal of Population,Resources and Environment 2007年第4期5卷 26-30页

作者： Cao man ye Wenhu Research Center for China Sustainable Development Peking University Beijing 100871 China

It is difficult to realize the transformation from tradi- tional economy industrial system to circular economy industrial system. Regarding primary raw materials as the indicators, the industrial system has been specified according to the divergence among the indicators and the circular utilization modes. In com- parison with the association among industrial systems, the rela- tionship among industrial sub-systems is named as industrial cross-linking in this paper. The industrial system which could completely utilize and recycle the indicators should be increased and strengthened, and the circular economy industrial system with complete industrial association and industrial cross-linking should also be constructed. Taking the development of circular agricul- tural system basing on the traditional agricultural system as an example, the traditional agricultural products are regarded as the indicators which have been divided into foodstuff and crop straws which are used to produce food and articles for use, like fertilizer, energy and papers etc. The way to construct the circular agricul- tural industrial system is to increase the industrial systems that could utilize the products generated from crop straws, feces and other castoffs and transform the wastewater and other trucks into environmental friendly products. It has also been pointed out that the construction of circular economy industrial system is condu- cive to the foundation of circular industrial economics and the establishment of the construction layout of circular economy and the application schemes. Suggestions to the theoretical and prac- tical work of the next step have also been brought forward in this paper.

关键词：循环经济工业系统工业结构环境保护

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Formation of non-equilibrium phases and associated structural transition in the Pd-Ta system induced by ion beam mixing

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Science China(Technological Sciences) 2011年第3期54卷 676-681页

作者： ZHAO man DAI ye LI JiaHao LIU BaiXin Advanced Materials Laboratory Department of Materials Science and Engineering Tsinghua University Beijing 100084 China

For the Pd-Ta system characterized by a negative heat of formation of -78 kJ/mol, 200 keV xenon ion beam mixing with nano-sized Pd-Ta multilayered films was conducted to study the non-equilibrium phase formation. The results showed that uniform amorphous alloys can be formed within a composition range of 25 at%-78 at% Ta, which falls in the maximum possible amorphization range of 22 at%-80 at% Ta predicted by the empirical model. Moreover, two metastable crystalline phases both of FCC structure, yet with different lattice constants were obtained. Interestingly, a self-assembled fractal pattern was observed in the Pd52Ta48 multilayered films after irradiation to a dose of 1×1015 Xe+/cm2 and its dimension was determined to be 1.75±0.05. The possible mechanisms for the formation of amorphous and metastable crystalline phases as well as for the growth of the fractal pattern were discussed.

关键词：面心立方结构非平衡相离子束混合系统 Ta 诱发非晶合金

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Pyrotinib is effective in both trastuzumab-sensitive and primary resistant HER2-positive breast tumors

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Chinese Journal of Cancer Research 2024年第2期36卷 124-137页

作者： Jialin Zhang Gengshen Yin Chunmiao ye man Feng Changhua Ji Wenzhong Zhou Fei Wang Lixiang Yu Shuya Huang Zhigang Yu Department of Breast Surgery the Second Hospital of Shandong UniversityJinan 250033China Institute of Translational Medicine of Breast Disease Prevention and Treatment Shandong UniversityJinan 250033China Shandong Provincial Engineering Laboratory of Translational Research on Prevention and Treatment of Breast Disease Jinan 250033China Department of Pathology the Third Affiliated Hospital of Shandong First Medical University(Affiliated Hospital of Shandong Academy of Medical Sciences)Jinan 250031China Department of Pathology the Second Hospital of Shandong UniversityJinan 250033China

Objective: Primary resistance to trastuzumab frequently occurs in human epidermal growth factor receptor 2(HER2)-positive(+) breast cancer patients and remains a clinical challenge. Pyrotinib is a novel tyrosine kinase inhibitor that has shown efficacy in the treatment of HER2+ breast cancer. However, the efficacy of pyrotinib in HER2+ breast cancer with primary trastuzumab resistance is unknown.Methods: HER2+ breast cancer cells sensitive or primarily resistant to trastuzumab were treated with trastuzumab, pyrotinib, or the combination. Cell proliferation, migration, invasion, and HER2 downstream signal pathways were analyzed. The effects of pyrotinib plus trastuzumab and pertuzumab plus trastuzumab were compared in breast cancer cells in vitro and a xenograft mouse model with primary resistance to trastuzumab.Results: Pyrotinib had a therapeutic effect on trastuzumab-sensitive HER2+ breast cancer cells by inhibiting phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT) and rat sarcoma virus(RAS)/rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase(MAPK)/extracellular-signal regulated kinase(ERK)pathways. In primary trastuzumab-resistant cells, pyrotinib inhibited cell growth, migration, invasion, and HER2 downstream pathways, whereas trastuzumab had no effects. The combination with trastuzumab did not show increased effects compared with pyrotinib alone. Compared with pertuzumab plus trastuzumab, pyrotinib plus trastuzumab was more effective in inhibiting cell proliferation and HER2 downstream pathways in breast cancer cells and tumor growth in a trastuzumab-resistant HER2+ breast cancer xenograft model.Conclusions: Pyrotinib-containing treatments exhibited anti-cancer effects in HER2+ breast cancer cells sensitive and with primary resistance to trastuzumab. Notably, pyrotinib plus trastuzumab was more effective than trastuzumab plus pertuzumab in inhibiting tumor growth and HER2 downstream pathways in HER2+ breast cancer with primary resistance to trastuzumab. These findings support clinical

关键词： Breast cancer HER2 pyrotinib trastuzumab primary resistance pertuzumab

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