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Hepatitis B virus genotypes:an overview

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Hepatobiliary & Pancreatic Diseases International 2008年第5期7卷 457-464页

作者： mamun-al Mahtab Salimur Rahman Mobin Khan Fazal Karim Department of Hepatology Bangabandhu Sheikh Mujib Medical UniversityDhaka Bangladesh

BACKGROUND:Hepatitis B virus(HBV)infection is a major cause of mortality and morbidity *** quest continues to identify viral factors that influence disease progression and severity as well as responses to treatment of HBV *** on variations in HBV,the virus has been divided into a number of genotypes. DATA SOURCES:Review of published literature on HBV genotypes. RESULTS:HBV genotypes are likely to be important in determining the severity and progression of HBV-induced liver disease as well as responses to different anti-viral agents. CONCLUSION:although HBV genotyping is not yet recommended for routine use in treating HBV infection, available data suggest that,as in hepatitis C virus infection, HBV genotyping is also likely to become a routine investigation for HBV treatment,perhaps in the not too distant future.

关键词： hepatitis B virus genotype

Quantitative Structure-Activity Relationship of (2-Methyl-3-Biphenylyl) Methanol (MBPM)Analogs as PD-L1 Inhibitor

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Quantitative Structure-Activity Relationship of (2-Methyl-3-...

作者： Abdulla al mamun 南京理工大学

学位级别：硕士

癌症是威胁人类生命中最严重的疾病之一。阻断程序性细胞死亡蛋白1(PD-1)和程序性死亡配体1(PD-L1)途径是近年来抑制癌细胞的重大创新之一,但只有少数抑制剂能够阻断。(2-甲基-3-联苯)甲醇(MBPM)衍生物就是其中之一。首先,建立了20个(2... 详细信息

癌症是威胁人类生命中最严重的疾病之一。阻断程序性细胞死亡蛋白1(PD-1)和程序性死亡配体1(PD-L1)途径是近年来抑制癌细胞的重大创新之一,但只有少数抑制剂能够阻断。(2-甲基-3-联苯)甲醇(MBPM)衍生物就是其中之一。首先,建立了20个(2-甲基-3-联苯)甲醇(MBPM)衍生物作为程序性死亡配体-1(PD-L1)抑制剂的定量构效关系。采用密度泛函理论(DFT)在B3LPY/6-31+G(d,p)水平上研究了所选化合物的化学结构和性质。观察并测定了最高占据分子轨道能量(E)、最低未占据分子轨道能量(E)、总能量E、偶极矩DM、绝对硬度η、绝对电负性χ、柔软度S、亲电性ω、能隙ΔE等。采用主成分分析(PCA)、多元线性回归(MLR)和多元非线性回归(MNLR)建立了QSAR模型。基于统计分析提出了定量模型和化合物的解释结果。MLR和MNLR的统计结果分别为0.661和0.758。对MLR和MNLR进行了单因素交叉验证(LOO-CV)、r指标、r检验和Golbraikh&Tropsha标准分析,结果表明,两个模型具有统计学意义,且在PD-L1的外部验证中数据变化稳定;MNLR模型比MLR模型更准确地预测了PD-L1抑制剂的生物活性。其次,我们设计了20种新型的MBPM卤化衍生物,在B3LYP/Midi X水平的DFT方法进行结构优化和频率计算,得到了这些化合物的Homo-Lumo能隙、硬度、柔软度和偶极矩。此外,对这些分子与PD-L1(PDB-ID 5j89)进行了3种不同的分子对接分析研究分子间的相互作用。进一步的,对29个蛋白质与5个候选蛋白进行了50 ns分子动力学模拟。分子动力学模拟表明,改性后的化合物比未改性的MBMP衍生物更有效,其中Tyr56、Asp122和Tyr123残基形成了氢键,并且这种氢键在药物-蛋白质相互作用中发挥重要作用。此外,化合物7在MD模拟和蛋白质数据库中的结果显示其与MBPM亲和力优异。强配体结合可能需要与ala121、Met 115和Try123的残基的π-烷基相互作用,与Tyr56的残基的π-π堆积以及与残基Met 115的烷基相互作用。此外,ADME/T分析表明,修饰的类似物毒性比母体化合物少。因此,卤素靶向抑制剂与PD-L1结合良好,有望成为治疗癌症的理想药物。最后,在B3LPY/6-31+G(d,p)水平上用DFT理论计算了100个合成的(2-甲基-3-联苯)甲醇(MBPM)衍生物或与PD-L1结合的小分子。Lipinski的五定律(RO5)被用来筛选所有优化的化合物。筛选后的化合物被进一步对接。利用Auto Dock-Vina和GOLD对接技术研究了这些抑制剂与PD-L1结合力。对M30、M38、M48、M51和M58 5种顶级抑制剂分子进行对接模拟结果表明M51能与PD-L1结合力最好。此外,A:Gln66、A:Tyr56、B:Asp122和B:Tyr123氨基酸参与了氢键的形成其他氨基酸A:Tyr56、A:Met 115、A:ala121、B:Tyr56、B:Met115和B:ala121强烈参与疏水作用。预测物质的吸收、分布、代谢、排泄、毒性和活性谱(PASS)结果表明比M51比其他四个分子更安全可靠,这说明M51很可能是一种非常有前途的抑制剂,可以与PD-L1结合,部分阻断PD-1/PD-L1。

关键词： QSAR (2-甲基-3-联苯)甲醇(MBPM)衍生物程序性死亡配体-1(PD-L1)抑制剂密度泛函理论对接分析分子动力学

FGF21 alleviates microvascular damage following limb ischemia/reperfusion injury by TFEB-mediated autophagy enhancement and anti-oxidative response

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Signal Transduction and Targeted Therapy 2022年第11期7卷 4014-4017页

作者： Fanfeng Chen Jiayu Zhan Xiaoqing Yan abdullah al mamun Yu Zhang Yitie Xu Hongyu Zhang Xiaokun Li Kailiang Zhou Jian Xiao Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Department of Vascular SurgeryThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Molecular Pharmacology Research Center School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhouChina Department of Orthopaedics The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouChina

Dear Editor,Microvascular damage is a pivotal pathological factor in lower limb ischemia/reperfusion(I/R)injury.1 Excessive reactive oxygen species(ROS)formation and disrupted autophagic flux have been recognized as the critical mechanism of cellular death,2,3 especially in I/R *** investigation has displayed that fibroblast growth factor 21(FGF21)exerts a protective effect against I/R injury via transcription factor EB(TFEB)-mediated autophagy and regulation of anti-oxidative response.4 However,the promising role of FGF21 in acute lower limb I/R injury remains elusive.

关键词： damage protective injury

Scalable Process to Develop Durable Conductive Cotton Fabric

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Advanced Fiber Materials 2020年第6期2卷 291-301页

作者： Md.abdullah al.mamun Md.Touhidul Islam Md.Momtaz Islam Kazi Sowrov Md.Afzal Hossain Dewan Murshed Ahmed Hasan Shahariar Bangladesh University of Textiles Dhaka 1208Bangladesh University of Manchester ManchesterUK Funxion Wear IncRaleighNC 27606USA

Developing a scalable process is critical to manufacture conductive fabric for commercial *** paper describes a scalable coating process that is compatible with existing industrial finishing processes of *** this process,the fabric is continuously dipped in water-based metal salt and the reducing agent solution to impart conductive particles on the fiber *** 10 consecutive cycles of dip coating,the fabric shows 6Ω/*** *** process is tuned to minimize process cost and material cost,and maximize the durability of the *** paper also introduces an easy protective coating technique of the conductive fabric that improves the durability of the conductive fabric without sacrificing the comfort properties of textile fabrics such as breathability and *** encapsulated conductive fabric shows good air-permeability and it is 6.96 cm^(3)/cm^(2)/***,the conductivity of the encapsulated fabric is quite stable after four accelerated washing ***,the fabric remains conductive on the surfaces and is suitable for using as a conductive track and connectors.

关键词： Conductive fabric Scalable process Layer by layer deposition Durability

Annual pattern of zooplankton communities and their environmental response in a subtropical maritime channel system in the northern Bay of Bengal, Bangladesh

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Acta Oceanologica Sinica 2018年第8期37卷 65-73页

作者： abdullah al mamun alAM Md.Didarul AKHTAR Aysha XU Henglong ISLAM Md.Shafiqul MUSTAFA KAMal Abu Hena UDDIN M Muslem alAM Md.Wahidul Laboratory of Microbial Ecology Ocean University of China Faculty of Marine Sciences and Fisheries University of Chittagong Department of Animal Science and Fishery Faculty of Agriculture and Food Sciences Universiti Putra Malaysia Campus Bintulu

Zooplankton plays an important role in aquatic food webs by fluxing of energy from primary producer to subsequent trophic levels in the food chain. The annual pattern of zooplankton communities and potential environmental drivers were studied in the Kohelia channel, Bangladesh from summer 2014 to spring *** were collected using net at a depth of 1 m. A total of 32 species belonged to 18 orders, 27 families and 15 taxonomic groups were identified. Of these species, 22 distributed in all four seasons of which 8 were dominant and highly contributing to the total communities. Species number peaked in summer next to winter and fall in spring while maximum abundance was in summer and minimum in spring. Multivariate analyses showed that there was a clear annual pattern in the zooplankton communities. Species diversity and evenness peaked in spring but fall in autumn while the high value of species richness was found in winter. Biological-environmental best matching（BIO-ENV） analyses conformed that community pattern of zooplankton was mainly driven by transparency salinity, and temperature individually or combined with water nutrients. These results demonstrate that annual pattern of the zooplankton community shaped by channel environmental factors in subtropical channel ecosystems, thus might be used for community-based subtropical coastal water bioassessment.

关键词： zooplankton trophic levels subtropical channel community structure multivariate approach

Human and ecological risks of metals in soils under different land-use types in an urban environment of Bangladesh

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Pedosphere 2020年第2期30卷 201-213页

作者： Md.Saiful ISLAM Md.Kawser AHMED Md.Habibullah al-mamun Dennis Wayne EATON Department of Soil Science Patuakhali Science and Technology UniversityDumkiPatuakhali 8602Bangladesh Graduate School of Environment and Information Sciences Yokohama National University79-7 TokiwadaiHodogaya-kuYokohamaKanagawa 240-8501Japan Department of Oceanography University of DhakaDhaka 1000Bangladesh Department of Fisheries University of DhakaDhaka 1000Bangladesh Contract Faculty Rutgers UniversityNew BrunswickNJ 08901-8554USA

Trace metal contamination in soil is of great concern owing to its long persistence in the environment and toxicity to humans and other *** of six potentially toxic trace metals,Cr,Ni,Cu,As,Cd,and Pb,in urban soils were measured in Dhaka City,*** from different land-use types,namely,agricultural field,park,playground,petrol station,metal workshop,brick field,burning sites,disposal sites of household waste,garment waste,electronic waste,and tannery wast,and construction waste demolishing sites,were *** concentration ranges of Cr,Ni,Cu,As,Pb,and Cd in soils were 2.4–1258,8.3–1044,9.7–823,8.7–277,1.8–80,and 13–842 mg kg^-1,*** concentrations of metals were subsequently used to establish hazard quotients(HQs)for the adult *** metal HQs decreased in the order of As>Cr>Pb>Cd>Ni>*** was the most vital exposure pathway of studied metals from soils followed by dermal contact and *** range of pollution load index(PLI)was 0.96–17,indicating severe contamination of soil by trace *** the comprehensive potential ecological risk(PER),soils from all land-use types showed considerable to very high ecological *** findings of this study revealed that in the urban area studied,soils of some land-use types were severely contaminated with trace ***,it is suggested that more attention should be paid to the potential health risks to the local inhabitants and ecological risk to the surrounding ecosystems.

关键词： hazard quotient health risk land use potential ecological risk soil pollution trace metals urban soil

Phytochemical analysis and antioxidant profile of methanolic extract of seed, pulp and peel of Baccaurea ramiflora Lour.

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Asian Pacific Journal of Tropical Medicine 2018年第7期11卷 443-450页

作者： Md.Sahab Uddin Md.Sarwar Hossain abdullah al mamun Devesh Tewari Md.Asaduzzaman Md.Siddiqul Islam Mohamed M.Abdel-Daim Department of Pharmacy Southeast University Department of Pharmaceutical Sciences Faculty of Technology Kumaun University Department of Pharmacology Suez Canal University

Objective: To analyze the phytochemical constituents responsible for the plausible antioxidant effect of methanolic extract of the seed, pulp and peel of Baccaurea ramiflora Lour. Methods: Fresh seed, pulp, and peel of Baccaurea ramiflora fruits were extracted with methanol(MEBRse, MEBRpu, MEBRpe) and evaluated by phytochemical analysis for their content of innumerable metabolites(primary and secondary) viz. carbohydrates, alkaloids, glycosides, tannins, phenols, terpenoids, flavonoids, proteins, and fixed oils. The antioxidant efficacy was assessed through different assay methods viz. 2,2-diphenyl-1-picrylhydrazyl(DPPH) free radical scavenging activity, total antioxidant capacity(TAC) and reducing power capacity(RPC). Estimation of total phenolic content(TPC), and total flavonoid content(TFC) was also done to confirm the presence of these phytochemicals. Results: It was revealed from the phytochemical analysis of MEBRse that alkaloids, glycosides, carbohydrates, phenols, and flavonoids were present, while that of MEBRpu showed the existence of carbohydrates, proteins, alkaloids, glycosides, phenols, saponins, flavonoids, and fixed oils. Presence of carbohydrates, alkaloids, phenols, tannins, flavonoids, and terpenoids were found in the MEBRpe. A significant antioxidant activity was revealed by the MEBRpu [EC_(50):(27.612 ± 1.375) μg/mL], compared to MEBRpe, and MEBRse in DPPH assay. The ranking order for RPC was MEBRpu > MEBRpe > MEBRse respectively. The EC_(50) value of TAC of the MEBRpu, MEBRpe, and MEBRse were(25.107 ±0.744) μg/mL,(241.127 ± 7.463) μg/mL and(372.364 ± 11.030) μg/mL, respectively. Quantity of TPC and TFC were the highest in the MEBRpu(124.360 ± 2.078 mg GAE/g and 107.527 ±1.900 mg QRE/g extract) rather than MEBRpe and MEBRse extracts. Conclusions: This study suggests that MEBRpu has a significantly higher antioxidant property than MEBRpe and MEBRse. These extracts might be advantageous in prevention or decelerating the progress of different disea

关键词： Oxidative stress Baccaurea ramiflora Phytochemical analysis Antioxidant activity

Hepatitis E virus is a leading cause of acute-on-chronic liver disease:experience from a tertiary centre in Bangladesh

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Hepatobiliary & Pancreatic Diseases International 2009年第1期8卷 50-52页

作者： mamun-al Mahtab Salimur Rahman Mobin Khan Md.Fazal Karim Department of Hepatology Bangabandhu Sheikh Mujib Medical University

BACKGROUND:Acute-on-chronic liver failure(ACLF) is common in *** viral E hepatitis is sporadically encountered in this country each year,with a rising incidence in the rainy *** study aimed to identify the etiology of ACLF in Bangladesh. METHODS:In this retrospective study,69 ACLF patients were *** presented to our department at the Bangabandhu Sheikh Mujib Medical University in *** of diseases was recorded and appropriate investigations were conducted in all patients. RESULTS:Acute hepatitis E virus(HEV)infection was positive in 21.7%(15/69)of the patients,while 14.5% (10/69)had *** gastrointestinal tract hemorrhage was seen in 4.3%of the patients(3/69),while another 4.3%(3/69)had a positive history for alcohol or *** of the patients tested positive for hepatitis A virus infection and no evidence of hepatitis B virus flare was found in any *** specific cause for ACLF could be identified. CONCLUSIONS:Acute HEV infection is a leading cause of ACLF in *** patients were thought to have decompensation of cirrhosis,but subsequently were recognized as having ACLF by a retrospective review according to the definition of the Asian Pacific Association for the Study of the Liver Working Party Meeting on ACLF in New Delhi in early 2008.

关键词： acute-on-chronic liver failure hepatitis E virus septicemia

Innovation of Neuropsychopharmacological Experimental Methods to Investigate Attention in Human Participants and Its Validation by Randomized Double Blind Placebo Controlled Clinical Trial

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Journal of Behavioral and Brain Science 2016年第7期6卷 280-293页

作者： Md. Sahab Uddin abdullah al mamun Md. Asaduzzaman Department of Pharmacy Southeast University Dhaka Bangladesh

In terms of advancement of life to meet the challenges new method for neuropsychopharmacological research are continually developing to ensure superior safety, accuracy, efficacy, precision etc. In this experiment, we suggested and validated two neuropsychopharmacological testing methods, these are Numeral Finding (NF) and Typo Revealing (TR) tests for the determination of attention in healthy aged human participants. The objective of this experiment was to generate more effective testing methods for the assessment of attention in human. The rationality of the aforementioned methods was checked by a randomized double blind placebo controlled clinical trial for the period of 21 days among healthy aged human participants. The experiment was conducted at Gazipur Sadar, Gazipur-1703, Dhaka, Bangladesh between the period of December 2015 and March 2016. The experiment center was the Department of Pharmacy, Southeast University, Dhaka-1213, Bangladesh. In this experiment, 60 healthy male participants between the age ranges of 40 to 50 years old were selected and randomly divided by simple randomization process into 3 groups with 20 participants in each. Ginkgo biloba standardized extract’s capsule (Giloba? and Kobi?) was used as a standard and as a placebo control psyllium seed husk (i.e., seed of the Plantago ovata) was used after filling in the hard gelatin capsule shell (size 0). Group 1 was treated with Giloba? in which each capsule contained 120 mg Ginkgo biloba standardized extract (GBG) and group 2 was treated with Kobi? in which each capsule contained 60 mg Ginkgo biloba standardized extract (GBK). The treatment procedure for group 3 was psyllium seed husk’s capsule that served as placebo control (PC). Throughout the experiment each capsule was administered 3 times daily. Treatment with Ginkgo biloba standardized extracts for successive days markedly increased the attention of the participants with respect to

关键词： Neuropsychopharmacology Numeral Finding Test Typo Revealing Test Attention Clinical Trial