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NLR’s a.a.ogs with Young Blood Cells in Monitoring of Toxicity of Long-Term Preventing Immunosuppression in the Liver Tra.spla.t’s Recipients

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Open Journa. of Biophysics 2022年第4期12卷 173-184页

作者： a.eksey N. Shoutko Olga.a. Gera.imova Depa.tment of Tra.spla.ta.ion Stem Cells of Russian Research Center of Radiology and Surgical Technologies named after A. M. Granov Saint-Petersburg Russia

The blood neutrophils to lymphocytes ra.io (NLR) reflects the physiologica. homeosta.is between lymphopoiesis a.d myelopoiesis, a.d its eleva.ion serves a. a.ha.mful sign in ma.y pa.hologies, pa.tia.ly, la.e rejection of a.logra.t. The stem a.d young lymphoid cells ha.e regenera.ive-trophic properties, which ca. a.fect the releva.ce of NLR, being opposed to immune properties, a.socia.ed with bulk lymphocytes. In the present a.ticle, we ha.e a.a.yzed for the first time the a.plica.ility of NLR’s a.a.ogs with stem a.d imma.ure blood cells for monitoring ha.mful long-term shifting from lymphopoiesis to myelopoiesis in tra.spla.t’s recipients received conventiona. immunosuppressive trea.ment. In opposition to conventiona. NLR, the ra.io of subpopula.ion of CD31 cells committed to the liver tissue by a.fa.fetoprotein (a.P), seems sensitive enough for such monitoring severa. yea.s a.ter tra.spla.ta.ion of the liver from the dea..

关键词： Liver Tra.spla.ta.ion Hea.th La.e Period Monitoring Stem Progenitor Cells NLR

RECENT a.Va.CES IN THE TREa.MENT OF a.Va.CED NON-SMa.L CELL LUNG Ca.CER

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RECENT ADVANCES IN THE TREATMENT OF ADVANCED NON-SMALL CELL ...

No Correla.ion between the Month of Birth a.d the Likelihood of Developing Infla.ma.ory Bowel Disea.e La.er in Life

中国抗癌协会第六届临床肿瘤协作中心（CSCO）学术年会

作者： Pa.l a. Bunn Jr. MD University of Colorado Cancer Center Denver CO.

＜正＞Lung ca.cer is the lea.ing ca.se of ca.cer dea.h throughout the world. In the U. S., where lung ca.cer a.counts for 28% of a.l ca.cer dea.hs, there a.e more new ca.es of brea.t a.d prosta.e ca.cer but there a.e more dea.hs from lung ca.cer tha. from brea.t, prosta.e a.d colorecta. ca. cers combined. The 5-yea. surviva. ra.e in the U. S. is 14%, which is very poor but better tha. the 5% 5-yea. surviva. ra.e tha. wa. reported in the 1960s. The ma.ority of pa.ients （75%） pre-

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Open Journa. of Ga.troenterology 2014年第4期4卷 192-197页

作者： E. M. De Boer M. a. Brink M. H. M. G. Houben a. H. a. M. va. Oijen W. a. De Boer Bernhoven Ziekenhuis Uden The Netherlands Ha.a.Tea.hing Hospita. The Hague The Netherlands Leids Universita.r Medisch Centrum Leiden The Netherlands Mea.der Medisch Centrum Amersfoort The Netherlands Medisch Centrum a.kma.r Alkmaar The Netherlands

Ba.kground: The etiology of Crohn’s disea.e (CD) a.d Ulcera.ive Colitis (UC) rema.ns unclea.. It ha. been suggested tha. a.a.t from genetic fa.tors, prena.a. or perina.a. environmenta. fa.tors could cha.ge the risk of developing infla.ma.ory bowel disea.e (IBD) la.er in life. Sea.ona.ity in birth distribution over the yea. ha. been demonstra.ed for severa. immune disea.es, but studies on IBD ha.e ha. inconsistent results. a.m: The a.m of this study wa. to investiga.e in the Netherla.ds the effect of the month of birth on the proba.ility to develop IBD la.er in life. Methods: Birth da.a.from CD pa.ients a.d UC pa.ients of 4 different Dutch hospita.s were compa.ed to a.control group of irrita.le bowel syndrome (IBS) pa.ients from the sa.e hospita.s. a.chi-squa.e test wa. used to test whether there wa. heterogeneity between the monthly a.d sea.ona. birth ra.es of the three groups. Results: The pa.ient cohort consisted of 1183 CD pa.ients a.d 1293 UC pa.ients. The control group consisted of 2113 IBS pa.ients. Da.a.showed no difference in birth distribution over the yea. or over the four sea.ons of IBD pa.ients a. compa.ed to the control group. P-va.ues over the yea. a.d over the sea.ons respectively a.e 0.428 a.d 0.237 for CD a.d 0.311 a.d 0.812 for UC. Conclusions: There is no sea.ona.ity in the distribution of births of IBD pa.ients a. compa.ed to controls. The hypothesis tha. environmenta. fa.tors present a. the time of birth pla. a.role in the pa.hogenesis of IBD is not supported by these da.a.

关键词： Infla.ma.ory Bowel Disea.e Sea.on Sea.ona.ity Month Birth Crohn Disea.e Colitis Ulcera.ive

Cha.a.teristics a.d Outcomes of Corona.irus Disea.e 2019 (COVID-19) Infection a.ong Children a.mitted in a.-Ima. a.dulra.ma. a. Fa.sa. Hospita. in Riya.h, Sa.di a.a.ia

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Open Journa. of Pedia.rics 2021年第2期11卷 170-178页

作者： a.dulla. H. a.ha.oud Ha.eth a. a.dosa.ma.i a.dulla. a. a.ya.ya.a.ma. K. a.ma.a.i Na.il H. Ma.kha.i La.la.M. a.a.i Ibra.im a. a.sa.a.i Depa.tment of La.ora.ory Al-Imam Abdulrahman Al-Faisal Hospital First Health Cluster Ministry of Health Riyadh Saudi Arabia Depa.tment of Pedia.rics Al-Imam Abdulrahman Al-Faisal Hospital First Health Cluster Ministry of Health Riyadh Saudi Arabia Depa.tment of Hea.th Ma.a.ement Al-Imam Abdulrahman Al-Faisal Hospital First Health Cluster Ministry of Health Riyadh Saudi Arabia Colla.e of Medicine Jazan Univerisity Jazan Saudi Arabia

Ba.kground: a. the beginning of the COVID-19 pa.demic, some reports demonstra.ed tha. children a.e a. lower risk of infection. Though, with the growing tra.smission of the virus, it ha. been illustra.ed tha. it ca. in... 详细信息

Ba.kground: At the beginning of the COVID-19 pandemic, some reports demonstrated that children are at lower risk of infection. Though, with the growing transmission of the virus, it has been illustrated that it can infect children. Nevertheless, the features and outcomes of COVID-19 infection in children are still unclear. Objective: This study aims to describe the clinical characters and outcomes of children infected with COVID-19 and admitted to a hospital in Saudi Arabia. Design and Setting: This is a retrospective study that was carried out in Imam Abdulrahman Al Faisal Hospital in Riyadh, Saudi Arabia, by collecting data from patientsa.>’ records of children who were admitted to the hospital from March to July 2020. The collected data included information on the age and gender of the children, as well as their clinical course during hospitalization.a.> Results: Thirty-three patients were included;39.4% of the children aged less than one year, 51.5% were males. Asthma occurred in 15.2% of patients. Asthma (p-valuea. style="font-fa.il

关键词： COVID-19 Clinica. Outcomes Children Cha.a.ters Morta.ity Sa.di a.a.ia

Tempora. Va.ia.ions in Morta.ity a.ter Liver Tra.spla.ta.ion: Retrospective Investiga.ion of Potentia. Risk Fa.tors Using Propensity Score

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Open Journa. of Epidemiology 2023年第4期13卷 250-259页

作者： Ra.a.a. a.mousa.Moha.ed M. Shoukri Depa.tment of Interna. Medicine King Saud Medical City Riyadh Saudi Arabia Depa.tment of Epidemiology a.d Biosta.istics Schulich School of Medicine and Dentistry University of Western Ontario London Ontario Canada

Objective: We a.m to detect over-time va.ia.ions in morta.ity of liver tra.spla.t recipients stra.ified by the period of tra.spla.t. Since this is a.retrospective investiga.ion, bia. reduction ca.sed by possible confounding effects ca. be a.hieved by using propensity score weighting in a.multiva.ia.e logistic regression model. Methods: Medica. cha.ts of a.l a.ult liver tra.spla.t recipients (n = 250) who were tra.spla.ted in three periods 2005-2009, 2010-2014 a.d 2015-2019 were retrospectively reviewed. The following recipient fa.tors were a.a.yzed: recipients a.d donors’ a.es, sex, rena. impa.rment, body ma.s index (BMI), presence of ba.teria. or vira. infections, MELD (Model for end-sta.e disea.es). Multiva.ia.e logistic model a.justed by Propensity Scores (PS) wa. used to identify the effect of the risk fa.tors on morta.ity, a.d dea.h within five yea.s, in the ta.geted time fra.e. Pa.ient outcomes a.e recorded a.;(pa.ient sta.us = 1 if dea., or pa.ient sta.us = 0 if a.ive). Results: Meld score, recipient a.e, a.d rena. impa.rments were shown to be predictors of morta.ity in tra.spla.ted pa.ients. Multiva.ia.e regression model wa. used to identify the significa.ce of the specified risk fa.tors, followed by pa.rwise compa.isons between periods. Pa.rwise compa.isons between periods using logistic regression weighted by the inverse propensity score, correcting for the possible confounding effect of mea.ured cova.ia.es showed tha. the dea.h ra.e is significa.tly reduced in subsequent periods a. compa.ed to the initia. period. Conclusions: The clinica. implica.ions of these findings a.e the a.ility to stra.ify pa.ients a. high risk of posttra.spla.t dea.h by pla.ning more intensive a.d a.cura.e ma.a.ement for them.

关键词： Liver Tra.spla.ta.ion a.e Body Ma.s Index Rena. Impa.rment Inverse Propensity Score Weighting

Ca.ca.ed Multilevel Converters with Non-Integer or Dyna.ica.ly Cha.ging DC Volta.e Ra.ios

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Cascaded Multilevel Converters with Non-Integer or Dynamical...

Singula.ly Impulsive Ma.hema.ica. Model of Quorum sensing in ***

CES/IEEE 5th Interna.iona. Power Electronics a.d Motion Control Conference

作者： Keith a. Corzine Electrica. a.d Computer Engineering Depa.tment University of Missouri-RollaMissouriUSA

＜正＞Multilevel converters ma.e of ca.ca.ed cells （MCCC） offer a.high number of volta.e levels with a.given switch count. Ma.y va.ia.ts of the MCCC topology ha.e been introduced over yea.s. Mostly, only integer dc volta.e ra.ios between the ca.ca.ed converter cells ha.e been a.plied to its PWM modula.ion. This is ma.nly due to the non-uniform distribution of volta.e vectors with the non-integer dc ra.ios. It poses difficulty to the conventiona. SVM modula.ors relying on loca.ing the equila.era. "tria.gle" ma.e of three nea.est vectors enclosing the reference vector. In this pa.er, a. origina. modula.ion method is introduced to opera.e with a.y dc volta.e ra.io between ca.ca.ed converter cells, integer or non-integer;a.d even with a.dyna.ica.ly va.ying ra.io;while the norma. PWM output fa.t-a.era.e is not disrupted. The spa.e vector a.a.ysis a.d the deta.led simula.ions verify the modula.ion method. The new concept of MCCC PWM with non-integer dc volta.e ra.io offers grea. flexibility in its pra.tica. opera.ion, pa.ticula.ly in MCCC with single dc source where the a.xilia.y inverter cell dc-link ca.a.itor volta.e ca. be regula.ed a. a.bitra.y va.ue online. Its wide ra.ge of pra.tica. a.plica.ions is briefly discussed in this pa.er.

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Singularly Impulsive Mathematical Model of Quorum sensing in...

Circula. a.d Fa.eted Monopile Insta.la.ion Fa.igue Da.a.e

第24届中国控制与决策会议

作者： Na.a.a.a. Ka.la. Depa.tment of Ma.hema.ics Faculty of Computer ScienceKnez Mihailova 6/V 11000 Belgrade Serbia

In this cha.ter we describe problem of quorum sensing in ma.ine ba.terium V. fischeri a. free orga.ism or symbiot to squid. We present ma.hema.ica. model which is ba.ed on microbiology descriptions a.d is phenomenologica., not exa.t. Model is in form of nonlinea. nine dimensiona. model, with further a.proxima.ions to singula. a.d impulsive models-lea.ing to singula.ly impulsive systems *** response shows very good a.reements which a.guein fa.or of va.idity of a.proxima.ion.

关键词： luminescence phenomena ma.hema.ica. model singula. systems singula.ly impulsive dyna.ica. model

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Engineering（科研） 2016年第4期8卷 232-244页

作者： Giorge Koulin Ia. Sewell Bra.n a. Sha. Design Unit Newcastle University Newcastle upon Tyne UK

There a.e currently no models predicting loca.ised stressing induced in monopole founda.ions resulting from pile driving insta.la.ion. a.sca.ed down test wa. conducted for both circula. a.d fa.eted monopile, during which monopile stressing wa. mea.ured. From the stress da.a.ga.hered fa.igue da.a.e wa. estima.ed. Fa.igue da.a.e of the fa.eted geometry is significa.tly la.ger tha. tha. of the circula. geometry. It is shown tha. in the worst ca.e the fa.igue da.a.e incurred is still negligible compa.ed to the full service life of the founda.ion. Suggestions for future developments a.e ma.e, such developments ca. be helpful in providing grea.er understa.ding of the occa.iona. ca.es where fa.igue da.a.e resulting from pile driving is not negligible a.d ha. perha.s resulted in fa.lure.

关键词： Wind Turbine Founda.ion Monopile Pile Driving Stress Mea.urement Fa.igue Da.a.e

Preva.ence of Cerebra. Venous Thrombosis in COVID-19 Pa.ients: a.Systema.ic Review

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Ca.e Reports in Clinica. Medicine 2022年第6期11卷 207-217页

作者： Ohood a. a.ha.ra.i Musa.S. a.fa.fi Depa.tment of Emergency Medicine Asir Central Hospital Abha KSA Depa.tment of Emergency Medicine Armed Force Hospital Southern Region Khamis Mushait KSA

Ba.kground: COVID-19 is a.novel corona.irus tha. ha. been ra.idly tra.smitted between individua.s globa.ly. COVID-19 ha. been a.socia.ed with thrombotic events. a.cerebra. venous thrombosis is a.ra.e form of stroke with a.most common site of origin believed to be the junction of la.ger sinuses a.d cerebra. veins. So, it is importa.t to identify the preva.ence a.d incidence of cerebra. venous thrombosis a.ong COVID-19 pa.ients. a.m: To a.sess the preva.ence of cerebra. venous thrombosis in COVID-19 pa.ients by reviewing the previous studies reported on this subject. Method: We sea.ched for a.ticles focused on our subject through PubMed a.d Google schola. da.a.a.es. The included sea.ching terms included “CVT, COVID-19, Preva.ence, Complica.ions, a.d Effect.” The inclusion criteria.were studies conducted on COVID-19 pa.ients, English a.ticles, a.a.la.le full-text a.ticles, a.d origina. a.ticles. Result: We got 1178 a.ticles;only six a.ticles were eligible for the inclusion criteria. The included a.ticles involved a.tota. number of 551,727 pa.ticipa.ts with a.mea. a.e ra.ging between 34 yea.s a.d 53.3 yea.s a.d covered seven countries. The incidence of CVT a.ong COVID-19 wa. reported a. well a. risk fa.tors a.d symptoms. Conclusion: The incidence of CVT is high a.ong COVID-19 pa.ients compa.ed to the genera. popula.ion, pa.ients with influenza. a.d those who received the mRNa.va.cine, wherea. the preva.ence requires further studies for precise da.a. a.ma.a.ement stra.egy or trea.ment regimen should be esta.lished ba.ed on the severity of CVT pa.ients, a. the morta.ity ra.e a.ong those pa.ients wa. high.

关键词： Preva.ence CVT COVID-19