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Place of Bone scintigraphy in the Assessment of Extension and Follow-Up of Breast Cancer in senegal: study of 165 Cases in the Nuclear Medicine Department of Idrissa Pouye General Hospital (Dakar)

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Open Journal of Medical Imaging 2024年第1期14卷 10-30页

作者： El Hadji Amadou Lamine Bathily mamoudou s.lif djigo Djimby Ba Gora Thiaw Ousseynou Diop Kalidou Gueye Olatounde Herbert Fachinan Boucar Ndong Omar Ndoye Mamadou Mbodj Nuclear Medicine Department Idrissa Pouye General Hospital (HOGIP) Dakar Senegal Biophysics Laboratory FMPO UCAD Dakar Senegal Nuclear Medicine Department Hospital Dalal Jamm Dakar Senegal Nursing and Obstetrics Training Institute Parakou University Parakou Benin

Introduction: Breast cancer is the most common cancer in women worldwide, accounting for an estimated 22% of all female cancers. It is the leading cause of cancer mortality in women, almost all of which is due to metastases, with 73% of metastases occurring in the bone. In oncology, metastable technetium 99-labelled methylene bisphosphonate bone scintigraphy (Bs) remains the standard examination for detecting and assessing the extent of bone metastases. The aim of this study was to assess the role of Bs in the evaluation and follow-up of breast cancer in senegal. Methodology: This was a retrospective study of breast cancer patients who underwent bone scintigraphy with sup>99msup>Tc-HMDP in the nuclear medicine department of Idrissa Pouye General Hospital (IPGHO), from July 2009 to June 2022. Results: We enrolled 165 patients, mean age 46.79 years (27 - 87 years). Bs was performed in 94.37% of cases for post-therapeutic monitoring and in 5.63% for pre-therapeutic assessment. Results were contributory in 131 patients (92.25%), of whom 72 cases (50.70%) were normal and 59 cases (41.55%) positive or presenting bone metastases;and non-contributory or doubtful in 11 cases (7.75%). secondary bone locations were multiple in 57 cases (96.61%) and single or solitary in 2 cases (3.39%). The scintigraphic appearance of bone metastases was hyper-fixative in 58 cases (98.31%) and mixed in 1 case (1.69%). Bone lesions were quantified using the soloway’s grading classification. Conclusion: Bs with sup>99msup>Tc-labelled bisphosphonates remains the examination of choice for skeletal exploration, in the detection and extension of bone metastases in breast cancer. Performance has been enhanced by the development of sPECT coupled with CT (sPECT-CT).

关键词： Breast Cancer Bone scintigraphy 99mTc-HMDP Bone Metastases

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Contribution of Bone scintigraphy in the Diagnosis of a Case of sAPHO in the Nuclear Medicine Department of Idrissa Pouye General Hospital (Dakar, senegal)

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Open Journal of Medical Imaging 2024年第1期14卷 1-9页

作者： El Hadji Amadou Lamine Bathily Kalidou Gueye serigne Moussa Badiane mamoudou s.lif djigo Gora Thiaw Ousseynou Diop Olatounde Herbert Fachinan Papa Mady sy Alfonse Rodrigue Djiboune Kokou Fofo Toussaint Adambounou Louis Augustin Diaga Diouf Boucar Ndong Gora Mbaye Omar Ndoye Mounibé Diarra Mamadou Mbodj Nuclear Medicine Department Idrissa Pouye General Hospital (HOGIP) Dakar Senegal Biophysical Laboratory FMPO Cheikh Anta Diop University (UCAD) Dakar Senegal Biophysical Laboratory UFR2S Gaston Berger University (UGB) Saint-Louis Senegal Nuclear Medicine Department Hospital Dalal Jamm Dakar Senegal Laboratory of Physical and Pharmaceutical Biophysics FMPO Cheikh Anta Diop University Dakar Senegal Biophysical Laboratory University of Lome Lome Togo

Introduction: The acronym sAPHO (synovitis, Acne, Pustulosis, Hyperostosis and Osteitis) is a syndrome combining osteoarticular and cutaneous manifestations. It occurs mainly between the ages of 30 and 50. sternocostoclavicular hyperostosis is one of the main distinguishing features. We report a case of sAPHO in Dakar diagnosed by bone scintigraphy. Observation: 28-year-old senegalese women presented with left shoulder pain and relative functional impotence for over 2 years. Examination revealed right sternoclavicular hyperostosis and left shoulder pain on palpation. Questioning revealed a history of acne and hyperostosis of the right first toe. Bone scintigraphy, performed after injection of 630 MBq of sup>99msup>Tc-HMDP, revealed: hyperfixation of the bilateral (right++) manubrio-sternal and sternoclavicular junction, producing the classic bull’s horn image;hyperfixation of the left shoulder with an inflammatory appearance;hyperfixation of the sacroiliac joints suggestive of bilateral sacroiliitis;hyperfixation of the right first toe;two mandibular hyper fixations probably related to dental damage. This scintigraphic appearance in one was strongly suggestive of sAPHO syndrome. Conclusion: sAPHO syndrome, related to spondyloarthropathy, associates cutaneous and osteoarticular signs. It is characterized by frequent delays in diagnosis due to poor recognition. soy is an invaluable diagnostic tool, enabling us to assess the extent of the disease and its evolution.

关键词： sAPHO Bone scintigraphy Young Woman senegalese

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Contribution of <sup>99m</sup>Tc-DPD scintigraphy in the Diagnosis of Cardiac Amyloidosis in Black Africans

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Open Journal of Biophysics 2022年第1期12卷 27-37页

作者： djigo mamoudou s.lif Ndong Boucar Bathily El Hadji Amadou Lamine Diop Ousseynou Gueye Kalidou Thiaw Gora Ndoye Oumar Mbodj Mamadou Department de Medecine Nucleaire Hô pital General Idrissa Pouye Dakar Senegal Department de Medecine Nucleaire Hô pital Dalal JAMM Dakar Senegal

Cardiac amyloidosis presents a picture of hypertrophic cardiomyopathy with heart failure with preserved ejection fraction. It is largely underdiagnosed, especially in black Africans, and therefore falls under the category of heart disease classified as idiopathic. Light chain amyloidosis (AL) is mainly found in Caucasian subjects and the mutant variant of transthyretin (TTRm) in negroid subjects. Numerous studies have shown that ATTRm was found predominantly in black American and black British patients. In African countries the entity of idiopathic heart failure is quite important because of lack of diagnosis, ETT, MRI and immuno-histochemistry are expensive or not available. We can probably assume that the proportion of cardiac amyloidosis is quite important in black Africans. The question is if sup>99msup>Tc-DPD really easy to perform, can probably help to investigate in the nuclear medicine department in Africa. No large-scale study has been able to demonstrate the prevalence or not of cardiac amyloidosis in black-African subjects and by extension reduce this nosological entity of idiopathic heart disease. The sup>99msup>Tc-DPD scintigraphy using Perrugini’s visual sore allows localization and classification of amyloid damage. The mechanism of binding of sup>99msup>Tc-DPD to amyloid fibril deposits is not well known, its binding to TTR-type (mutated or wild type) amyloidosis is greater than the AL variant. In the diagnostic algorithm, endomyocardial biopsy is the gold standard but remains invasive, ETT with the strain allows a presumptive diagnosis and remains an operative examination dependent and is not reproducible. Cardiac MRI allows some localization of amyloid deposits but still remains less sensitive than scintigraphy. In addition, performing the whole-body MRI is very restrictive (time, antenna change and cost). The aim of this literature review was to show the superiority of sup>99msup>Tc-DPD scintigraphy compared to other diagnostic modaliti

关键词： Amyloidosis TTRm AL 99mTc-DPD Bone scintigraphy

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Kohonen’s Algorithm Applied to the scintigraphic Image for an Aid in the Diagnosis of Prostate Cancer Metastasis

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Open Journal of Medical Imaging 2022年第2期12卷 37-47页

作者： Boucar Ndong El Hadji Amadou Lamine Bathily mamoudou s.lif djigo Mamadou Lamine Mboup François Kaly Kanta Ka Ousseynou Diop Ibrahima Thiam Gora Mbaye Omar Ndoye Mamadou Mbodj Biophysics and Nuclear Medicine Laboratory Cheikh Anta Diop University Dakar Senegal sustainable Development and society Doctoral school Thies University Thies Senegal Laboratoire du traitement de l’information/EsP/UCAD Senegal Radiotherapy Department of the National Hospital University Center Dalal Jamm Guédiawaye Dakar Sénégal Physics Pharmaceutical Laboratory Cheikh Anta Diop University Dakar Senegal

To partition the scintigraphic image, several methods are used, among which is Kohonen’s self-organizing map algorithm. The objective of this study was to perform an ascending hierarchical classification (HAC) on the results of the Kohonen self-organizing map. This makes it possible to carry out the second phase necessary for the elaboration of the classifier by grouping the neurons as well as possible into 3 classes then by reconstituting the scintigraphic image from the 3 classes. This partition proceeds by successive groups, thus merging at each iteration two subsets of neurons using a measure of similarity which is Ward’s method. In this method, the algorithm aggregates the nearest neurons into classes. This allows us to obtain a dendrogram that looks like a tree. And this one needs to be cut. And to have an adequate cut-off level, we have established the variation of the Davies Bouldin index as a function of the number of classes. The minimum value of this index gave the optimal number of classes which corresponded to 3 in the study. These three groups A, B, C have a variable intensity. This intensity can be high, it can be medium or low. The high, medium and low intensities corresponded respectively to metastases for class A, to degenerative or inflammatory phenomena for class B and to normal radiopharmaceutical uptake for class C. To confirm this strong suspicion, we performed reconstructions using a filter. And after this reconstruction, we had images like at the entrance. And for the interpretation of these images, we used a visual metric. This enabled us to note that for the interval [0 - 50[, the image is not contrasted and no lesion could be detected. Over the interval [50 - 200[, we observed the distribution of the radiopharmaceutical over the entire skeletal whole body. On this reconstruction interval, the visual metric shows hypofixation in the bladder and areas suspected of metastases. Over the interval [200 - 250[, we detected hyperfixations linked

关键词： Neural Networks Hierarchical Ascending Classification scintigraph

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Assessment of Carestart G6PD rapid diagnostic test and Carestart G6PD biosensor in Mauritania

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Infectious Diseases of Poverty 2021年第4期10卷 33-45页

作者： Oum Kelthoum Mamadou djigo Yacoub Ould Khalef Mohamed salem Ould Ahmedou salem Nicolas Gomez Leonardo Basco sebastien Briolant Ali Ould Mohamed salem Boukhary Unite de Recherche"Genomes et Milieux"(Jeune Equipe Associee a I'lnstitut de Recherche pour le Developpement) Faculte des Sciences et lechniquesUniversite de Nouakchott Al-AasriyaNouakchottMauritania service de Pediatrie Centre Hospitalier Mere et EnfantNouakchottMauritania IHU Mediterrande InfectionMarseilleFrance Aix Marseille Univ IRDAP-HMSSAVITROMEMarseilleFrance Unite de Parasitologie Entomologie Departement de Microbiologie et Maladies InfectieusesInstitut de Recherche Biomedicale des Armees(IRBA)MarseilleFrance

Background::The elimination of Plasmodium vivax malaria requires 8-aminoquinolines,which are contraindicated in patients with glucose-6-phosphate dehydrogenase(G6PD)deficiency due to the risk of acute haemolytic *** point-of-care devices have been developed to detect G6PD *** objective of the present study was to evaluate the performance of two of these devices against G6PD genotypes in ***::Outpatients were screened for G6PD deficiency using Carestart?rapid diagnostic test(RDT)and Carestart?G6PD biosensor in Nouakchott,Mauritania,in ***-type and Mediterranean-type G6PD genotypes commonly observed in Africa were determined by polymerase chain reaction-restriction fragment length polymorphism and *** variables were compared using Fisher’s exact ***::Of 323 patients(74 males and 249 females),5 males and 2 homozygous females had the African-type A-genotype:A-(202)in 3 males and 2 females and G6PD A-(968)in 2 *** heterozygous females,13 carried G6PD A-(202),12 G6PD A-(968),and 3 G6PD A-(542)*** had the Mediterranean-type G6PD *** had a positive G6PD RDT result,including all 7 hemizygous males and homozygous females with A-or A-A-(0.12 to 2.34 IU/g haemoglobin,according to G6PD biosensor),but RDT performed poorly(sensitivity,11.1%at the cutoff level ofse negative ***-seven(50.0%)males and 141(56.6%)females were *** adjusted median values of G6PD activity were 5.72 and 5.34 IU/g haemoglobin in non-anaemic males(n=35)and non-anaemic males and females(n=130)with normal G6PD genotypes using G6PD biosensor,*** on the adjusted median of 5.34 IU/g haemoglobin,the performance of G6PD biosensor against genotyping was as follows:at 30%cut-off,the sensitivity and specificity were 85.7%and 91.7%,respectively,and at 80%cut-off,the sensitivity was 100%while the specificity was 64.9%.Conclusions::Although this pilot study

关键词： Glucose-6-phosphate dehydrogenase Malaria Plasmodium vivax Primaquine Tafenoquine

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Contribution of scintigraphy in the Assessment of Extension of Osteophilic Cancers in senegal from 2018 to 2021

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Open Journal of Biophysics 2023年第1期13卷 1-13页

作者： Olatoundé Herbert Fachinan El Hadji Lamine Bathily Mamadou s.lif djigo Gilles David Houndétoungan Djibrillou Moussa Issoufou Boucar Ndong Kuassi Marcellin Amoussou-Guénou Mamadou Mbodj Institut de Formation en soins Infirmiers et Obstétricaux Université de Parakou Parakou Bénin service de Médecine Nucléaire H&ocirc pital Général Idrissa Pouye Dakar Sénégal Laboratoire de Biophysique Médecine Nucléaire Université Cheikh Anta Diop Dakar Sénegal Unité D’Enseignement et de Recherche de Biophysique et Médecine Nucléaire Faculté des Sciences de Santé Université d’Abomey-Calavi Cotonou Bénin Département de Médecine Nucléaire Institut des Radio-Isotopes Niamey Niger

The aim of this study was to highlight the contribution of bone scintigraphy in the assessment of extension of osteophilic cancers in senegal. This was a retrospective study, with a descriptive and analytical purpose, carried out over a period of four (04) years between January 01, 2018 and December 31, 2021. It focused on the files of patients who underwent bone scintigraphy for extension assessment of an osteophilic cancer during the study period. According to the study, prostate cancer was by far the most representative primary cancer (86.9%). scintigraphy contributed in 75% of cases (362 cases) with 35% positive scintigraphy and 40% negative scintigraphy. The result was doubtful in 25% of cases (120 cases). The metastatic lesions were located preferentially at the level of the axial skeleton and only one case was of an exclusive appendicular site. More than half of patients with metastases (70%) had a poor prognosis with the sOLOWAY score greater than or equal to II. With the improvement of the nuclear imaging technical platform in senegal (performance of sPECT/CT examinations), doubtful cases in our sample could be better explored with the advantage of adequate patient care.

关键词： Bone scintigraphy Osteophilic Cancers Bone Metastases

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Experiences on Participation in Literary Activities: Intellectual stimuli Empower People with Mental Health Problems

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Open Journal of Nursing 2017年第11期7卷 1307-1323页

作者： Lisbeth Kristiansen Ulrika lif Helen Asklund Mid sweden University Sundsvall Sweden

some research acknowledges engagement in creative and literary activities as constructively impacting rehabilitation and recovery. Nevertheless, there is a deficit of literature describing experiences of participation in literary activities. This study examined how members of a non-profit association for mental health, with experiences of mental problems or illnesses, experienced group-based literary activities facilitated of a bi-disciplinary research team during one semester. This study held a constructive/naturalistic design and used a qualitative methodology with a latent analysis to describe how participants experienced literary activities (creative writing, reading and conversations about published and own written poetry and prose texts). Both individual and focus-group interviews were performed early 2014. Despite previous negative experiences, the findings showed that the participants perceived the literary activities empowering. Four categories were created: Presumptions of personal literacy, leadership role, participants’ role, and literacy development. These were abstracted and interpreted into three themes: Identifying a reading and writing self-image, challenging and redefining one’s reading and writing identity, and strengthening one’s intellectual and humanistic capacity. Literary activities seemed to positively change the participants’ attitudes towards writing and reading, and also enhanced their literacy skills. We argue that literacy skills are interconnected with health literacy. Involvement of literary activities into rehabilitation in mental health practice may be beneficial for some groups, and merits further studies.

关键词： Alternative Interventions Literary Activities Mental Health Promotion Multidisciplinary Care Qualitative Methodology User Involvement

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Common mtDNA variations at C5178a and A249d/T6392C/G10310A decrease the risk of severe COVID-19 in a Han Chinese population from Central China

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Military Medical Research 2022年第1期9卷 53-62页

作者： Yi Wu Xian-Hui Wang Xi-Hua lif Li-Yuan song shi-Long Yu Zhi-Cheng Fang Yu-Quan Liu Le-Yong Yuan Chun-Yan Peng shen-Yi Zhang Wang Cheng Hong-Chao Ma Li-Feng Wang Jun-Ming Tang Yun-Fu Wang Fu-Yun Ji Department of Medical Biology School of Basic Medical ScienceHubei University of MedicineShiyan 442000HubeiChina Institute of Biomedical Research Hubei University of MedicineShiyan 442000HubeiChina Institute of Human Respiratory Disease Xinqiao HospitalThe Army Medical University(Third Military Medical University)400037 ChongqingChina Department of Emergency Medicine Taihe HospitalHubei University of MedicineShiyan 442000HubeiChina department of Geriatric Medicine Taihe HospitalHubei University of MedicineShiyan 442000HubeiChina Department of Immunology School of Basic Medical SciencesHubei University of MedicineShiyan 442000HubeiChina department of Laboratory Medicine Taihe HospitalHubei University of MedicineShiyan 442000HubeiChina Hubei Key Laboratory of Embryonic stem Cell Research School of Basic Medical ScienceHubei University of MedicineShiyan 442000HubeiChina Department of Neurology Taihe HospitalHubei University of MedicineShiyan 442000HubeiChina.

Background:Mitochondria have been shown to play vital roles during severe acute respiratory syndrome coronavirus 2(sARs-CoV-2)infection and coronavirus disease 2019(COVID-19)***,it is unclear whether mitochondrial DNA(mtDNA)variants,which define mtDNA haplogroups and determine oxidative phosphorylation performance and reactive oxygen species production,are associated with COVID-19 ***:A population-based case-control study was conducted to compare the distribution of mtDNA variations defining mtDNA haplogroups between healthy controls(n=615)and COVID-19 patients(n=536).COVID-19 patients were diagnosed based on molecular diagnostics of the viral genome by qPCR and chest X-ray or computed tomography *** exclusion criteria for the healthy controls were any history of disease in the month preceding the study *** variants defining mtDNA haplogroups were identified by PCR-RFLPs and HVs-I sequencing and determined based on mtDNA phylogenetic analysis using Mitomap ***’s t-test was used for continuous variables,and Pearson’s chi-squared test or Fisher’s exact test was used for categorical *** assess the independent effect of each mtDNA variant defining mtDNA haplogroups,multivariate logistic regression analyses were performed to calculate the odds ratios(OR)and 95%confidence intervals(CI)with adjustments for possible confounding factors of age,sex,smoking and diseases(including cardiopulmonary diseases,diabetes,obesity and hypertension)as determined through clinical and radiographic ***:Multivariate logistic regression analyses revealed that the most common investigated mtDNA variations(>10%in the control population)at C5178 a(in NADH dehydrogenase subunit 2 gene,ND2)and A249 d(in the displacement loop region,D-loop)/T6392 C(in cytochrome c oxidase I gene,CO1)/G10310 A(in ND3)were associated with a reduced risk of severe COVID-19(OR=0.590,95%CI 0.428–0.814,P=0.001;and OR=0.654,95%CI 0.45

关键词： Mitochondrial DNA variations severe acute respiratory syndrome coronavirus 2 Coronavirus disease 2019 Risk Han Chinese

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Contribution of Bone scintigraphy in the Diagnosis of a Calcaneus Fatigue Fracture in a Case at the Nuclear Medicine Department of Idrissa Pouye General Hospital (HOGIP) in Dakar

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Open Journal of Medical Imaging 2020年第1期10卷 62-71页

作者： El-Hadji Amadou Lamine Bathily B. Ndong O. Diop M. s. djigo K. Gueye A. Kokou G. Thiaw G. Mbaye L. A. D. Diouf M. soumboundou A. R. Djiboune P. M. sy O. Ndoye M. Diarra M. Mbodj Nuclear Medicine Department General Hospital of Idrissa Pouye (HOGIP) Dakar Senegal Biophysical Laboratory FMPO Cheikh Anta Diop University (UCAD) Dakar Senegal Nuclear Medicine Department Hospital Dalal Jamm Dakar Senegal Biophysical Laboratory University of Lome Lome Togo Laboratory of Physical and Pharmaceutical Biophysics FMPO Cheikh Anta Diop University Dakar Senegal

Introduction: Fatigue fractures are secondary to excessive, unusual, repeated mechanical stress, occurring on healthy bone. Bone scintigraphy (Bs) with 99mTc-HMDP is an excellent means of diagnosis. We report a case of stress fracture of the calcaneus with scintigraphic diagnosis, in a marathon runner. Patient and Methods: He is a 40-year-old athlete in overtraining with right calcaneal pain on running, intense at first, moderate in the middle and then persistent after exercise. The interrogation found no trauma to the right foot and the x-ray of the foot was without abnormality. The so 3 phases were performed following an injection of 564 MBq of 99mTc-HMDP, with a sPECT gamma camera. Results: Bone scintigraphy found in the early phase, hyper-perfusion and hyper-fixation of the right calcaneal region compared to its left counterpart and in the bone phase persistence of focal hyperfixation opposite the right calcaneus. This scintigraphic aspect of the right calcaneus in an overtrained marathon runner, in a painful context and in front of a normal X-ray, made us evoke a fracture of fatigue. A complementary CT scan performed two days after the Bs was without abnormality. Conclusion: Fatigue fractures are micro-fractures generally not noticed on radiography and CT. Bs due to its high sensitivity is an excellent or the best tool for the early diagnosis of stress fractures.

关键词： Fatigue Fracture Bone scintigraphy sports

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Contribution of Myocardial Perfusion’s Tomoscintigraphy in the Management of Coronarian Disease in senegal: About 42 Cases

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Open Journal of Biophysics 2017年第4期7卷 175-182页

作者： B. Ndong G. Mbaye E. A. L. Bathily O. Diop A. D. Diop L. A. D. Diouf A. Mbaye R. s. senghor M. soumboundou A. R. Djiboune P. M. sy N. Badji A. Dia M. s. djigo M. Mbodj O. Ndoye M. Diarra A. Kane s. seck-Gassama Department of Nuclear Medicine General Hospital of Grand Yoff (GHOGY) Dakar Senegal Laboratory of Physical and Pharmaceutical Biophysics Faculty of Medicine Pharmacy and Odontology Cheikh Anta Diop University Dakar Senegal Radiology Department Fann University Hospital Dakar Senegal Cardiology HOGGY General Hospital of Grand Yoff (GHOGY) Dakar Senegal Training and Health Research of Thiès Thiès Sénégal

The aim of the study was to evaluate the contribution to moscintigraphy of myocardial perfusion (TsMP) with 99mTc-sestamibi in the management of suspected or known coronary patients’s population. It included 42 patients with an average age of 57.02 ±9.77 years with extremes ranging from 36 to 77 years. The pre-test probability in 38 patients was high in 7 patients (18.42%), intermediate in 29 patients (76.31%) and low in 2 patients (5.26%). Patients with a high pre-test probability had a positive scintigraphy. Among the 26 patients who underwent transthoracic ultrasound (TTU), 10 with normal kinetics on trans-thoracic ultrasound (TTU) had positive scintigraphy. For 16 patients with TTU abnormalities, 6 had negative scintigraphy and 10 had positive scintigraphy. The TsMP was positive for 28 patients (66.66%). Among these patients, 16 had pure ischemia, 57.14% (16/28), 7 pure necrosis (25%), and 5 both necrosis and ischemia. Myocardial perfusion scintigraphy remains a very contributory consideration in the management of coronary disease. This is synchronized with the electrocardiogram (ECG) and is an important diagnostic and prognostic tool for coronary artery disease. It also provides a good indication of coronary angiography.

关键词： Tomoscintigraphy Myocardial Perfusion Coronary Artery Disease

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