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Assessment of the Quality of Life of Patients with Mycobacterial Pulmonary Diseases

Open Journal of Respiratory Diseases 2022年第2期12卷 56-63页

作者： Khadidia Ouattara Bocar Baya Dianguina Soumaré Tenin Kanouté Mohamed Tolofodie Kafui Komla Gaglo Koudemon Salif Koné Bassirou Diarra Yaya Sadio Sarro Yacouba Toloba mamoudou maiga Pneumology Department CHU Point-G Bamako Mali University of Sciences Techniques and Technologies of Bamako (USTTB) Bamako Mali University Clinical Research Center (UCRC) Bamako Mali

Introduction: Mycobacteria pulmonary diseases are chronic illnesses with various impacts on patients’ health status, and wellbeing. These diseases currently represent a global health issue due to increasing burdens and the lack of new development on therapeutic options. Policies based on the quality of life may help to improve the management of this chronic respiratory disease;this study was designed to assess the quality of life of patients treated for the pulmonary mycobacterial disease. Materials and Methods: Participants diagnosed with a mycobacterial pulmonary disease were selected from the University Clinical Research Centers’ (UCRC) 2019 mycobacterial cohort database. A telephone interview was conducted using the Medical Outcome Study Short Form (SF-36) which has 36 items evaluating physical and mental wellbeing. Scores range from 0 - 100, with higher scores indicating greater Health-related quality of life (HRQOL). Statistical analysis was performed with SPSS 23.0 and the Fisher test was used to compare percentages. A p-value less than 0.05 was considered significant. Results: A total of 26 participants were reached and interviewed by phone. The mean age was 42 ± 10.6 years, and 76.9% (20/26) were male. The most common cause of the mycobacterial pulmonary disease was Mycobacterium tuberculosis, with 84.6% (22/26). Four cases of Non-Tuberculous Mycobacteria (NTM) were diagnosed including one Mycobacterium avium complex strain (MAC). HIV-positive cases were 46.2% (12/26), and the main respiratory sign was cough for all the participants (100%), followed by dyspnea 46.2% (12/26), chest pain 38.5% (10/26). The mean BMI was 19.7 ± 6.9 kg/m2, the mean respiratory rate was 24.7 ± 8.6, and the mean hemoglobin was 11.8 ± 2.2 g/dl. The mean SF-36 score was 75.1 ± 16.6, and impairment was mainly related to mental problems in 59.6%. The mean total score was significantly lower with age more than 42 years than age less than 42 years. But HIV positive and BMI le

关键词： Quality of Life Mycobacteria Lung

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Prevalence and Clinical Relevance of Schistosoma mansoni Co-Infection with Mycobacterium tuberculosis: A Systematic Literature Review

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Open Journal of Epidemiology 2023年第1期13卷 97-111页

作者： Bocar Baya Bourahima Kone Amadou Somboro Ousmane Kodio Anou Moise Somboro Bassirou Diarra Fah Gaoussou Traore Drissa Kone Mama Adama Traore Mahamadou Kone Antieme Georges Togo Yeya Sadio Sarro Almoustapha maiga mamoudou maiga Yacouba Toloba Souleymane Diallo Robert L. Murphy Seydou Doumbia University Clinical Research Center (UCRC) of the University of Sciences Techniques and Technologies of Bamako (USTTB) Bamako Mali Service of Pneumopthisiology of the University Teaching Hospital of Point G Bamako Mali Clinical Laboratory of the University Teaching Hospital of Point G Bamako Mali Havey Institute for Global Health (Havey IGH) Northwestern University (NU) Chicago USA

Tuberculosis disease stands for the second leading cause of death worldwide after COVID-19, most active tuberculosis cases result from the reactivation of latent TB infection through impairment of immune response. Several factors are known to sustain that *** mansoni, a parasite of the helminth genus that possesses switching power from an immune profile type Th1 to Th2 that favors reactivation of latent TB bacteria. The aim of the study was to assess the prevalence of the co-infection between the two endemic infections. Systematic literature was contacted at the University Clinical Research Center at the University of Sciences, Techniques, and Technologies of Bamako in Mali. Original articles were included, and full texts were reviewed to assess the prevalence and better understand the immunological changes that occur during the co-infection. In total, 3530 original articles were retrieved through database search, 53 were included in the qualitative analysis, and data from 10 were included in the meta-analysis. Prevalence of the co-infection ranged from 4% to 34% in the literature. Most of the articles reported that immunity against infection with helminth parasite and more specifically Schistosoma mansoni infection enhances latent TB reactivation through Th1/Th2. In sum, the impact of Schistosoma mansoni co-infection with Mycobacterium tuberculosis is under-investigated. Understanding the role of this endemic tropical parasite as a contributing factor to TB epidemiology and burden could help integrate its elimination as one of the strategies to achieve the END-TB objectives by the year 2035.

关键词： Schistosoma mansoni Tuberculosis Co-Infections LTBI Reactivation

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Prevalence and Clinical Relevance of Schistosoma mansoni Co-Infection with Mycobacterium tuberculosis : A Systematic Literature Review

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Open Journal of Epidemiology（流行病学期刊） 2023年第1期

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Cardiovascular Risk Factors among Outpatients: An Alarming Sign of the Epidemiological Transition in Developing Country?

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World Journal of Cardiovascular Diseases 2021年第3期11卷 181-194页

作者： Modibo Coulibaly Dramane Samaké Sonfo Boubacar Lamine Sidibé Moussa Diawara mamoudou Barry Valentin Sagara Bréhima Traoré Oumar Guindo Bakary maiga Amagana Dolo Department of Biomedical Laboratory Hospital of Mopti Mopti Mali Department of Medicine Hospital of Mopti Mopti Mali Department of Cardiology Teaching Hospital of Kati Bamako Mali Department of Public Health Hospital of Mopti Mopti Mali Faculty of Medicine and Odonto Stomatology University of Science Technical and Technologies de Bamako Bamako Mali Faculty of Pharmacy University of Science Technical and Technologies de Bamako Bamako Mali

Background: Noncommunicable diseases are the leading cause of death in the world and low and middle-income countries suffer from preventable premature death. The aim of this study was to assess the risk factors for non- communicable disease (NCDs) in general and particular cardiovascular diseases (CVDs) among the outpatients of our department of medicine. Methods: We performed a cross-sectional study from April to December 2017 by the consecutive enrollment of outpatients who attended in our department of medicine of Hôpital Sominé DOLO de Mopti, Mali. Clinical and laboratory data were measured for cardiovascular risk assessment. Framingham Risk Score (FRS) and Systemic Coronary Risk Estimation (SCORES) were computed by using Framingham and SCORE equations. Metabolic syndrome was defined using the harmonized criteria from the International Diabetes Federation (IDF) and the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI). Data were captured in excel and analyzed with R version 4.0.3. The statistical significance was set at p = 0.05. Results: A total of 292 patients were enrolled in this study. The prevalence of traditional cardiovascular risk factors was 36.64%, 21.57%, 14.04%, and 13.01% for high blood pressure, hyperglycemia, smoking, and alcohol consumption, respectively. The metabolic syndrome accounted for 23.63%. The mean body mass index was 26.10 ± 7 kg/m2. The overall 10-year risk for cardiovascular events or death was 26.3% and 8.6% according to the FRS and SCORE equation, respectively. The 10-year risk of cardiovascular events according to the FRS was significantly higher in subjects aged 50 and above compared to subjects aged under 50 years, 34.46% vs 13.16%, p < 0.001. Likewis

关键词： Cardiovascular Risk Factors Framingham Risk Score SCORE Metabolic Syndrome

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