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FTY720,Sphingosine 1-Phosphate Receptor Modulator,Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibition of T Cell Infiltration

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Cellular & Molecular Immunology 2005年第6期2卷 439-448页

作者： Hirotoshi Kataoka Kunio Sugaharal Kyoko Shimano Koji Teshima mamoru Koyama Atsyshi Fukunari Kenji Chiba Research Laboratory Ⅲ(Immunology) Pharmaceutical Research UnitResearch and Development DivisionMitsubishi Pharma CorporationYokohamaJapan Research Laboratory 1(CNS) Pharmaceutical Research UnitResearch and Development DivisionMitsubishi Pharma CorporationYokohamaJapan Discovery Technology Laboratory Ⅰ Pharmaceutical Research UnitResearch and Development DivisionMitsubishi Pharma CorporationYokohamaJapan Research Laboratory Ⅲ(Immunology) Pharmaceutical Research UnitResearch and Development DivisionMitsubishi Pharma Corporation1000 Kamoshida-choAoba-kuYokohama 227-0033.Japan.

FTY720, a sphingosine 1-phosphate receptor modulator, induces a marked decrease in the number of peripheral blood lymphocytes and exerts immunomodulating activity in various experimental allograft and autoimmune disease models. In this study, we evaluated the effect of FTY720 and its active metabolite, （S）-enantiomer of FTY720-phosphate [（S）-FTY720-P] on experimental autoimmune encephalomyelitis （EAE） in rats and mice. Prophylactic administration of FTY720 at 0.1 to 1 mg/kg almost completely prevented the development of EAE, and therapeutic treatment with FTY720 significantly inhibited the progression of EAE and EAE-associated histological change in the spinal cords of LEW rats induced by immunization with myelin basic protein. Consistent with rat EAE, the development of proteolipid protein-induced EAE in SJL/J mice was almost completely prevented and infiltration of CD4^＋ T cells into spinal cord was decreased by prophylactic treatment with FTY720 and （S）-FTY720-P. When FTY720 or （S）-FTY720-P was given after establishment of EAE in SJL/J mice, the relapse of EAE was markedly inhibited as compared with interferon-β, and the area of demyelination and the infiltration of CD4^＋ T cells were decreased in spinal cords of EAE mice. Similar therapeutic effect by FTY720 was obtained in myelin oligodendrocyte glycoprotein-induced EAE in C57BL/6 mice. These results indicate that FTY720 exhibits not only a prophylactic but also a therapeutic effect on EAE in rats and mice, and that the effect of FTY720 on EAE appears to be due to a reduction of the infiltration of myelin antigen-specific CD4^＋ T cells into the inflammation site. Cellular ＆ Molecular Immunology. 2005;2（6）：439-448.

关键词： FTY720 S1P receptor modulator lymphopenia EAE T cell infiltration

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Polymorphism Near the Interleukin-28B Gene and Anti-Hepatitis C Viral Response

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Journal of Clinical and Translational Hepatology 2013年第1期1卷 39-44页

作者： Yasuhiro Asahina Mina Nakagawa Sei Kakinuma mamoru Watanabe Department of Gastroenterology and Hepatology Tokyo Medical and Dental University Yushima Bunkyo-ku Tokyo Japan Department of Liver Disease Control Tokyo Medical and Dental University Yushima Bunkyo-ku Tokyo Japan Department of Gastroenterology and Hepatology Tokyo Medical and Dental University Yushima Bunkyo-ku Tokyo Japan

In a recent genome-wide association study, single nucleotide polymorphisms (SNPs) located near the interleukin-28B gene (IL28B), which encodes type Ⅲ interferon (IFN) λ3, were shown to be strongly associated with a viral response to pegylated IFNα (PEG-IFNα) and ribavirin (RBV) combination therapy and spontaneous viral clearance in patients chroni-cally and acutely infected with hepatitis C virus (HCV), respectively. The global distribution of allele frequencies shows a remarkable pattern, in which a favorable allele is nearly fixed in East Asia, has an intermediate frequency in Europe, and is least frequent in Africa. Although the under-lying mechanisms responsible for viral responses associated with IL28B SNPs have not been completely elucidated, IFN-stimulated gene expression in patients with unfavorable IL28B genotypes tends to be high at baseline and is insufficiently induced by exogenous IFN administration, resulting in poor treatment outcomes. Clinically, triple therapy with PEG-IFNα/RBV together with direct-acting anti-viral agents (DAAs) is currently used to treat chronic hepatitis C as a first-line therapy. Although the predictive power of IL28B status may be attenuated, the IL28B genotype will remain relevant to the outcomes of DAA therapy when used in combination with PEG-IFNα as a backbone. Even with the introduction of IFN-free therapies with a new class of highly effective DAAs, IL28B SNPs are still useful predictors of treatment outcomes and can be used to individualize treat-ment strategies to maximize cost-effectiveness and identify patients at risk of being refractory to treatment. This review summarizes the current understanding of the clinical sig-nificance and role of IL28B in HCV infection and response to therapy.

关键词： IL28B IFNλ Innate immunity Interferon-stimulated gene

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Theoretical Analysis and Simulation of Jacking Procedure of Pantadome System

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Transactions of Tianjin University 2005年第2期11卷 137-140页

作者：王小盾石永久王元清 Kawaguchi mamoru Civil Engineering Department Key Laboratory of Structural Engineering and Vibration of Education Ministry of China Tsinghua University Beijing 100084 China Hosei University Tokyo Japan

In order to obtain the principle of Pantadome lifting process and make theoretical foundation for practical applications, the core idea of Pantadome was introduced, which is to make a structure become a mechanism by temporarily removing some members during the process of *** Abstract motion model was built. By determining the change of the coordinates of the hinge joint and that of each point of the structure, simulative analysis of the mechanical motion of Pantadome was realized. Then general program that simulates the lifting process of Pantadome was developed based on AutoCAD environment by Auto Lisp language. By completing the theoretical analysis of the lifting process of Pantadome, three-dimensional simulation of the lifting process of Pantadome was realized. And it is successfully applied to bidding work of practical engineering.

关键词： Pantadome hinge point lifting simulation

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Safety of rectal indomethacin(100 mg)for the prevention of post-ERCP pancreatitis in the Japanese population:A single-center prospective pilot study

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 406-408页

作者： Kotaro Takeshita Satoshi Asai Naoki Fujimoto Takumi Ichinona Eisuke Akamine mamoru Takenaka Department of Gastroenterology Tane General HospitalOsaka 550-0025Japan Department of Gastroenterology and Hepatology Kindai University Faculty of MedicineOsaka-Sayama 589-8511Japan

To the Editor:Endoscopic retrograde cholangiopancreatography(ERCP)causes adverse events;post-ERCP pancreatitis(PEP)is one of the frequent adverse ***,the efficacy of rectal administration of non-steroidal anti-inflamm... 详细信息

关键词： prevention ERCP drugs

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Development of tailored TiO_2 mesocrystals for solar driven photocatalysis

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Journal of Energy Chemistry 2016年第6期25卷 917-926页

作者： Peng Zhang mamoru Fujitsuka Tetsuro Majima The Institute of Scientific and Industrial Research (SANKEN) Osaka University

Ordered metal oxides superstructures have attracted much more attention in the fields of fuel generation and environmental purification owing to their unique physiochemical characteristics such as large surface area, fine pore structure, efficient electronic mobility, and good stability. Very recently, TiOmesocrystals（TMCs） having superstructures self-assembled by TiOnanoparticle building blocks, are of considerable interest in current research and application ranging from UV to visible light attributed to their efficient charge separation and superior photocatalytic activity. In this review, we describe the common procedures to prepare unique TMCs and overview of recent developments of TMCs during last 3 years, especially the structure-related or electronic-effected mechanism in photocatalytic reaction. Further, we introduce the characterization and fundamental properties of modified TMCs by the means of single-particle fluorescence microscopy for unraveling the charge transport and photocatalytic properties of individual TMCs and time-resolved diffuse reflectance spectroscopy（TDR） for monitoring the charge transfer dynamics. Finally, various aspects on TMCs are discussed for the future developments of energy and environmental fields.

关键词： TiO2 Mesocrystal Photocatalyst Topotactic transformation Doping Charge separation Co-catalyst Electron flow

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Computer generated hologram from full-parallax 3D image data captured by scanning vertical camera array(Invited Paper)

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Chinese Optics Letters 2014年第6期12卷 80-85页

作者： Masahiro Yamaguchi Koki Wakunami mamoru Inaniwa Global Scientific Information and Computing Center Tokyo Institute of Technology2-12-1-I7-6Ookayama Meguro-ku Tokyo 152-8550 Japan

Full-parallax light-field is captured by a small-scale 3D image scanning system and applied to holographic display. A vertical camera array is scanned horizontally to capture full-parallax imagery, and the vertical views between cameras are interpolated by depth image-based rendering technique. An improved technique for depth estimation reduces the estimation error and high-density light-field is obtained. The captured data is employed for the calculation of computer hologram using ray-sampling plane. This technique enables high-resolution display even in deep 3D scene although a hologram is calculated from ray information, and thus it makes use of the important advantage of holographic 3D display.

关键词： Computer generated hologram from full-parallax 3D image data captured by scanning vertical camera array data

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Airglow observation by Fabry-Perot Interferometer

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Wuhan University Journal of Natural Sciences 1998年第2期3卷 175-180页

作者： Ai Yong mamoru Ishii Minoru Kubota Shoichi Okano Zhang Xunjie Lu Shu College of Electronic Information Wuhan University Wuhan China Communications Research Laboratory Tokyo Japan National Institute of Polar Research Tokyo Japan Wuhan Institute of Physics and Mathematics the Chinese Academy of Science Wuhan China

An all-sky and a scanning Fabry-Perot interferometers (FPI) have been developed for observations of vertical winds and two-dimensional atmospheric motions in the low-thermosphere and the mesosphere region by the measurement of Doppler shift and broadening of airglow emission lines. The system of FPI is described and the method of data analysis is proposed, an example of observation is also given.

关键词： airglow imterferometer observation mesosphere

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Verrucous antral gastritis in relation to Helicobacter pylori infection,nutrition,and gastric atrophy

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Gastroenterology Report 2020年第4期8卷 293-298,I0002页

作者： Naoko Tsuji Yasuko Umehara mamoru Takenaka Yasunori Minami Tomohiro Watanabe Naoshi Nishida Masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of MedicineOsaka-SayamaJapan

Background:There have been few studies in the English literature regarding verrucous gastritis(VG).The present study investigated the clinical and endoscopic features of verrucous antral gastritis,especially focusing on Helicobacter pylori infection,nutrition,and gastric ***:We performed a retrospective study of patients who underwent routine endoscopy with indigo carmine chromoendoscopy and a comparative study was conducted between VG-positive and VG-negative *** was subdivided into classical and numerous types based on the number and distribution of verrucous ***,clinical,and endoscopic data including body mass index(BMI),serum albumin and cholesterol,gastric atrophy,reflux oesophagitis,Barrett’s oesophagus,and *** status were *** and multivariable analyses were performed to identify factors associated with ***:We analysed the data of 621 patients undergoing routine endoscopy and found that VG(n=352)was significantly associated with increased BMI(1.12[1.05-1.18],P<0.01),reflux esophagitis(1.96[1.10-3.28],P<0.01),and *** negativity with or without a history of eradication(9.94[6.00-16.47]and 6.12[3.51-10.68],P<0.001,respectively).Numerous-type(n=163)VG was associated with both closed-and open-type gastric atrophy(9.9[4.04-21.37]and 8.10[3.41-19.24],P<0.001,respectively).There were no statistical differences between groups regarding age,sex,total cholesterol,albumin,and bile-colored gastric ***:Verrucous antral gastritis was related to increased BMI,reflux esophagitis,and *** ***-type verrucous lesions were associated with gastric *** indicate that VG may be a physiological phenomenon due to high gastric acidity,mechanical overload,and vulnerability of background mucosa.

关键词： verrucous gastritis chromoendoscopy BMI Helicobacter pylori eradication gastric atrophy

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基于逆康普顿光束的核光科学(英文)

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复旦学报（自然科学版） 2007年第1期46卷 41-49页

作者： mamoru Fujiwara Research Center for Nuclear Physics Osaka University Mihogaoka 10-1 IbarakiOsaka 567-0047 Japan

Recent developments of the synchroton radiation facilities and intense lasers are now guiding us to a new research frontier with probes of a high energy GeV photon beam and an intense and short pulse MeV γ-ray *** discuss new directions of the science developments with photo-nuclear reactions with the inverse Compton γ-rays for studying hadron structure, nuclear structure, astrophysics, materials science, as well as for nuclear technologies.

关键词：核光科学激光逆康普顿散射核反应

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Non-transmissible Sendai virus vector encoding c-myc suppressor FBP-interacting repressor for cancer therapy

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World Journal of Gastroenterology 2014年第15期20卷 4316-4328页

作者： Kazuyuki Matsushita Hideaki Shimada Yasuji Ueda Makoto Inoue mamoru Hasegawa Takeshi Tomonaga Hisahiro Matsubara Fumio Nomura Department of Molecular Diagnosis Graduate School of MedicineChiba UniversityChiba 260-8670Japan Department of Surgery School of MedicineToho UniversityTokyo 143-8541Japan DNAVEC Corporation 6 OhkuboTsukuba CityIbaraki 300-2611Japan Proteome Research Center Proteome Research ProjectNational Institute of Biomedical InnovationOsaka 567-0085Japan Department of Frontier Surgery Chiba UniversityGraduate School of MedicineChiba 260-8670Japan

AIM: To investigate a novel therapeutic strategy to target and suppress c-myc in human cancers using far up stream element (FUSE)-binding protein-interacting repressor (FIR).

关键词： Cancer gene therapy c-myc suppressor Far up stream element-binding protein-interacting repressor Sendai virus vector

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