检索结果-南通市图书馆

natural polymer-based bilayer adhesive skin substitute for infected burned wound healing

Bioactive Materials 2023年第11期 177-195页

作者： Mina Shahriari-Khalaji mamoona sattar Ran Cao Meifang Zhu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China Research Group of Microbiological Engineering and Medical Materials College of Biological Science and Medical EngineeringDonghua UniversityShanghai201620China Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine Donghua UniversityShanghai201620China

Thermal wounds are complex and lethal with irregular shapes, risk of infection, slow healing, and large surface area. The mortality rate in patients with infected burns is twice that of non-infected burns. Developing multifunctional skin substitutes to augment the healing rate of infected burns is vital. Herein, we 3D printed a hydrogel scaffold comprising carboxymethyl chitosan (CMCs) and oxidized alginate grafted catechol (O-AlgCat) on a hydrophobic electrospun layer, forming a bilayer skin substitute (BSS). The functional layer (FL) was fabricated by physiochemical crosslinking to ensure favorable biodegradability. The gallium-containing hydrophobic electrospun layer or backing layer (BL) could mimic the epidermis of skin, avoiding fluid penetration and offering antibacterial activity. 3D printed FL contains catechol, gallium, and biologically active platelet rich fibrin (PRF) to adhere to both tissue and BL, show antibacterial activity, encourage angiogenesis, cell growth, and migration. The fabricated bioactive BSS exhibited noticeable adhesive properties (P ≤ 0.05), significant antibacterial activity (P ≤ 0.05), faster clot formation, and the potential to promote proliferation (P ≤ 0.05) and migration (P ≤ 0.05) of L929 cells. Furthermore, the angiogenesis was significantly higher (P ≤ 0.05) when evaluated in vivo and in ovo. The BSS-covered wounds healed faster due to low inflammation and high collagen density. Based on the obtained results, the fabricated bioactive BSS could be an effective treatment for infected burn wounds.

关键词： Infected burn wound Bioactive skin substitute Double cross-linked Anti-inflammation Tissue adhesion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Assessment of biosafety implementation in clinical diagnostic laboratories in Pakistan during the COVID-19 pandemic

引用

Journal of Biosafety and Biosecurity 2022年第1期4卷 43-49页

作者： Samreen Sarwar Faheem Shahzad Ayesha Vajeeha Rimsha Munir Amina Yaqoob Aniqa Naeem mamoona sattar Sheereen Gull Health Security Partners LahorePunjabPakistan Department of Immunology University of Health Sciences LahorePunjabPakistan Centre for Applied Molecular Biology University of the PunjabLahorePunjabPakistan Cancer Biology Lab Institute of Microbiology and Molecular GeneticsUniversity of the Punjaband Molecular GeneticistHormone LabLahorePunjabPakistan Center of Excellence in Molecular Biology University of the PunjabLahorePakistan Food and Meal Science Kristianstad UniversityKristianstadSweden Microbiological Engineering and Industrial Biotechnology Group College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghaiChina School of Biological Sciences University of the PunjabLahorePakistan

Laboratory diagnostic capacity is crucial for an optimal national response to a public health emergency such as the COVID-19 *** laboratory-acquired infections and the loss of critical human resources,especially during a public health emergency,requires laboratories to have a good biorisk management system in *** this study,we aimed to evaluate laboratory biosafety and biosecurity in Pakistan during the COVID-19 *** this cross-sectional study,a self-rated anonymous questionnaire was distributed to laboratory professionals(LPs)working in clinical diagnostic laboratories,including laboratories performing polymerase chain reaction(PCR)-based COVID-19 diagnostic testing in Punjab,Sindh,Khyber Pakhtunkhwa,and Gilgit-Baltistan provinces as well as Islamabad during March 2020 to April *** questionnaire assessed knowledge and perceptions of LPs,resource availability,and commitment by top management in these *** total,58.6%of LPs performing COVID-19 testing reported that their laboratory did not conduct a biorisk assessment before starting COVID-19 testing in their *** 31%of LPs were aware that COVID-19 testing could be performed at a biosafety level 2 laboratory,as per the World Health Organization interim biosafety guidelines.A sufficiently high percentage of LPs did not feel confident in their ability to handle COVID-19 samples(32.8%),spills(43.1%),or other accidents(32.8%).These findings demonstrate the need for effective biosafety program implementation,proper training,and establishing competency assessment *** findings also suggested that identifying and addressing gaps in existing biorisk management systems through sustainable interventions and preparing LPs for surge capacity is crucial to better address public health emergencies.

关键词： Biosafety Laboratory professionals COVID-19 pandemic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：