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Enhancement of pre-pulse and picosecond pedestal contrast of the petawatt J-KAREN-P laser

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High Power Laser Science and Engineering 2021年第4期9卷 192-199页

作者： Hiromitsu Kiriyama Yasuhiro Miyasaka Akira Kon mamiko nishiuchi Akito Sagisaka Hajime Sasao Alexander S.Pirozhkov Yuji Fukuda Koichi Ogura Kotaro Kondo Nicholas P.Dover Masaki Kando Kansai Photon Science Institute National Institutes for Quantum Science and Technology(QST)Kizugawa 619-0215Japan Naka Fusion Institute National Institutes for Quantum Science and Technology(QST)Naka 311-0193Japan

We have experimentally improved the temporal contrast of the petawatt J-KAREN-P laser *** have investigated how the generation of pre-pulses by post-pulses changes due to the temporal overlap between the stretched pulse and the post-pulse in a chirped-pulse amplification *** have shown that the time at which the pre-pulse is generated by the post-pulse and its shape are related to the time difference between the stretched main pulse and the *** this investigation,we have found and identified the origins of the pre-pulses and have demonstrated the removal of most pre-pulses by eliminating the post-pulse with wedged *** have also demonstrated the impact of stretcher optics on the picosecond *** have realized orders of magnitude enhancement of the pedestal by improving the optical quality of a key component in the stretcher.

关键词： chirped-pulse amplification temporal contrast ultra-high-intensity lasers

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Induction heating for desorption of surface contamination for high-repetition laser-driven carbon-ion acceleration

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Matter and Radiation at Extremes 2023年第5期8卷 19-25页

作者： Sadaoki Kojima Tatsuhiko Miyatake Hironao Sakaki Hiroyoshi Kuroki Yusuke Shimizu Hisanori Harada Norihiro Inoue Thanh Hung Dinh Masayasu Hata Noboru Hasegawa Michiaki Mori Masahiko Ishino mamiko nishiuchi Kotaro Kondo Masaharu Nishikino Masaki Kando Toshiyuki Shirai Kiminori Kondo Kansai Institute for Photon Science National Institutes for Quantum Science and Technology(QST)8-1-7 UmemidaiKizugawaKyoto 619-0215Japan Interdisciplinary Graduate School of Engineering Sciences Kyushu University6-1Kasuga-KoenKasugaFukuoka 816-8580Japan Hitachi Zosen Corporation 7-89 Nanko-Kita 1-chomeSuminoe-kuOsaka 559-8559Japan Department of Accelerator and Medical Physics Institute for Radiological ScienceNational Institutes for Quantum Science and Technology(QST)4-9-1 AnagawaInage-kuChiba 263-8555Japan

This study reports the first experimental demonstration of surface contamination cleaning from a high-repetition supply of thin-tape targets for laser-driven carbon-ion *** adsorption of contaminants containing protons,mainly water vapor and hydrocarbons,on the surface of materials exposed to low vacuum(>10^(−3)Pa)suppresses carbon-ion *** newly developed contamination cleaner heats a 5-μm-thick nickel tape to over 400℃in 100 ms by induction *** the future,this heating method could be scaled to laserdriven carbon-ion acceleration at rates beyond 10 *** contaminant hydrogen is eliminated from the heated nickel surface,and a carbon source layer—derived from the contaminant carbon—is spontaneously formed by the catalytic effect of *** species of ions accelerated from the nickel film heated to various temperatures have been observed *** the nickel film is heated beyond∼150℃,the proton signal considerably decreases,with a remarkable increase in the number and energy of carbon *** Langmuir adsorption model adequately explains the temperature dependence of desorption and re-adsorption of the adsorbed molecules on a heated target surface,and the temperature required for proton-free carbon-ion acceleration can be estimated.

关键词： acceleration heated nickel

High-intensity laser-driven particle and electromagnetic wave sources for science, industry, and medicine

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Frontiers of Optoelectronics 2009年第3期2卷 299-303页

作者： Akito SAGISAKA Hiroyuki DAIDO Alexander S.PIROZHKOV Michiaki MORI Akifumi YOGO Koichi OGURA Satoshi ORIMO mamiko nishiuchi Jinglong MA Hiromitsu KIRIYAMA Shuhei KANAZAWA Shuji KONDO Yoshiki NAKAI Takuya SHIMOMURA Manabu TANOUE Atsushi AKUTSU Hajime OKADA Tomohiro MOTOMURA Tetsuya KAWACHI Sergei V.BULANOV Timur Zh.ESIRKEPOV Shigeki NASHIMA Makoto HOSODA Hideo NAGATOMO Yuji OISHI Koshichi NEMOTO Il Woo CHOI Seong Ku LEE Jongmin LEE Advanced Photon Research Center and Photo-Medical Research Center Japan Atomic Energy Agency A.M.Prokhorov Institute of General Physics Russian Academy of Sciences Moscow Institute of Physics and Technology Department of Applied Physics Graduate School and Faculty of Engineering Osaka City University Institute of Laser Engineering Osaka University Central Research Institute of Electric Power Industry Advanced Photonics Research Institute Gwangju Institute of Science and Technology

We simultaneously observed both the fast proton generation and terahertz(THz) radiation in the laser pulse interaction with a thin-foil target. The maximum proton energy of ～2.3 Me V and an intense THz radiation were observed at the pulse duration of～30 fs. We also measured the proton beam and UV harmonics from a thin-foil target by changing the laser pulse duration. In the case of the ～500 fs, peaks of UV harmonics up to fourth order appeared. This unique combination of the multiple beams will provide useful applications such as pump-probe experiments.

关键词： high-intensity laser thin-foil target plasma proton electromagnetic wave

Enhanced ion acceleration from transparency-driven foils demonstrated at two ultraintense laser facilities

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Light(Science & Applications) 2023年第4期12卷 593-604页

作者： Nicholas P.Dover Tim Ziegler Stefan Assenbaum Constantin Bernert Stefan Bock Florian-Emanuel Brack Thomas E.Cowan Emma J.Ditter Marco Garten Lennart Gaus Ilja Goethel George S.Hicks Hiromitsu Kiriyama Thomas Kluge James K.Koga Akira Kon Kotaro Kondo Stephan Kraft Florian Kroll Hazel F.Lowe Josefine Metzkes-Ng Tatsuhiko Miyatake Zulfikar Najmudin Thomas Püschel Martin Rehwald Marvin Reimold Hironao Sakaki Hans-Peter Schlenvoigt Keiichiro Shiokawa Marvin E.P.Umlandt Ulrich Schramm Karl Zeil mamiko nishiuchi Kansai Photon Science Institute National Institutes for Quantum Science and Technology8-1-7 UmemidaiKizugawaKyoto 619-0215Japan The John Adams Institute for Accelerator Science Blackett LaboratoryImperial College LondonLondon SW72AZUnited Kingdom Helmholtz-Zentrum Dresden-Rossendorf 01328 DresdenGermany Technische Universitat Dresden 01069 DresdenGermany Interdiscipllinary Graduate School of Engineering Sciences Kyushu University6-1Kasuga-KoenKasugaFukuoka 816-8580Japan

Laser-driven ion sources are a rapidly developing technology producing high energy,high peak current *** suitability for applications,such as compact medical accelerators,motivates development of robust acceleration schemes using widely available repetitive ultraintense femtosecond *** applications not only require high beam energy,but also place demanding requirements on the source stability and *** can be seriously affected by the laser temporal contrast,precluding the replication of ion acceleration performance on independent laser systems with otherwise similar ***,we present the experimental generation of>60 MeV protons and>30 MeV u-1 carbon ions from sub-micrometre thickness Formvar foils irradiated with laser intensities>1021 *** are accelerated by an extreme localised space charge field≥30TVm-1,over a million times higher than used in conventional *** field is formed by a rapid expulsion of electrons from the target bulk due to relativistically induced transparency,in which relativistic corrections to the refractive index enables laser transmission through normally opaque *** replicate the mechanism on two different laser facilities and show that the optimum target thickness decreases with improved laser contrast due to reduced *** demonstration that energetic ions can be accelerated by this mechanism at different contrast levels relaxes laser requirements and indicates interaction parameters for realising application-specific beam delivery.

关键词： acceleration intense transparency

Optical nature of non-substituted triphenylmethyl cation:Crystalline state emission,thermochromism,and phosphorescence

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Aggregate

Aggregate 2021年第6期2卷 99-108页

作者： Tomohiko nishiuchi Hikaru Sotome Risa Fukuuchi Kenji Kamada Hiroshi Miyasaka Takashi Kubo Department of Chemistry Graduate School of ScienceOsaka UniversityToyonakaOsakaJapan Innovative Catalysis Science Division Institute for Open and Transdisciplinary Research Initiatives(ICS-OTRI)Osaka UniversitySuitaOsakaJapan Division of Frontier Materials Science and Center for Advanced Interdisciplinary Research Graduate School of Engineering ScienceOsaka UniversityToyonakaOsakaJapan Nanomaterial Research Institute(NMRI) National Institute of Advanced Industrial Science and Technology(AIST)IkedaOsakaJapan Department of Chemistry Graduate School of Science and TechnologyKwansei Gakuin UniversitySandaHyogoJapan

Since the discovery of the triphenylmethyl(trityl)cation 120 years ago,a variety of aromatic cations having various colors and luminescence properties have been rigorously ***,differently substituted trityl cations have been synthesized,and their optical properties have been ***,the optical properties of the parent,non-substituted and highly reactive trityl cation,which was observed to be very weakly luminescent,have not been subjected to detailed *** the effort described herein,we explored the optical nature of non-substituted trityl hexafluorophosphate(PF_(6))in the crystalline *** PF_(6) was found to exist as two crystal polymorphs including a yellow(Y)and an orange(O)***,we observed that these crystalline forms display crystalline-state emission with different *** results of X-ray crystallographic analysis showed that the two polymorphs have totally different molecular packing ***,an investigation of their optical properties revealed that the O-crystal undergoes a distinct color change to yellow upon cooling as a consequence of a change in the nature of the charge transfer interaction between the cation and PF6 anion,and that both the Y-and O-crystal exhibit phosphorescence.

关键词： aggregation induced emission carbocation phosphorescence crystal phase transition thermochromism

Short Hydration in Chemotherapy with Cisplatin plus S-1 for Advanced or Recurrent Gastric Cancer: A Retrospective Study

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Journal of Cancer Therapy 2015年第15期6卷 1254-1261页

作者： Akihito Tsuji Yuji Negoro Yoshihiro Okita Masahito Kotaka Takamasa nishiuchi Takeshi Kotake Hironaga Satake Yukimasa Hatachi Department of Medical Oncology Kobe City Medical Center General Hospital Hyogo Japan Department of Clinical Oncology Faculty of Medicine Kagawa University Kagawa Japan Department of Medical Oncology Kochi Health Sciences Center Kochi Japan Gastrointestinal Cancer Center Sano Hospital Hyogo Japan

Background: Despite there are a few reports that assessed the S-1 + CDDP regimen with short hydration regimen for unresectable or metastatic gastric cancer, there is no consensus on the best regimen for short hydration. The aim of study was to evaluate the safety and the efficacy of S-1 plus cisplatin doublet chemotherapy with short hydration. Methods: S-1 was administered orally (p.o.) twice daily for the first 3 weeks of a 5-week cycle. Dose of S-1 administered was calculated according to the body surface area. CDDP was given as an intravenous (i.v.) infusion of 60 mg/m2 on day 8 of each cycle. Patients received the total of 1900 ml infusion containing 1000 ml of acetate Ringer’s solution as pre- and post-hydraion. 300 ml of 20% mannitol was administered as a diuretic. Results: 35 patients with unresectable or recurrent gastric cancer were enrolled. The reasons for termination of S-1 + CDDP were as follows: 21 (63.6%) by progressive disease;12 (31.4%) by toxicity. Even though 12 of 35 patients (34.2%) were discontinued S-1 + CDDP chemotherapy, only one patient was discontinued by Grade 2 of increased creatinine. TTF (time to progression) was 174 days (3 - 586 days), and the median of the total number of treatment cycles of S-1 + CDDP was 3.31. Median overall survival, as secondary endpoint, was 518 days. Conclusions: Our study suggested that the short hydration regimen is as safe and efficient as the continuous hydration regimen.

关键词： Short Hydration Cisplatin Plus S-1 Gastric Cancer

<i>Cordyceps sinensis</i>Acts As an Adenosine A<sub>3</sub>Receptor Agonist on Mouse Melanoma and Lung Carcinoma Cells, and Human Fibrosarcoma and Colon Carcinoma Cells

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Pharmacology & Pharmacy 2011年第4期2卷 266-270页

作者： Noriko Yoshikawa Arisa nishiuchi Erika Kubo Yu Yamaguchi Masaru Kunitomo Satomi Kagota Kazumasa Shinozuka Kazuki Nakamura 不详

Cordyceps sinensis, a parasitic fungus on the larva of Lapidoptera, has been used as a traditional Chinese medicine. We previously reported that the growth of B16-BL6 mouse melanoma (B16-BL6) cells and mouse Lewis lung carcinoma (LLC) cells was inhibited by cordycepin (3’-deoxyadenosine), an ingredient of Cordyceps sinensis, and its effect was antagonized by MRS1191, a selective adenosine A3 receptor (A3-R) antagonist although adenosine (up to 100 μM) had no effect on the growth of B16-BL6 and LLC cells. In this study, we investigated whether water extracts of Cordyceps sinensis (WECS) inhibit the growth of B16-BL6 cells, LLC cells, HT1080 human fibrosarcoma (HT1080) cells and CW-2 human colon carcinoma (CW-2) cells via their A3-R. As a result, the growth of all cell lines were potently inhibited by WECS (10 μg/mL) and the inhibitory effect of WECS was significantly antagonized by MRS1191 (1 μM). Furthermore, WECS included 2.34% w/w cordycepin and 0.12% w/w adenosine as components according to the HPLC- ECD system. In conclusion, WECS inhibited the proliferation of four cancer cell lines by stimulation of A3-R and the main component in WECS with anticancer action might be cordycepin instead of adenosine.

关键词： Cordyceps Sinensis Adenosine A3 Receptor Cordycepin HPLC-ECD

Short Hydration in Chemotherapy with Cisplatin plus S-1 for Advanced or Recurrent Gastric Cancer: A Retrospective Study

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拟南芥硫氧还蛋白M1型基因(AtTRX m1)与环境逆境之间的关系

Journal of Cancer Therapy（癌症治疗） 2015年第15期

作者： Akihito Tsuji Yuji Negoro Yoshihiro Okita Masahito Kotaka Takamasa nishiuchi Takeshi Kotake Hironaga Satake Yukimasa Hatachi

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分子植物育种 2007年第1期5卷 21-26页

作者：夏德习管清杰金淑梅李宇佳梁涵张欣欣西内俊策高野哲夫柳参奎东北林业大学盐碱地生物资源环境研究中心抗性分子生物学实验室哈尔滨150040 东京大学亚洲生物资源环境研究中心

硫氧还蛋白家族是约12 kD的小分子蛋白质,含有高度保守的活性反应位点WCG/PPC,催化硫醇—二硫键相互交换,调节细胞内的氧化还原作用。在本研究中,通过RT-PCR法获得目的基因拟南芥硫氧还蛋白M1型基因 (AtTRX m1, GenBank Accession No. A... 详细信息

硫氧还蛋白家族是约12 kD的小分子蛋白质,含有高度保守的活性反应位点WCG/PPC,催化硫醇—二硫键相互交换,调节细胞内的氧化还原作用。在本研究中,通过RT-PCR法获得目的基因拟南芥硫氧还蛋白M1型基因 (AtTRX m1, GenBank Accession No. At1g03680)。通过Northern杂交分析拟南芥悬浮细胞系在 100 mmol/L NaCl、10mmol/L NaHCO3、50μmol/L ABA、10mmol/L H2O2 等逆境处理下mRNA表达水平的变化和硫氧还蛋白 M1 型转基因植株对NaCl、NaHCO3盐及ABA逆境的抗性分析,表明硫氧还蛋白M1型基因与生物环境胁迫有一定的相关性,尤其是氧化胁迫,能够增强植物对逆境的耐受力。从而为进一步研究硫氧还蛋白基因家族与逆境之间的相关作用奠定了基础。

关键词：拟南芥(哥伦比亚型) 硫氧还蛋白M1型基因非生物逆境转基因 Northern杂交

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