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CD9 role in proliferation, rejuvenation, and therapeutic applications

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Genes & Diseases 2024年第3期11卷 95-97页

作者： sai Priyanka Kodam Neda Baghban Mujib Ullah Institutefor Immunityand Transplantation Stem Cell Biology and Regenerative MedicineSchool of MedicineMolecular Medicine Department of MedicineStanford UniversityPaloAltoCA94304USA

The CD9 gene,also known as the Tspan29 gene,codes for a protein called CD9,which is a member of the tetraspanin family of transmembrane proteins.^(1) The CD9 protein is involved in various cellular processes,including cell proliferation,differentiation,adhesion,and migration.^(1,2) CD9 has also been found to play a role in the regulation of stem cell proliferation and differentiation.

关键词： migration. therapeutic CD9

Hepatocellular carcinoma immune microenvironment and check point inhibitors-current status

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World Journal of Hepatology 2024年第3期16卷 353-365页

作者： Tarana Gupta Nikhil sai Jarpula Division of Hepatology Department of MedicinePandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia

Hepatocellular carcinoma(HCC)is the most common primary tumor of the liver and has a high mortality rate.The Barcelona Clinic Liver Cancer staging system in addition to tumor staging also links the modality of treatment available to a particular stage.The recent description of the tumor microenvironment(TME)in HCC has provided a new concept of immunogenicity within the HCC.Virusrelated HCC has been shown to be more immunogenic with higher expression of cytotoxic T lymphocytes and decreased elements for immunosuppression such as regulatory T cells.This immunogenic milieu provides a better response to immunotherapy especially immune checkpoint inhibitors(ICIs).In addition,the recent data on combining locoregional therapies and other strategies may convert the less immunogenic state of the TME towards higher immunogenicity.Therefore,data are emerging on the use of combinations of locoregional therapy and ICIs in unresectable or advanced HCC and has shown better survival outcomes in this difficult population.

关键词： Hepatocellular carcinoma Tumor immune microenvironment Immune checkpoint inhibitor Atezolizumab Bevacizumab Pembrolizumab

Circulating RNA ZFR promotes hepatocellular carcinoma cell proliferation and epithelial-mesenchymal transition process through miR-624-3p/WEE1 axis

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 52-63页

作者： Li Zhang sai He Hao Guan Yao Zhao Di Zhang Department of General Surgery the Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004China Department of Breast Cancer Shaanxi Provincial Cancer HospitalXi’an 710000China

Background:Hepatocellular carcinoma(HCC),the most common type of primary liver cancer,is the fourth leading cause of cancer-related deaths worldwide.Previous evidence shows that the expression of circulating RNA ZFR(circZFR)is upregulated in HCC tissues.However,the molecular mechanism of circZFR in HCC is unclear.Methods:Quantitative reverse transcriptase polymerase chain reaction(qRT-PCR)was employed to detect the expression of circZFR,microRNA-624-3p(miR-624-3p)and WEE1 in HCC tissues and cells.RNase R assay and actinomycin D treatment assay were used to analyze the characteristics of circZFR.For functional analysis,the capacities of colony formation,cell proliferation,cell apoptosis,migration and invasion were assessed by colony formation assay,5-ethynyl-2-deoxyuridine(EdU)assay,flow cytometry assay and transwell assay.Western blot was used to examine the protein levels of WEE1 and epithelial-mesenchymal transition(EMT)-related proteins.The interactions between miR-624-3p and circZFR or WEE1 were validated by dual-luciferase reporter assay and RNA immunoprecipitation(RIP)assay.Xenograft models were established to determine the role of circZFR in vivo.Results:circZFR and WEE1 were upregulated,while miR-624-3p expression was reduced in HCC tissues and cells.circZFR could sponge miR-624-3p,and WEE1 was a downstream gene of miR-624-3p.Knockdown of circZFR significantly reduced the malignant behaviors of HCC and that co-transfection with miR624-3p inhibitor restored this change.Overexpression of WEE1 abolished the inhibitory effect of miR624-3p mimic on HCC cells.Mechanistically,circZFR acted as a competitive endogenous RNA(ceRNA)to regulate WEE1 expression by targeting miR-624-3p.Furthermore,in vivo studies have illustrated that circZFR knockdown inhibited tumor growth.Conclusions:circZFR knockdown reduced HCC cell proliferation,migration and invasion and promoted apoptosis by regulating the miR-624-3p/WEE1 axis,suggesting that the circZFR/miR-624-3p/WEE1 axis might be a potential target for HCC treatment.

关键词： Hepatocellular carcinoma circZFR miR-624-3p WEE1 Liver cancer

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Aryl hydrocarbon receptor:Linking environment to aging process in elderly patients with asthma

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Chinese Medical Journal 2024年第4期137卷 382-393页

作者： Tianrui Yang Rongjun Wan Wei Tu sai Nithin Avvaru Peisong Gao Division of Allergy and Clinical Immunology Department of MedicineJohns Hopkins University School of MedicineBaltimoreMD 21224USA Department of Geriatric Medicine The First People’s Hospital of Yunnan ProvinceKunmingYunnan 650032China Department of Respiratory Medicine Xiangya HospitalCentral South UniversityChangshaHunan 410008China The State Key Laboratory of Respiratory Disease for Allergy Shenzhen Key Laboratory of Allergy and ImmunologyShenzhen University School of MedicineShenzhenGuangdong 518055China

Aging is a significant risk factor for various diseases,including asthma,and it often leads to poorer clinical outcomes,particularly in elderly individuals.It is recognized that age-related diseases are due to a time-dependent accumulation of cellular damage,resulting in a progressive decline in cellular and physiological functions and an increased susceptibility to chronic diseases.The effects of aging affect not only the elderly but also those of younger ages,posing significant challenges to global healthcare.Thus,understanding the molecular mechanisms associated with aging in different diseases is essential.One intriguing factor is the aryl hydrocarbon receptor(AhR),which serves as a cytoplasmic receptor and ligand-activated transcription factor and has been linked to the aging process.Here,we review the literature on several major hallmarks of aging,including mitochondrial dysfunction,cellular senescence,autophagy,mitophagy,epigenetic alterations,and microbiome disturbances.Moreover,we provide an overview of the impact of AhR on these hallmarks by mediating responses to environmental exposures,particularly in relation to the immune system.Furthermore,we explore how aging hallmarks affect clinical characteristics,inflammatory features,exacerbations,and the treatment of asthma.It is suggested that AhR signaling may potentially play a role in regulating asthma phenotypes in elderly populations as part of the aging process.

关键词： Aging Environment Reactive oxygen species Senescence Aryl hydrocarbon receptor Asthma

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High Dynamic Bounding and Jumping Motion of Quadruped Robot Based on Stable Optimization Control

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Journal of Bionic Engineering 2024年第1期21卷 101-111页

作者： sai Gu Fei Meng Botao Liu Junyao Gao Qiang Huang School of Mechatronical Engineering Beijing Institute of Technology100081 BeijingChina Key Laboratory of Biomimetic Robots and Systems Ministry of EducationBeijing 100081China

Aiming at the environment such as ravines and obstacles that may be encountered in the actual movement,this paper proposes a method for optimizing the bounding and jumping motion based on the ground touching force trajectory and the air motion trajectory of the quadruped robot.The method of optimizing the ground reaction force according to the speed of the demand and the height of the jump,and adjusting the stance and swing time according to the relationship of dynamics and momentum conservation.At the same time,under the constraints of dynamics and energy consumption of the robot system,considering the jumping distance and height,a method for optimizing the air trajectory of bounding and jumping is proposed.State switching and landing stability control are also added.Finally,the experimental results show that the quadruped robot has strong bounding and jumping ability,and has achieved stable bounding movement and forward jump movement of 0.8 m.

关键词： Quadruped robot High dynamic motion control-Periodic limit cycle Trajectory optimization

A Task Scheduling Algorithm Based on Clustering Pre-processing in Space-Based Information Network

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Chinese Journal of Electronics 2024年第1期33卷 217-230页

作者： Yufei WANG Jun LIU Shengnan ZHANG sai XU Jingyi WANG School of Computer Science and Engineering Northeastern University

With the diversification of space-based information network task requirements and the dramatic increase in demand, the efficient scheduling of various tasks in space-based information network becomes a new challenge. To address the problems of a limited number of resources and resource heterogeneity in the space-based information network, we propose a bilateral pre-processing model for tasks and resources in the scheduling pre-processing stage. We use an improved fuzzy clustering method to cluster tasks and resources and design coding rules and matching methods to match similar categories to improve the clustering effect. We propose a space-based information network task scheduling strategy based on an ant colony simulated annealing algorithm for the problems of high latency of space-based information network communication and high resource dynamics. The strategy can efficiently complete the task and resource matching and improve the task scheduling performance. The experimental results show that our proposed task scheduling strategy has less task execution time and higher resource utilization than other algorithms under the same experimental conditions. It has significantly improved scheduling performance.

关键词： Space-based information network Task scheduling Resource clustering Ant colony optimization Simulated annealing

Robust Correlation Clustering Problem with Locally Bounded Disagreements

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Tsinghua Science and Technology 2024年第1期29卷 66-75页

作者： sai Ji Min Li Mei Liang Zhenning Zhang Institute of Mathematics Hebei University of TechnologyTianjin 300401China School of Mathematics and Statistics Shandong Normal UniversityJinan 250358China College of Statistics and Data Science Beijing University of TechnologyBeijing 100124China Department of Operations Research and Information Engineering Beijing University of TechnologyBeijing 100124China

Min-max disagreements are an important generalization of the correlation clustering problem(CorCP).It can be defined as follows.Given a marked complete graph G=(V,E),each edge in the graph is marked by a positive label"+"or a negative label"_"based on the similarity of the connected vertices.The goal is to find a clustering C of vertices V,so as to minimize the number of disagreements at the vertex with the most disagreements.Here,the disagreements are the positive cut edges and the negative non-cut edges produced by clustering C.This paper considers two robust min-max disagreements:min-max disagreements with outliers and min-max disagreements with penalties.Given parameter δ∈(0,1/14),we first provide a threshold-based iterative clustering algorithm based on LP-rounding technique,which is a(1/δ,7/(1-14δ))-bi-criteria approximation algorithm for both the min-max disagreements with outliers and the min-max disagreements with outliers on one-sided complete bipartite graphs.Next,we verify that the above algorithm can achieve an approximation ratio of 21 for min-max disagreements with penalties when we set parameter δ=1/21.

关键词： min-max disagreements outliers penalties approximation algorithm LP-rounding

Improved photocatalytic performance of acetaldehyde degradation via crystal plane regulation on truncated octahedral CeO2

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Rare Metals 2024年第5期43卷 2026-2038页

作者： Bin Xu Lu Jia Hui Yang Yue Wang Si-Yu Fan sai-sai Yuan Qi-Tao Zhang Ming Zhang Teruhisa Ohno School of Chemistry and Chemical Engineering Yangzhou University College of Environmental Science and Engineering Yangzhou University Department of Applied Chemistry Faculty of EngineeringKyushu Institute of Technology School of Environmental and Chemical Engineering Jiangsu University of Science and Technology National & Local Joint Engineering Research Center for Mineral Salt Deep Utilization Huaiyin Institute of Technology School of Materials Science and Engineering Henan University of Science and Technology International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale Optoelectronics Shenzhen University

In this study,the truncated octahedral Ce O2（Ce O2-to） with special morphology was prepared by the solvothermal method with oleic acid （OA） and oleamine（OM） as the morphology-directing agents.High-resolution transmission electron microscopy （HRTEM） results show that Ce O2-to exposes composite{100}and{111}facets,while Ce O2cubic （Ce O2-c） and Ce O2octahedral （Ce O2-o）only expose single crystal facets of{100}plane and{111}plane,respectively.Interestingly,this Ce O2-to photocatalyst exhibits remarkable photooxidation performance of gaseous acetaldehyde （CH3CHO） degradation,in which CO2generation value reaches 1.78 and 7.97-times greater than that of Ce O2-c and Ce O2-o,respectively.In addition,the active species trapping experiment signifies that superoxide （·O2-） and holes （h+） are the main reactive substances during the CH3CHO degradation process,and the electron paramagnetic resonance （EPR） spectra indicates that the former is the major contributor.Notably,the electron transfer mechanism between Ce O2-to{100}and{111}facets and the surface oxygen adsorption ability are revealed via density functional theory （DFT） calculations.It is also confirmed that{100}facets are more conducive to the absorption of acetaldehyde than{111}facets.Finally,a reasonable mechanism for improved photocatalytic CH3CHO degradation on Ce O2-to is proposed based on relevant experiments and DFT calculations.This study demonstrates that the systematic development of surface homojunction structured photocatalysts can efficiently increase the degradation activity for volatile organic compounds （VOCs）.It also offers additional direction for optimizing the photocatalytic activity of other ceriumbased photocatalysts.

关键词： Truncated octahedral CeO 2 (CeO 2 -to) Composite crystal faces Surface energy level Efficient electron transfer

Removal of intrahepatic bile duct stone could reduce the risk of cholangiocarcinoma

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World Journal of Clinical Cases 2024年第11期12卷 1881-1884页

作者： Gowthami sai Kogilathota Jagirdhar Yatinder Bains Salim Surani Department of Medicine Saint Francis Health Science CenterNewarkNJ 07107United States Department of Gastroenteroly Saint Michaels Medical CenterNewarkNJ 07102United States Department of Medicine and Pharmacology Texas A&M UniversityCollege StationTX 77843United States

Hepatolithiasis(HL)poses a significant risk for cholangiocarcinoma(CCA)development,with reported incidences ranging from 5%-13%.Risk factors include older age,smoking,hepatitis B infection,and prolonged HL duration.Chronic inflammation and mechanical stress on the biliary epithelium contribute to CCA pathogenesis.Hepatectomy reduces CCA risk by removing stones and atrophic liver segments.However,residual stones and incomplete removal increase CCA risk.Kim et al identified carbohydrate antigen 19-9,carcinoembryonic antigen,and stone laterality as CCA risk factors,reaffirming the importance of complete stone removal.Nonetheless,challenges remain in preventing CCA recurrence post-surgery.Longer-term studies are needed to elucidate CCA risk factors further.

关键词： Hepatolithiasis Cholangiocarcinoma Biliary stone Common bile duct stone Cholangitis