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Effect of Transcranial Direct Current Stimulation of Motor Cortex versus Insula Cortex on Chronic Post-Mastectomy Pain: Randomized Sham-Controlled Trial

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Open Journal of Anesthesiology 2023年第10期13卷 197-211页

作者： Shereen mamdouh Kamal Khaled Mohamed Fares Sahar Abdel-Baky Mohamed Mohanad Ahmed Mohamed Fatma Adel El Sherif Anaesthesia Intensive Care and Pain Management Department South Egypt Cancer Institute Assiut University Assiut Egypt

Background: Transcranial direct current stimulation (tDCS) across cortical brain areas appears to improve various forms of pain, yet evidence of tDCS efficiency and ideal stimulation target is lacking. This study aimed to compare the add-on analgesic efficacy of concentric electrode transcranial direct current stimulation (CE-tDCS) stimulation over the primary motor cortex versus the insular cortex on the management of chronic postmastectomy pain. Method: Prospective randomized double-blind sham-controlled study enrolled eighty patients with chronic postmastectomy pain that were randomly assigned to four groups: active motor (AM), sham motor (SM), active insula (AI) and sham insula (SI) group, each received 5 sessions for 20-minute duration with 2 mA tDCS over the targeted area of the contralateral side of pain. Our primary outcome was VAS score, the secondary outcomes were VDS score, LANSS score and depression symptoms by HAM-D scores, assessment was done at 4 time points (prestimulation, after 5th session, 15th day and one month after the last session). Results: Both active tDCS groups (motor and insula) showed reduction of VAS (P Conclusion: Active tDCS stimulation either targeting the primary motor cortex or the insula cortex has add-on analgesic effect for controlling neuropathic chronic post mastectomy pain and the maximum effect was at 15 days after the last session.

关键词： Transcranial Direct Current Stimulation tDCS Postmastectomy Pain Motor Cortex Insular Cortex

A New Fast Iterative Blind Deconvolution Algorithm

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Journal of Signal and Information Processing 2012年第1期3卷 98-108页

作者： mamdouh F. Fahmy Gamal M. Abdel Raheem Usama S. Mohamed Omar F. Fahmy Department Electrical Engineering Assiut University Assiut Egypt Department of Electrical Engineering Future University Cairo Egypt

Successful blind image deconvolution algorithms require the exact estimation of the Point Spread Function size, PSF. In the absence of any priori information about the imagery system and the true image, this estimation is normally done by trial and error experimentation, until an acceptable restored image quality is obtained. This paper, presents an exact estimation of the PSF size, which yields the optimum restored image quality for both noisy and noiseless images. It is based on evaluating the detail energy of the wave packet decomposition of the blurred image. The minimum detail energies occur at the optimum PSF size. Having accurately estimated the PSF, the paper also proposes a fast double updating algorithm for improving the quality of the restored image. This is achieved by the least squares minimization of a system of linear equations that minimizes some error functions derived from the blurred image. Moreover, a technique is also proposed to improve the sharpness of the deconvolved images, by constrained maximization of some of the detail wavelet packet energies. Simulation results of several examples have verified that the proposed technique manages to yield a sharper image with higher PSNR than classical approaches.

关键词： Blind Image Deconvolution Image Enhancement

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人与环境徒手表现及技法 4

Primary Intimal Sarcoma of the Pulmonary Vein with Extension into the Left Atrium: A Case Report

2005年

作者：（美）费耶克（mamdouh Fayek）孙晶译

本书通过1500多张图解释了如何运用人物、植物以及天然装饰品等环境因素，进行室内设计、办公室设计、餐馆设计、宾馆设计、零售店设计、保健场所设计以及住宅设计等。

ISBN: (数字)7508334779

ISBN: (纸本)7508334779

关键词：建筑设计现代美国

来源：畅想之星图书光盘版（南... 评论

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Open Journal of Thoracic Surgery 2012年第2期2卷 25-28页

作者： Constantine D. Mavroudis Alfred Casillan Mark Rabbat Aileen Go Edward Melian mamdouh Bakhos Christopher H. Wigfield Department of Cardiology Stritch School of Medicine Loyola University Chicago Maywood USA Department of Oncology Stritch School of Medicine Loyola University Chicago Maywood USA Department of Radiation Oncology Stritch School of Medicine Loyola University Chicago Maywood USA Department of Thoracic and Cardiovascular Surgery Stritch School of Medicine Loyola University Chicago Maywood USA

Sarcoma originating from the pulmonary veins represents one of the rarest subtypes of sarcoma. We report the case of a 52-year-old woman presenting with cough and scant hemoptysis and ultimately diagnosed with a primary intimal sarcoma of the left inferior pulmonary vein extending into the left lower lobe of the lung. To our knowledge, this is the first reported case of such pathology in the literature. We present the case and critically appraise the literature for sarcomas of the great vessels.

关键词： Sarcoma Pulmonary Vein

Synthesis and Screening of New 5-Substituted-1,3,4-oxadiazole-2-thioglycosides as Potent Anticancer Agents

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Pharmacology & Pharmacy 2012年第2期3卷 254-261页

作者： mamdouh A .Z. Abu-Zaied Galal A. M. Nawwar Randa H. Swellem Shahinaz H. El-Sayed Chemistry Department Faculty of Science Helwan Univer- sity Cairo Egypt. Green Chemistry Department National Research Centre Cairo Egypt

A series of newly 1,3,4-oxadiazole-2-thioglycoside derivatives were synthesized. The key step of this protocol is the coupling between 5-herteroaryl-1,3,4-oxadiazole-2-thione and activated sugars (cyclic or acyclic sugar analogues) in the presence of basic medium. Among of the synthesized compounds, compounds 7, 10, 11 and 13 were screened for them in vitro anticancer activity against four human cancer cells. MCF-7 (Breast), HEPG2 (Liver), HCT116 (Colon) and HEP2 (Larynx) carcinoma cell lines with IC50 values ranging from 2.08 - 8.72 μg/well. Compounds 11 and 13 were highly specific and potent for four cell lines (MCF-7, HCT116, HEPG2 and HEP2).

关键词： 1 3 4-Oxadiazoles Thioglycosides Acyclic Sugars Antitumor

Midterm Results of Leaflet Augmentation in Mitral Valve Repairin Rheumatic Valves Experience in One Center

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World Journal of Cardiovascular Surgery 2013年第2期3卷 90-96页

作者： Abd Allah Badr Alaa Brik Abdel Maged Salem Ali Refat Khaled Mostafa Usama Badr mamdouh Sharawy El-Rady Kamal Department of Anesthesia Azhar University Hospital Asuet Egypt Department of Anesthesia Zagazig University Hospital Zagazig Egypt Department of Cardiothoracic Surgery Zagazig University Hospital Zagazig Egypt

Patients with severe mitral regurgitation (MR) should undergo surgery when they present symptoms or if asymptomatic when there is objective evidence of left ventricular dysfunction. In this work, we analyze the midterm results of leaflet augmentation in mitral valve repair of rheumatic valves with gluteraldehyde preserved autologous pericardium. Patients and Methods: In our department 48 patients were exposed to mitral valve repair by leaflet augmentation either anterior or posterior beside other technique and all patients supported by flexible annuloplasty ring and followed for five years clinically and by echocardiography. Results: Age of the patients ranging from 12 to 47 years, mean age 25.9 ± 8.9 and there were 12 males (25%) and 36 females (75%) with male to female ratio of 1:3. All patients presented with shortness of breath (100%);with 14 patients were in NYHA class III (29.17%) and 34 patients were in NYHA class IV (70.83%). During follow-up period 5 patients needed reoperation by valve replacement, causes of reoperation were restrictive valve motion in one patient, left atrial thrombus in 1 patient and sever mitral regurgitation in 3 patients. Freedom from reoperation was 87.5%. At 5 years, (92.9%) were in New York Heart Association functional class I, three patients (7.1%) were in class II. Echocardiography at follow-up showed satisfactory mitral valve function. Conclusion: leaflet augmentation is a simple and reproducible method of valve repair for rheumatic MR with good midterm result.

关键词： Mitral Repair Valve Surgery

N-Butylpyridoquinoxaline 1,4-dioxide (NBPQD) as a new potent for tumor imaging and therapy

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Natural Science 2012年第12期4卷 1074-1084页

作者： Salem A. Habib Ismail T. Ibrahim Mohamed A. Abd-Eldaye mamdouh M. El-Sheshtawey Heba M. Waly Atomic Energy Authority Cairo Egypt Biochemistry Department Faculty of Pharmacy Mansoura University Mansoura Egypt Biochemistry Division Faculty of Science Damietta University Damietta Egypt Pharmacology department Faculty of Veterinary medicine Ismailia University Ismailia Egypt

The development of new and effective antitumor agents is one of the main goals of medicinal and biochemical research at present. The present study is concerned with the evaluation of the previously synthesized N-Butylpyridoquinoxaline 1,4-dioxide (NBPQD) as an antitumor agent against Ehrlich ascites carcinoma (EAC). The first part of the study (tumor imaging) was to investigate the biodistribution of NBPQD in the organs of EAC-bearing mice using iodine-125 isotope stressing on its distribution in the main organs (stomach, liver, spleen, kidney) in addition to blood and ascetic fluid. The second part was the assessment of the antitumor activity of NBPQD by estimating the tumor volume and the contents of total protein, total lipid, DNA and RNA in liver tissues. In addition, liver function tests and the redox status were assessed. Tumor volume and DNA, RNA, urea and malondialdehyde (MDA) levels and the liver enzymes activity were highly significantly increased (P < 0.001) in untreated EAC-bearing mice compared to control. However, total lipid and total protein in liver tissues in addition to serum albumin, glucose, reduced glutathione (GSH) as well as activities of glutathione reductase (GSH-R) and superoxide dismutase (SOD) all were highly significantly decreased in untreated EAC-bearing mice compared to controls. All these decreased parameters were highly significantly restored to their normal levels in NBPQD treated mice compared to the untreated EAC-bearing mice. The survival time of the NBPQD treated mice was longer than that of the untreated ones. It is thus, evident that NBPQD had a remarkable antitumor activity against EAC in Swiss albino mice.

关键词： Ehrlich Ascites Carcinoma SOD MDA 125I-NBPQD GSH-R GSH

An Improved Design of a Fully Automated Multiple Output Micropotentiometer

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Energy and Power Engineering 2010年第2期2卷 103-110页

作者： Hala Mohamed Abdel Mageed Ahmed Faheem Zobaa Mohamed Helmy Abdel Raouf Abla Hosni Abd El-Rahman Mohamed mamdouh Abdel Aziz National Institute for Standards GizaEgypt University of Exeter ExeterUK Cairo University GizaEgypt

This paper describes in details a new design of a fully automated multiple output micropotentiometer (?pot). A prototype has been built at the National Institute for Standards (NIS), Egypt to establish this highly improved AC voltage source in the millivolt range. The new device offers three different outputs covering a wide frequency range from only one outlet. This valuably supports the precise sourcing ranges of low AC voltage at NIS. The design and the operation theory of this prototype have been discussed in details. An automatic calibration technique has been introduced through specially designed software using the LabVIEW program to enhance the calibration technique and to reduce the uncertainty contributions. Relative small AC-DC differences of our prototype in the three output ranges are fairly verified. The expanded uncertainties of the calibration results for the three output ranges have been faithfully estimated. However, further work is needed to achieve the optimum performance of this new device.

关键词： Multiple Output μpot AC-DC Transfer Standard Single Junction Thermal Converter Calibration Uncertainty

Behavior of circulating epithelial tumor cells(CETC)and FISH(fluorescence in situ hybridisation)of epidermal growth factor receptor(EGFR)-gene amplification in lung cancer patients during the course of therapy

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Advances in Lung Cancer 2013年第1期2卷 1-8页

作者： May El Sherif Claus Peter Schneider Carola Rabenstein Amina Hessein Hassab Magdy mamdouh El Bordiny Mona Wagdy Ayad Katharina Pachmann Departement of Experimental Heamatology and Oncology Clinic for Internal Medicine II Friedrich-Schiller-Universität JenaJenaGermany Oncology Departement Bad Berka Central Clinic Bad BerkaGermany Transfusion Center Bayreuth BayreuthGermany Clinical Pathology Department Faculty of MedicineAlexandria UniversityAlexandriaEgypt

Introduction: Monitoring the response of CETC to therapy in lung cancer allows early detection of patients at risk of progression. Analysis of the EGFR-gene amplification in these cells may help to characterize patients who might benefit from tyrosine kinase inhibitors. Methods: CETCs were quantified at least twice during treatment from blood of 52 patients with advanced non small cell lung cancer (NSCLC) using fluorescence labelled anti-EpCAM. EGFR-gene amplification was analysed in these cells with double probe (EGFR/CEP7) using FISH analysis. Results: Progression of the tumor was observed in 30 of the 52 patients (58%). With respect to changes in CETCs during therapy and progression free survival 31 patients showed a decrease in CETCs, 2 developing a single brain metastasis and 12 progressive disease;20 patients showed an increase in CETC more than twofold 16 of which developed progressive disease. The difference was highly significant (p=0.007 Fisher’s exact test) irrespective of age, sex, tumor size, pathological type and therapy. Kaplan-Meier progression free survival was significantly different between patients with decreasing and increaseing CETC (p=0.038). 5/20 patients tested were positive for EGFR amplification with 85-100% of EpCAM positive cells showing this chromosomal abnormality. One patient could be followed during therapy with increasing CETC during therapy with bevacizumab followed by relapse. He subsequently received erlotinib resulting in a decrease in CETC and is still free of progress after 516 days. Conclusions: These results show that peripherally circulating tumor cells in patients with advanced NSCLC are influenced by systemic chemotherapy and an increase in spite of therapy is a marker of aggressiveness of the tumor cells. Determination of the EGFR amplification might help to better treat part of these patients.

关键词： Circulating Epithelial Tumor Cells Lung Cancer EGFR-Gene Mutation Amplification FISH