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The C161T Polymorphism in Peroxisome Proliferator-Activated Receptor ɣ2, but Not Pro12Ala, Is Associated with Diabetic Retinopathy in Type 2 Diabetes Mellitus in an Egyptian Population

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Journal of Diabetes Mellitus 2016年第1期6卷 1-9页

作者： Ragaa Abelkader Ramadan Moyassar Ahmad zaki Rania Mohamed El Sharkawy Lubna Mohamed Desouky Marwa ahmed Madkour Karim Mahmoud Nabil Mohamed Kamel Chemical Pathology Department Medical Research Institute Alexandria University Alexandria Egypt Department of Human Genetics Medical Research Institute Alexandria University Alexandria Egypt Clinical and Experimental Internal Medicine Department Medical Research Institute Alexandria University Alexandria Egypt Department of Ophthalmology Faculty of Medicine Alexandria University Alexandria Egypt

Objectives: Diabetic retinopathy (DR) is one of the most common microvascular complications of type 2 diabetes mellitus (T2DM). It is multifactorial with the contribution of multiple genetic factors. We questioned the association of polymorphisms in the peroxisome proliferator-activated receptor ?2 (PPAR?2) gene (Pro12Ala and C161T) with DR in an Egyptian population. Methods: This case control study included one hundred healthy individuals and 252 T2DM among them 122 with DR and 130 without DR. Genotyping was done by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Results: The Pro12Ala Ala allele was associated with decreased risk of DR with an odds ratio (OR) of 0.484, 95% confidence interval (CI) (0.254 - 0.920), and a p value = 0.024. The C161T T allele was associated with increased risk of DR with OR = 2.593, 95% CI (1.672 - 4.020), p 1c) in multivariate regression analysis only C161T was associated with increased risk of DR with OR = 3.479, 95% CI (1.907 - 6.346), p 1c was higher in Pro/Pro genotype when compared to those with Ala/Ala and Pro/Ala genotypes. Conclusion: We report that T allele of C161T increased risk of DR in the studied population. Further studies are warranted to investigate functional implications of polymorphisms of the PPAR-? gene in DR development.

关键词： Type 2 Diabetes Mellitus Diabetic Retinopathy Polymorphism PPAR០ Pro12Ala C161T

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Clinical and Radiological Localization of Language Dysfunctions in Acute Ischemic Stroke

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Open Journal of Medical Imaging 2014年第2期4卷 80-85页

作者： Amira ahmed zaki Dwidar Taha Kamel Alloush Mahmoud Youssef Abou El-Ella Nahed Salah El-Din ahmed Karima Moustafa Maher Maha Ali Mohamed Nada Mohamed Hamdy Ibrahim Faculty of Medicine Ain Shams University Cairo Egypt

Objective: To study the effect of cerebral ischemic vascular insult on the localization of language areas as regard to automatic speech, initiation, and mutism. Materials and Methods: Seventy ischemic stroke patients were selected within the first 48 h of the onset of stroke with left hemispheric stroke with aphasia. Inclusion criteria: any age above seven years, both sexes, first ever clinical stroke, admitted within the first 2 days of stroke insult. Patients underwent careful history taking, neurological examination, routine laboratory investigations, echo cardiography, and carotid duplex and language assessments. Results: Automatic speech disorders were mainly seen along left insular, left supramarginal and left frontal inferior orbital lesions. Initiation difficulty is seen mainly along as left insular, left temporal superior and left periventricular lesions. Mutism is seen along left external capsule, left internal capsule, left pallidum, left frontal inferior orbital and left inferior trigone lesions. Conclusions: Deep periventricular white matter and insular area in the dominant hemisphere play an important role in many language tasks. Thus aphasia is not a mere cortical function.

关键词： Clinicoradiological Localization Aphasia Stroke White Matter Perventricular

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Phytochemical screening, antioxidant and cytotoxic activity of fruit extracts of Calamus tenuis Roxb

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Journal of Coastal Life Medicine 2014年第8期 645-650页

作者： zaki Uddin ahmed Seheli Sejuti Bithi Md.Minhazur Rahman Khan Md.Mofazzol Hossain Suriya Sharmin Satyajit Roy Rony Department of Pharmacy Jahangirnagar UniversitySavarDhaka-1342Bangladesh University of Information Technology and Sciences(Uits) Gulshan-2Dhaka-1212Bangladesh Pharmaceutical Sciences Research Division BCSIR LaboratoriesDhakaBCSIRDhaka-1205Bangladesh

Objective:To investigate the antioxidant and cytotoxic activity of the fruits of Calamus tenuis ***:The preliminary phytochemical group tests were done,which revealed the presence of alkaloid,tannin,flavonoid and *** dried fruit was extracted in soxhlet apparatus using petroleum ether,ethyl acetate and *** potential of each extract was evaluated using total phenol content,total flavonoid content,cupric reducing antioxidant capacity,1,1-diphenyl-2-picrylhydrazyl radical scavenging activity,and total antioxidant capacity ***:The extracts were found to possess moderate to high amounts of phenolic and flavonoid *** cupric reducing antioxidant capacity assay the extracts showed moderate reducing power which increases with *** of 1,1-diphenyl-2-picrylhydrazyl radical was found to rise with concentration with lowest IC_(50)value for methanol extract,which was confirmed by total antioxidant activity test that shows highest(95 mg/g of extract)in ascorbic acid equivalent for methanol *** Brine shrimp lethality bioassay the methanol and petroleum ether extracts were found to be toxic to Brine shrimp nauplii,with LC_(50)of 25.53μg/mL and 28.07μg/mL respectively while the LC_(50)of the reference vincristine sulphate was 1.32μg/*** acetate extract was found to be moderately cytotoxic showing LC_(50)of 47.79μg/***:The results of the present study suggest that the fruits of Calamus tenuis Roxb possess antioxidant and cytotoxic ***,phytochemical screening reveals the presence of alkaloid,tannin,flavonoid and steroid,which may be responsible for the observed bioactivities.

关键词： Calamus tenuis Roxb Phytochemical screening Antioxidant Cytotoxicity

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负载对电力变压器涌流的影响

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变压器 1981年第10期 26-31页

作者： F.I.ahmed M.zaki 邓隐北

本文研究了电力变压器的激磁涌流现象。当变压器合闸、排除外部故障以及并联运行时,这一电流可能流过变压器的一次线圈。

关键词：激磁涌流电力变压器变压器铁心磁芯

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Evaluation of the Quality for the Egyptian Red Sea Coastal Waters during 2011-2013

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Journal of Environmental Protection 2016年第12期7卷 1810-1834页

作者： mamdouh A. Fahmy Laila M. Abdel Fattah ahmed M. Abdel-Halim Mohamed A. Aly-Eldeen Ehssan M. Abo-El-Khair Hoda H. Ahdy Hoda H. Ahdy ahmed Hemeilly ahmed Abu El-Soud Mohamed A. Shreadah National Institute of Oceanography and Fisheries Alexandria Egypt Environmental Affairs Agency Ministry of Environmental Affairs Cairo Egypt

To assess the quality of the Egyptian Red Sea coastal waters for the sustainable use and development, due to its importance for the national income, four field campaigns were annually carried out during the period from 2011-2013 to investigate the hydrography, nutrient salts, heavy metals and petroleum hydrocarbons. Except for the area of Bir Shalatein, the results of beach litter cleared out that the shoreline of the studied area is not affected by man-made litter. No sewage could be observed. The results of the present study showed that water temperature followed seasonal changes in air temperature. Red Sea water is more saline than adjacent Arabian Sea. DO revealed high values and presence of well oxygenated waters. Minor changes in the distribution of pH, BOD, DOM and COD, revealed that limited effects of human impacts and depend mainly on the dynamics of its water as well as on the geographical location. Low Chl-a and TSM concentrations and high transparency revealed that also the effect of human impacts is almost negligible. Significantly higher sea water temperatures, TSM, pH, DO, BOD, DOM, and COD were observed in summer season compared to their corresponding values in winter season. Dissolved inorganic nitrogen concentrations were quite low because there is little nutrient input from soil, agriculture and pollution on land. Based on the annual mean values, the pattern concentrations of dissolved inorganic nitrogen forms followed the order: NO3 > NH4 > NO2. The Red Sea coastal waters are classified as oligotrophic to mesotrophic state. A remarkable increase of PO4 concentration was observed in the middle Red Sea stations due to huge amounts of effluents enriched with phosphate from the main shipping and industry of Phosphate Companies. SiO4 displayed a large variability due to the supply of SiO4, which flows in the Red Sea through the strait of Bab El-Mandab, biological consumption, organic ma

关键词： Hydrography Nutrient Salts Heavy Metals Petroleum Hydrocarbons Coastal Water Red Sea

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Irritable Bowel Syndrome and Dietary Habits in Northern Saudi Arabia

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Health 2019年第3期11卷 289-297页

作者： Saleh Hadi Alharbi Fahad A. Alateeq Khalil Ibrahim Alshammari Abdulaziz Saad Sharea Alshammri Naif Abdulmohsen Naif Alabdali Motab Ali Saud Alsulaiman Sami mamdouh Ibrahim Algothi Abdulrahman Sulaiman Altoraifi Maha Qasem Almutairi Hussain Gadelkarim ahmed Faculty of Medicine Al-Imam Mohammad Ibn Saud Islamic University Riyadh KSA College of Medicine University of Hail Hail KSA Department of Histopathology and Cytology FMLS University of Khartoum Khartoum Sudan

Background: dietary habit is one of the most universally recounted initiators of irritable bowel syndrome (IBS). The objective of the present study was to determine the role of some dietary habits in the etiology of IBS in Northern Saudi Arabia. Methodology: In this community based cross-sectional survey, data about IBS were obtained from 930 Saudi volunteers living in the city of Hail, Northern Saudi Arabia. IBS was diagnosed using Rome IV criteria. Results: The prevalence of IBS was 11% among males vs. 12.5% among females. The prevalence of IBS symptoms among males was 30% vs. 36.5% females. IBS was significantly associated with reduced water intake, the RR (95% CI) = 1.1800 (1.0146 to 1.3722), P = 0.0316. In the present study, the majority of the study population 904/929 (97.3%) didn’t accustom to vegetables/fruits intake. Conclusion: IBS is prevalent in Northern Saudi Arabia, both among males and females with relatively increasing among females. Low water intake and insufficient fibers intake (particularly, in vegetables and fruits) might be behind the growing prevalence of IBS in Saudi Arabia.

关键词： Irritable Bowel Syndrome Dietary Habits Saudi Arabia

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Whole Exome Sequencing: Novel Genetic Polymorphisms in Saudi Arabian Attention Deficit Hyperactivity Disorder (ADHD) Children

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Natural Science 2019年第2期11卷 45-60页

作者： Neda Mostafa Bogari Amr ahmed Amin Ashwag Aljohani Ghida Dairi Mahmoud zaki El-Readi Anas Dannoun Udaya Raja Mohammad Adil Nermeen Qutub Suhair Alhelfawi Amal Alobaidi Derar Alqudah Hussain Banni Safaa Yehia Eid Huda Balto Faisal Al-Allaf Mohiuddin Taher Hiba Saed Al-Amoodi ahmed Fawzy Department of Medical Genetics Faculty of Medicine Umm Al-Qura University Makkah KSA Biochemistry Department Faculty of Medicine Umm Al-Qura University Makkah KSA Faculty of Medicine Ain Shams University Cairo Egypt Umm Al-Qura University Makkah KSA Biochemistry Department Faculty of Pharmacy Al-Azhar University Assuit Egypt Integrated Gulf Biosystems Jeddah KSA Special Needs Department School of Education Umm Al-Qura University Mecca KSA Sinad City for Special Needs Makkah KSA Institute of Education University of Reading Reading UK Faculty of Medicine King Abdulaziz University Jeddah KSA Science and Technology Unit Umm Al-Qura University Makkah KSA Division of Human Genetics & Genome Researches Department of Molecular Genetics and Enzymology National Research Centre Dokki Egypt

Background: Attention-deficit hyperactivity disorder (ADHD) is a widespread and debilitating disorder with relatively high prevalence in Saudi Arabia. Neuropsychological and radiological investigations have revealed that there are some differences in the components of the brain regions in children with and without ADHD. In this study we have performed whole exome sequencing (WES) in four non-familial cases of ADHD from Makkah Region to identify the genetic polymorphisms associated with the disease in our Saudi population. Methods: Exome sequencing was carried out using Ion Proton with AmpliSeq Exome library methods, and the data were analysed by Ion Reporter 5.6 software. Results: A total of 33 variants were identified from 222 genes selected from the GWAS catalogue for ADHD associated genes. However, the SNPs we identified in these genes were not reported to be associated with ADHD in previous studies. We have identified 2 novel missense variants;one in c.3451G > T;p. (Ala1151Ser) in ITGA1 gene and another is c.988G > A;p. (Ala330Thr) in SPATA13 genes. The variants rs928661, rs11150370 and rs386792899 were the only three variants that appeared on all the 4 patients studied. Six missense variants, rs16841277, rs2228209, rs2230283, rs3741883, rs1716 and rs2272606, were found in 3 different patients, respectively. However, the three documented variants are rs13166360 with bipolar disorder, rs920829 with neuropathic pain, and rs6558702 with schizophrenia. Conclusion: We have identified 2 novel variants in ADHD children. SIFT score of all variants indicates that these substitutions have damaging effects on the protein function. Further screening studies are recommended for confirmation.

关键词： Next Generation DNA Sequencing Single Nucleotide Polymorphisms Saudi Children Attention-Deficit Hyperactivity Disorder ADHD

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Indentation Creep Behavior and Microstructure of Cu-Ge Ferrites

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Materials Sciences and Applications 2011年第8期2卷 1076-1082页

作者： Hesham Mohaned zaki Ali Mohamed Abdel-Daiem Yahia Ibrahim Swilem Farid El-Tantawy Fahad Masoud Al-Marzouki ahmed Abdallah Al-Ghamdi Saleh Al-Heniti Farag Said Al-Hazmi Talal Sadaka Al-harbi 不详

Cu-Ge ferrite was prepared using the standard ceramic method. The creep rate of polycrystalline Cu1+xGexFe2-2xO4 ferrite has been measured as a function of time at room temperature. It is found that the indentation length increases with the increase of both time and applied load. A regime of individual creep curves is observed for the first and second stages. It is not possible to record the third stage of the curve as usually happened in an ordinary creep test, because fracture of the samples does not occur. The slope is found to increase with increasing germanium and copper content in the steady state region. The high value of n (stress exponent factor) indicates that the dislocation creep is the dominate mechanism. The porosity arrangements developed within the specimens were examined using optical microscope. The results are discussed with regard to models describing the role of the steady state creep rate of metals. The morphology of the samples shows that the porosity is increased by increasing both copper and germanium ions.

关键词： Ferrites Indentation Creep Microstructure

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Migration of a biliary stent causing duodenal perforation and biliary peritonitis

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World Journal of Gastrointestinal Endoscopy 2013年第10期5卷 523-526页

作者： Hussain Issa mamdouh Nahawi Bahaa Bseiso ahmed Al-Salem Department of Internal Medicine King Fahad Specialist Hospital Department of Surgery King Fahad Specialist Hospital Department of Pediatric Surgery Maternity and Children Hospital

Migration of endoscopically placed biliary stents is a well-recognized complication of endoscopic retrograde cholangiopancreatography. Less than 1% of migrated stents however cause intestinal perforation. We present a... 详细信息

关键词： Biliary stents Migration Duodenal perforation Biliary peritonitis

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Numerical Taxonomic Study of Some Tribes of Gramineae from Egypt

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American Journal of Plant Sciences（美国植物学期刊） 2011年第1期

作者： ahmed Osman Mohammed zaki Sohar Hamed Nagwa Hussein

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