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Alternative Phenotypic Profile for B-Cell Abnormality in a Case at Zinder National Hospital

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Open Journal of Blood Diseases 2024年第1期14卷 8-16页

作者： brah moustapha maman Amadou Djibrilla-Almoustapha moustapha Elhadji-Chefou Abdoul-Aziz Garba Badé Malam-Abdou Department of Medicine Université André Salifou de Zinder Zinder Niger Department of Medicine H&#244pital National de Zinder Zinder Niger Department of Medicine Université Abdou Moumouni de Niamey Niamey Niger Department of Medicine Université Dan Dicko Dan Koulodo de Maradi Maradi Niger

Introduction: Since it is impossible to establish a diagnosis in the presence of hyperlymphocytosis not secondary to lymphocytic hyperactivation, we considered a B-lymphoid hematopathy with a non-specific phenotypic profile. We report one case of this. Observation: This is a forty-eight (48) year old patient with hyperlymphocytosis at 139,000 elements per cubic millimeter, heterogeneous splenomegaly at 25.6 cm in diameter on abdominal ultrasound without detectable deep or peripheral lymphadenopathy. Peripheral blood cytology shows lymphocyte cell proliferation suggestive of the circulating phase of chronic lymphoproliferative B syndrome. The expression profile of cell membrane markers did not allow for the definition of a specific phenotypic profile. Faced with this immunophenotyping result, we considered a B-lymphoid hemopathy with a non-specific phenotypic profile. After three courses, the MINICHOP treatment was used to achieve partial remission with wasting of more than 80% of the evaluable masses. Conclusion: Despite the contribution of immunophenotyping in the diagnosis of lymphoproliferative syndromes, it is possible to consider the diagnosis of a B-lymphoid hemopathy with a phenotypic non-specific profile of CD45+, monotypic kappa, CD19+, FMC7+, CD22+, CD5−, CD79b−, CD23−, CD43−, CD38−, CD200−.

关键词： Hyperlymphocytosis CLL Immunophenotyping MINICHOP

Sickle Cell Disease in the Zinder Region in 2023: Prevalence and Sociodemographic Factors

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Open Journal of Blood Diseases 2024年第1期14卷 1-7页

作者： brah moustapha maman Amadou Djibrilla-Almoustapha moustapha Elhadji-Chefou Illa Hamidine Moussa Diongolé Hassane Badé Malam-Abdou Department of Medicine Université André Salifou de Zinder Zinder Niger Department of Medicine H&#244pital National de Zinder Zinder Niger Department of Medicine Université Abdou Moumouni de Niamey Niamey Niger Department of Medicine Université Dan Dicko Dan Koulodo de Maradi Maradi Niger

Introduction: In view of the number of sickle cell patients and due to a low production of descriptive studies, we decided to determine the prevalence of genes S and C of the disease in the Zinder region. The objective was to contribute to improving the management of sickle cell disease in Zinder. Methodology: This was a systematic screening by the “Sickle Scan” test of any blood donor admitted to the Zinder Regional Blood Transfusion Center during the 6-month study period, from January to June 2023. The Sickle Scan is a qualitative lateral flow chromatography immunoassay using whole blood samples that aid in the rapid diagnosis of sickle cell disease. Results: The study was carried out on 613 samples during the period concerned. The frequency of sickle cell genes was 26.9% (n = 165) in all samples collected, with 23.1% (n = 142) and 3.8% (n = 23) for the S gene and the C gene, respectively. The 18 - 30 age group was the most represented with 64.4% (n = 395) cases. The median age of blood donors was 26 years ± 10 years (min = 18 years/max = 60 years). The sex ratio was 2.5. Donors of Nigerien nationality accounted for 84.1% (n = 516). There is a predominance of blood donors with an average monthly income between 34,000 and 70,000 CFA francs in 44.3% (n = 272), lived in permanent housing with drinking water supply. Sickle cell trait (SMA) was found in 22.5% (n = 138). Conclusion: The analysis of these results highlights a high frequency of the S gene for sickle cell disease. The population with an average monthly income is the most affected, with a male predominance.

关键词： Sickle Cell Anemia Blood Donors Sickle Scan

Chronic Lymphocytic Leukemia of del 17p in a Young Subject: About a Case and Reviewed a Literature

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Open Journal of Blood Diseases 2022年第4期12卷 103-109页

作者： Amadou Djibrilla-Almoustapha moustapha mamane-brah moustapha Elhadj-Chefou maman Rabiou Badé Faiza Abba-Ousmane Fanta Ousseini Oumoulkairou Abdoulaye-Soumana Badé Malam-Abdou Departement of Onco-Hematology of the National Hospital of Niamey Niamey Niger Faculty of Health Science Abdou Moumouni University of Niamey Niamey Niger Faculty of Health Science André Salifou University of Zinder Zinder Niger Faculty of Health Science of Maradi Maradi Niger

Objective: To report a case of Chronic Lymphoid Leukemia in a 28-year-old young subject, with variable clinical features and a TP53 mutation, diagnosed and followed up in the Onco-Hematology department of the HNN. Observation: 28-year-old patient, having consulted for polyadenopathy and physical asthenia, whose clinical examination found a conscious patient, submaxillary, laterocervical, axillary and inguinal lymphadenopathy, bilateral, symmetrical, painless and non-compressive whose largest measures 3 cm in diameter. Hepato-splenomegaly and epistaxis. Predominantly lymphocyte hyperleukocytosis, immunophenotyping revealed low CD19+, CD5+, CD23+, CD20 monoclonal B lymphoid proliferation. The Matutes score was 4. A karyotype showed a three-chromosome translocation;the short arm of a chromosome 2, the long arm of a chromosome 11 and the long arm of a chromosome 13, and a translocation between the long arm of a chromosome 6 and the long arm of a chromosome 18. A FISH objectified a led 17p. The diagnosis of Binet Stage C CLL with positive del 17p and complex karyotype was retained. Despite the poor prognosis, the R-C (Rituximab-Chlorambucil) protocol was instituted with once-weekly transfusions. The patient is still alive in partial clinical and biological remission. Conclusion: Despite therapeutic progress, the presence of the deletion of chromosome 17p with TP53 mutation and the young age of the patient does not change the patient’s prognosis.

关键词： Chronic Lymphocytic Leukemia Young Subject del 17 p HNN Niger

First Case of Von Willebrand Disease in Niger

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Open Journal of Blood Diseases 2021年第1期11卷 1-5页

作者： Amadou Djibrilla-Almoustapha moustapha maman-brah moustapha Elhadji-Chefou maman Rabiou Badé Amal Al-Azhari Youssoufa Seydou-Moussa maman Aminou Mahamane Sani mamane Daou Souleymane brah Badé Malam-Abdou Hematology Department of the Niamey National Hospital Niamey Niger Department of Internal Medicine of the National Hospital of Niamey Niamey Niger Endocrinology Department of the Niamey General Reference Hospital Niamey Niger Department of Internal Medicine of the General Reference Hospital of Niamey Niamey Niger

Von Willebrand’s disease was first described in 1926 by Erik Von Willebrand. It is a genetic, constitutional defect of hemostasis that is different from hemophilia. It is classified among the rare diseases whose clinical manifestations are dominated by a hemorrhagic profile, which varies from patient to patient. It is an easily diagnosed disease based on a quantitative and qualitative bioassay of VWF. Treatment is multidisciplinary and is based on well-structured prevention. We report the first case of von Willebrand disease in Niger, diagnosed in the Hematology Department of Niamey’s National Hospital.

关键词： Willebrand Disease Onco Hematology Niamey Niger

Understanding China’s Success in Africa

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Understanding China’s Success in Africa

消费者信任来源对发展中国家电子商务的影响评估--以加纳为例

2012 2nd International Conference on Applied Social Science(ICASS 2012)

作者： Mijitaba maman moustapha Randriamalala Jean Luc Stevens School of Management Huazhong University of Science and Technology School of Management Wuhan University of Technology Wuhan

China is becoming undeniably a world economic leader. The present work tries to explore the reasons of such success by considering the relationship between the country and the African continent. Conversely to developed economies such as America and European nations, China emphasizes on mutual benefits through a dynamic politico-economic strategy relying on five dimensions: understanding Africa’s development needs, supporting in-difficulties countries, building a win-win relationship, a non-interference principle, and a dynamic diplomacy. To implement and support its strategy, China offers foreign aids and promotes cultural integration and studies. With the establishment of the Forum on China-Africa Cooperation （FOCAC） in 2000, the country looks forward to overcome any obstacle to the bi-partite relationship.

关键词： China-Africa cooperation international trade strategies

来源： cnki会议评论

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时代经贸 2018年第28期16卷 53-55页

作者： benjamin adjei danquah 陈冬林 maman ali m.moustapha 武汉理工大学经济学院湖北武汉430070

当今电子商务的风暴已经席卷全球,一些发达国家的电子商务正高速发展,而发展中国家则相对落后。本文的目的在于评估加纳电子商务增长的消费者信任来源。研究利用632份问卷调查所收集到的原始数据,并采用结构方程模型(SEM)—偏最小二乘法... 详细信息

当今电子商务的风暴已经席卷全球,一些发达国家的电子商务正高速发展,而发展中国家则相对落后。本文的目的在于评估加纳电子商务增长的消费者信任来源。研究利用632份问卷调查所收集到的原始数据,并采用结构方程模型(SEM)—偏最小二乘法(Smart PLS)对数据进行分析。其结果表明,企业特征、交互作用、亲和力和整体信任对加纳电子商务具有积极影响。加纳企业家应该将政策方向更多地放在打造强势品牌、改善服务和努力满足客户期望的方向上来。

关键词：电子商务信任服务质量品牌认可度客户满意度