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Transient Diabetes Induced by L-Asparaginase

Open Journal of Pediatrics 2023年第6期13卷 862-865页

作者： mamadou mous.apha diop M’mah Aminata Bangoura Aissata Barry Emmanuel Camara Kolié Ouo Ouo Pé Neabei Beimy Mohamed Lamine Diallo Kaba Bangoura mous.apha Kouyate Mohamed Lamine Kaba Aka Nbga Department of Paediatrics Faculty of Health Sciences and Techniques Gamal Abdel Nasser University Conakry Republic of Guinea Urgence Pédiatrique CHU Donka Ministère de l’enseignement de la recherche scientifique et de l’innovation Conakry Republic of Guinea Haemodialysis Department CHU Donka Ministry of Education Scientific Research and Innovation Conakry Republic of Guinea

Background: Although hyperglycaemia is one of the known side effects of L-asparaginase, its contribution to the development of diabetic ketoacidosis (DKA) is less well known in the literature. Asparaginase is an essential component of treatment protocols for acute lymphoblastic leukaemia (ALL) in combination with other chemotherapeutic drugs. On further evaluation, she was found to have high anion gap metabolic acidosis, hyperglycaemia and ketonuria. In recent decades, the use of these chemotherapeutic agents has led to a decrease in mortality and disease-free survival in ALL. L-asparaginase is one of the chemotherapy protocols used in the treatment of acute lymphoblastic leukaemia (ALL) and can induce hyperglycaemia which is aggravated by the concomitant use of corticosteroids. We report the observation of a 14-year-old girl treated with chemotherapy (GFA LAL protocol) who developed transient diabetes following the use of L-asparaginase. She was treated at the Donka paediatric haemato-oncology unit by a multidisciplinary team including a paediatric oncologist, a psychologist and a diabetologist. The aim of this study was to highlight blood glucose monitoring before and after the use of asparaginase in acute lymphoblastic leukaemia. Conclusion: We conclude that the occurrence of ketoacidosis following the use of asparaginase is a rare event. We recommend close monitoring of blood glucose levels for hyperglycaemia in patients with ALL receiving L-asparaginase.

关键词： Asparaginase Diabetes ALL Donka

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The Magnetic Field as Trigger for Disturbances of a Flow of a Newtonian Fluid through a Cylindrical Pipe with a Horizontal Axis

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Modern Mechanical Engineering 2022年第4期12卷 83-97页

作者： Ibrahima Kama mamadou Lamine Sow Cheikh Mbow Department of Physics University Cheikh Anta Diop (UCAD) Dakar Senegal

A Fourrier Petrov Galerkin spectral method is described for high accuracy computation of linearized dynamics for flow in a circular pipe. The code used here is based on solenoidal velocity variables. It is written in FORTRAN. Systematic studies are presented on the dependence of eigenvalues and other quantities on the axial and azimuthal wave number;the reynolds’ number Re and a new none-dimensional number Ne. The flow will be considered stable if all the real parts of the eigenvalues are negative and unstable if only one of them is positive.

关键词： Newtonian Fluids Magnetic Field Linear Stability Petrov-Galerkin Generalized Eigenvalue Problem

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Epidemioclinical Aspects of Childhood Domestic Accidents in the Emergency Department of Boffa Hospital

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Open Journal of Pediatrics 2023年第6期13卷 947-954页

作者： Bangoura Mmah Aminata Kolié Ouo Ouo Bangoura Kaba Camara Salématou Hassimiou diop mamadou mous.apha Touré Oumar Deen Camara Emmanuel Diallo Fatoumata Binta Bémy Pé Néabey Touré Mariame Oumar Institut de Nutrition et de Santé de l’Enfant Conakry Guinée Service de pédiatrie Hô pital national Donka Conakry Guinée Service de chirurgie pédiatrique Hô pital national Donka Conakry Guinée Hô pital préfectoral de Boffa Boffa Guinée

Introduction: Domestic accidents are defined as accidents that occur in the home or its immediate surroundings. Objective: To describe the epidemioclinical and therapeutic aspects. Patients and Methods: Prospective, descriptive study from July 1, 2019 to June 30, 2020 in the emergency department of Boffa prefectural hospital included all children aged 0 to 15 years admitted for domestic accidents. Results: Of 120 cases of accidental trauma, 56 were domestic accidents. The mean age was 7.08 years. The 0 - 5 and 11 - 15 age groups were the most represented (35.71%). The sex ratio was 1.55 in favor of boys. Domestic accidents were represented by falls (26.78%), thermal burns (21.43%), snakebite wounds (17.86%) and dog bites (10.71%), drowning (5.36%), and electrification by lightning (3.60%), one case or 1.78% of each of the following: esophageal foreign body by palm nut, firearm, wall collapse, stretching of upper limb. Paracetamol was the molecule most frequently used (89.28%). The outcome was favorable in 92.86% of cases. However, four (4) deaths were recorded. Conclusion: Domestic accidents remain a significant pathology at Boffa prefectural hospital.

关键词： Domestic Accidents Children Hospital Prefecture Boffa Guinea Conakry

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Neonatal Thrombocytopenia at Dakar Principal Hospital

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Advances in Infectious Diseases 2023年第4期13卷 586-595页

作者： Guèye mamadou Wagué Fall Khadija Gadji Macoura Diawara Papa Silman Ndoye Maguette Nakoulima Aminata diop Daffé Sokhna Moumi Mbacké Ngom Mor Fall Mbène Niang Tagouthie Seye Meissa Ndew Fall Bécaye Laboratory Federation Dakar Principal Hospital (DPH) Dakar Senegal Pediatrics Department Dakar Principal Hospital Dakar Senegal Biological Hematology and Oncological Hematology Department (BHOH) National Blood Transfusion Centre (CNTS)/FMPOS Cheikh Anta Diop University Dakar Senegal

Neonatal thrombocytopenia accounts for 20% of neonates hospitalized in the neonatal intensive care unit (NICU) at DPH. The etiologies are multiple, but bacterial infection is the third leading cause of neonatal mortality worldwide. We therefore set out to assess the frequency of neonatal thrombocytopenia associated or not with bacterial infection in the NICU. We conducted a retrospective and prospective study with the DPH NICU, over 10 months (August 2018 and April 2019). Thrombocytopenia encountered in the NICUs, were the subject of research into bacteriological, inflammatory, and epidemiological parameters using Inlog laboratory data processing software. During this period, 1280 babies were hospitalized, 94 of whom underwent thrombocytopenia, corresponding to 7.34%, with a sex ratio of 0.92. The number of babies presenting with thrombocytopenia during the first week of hospitalization was 72, accounting for 76.6%. The clinical context was usually low birth weight in 30.8% of cases and perinatal asphyxia (25%). Thrombocytopenia ranged from 2000 to 137,000 with an average of 69,520/mm3. Among these thrombocytopenias, 64 cases (68%) were below 100,000 mm3 and 44 cases had a CRP >5 mg/l. A total of 30 bacteria were isolated, including 23 Enterobacteria, 2 Streptococci, and 1 Acinetobacter. Among these enterobacteria, 14 were multidrug-resistant (MDR). Thrombocytopenia associated with a multidrug-resistant bacterial infection is a real challenging management.

关键词： Neonatal Thrombocytopenia Bacterial Infection Enterobacteria Newborns

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Tuberculosis Meningitis Associated with Poncet’s Disease: A Rare Case in a Young Senegalese Patient

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Case Reports in Clinical Medicine 2023年第7期12卷 223-226页

作者： Thioub Daouda Alassane Sarr Papa L. J. Diouf Aboubakar S. Badiane Seck mamadou Ndèye A. Lakhe Agbogbenkou T. D. Lawson Sylvie A. diop moussa Seydi Service des Maladies Infectieuses et Tropicales CHNU Fann Dakar Sénégal UFR des Sciences de la santé Université Iba Der Thiam de Thiès Thiès Sénégal

Described by Antonin Poncet in 1897, Poncet’s disease is a non-destructive (non-erosive) inflammatory arthritis secondary to a mycobacterial infection, without an identified infectious agent in the affected joints. Neuromeningeal localization of tuberculosis (TB) is rare but remains the most severe with hight mortality and permanent neurological damage. Association of Poncet’s rheumatism and TB is rare, even less a neuromeningeal localization. We report here a case of optic nerve compression syndrome complicating tuberculous meningitis associated with Poncet’s rheumatism characterized by a good outcome. This was an 18-year-old female with no reported pathological history, who was admitted for obnubilation. The symptoms started two weeks before her hospitalization and were marked by fever and headache. On admission, the examination revealed obnubilation, bilateral pyramidal deficit syndrome, right ptosis and areactive mydriasis predominating on the right, meningeal syndrome, and intense inflammatory polyarthralgia. The brain CT showed meningeal contrast enhancement with moderate dilatation of ventricles. GeneXpert MTB/rif in CSF was positive. Rheumatoid factors (latex and Waaler-Rose test) and anti-CCP antibodies were negative. Anti-nuclear, anti-native DNA and anti-NAS antibodies were negative. Ophthalmological examination revealed optic nerve compression syndrome associated with extrinsic and intrinsic oculomotor paralysis in the right eye. Orbito-encephalic MRI showed compression of the optic nerve, and hydrocephalus. Under antituberculosis treatment, we noticed disappearance of arthralgia in three weeks, regression of intracranial hypertension and improvement of vision.

关键词： Tuberculosis Meningitis Poncet’s Disease

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Physico-Chemical and Mineralogical Characterizations of Tchiky Clays (Thies, Senegal) for Pharmaceutical Uses

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Journal of Minerals and Materials Characterization and Engineering 2023年第2期11卷 36-48页

作者： Rokhaya Sylla Gueye Nango Gaye Ousmane Ka mamadou Baldé Adama Diedhiou Ngoné Diouf Samba F. Ndoye Idrissa Ndoye Yoro Tine Rokhaya Gueye Mouhamadou B. diop Matar Seck Djibril Fall Alassane Welé Laboratory of Physical Mineral Organic and Therapeutic Chemistry Cheikh Anta Diop University (UCAD) Dakar Senegal Laboratory of Analytical Chemistry and Bromatology UCAD Dakar Senegal Laboratory of Geomaterials Institute of Earth Sciences UCAD Dakar Senegal

Our study focused on the valuation of Tchiky clays. This work aims to evaluate its properties to explore possible uses in pharmacy. Physico-chemical and mineralogical characterizations were carried out, as well as pharmacopoeial tests and an evaluation of the antioxidant activity. Thus, chemical analysis by X-ray fluorescence spectrometry gave silicon (55.65%), iron (15.73%), aluminum (13.53%), potassium (6.05%), titanium (3.98%), magnesium (2.10%), and calcium (0.82%). X-ray diffraction showed the presence of kaolinite, quartz and illite. This study also revealed that the sample studied was essentially a plastic clay of hard consistency, with average flowability. The evaluation of the antioxidant activity gave a percentage inhibition of 62.97% for a concentration of 7.5 g/l with an IC50 of 5.5 g/l. These results should allow use as an excipient in pharmacy, particularly in liquid, semi-liquid and pasty formulations.

关键词： Clays Tchiky Minerals Pharmacopoeia Antioxidant Activity

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Monazite Recovery by Magnetic and Gravity Separation of Medium Grade Zircon Concentrate from Senegalese Heavy Mineral Sands Deposit

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Journal of Minerals and Materials Characterization and Engineering 2021年第6期9卷 590-608页

作者： Moumar Dieye Mohamadou mous.apha Thiam Anthony Geneyton mamadou Gueye Earth Science Institute Cheikh Anta Diop Dakar University Dakar Senegal Eramet Ideas Trappes France

Gravity, magnetic and electrostatic separation methods allowed to obtain different titanium oxide concentrates (ilmenite, leucoxene, rutile) and different varieties of zircon concentrates (premium zircon, standard zircon, medium grade zircon standard) from Senegal’s heavy mineral sands. During mining separation, monazite, which is a paramagnetic mineral, was found in a non-negligible concentration of 0.57 wt% on average in the medium grade zircon standard which also contains 37.96 wt% zircon and 44.46 wt% titanium oxides. Magnetic and gravity separation tests were carried out on the Medium grade zircon standard (MGZS) to produce a monazite concentrate at Eramet Ideas laboratory. Magnetic separation at 1.5 teslas intensity resulted in the recovery of 94.8% of the monazite from the MGZS. Gravity separation also recovered 76.6% of the monazite from the MGZS. The combination of these two treatment methods can thus produce three concentrates from MGZS (a monazite concentrate, a zircon concentrate, and a titanium oxide concentrate).

关键词： Monazite Heavy Mineral Sands Separation Gravity Magnetic

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Tele-Analytical Characterization of the Eburnean Tectonic Structures within the Birimian Formations of Mako Area, Eastern Senegal

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International Journal of Geosciences 2022年第1期13卷 12-32页

作者： Ibrahima Gassama moussa Dabo Emmanuel Tama Samoura mamadou Ndiaye Department of Geology School of Science and Technology Sheikh Anta Diop University Dakar Senegal Géosciences Rennes UMR 6118 CNRS Université de Rennes 1 Campus de Beaulieu Rennes France

The tectonic structures of the Mako area in the Kédougou-Kéniéba inlier (KKI) were mapped with tele-analytical investigation which is validated by field data. This study is based on different images processing in particular: 1) the colored combinations (1 to 5) and panchromatic (8) thematic mapping bands of the Landsat-8 (ETM+) satellite;2) Digital Elevation Model (DEM) image of Space Shuttle Radar Topography Mission (SRTM);3) airborne geophysics (aeromagnetic and radiometric) images. In these images, four major directions of lineaments NS, NNE-SSW, NW-SE and EW would be related to the tectonic structures, have been identified and mapped. Field data confirm these four structural directions and show that most of these lineaments are related to faults, shear and/or thrust zones, or even basic rock dykes. N-S to NE-SW oriented lineaments are more frequent followed by those NW-SE oriented. These two directions of lineaments are generally in correlation with trajectories of major sinistral shear zones in the Mako area. They would be associated with the S2a and S2b schistosities relative to the D2 Eburnean major deformation. They often intersect the E-W oriented lineaments which are less frequent and sometimes folded and crenulated. This E-W oriented linea

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State of the Art of Artificial Intelligence Applications in Oncology

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Open Journal of Applied Sciences 2023年第12期13卷 2245-2262页

作者： Idrissa Sy mamadou Bousso Ayoub Insa Correa Madieng Dieng Faculty of Science and Technology Iba Der THIAM University of Thies Thies Senegal Faculty of Medicine Cheikh Anta DIOP University of Dakar Dakar Senegal

Artificial intelligence (AI) operates by using algorithms and statistical models based on data, enabling computers to imitate a real form of intelligence. The structure of the data available and the aim of the research define the technique to be adopted, which will be evaluated by its degree of accuracy and its capacity for generalization. In recent years, several applications of artificial intelligence have emerged in the fight against cancer, due to its development, computing power and learning potential. This article presents the current state of AI systems, describing the techniques and innovations that have led to satisfactory results in the fight against cancer. .

关键词： Artificial Intelligence Cancer Prognosis

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Evaluation of Quantitative and Qualitative Losses on Millet and White Rice in Storage Grains Caused by <i>Corcyra cephalonica</i>(Stainton) in Senegal

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Advances in Entomology 2021年第1期9卷 30-43页

作者： mamadou LO Toffène Diome Cheikh Thiaw Mbacké Sembene Genetics and Population Management Team Department of Animal Biology Faculty of Science and Technology Cheikh Anta Diop University Dakar Senegal UFR Sciences and Techniques in Agronomy and Vegetable Production (STAPV) University of Sine Saloum El-Hadji Ibrahima Niass (USSEIN) Sing-Sing Kaolack Senegal

In Senegal, millet (Pennisetum glaucum (L.) R. Br.) and rice (Oryza sativa (L., 1753)) are the most widely consumed foods. This study is part of improving the conservation of these two cereals in Senegal by assessing the quantitative and qualitative losses caused by a lepidopteran, Corcyra cephalonica (Stainton) subservient to millet and rice stocks. For this purpose, samples of millet and rice from an area of the center of the groundnut basin (Diourbel) were collected, sterilized in the cold and infected with C. cephalonica eggs from the same locality. These infected samples were tracked during a development period of two successive generations. The samples were scrutinized before being infected and after a larval cycle of codling moth. The results showed that rice grains are richer in water (10.75% ± 0.4249%, on average) than millet (9.40% ± 0.3944%, on average) and the difference in rank is very significant (p-value = 0.0001 Moreover, the attack percentage on millet grains is three times higher (36.31% ± 25.18%) than rice (12.95% ± 6.69%) with a non-significant difference (p-value =

关键词： Millet Rice C. cephalonica Attack Percentage Loss Percentage

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