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Metastatic Prostate Cancer under Androgen Deprivation Therapy: Factors Influencing Castration Resistance

Open Journal of Urology 2020年第7期10卷 225-232页

作者： Modou ndiaye Ousmane Sow babacar Sine Omar Gaye Alioune Sarr Abdoulaye Ndiath Cyrille Ze Ondo Amath Thiam Ndeye Aissatou Bagayogo Samba Thiapato Faye Ndiaga Seck Ndour Aboubacar Traore Ngor Mack Thiam El Hadj Malick Diaw Yaya Sow Boubacar Fall babacar Diao Alain Khassim Ndoye Urology-Andrology Department Aristide Le Dantec Hospital Dakar Senegal Urology-Andrology Department De la Paix Hospital Ziguinchor Senegal

Objective: To evaluate the factors predicting the time to progression to castration-resistant in metastatic prostate cancer under Androgen Deprivation Therapy (ADT) in our center. Patients and Methods: This is a retrospective, descriptive, analytical study in a single center over a period of 2 years. It has interest patients followed for metastasized prostate cancer under ADT. The parameters studied were: epidemiological, clinical, paraclinical, prostate specific antigen (PSA) nadir, time to nadir (TTN) and their link with the castration resistance. Results: The frequency of castration resistant prostate cancer was 28 patients per year. The mean age was 70.4 ± 7.9 years. An ECOG score ≥ 3 was more common as was the cT2c stage. The median of the initial total PSA was 489.6 ng/ml (203.3;1653.2). All patients had adenocarcinoma. The International Society of Urological Pathology (ISUP) 1 was more frequent. Bone metastases were more frequent. The medians of nadir, TTN and the castration resistance were 19.3 ng/ml (3.7;102.1), 5.5 months (3;9) and 11 months (6;15.3), respectively. The Eastern Cooperative Oncology Group (ECOG) score, clinical stage, metastatic site, the nadir and its TTN influenced the DSR. Age, lymph node involvement, initial total PSA and Gleason score did not influence the castration resistance. Conclusion: ADT should be initiated as soon as possible before an attack of general and/or clinical stage advanced to delay resistance. A drilling should be associated with this hormone therapy as much as possible because of its gain on resistance.

关键词： Cancer Prostate Androgen Deprivation Therapy Resistance Prognoses

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Hypospadias: Evaluation of Therapeutic Outcomes and Sexual Function in Adulthood in a University Hospital Setting

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Open Journal of Urology 2020年第9期10卷 245-252页

作者： El Hadji Malick Diaw Modou ndiaye Ousmane Sow Abdoulaye Ndiath Alioune Sarr Boubacar Fall babacar Sine Aboubacar Traore bdourahmane Ndong Cyrille Ze Ondo Amath Thiam Oumar Gaye Ndiaga Seck Ndour Ngor Mack Thiam Yaya Sow babacar Diao Papa Ahmed Fall Alain Khassim Ndoye Urology-Andrology Department Aristide Le Dantec Hospital Dakar Senegal Urology-Andrology Department De la Paix Hospital Ziguinchor Senegal Departement of Surgery Gaston Berger University Saint-Louis Senegal Urology-Andrology Department Dalal Jamm Hospital Dakar Senegal

Background: Hypospadias is a congenital malformation resulting from hypoplasia of the tissues forming the ventral face of the penis. It is associated to variable degrees with an ectopic urethral meatus, a penis curvature and a sapper’s apron foreskin [1]. The incidence of this malformation varies from country to country. It is estimated at 1/300 male births in France and 0.26/ 1000 in Mexico [1]. In Senegal, the prevalence of this malformation is unknown. Hypospadias surgery has improved significantly in recent years due to a better understanding of the anatomy on the one hand and the improvement of the instruments used during surgery on the other (suture material, surgical magnification, urethral catheter of suitable size). In sub-Saharan Africa and particularly in Senegal, hypospadias surgery remains a challenge due to the unavailability of adequate equipment (lack of microsurgical instruments and surgical loupes). Objective: To evaluate the outcomes of the treatment of hypospadias by the different surgical techniques used in our center as well as their sexual function in adulthood. Patients and Methods: This is a retrospective study, including all patients operated for hypospadias between January 2009 and December 2017 in Urology-Andrology department of Aristide Le Dantec hospital. The studied parameters were: frequency, age, clinical and therapeutic aspects, and their sexual function in adulthood after treatment. The outcomes of the treatment were judged good or poor depending of the quality of penile straightening, the aesthetic appearance of the penis, the position of the urethral neo-meatus, the permeability of the urethra and the existence or not of fistula. The sexual function was assessed by the International Index of Erectile Function 15 (IIEF) score. Results: Fifty-five patients were included. The median age was 6 years (P25 = 2.8 and P75 = 13 year

关键词： Urogenital Malformation Penile Enlargement Urethroplasty Urethrocutaneous Fistula

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Sociodemographic and Scanographic Aspects of Primary Bronchopulmonary Cancer in a Hospital in Mali

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Open Journal of Medical Imaging 2021年第4期11卷 104-114页

作者： Mody Abdoulaye Camara Moussa Abdoulaye Ouattara Hawa Diarra Mohamed Maba Traore Boubacar Mama Toure Nouhoum Simpara Néné Koumare mamadou ndiaye Salia Coulibaly Abdoulaye Kone Moussa Konate Ilias Guindo Konate Zakaria mamadou Bakary Coulibaly Seydou Coulibaly Siaka Sidibe Department of Medical Imaging of the Mali Hospital Bamako Mali Department of Thoracic Surgery of the Mlai Hospital Bamako Mali Pediatric Unit at the Common Reference Health Center VI Bamako Mali Department of Medical Imaging of the CHU of Kati Bamako Mali Bamako Infirmary Hospital Bamako Mali Medical Imaging Department of CHME Luxembourg Bamako Mali Department of Gynecology of the Mali Hospital Bamako Mali

Summary: A malignant tumour that develops from the bronchial epithelium and then invades the lungs. It ranks third after colorectal and breast cancer. In Mali, computed tomography (CT) is the main imaging tool used at all stages of treatment. We had initiated this study with the objective of specifying the place of CT in the diagnosis of primary bronchopulmonary cancer at the hospital of Mali. Method: This is a prospective and descriptive study conducted by the Medical Imaging and Thoracic Surgery departments at Mali Hospital from March 2014 to February 2015. All the patients who have benefited from a CT scan and presenting at least one histologically confirmed bronchopulmonary tumor were included. Results: We were recruiting 60 patients with bronchopulmonary cancers out of 500 referred for a thoracic CT scan performed, a frequency of 12%. There was one male patient with a sex ratio of 4H/1F. The average age was 60 years. The history of smoking was 85%. The symptoms were dominated by general condition (63.33%), cough (25%) and haemoptysis (58.33%). CT scans were performed in all patients. The lesions were located more in the lower lobes (71%). The tumours were: heterogeneous tissue density (70%), spiculated contours (80%), and the histology was more non-small cell carcinoma. Conclusion: The incidence of bronchopulmonary cancer is very high and its prognosis is poor at an advanced stage. The evaluative role of CT and biopsy guidance has given it a place of choice in its management. The diagnosis of certainty remains histology.

关键词： Sociodemographic and Scanographic Aspects of Primary Bronchopulmonary Cancer in a Hospital in Mali

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Particularities of Tuberculosis in Children and Adolescents with Sickle Cell Disease in Senegal

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Open Journal of Pediatrics 2022年第1期12卷 59-66页

作者： Idrissa Demba Ba Indou Deme/Ly Yaye Joor Dieng Abou Ba babacar Niang Aliou Abdoulaye Ndongo Papa Moctar Faye Guillaye Diagne Amadou Sow Fatima Tall/Fall Amadou Lamine Fall Ousmane ndiaye Hô pital d’enfants Albert-Royer de Fann-Dakar Université Cheikh Anta Diop de Dakar Fann Dakar Senegal

Introduction: Tuberculosis and sickle cell disease are one of the main global health priorities particularly in Africa. We aimed to determine the epidemiological, diagnostic and therapeutic aspects of tuberculosis in children and adolescents with sickle cell disease. Patients and methods: Patients aged 0 - 20 years with sickle cell anemia presented with tuberculosis at the Centre Hospitalier National d’Enfants Albert Royer (CHNEAR), Dakar, Senegal were included in the study. Medical history, risk factors, clinical, bacteriological, and outcome data was collected. Data was analyzed using the SPSS software, version 16. Results: A total of 25 cases of tuberculosis were documented from January 1st, 1991 to December 31st, 2019 (hospital prevalence: 0.97%). Mean age was 12.5 years. The sex ratio was 1.5 (15 girls and 10 boys). Pulmonary tuberculosis in 14 cases was the most frequent followed by lymph nodes in 7 cases involvement and Pott’s disease in 4 cases. In 5 patients Tb was multifocal. Mean duration of treatment was 8.27 months (6 to 12 months). Outcome was good on antituberculosis treatment. None patient died. Conclusion: Children and adolescents with sickle cell disease can be infected with Mycobacterium tuberculosis. Pulmonary tuberculosis, lymph nodes and bone involvement are the most frequent localizations. Outcome is good on antituberculosis treatment.

关键词： Tuberculosis Sickle Cell Disease Children Adolescent Senegal

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Influence of Temperature and Frequency on Minority Carrier Diffusion Coefficient in a Silicon Solar Cell under Magnetic Field

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Energy and Power Engineering 2019年第10期11卷 355-361页

作者： Seydina Diouf Mor ndiaye Ndeye Thiam Youssou Traore mamadou Lamine Ba Ibrahima Diatta Marcel Sitor Diouf Oulimata Mballo Amary Thiam Ibrahima Ly Grégoire Sissoko Laboratory of Semiconductors and Solar Energy Physics Department Faculty of Science and Technology University Cheikh Anta Diop Dakar Senegal Electromechanical Department Polytechnic School of Thiès Thiès Senegal.

In this study, the effects of temperature and frequency on minority carrier diffusion coefficient in silicon solar cell under a magnetic field are presented. Using two methods (analytic and graphical), the optimum temperature corresponding to maximum diffusion coefficient is determined versus cyclotronic frequency and magnetic field.

关键词： Solar Cell Diffusion Coefficient Temperature Magnetic Field Frequency

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Characterization of Spatio-Temporal Variability of Irradiation, Nebulosity and Aerosols Optical Depth in 10˚North-20˚North African Band

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American Journal of Climate Change 2022年第2期11卷 155-171页

作者： Abdoulaye Bouya Diop Abdoulaye Sy Malick Wade Abdoul Karim Mbodj Abdou Karim Farota Adoum Mahamat Moussa babacar Niang Aicha Dia Diop Bara ndiaye Bouya Diop Amadou Thierno Gaye Aboubakary Diakhaby LSAO-MED Gaston Berger University Saint Louis Senegal CERDI Clermont Auvergne University Clermont Auvergne France University of Tchad Djamena Tchad LPAOSF ESP Cheikh Anta Diop Univesity Dakar Senegal

This work concerns the 10? North, 20? North African band. Area renowned for having some of the poorest countries in the world. It is also home to the Sahelian strip and part of the Sahara. The countries in this zone have a relatively low electrification rate compared to the enlightened country. To solve this problem, these countries want to turn to renewable energies such as photovoltaics (renewable energy obtained through solar radiation). Therefore, understanding the behavior of irradiation and cloudiness in the 10 - 20 band becomes necessary. The application of the empirical orthogonal functions to the different cloud layers and to the irradiation reveals a seasonality of the latter, in particular compared to the first modes of the empirical orthogonal functions (EOF1). Indeed, by filtering in time and space to isolate solar radiation and cloudiness, the EOF1 expresses respectively 94.3% of the variation of descending solar radiation in clear sky in the 10 - 20 band. Note 65.7% for global radiation, 54.4% for cloudiness at 450 hPa, 69.6% for cloudiness between 800 hPa and 450 hPa, 76.6% for low cloudiness, 61.4% for total cloudiness. These results allow us to say that we have generally good sunshine over several months, with little cloud cover in this band. However, since this zone is considered to be part of the main aerosol emission source zones, it is important in their temporal consideration of the optical depth. By doing the wavelet analysis on the optical depth data from Dakar and Banizoumbou, we note that the average dust presence spectrum over the entire period from 1997 to 2019 in the two stations with a slight shift compared to the peaks and the maximum observed value. A sign that there is a strong presence of dust in this area and that it should be taken into account for any photovoltaic installation in this area.

关键词： Sahel Irradiation Cloudiness Aerosol EOF Wavelet

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Study of Descriptive Determinants of Moral Harassment at Work in a Factory in Senegal

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Health 2020年第2期12卷 106-117页

作者： Abou Sy Ekué Kafui Kokou Jean Augustin Diegane Tine Ndeye Amelie Makareme Sy Aissatou Diallo Ibrahima Seck Mor ndiaye Taiwo Lateef Sheikh mamadou Habib Thiam Department of Psychiatry University Cheikh Anta DIOP Dakar Senegal Department of Public Health University Cheikh Anta DIOP Dakar Senegal Department of Labor Medicine University Cheikh Anta DIOP Dakar Senegal Department of Psychiatry Ahmadu Bello University Zaria Nigeria

Introduction: Globalization and the attendant contemporary system of work organization, industrial competitiveness and workplace hostility could be a source of stress. Behaviors considered to be hostile tend to constitute the foundation on which moral harassment at work rests and contributes significantly to work place mental health. Methodology: We conducted a quantitative, cross sectional descriptive study between April 1 and June 30, 2018 at the Grands Moulins de Dakar “GMD”. We used a questionnaire containing the socio-demographic data to which we added the Masson Meret and Steiner questionnaire called, “Ambiance in professional environment”. We used the Epi info software for data entry and analysis. Results: Sample population was 100 subjects with average age of 42.18 years ± 7.6, a male predominance of 91% and average length of service in the company was 15.27 years ± 10.1. Hostile behavior was more frequently reported than stress, with 49% and 28% respectively. Among the hostile behavior we found criticism in the professional field in 35% of the cases and rumors mongering was observed in 25% of the cases. The most reported stress symptom was general fatigue (45%), hostile behavior was more common in males (40 - 49 years of age and those with more than 10 dependents). Of the officers who felt generally unwell, 78.9% were victims of hostile behavior. Conclusion: Hostile behavior forms the basis of moral harassment at work and their devious nature makes them difficult to detect, this contrasts with its harmful consequences on the health of the staff. Potentially harmful workplace stress has become more frequently encountered in the contemporary workplace and has constituted an occupational hazard. The most common symptoms reported are feeling unwell and general fatigue.

关键词： Bulling Moral Harassment Psychosocial Violence Stress Senegal

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Profile of Pituitary Adenomas in Senegal: Epidemiological, Clinical and Therapeutic Aspects about 241 Collected Cases

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Open Journal of Internal Medicine 2023年第3期13卷 144-154页

作者： Diédhiou Demba Diallo Ibrahima Mané Mbaye Maguette Sow Djiby ndiaye Fama Mody Ndour Michel Assane Dieng Mouhamed Gadji Fatou Kiné Thioye Elhadj mamadou Halim Charles Ndao Cheikh Matar ndiaye Boun Khatab Diouf Sarr Anna Ndour Mbaye Maimouna Medical Clinic II AbassNdao Hospital Center Cheikh Anta Diop University Dakar Senegal Department of Neurosurgery Fann Hospital Center Cheikh Anta Diop University Dakar Senegal

Introduction: in adults, adenomas are the most frequent causes of pituitary tumours. The objective was to characterize its epidemiological and clinical aspects, as well as its therapeutic modalities in Senegal. Methodology: this was a multicenter, retrospective, descriptive and analytical study carried out from the Senegalese register of pituitary adenomas (2008-2022). Results: 242 patients were collected with an average age of 42.4 ± 13 years and a sex ratio (M/F) of 0.91. The mean consultation time was 19.7 ± 23 months. The circumstances of discovery were pituitary apoplexy (11 cases, 4.54%), tumor syndrome (176 cases, 72.72%), gonadal manifestations (103 cases, 42.56%), dysmorphic syndrome (21 cases, 8.68%), hypercorticism (15 cases, 6.19%). Morphologically, it was a macroadenoma (197 cases, 81.40%), an extensive adenoma (22 cases, 9.10%). The hormonal profile was lactotropic hypersecretion (80 cases, 33.05%), somatotropic (13 cases, 5.39%), corticotropic (14 cases, 5.78%), mixed (9 cases, 3.71%). The factors significantly associated with prolactinoma were young age (p = 0.000), female sex (p = 0.000), long consultation delay (p = 0.000) and microadenoma (p = 0.001). Only arterial hypertension was associated with acromegaly (p = 0.000). We found a significant correlation between Cushing’s disease and microadenomas (p = 0.000). Non-secreting adenomas were significantly associated with advanced age (p = 0.000), long delay in consultation (p = 0.000), male gender (p = 0.000), tumor syndrome (p = 0.001) and macroadenomas (p = 0.000). Pituitary surgery was effective in 173 patients (71.49%) including 166 cases (68.59%) by transphenoidal approach. Postoperative incidents were transient diabetes insipidus in 82 cases (47.39%), cerebrospinal fluid leak (20 cases, 11.56%). Death was observed in 18 patients in the entire series (7.44%). The latter had a tumor syndrome (88.88%), a macroadenoma (83.33%) and had undergone pituitary surgery (72.22%). Conclusion: pituitary path

关键词： Pituitary Adenoma Prognosis Management Senegal

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The Dust Comportment in the Latitudinal Band 10°North - 20°North in Africa: Emission and Deposition

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Journal of Geoscience and Environment Protection 2022年第5期10卷 139-159页

作者： Abdoulaye Bouya Diop Abdoulaye Sy Abdoul Karim Mbodji Abdou Karim Farota Malick Wade Adoum Mahamat Moussa babacar Niang Aichetou Dia Diop Bara ndiaye Bouya Diop Amadou Thierno Gaye Aboubakary Diakhaby Gaston Berger University of Saint Louis Saint Louis Senegal University of Clermont Auvergne Clermont-Ferrand France University of Chad Ndjamena Chad Cheikh Anta Diop University of Dakar Dakar Senegal

The three measurement periods: the TOMS Nimbus-7 TOMSN7L3 v008 from 1978 to 1993, the TOMS EP TOMSEPL3 v008 from 1996 to 2005 and the OMI OMTO3d v003 from 2004 to 2008 have allowed the presence of dust to be observed in the 10°North to 20°North latitudinal band (10 - 20 band) of Africa. The 10 - 20 band has a permanent dust presence. The AERONET data show AOD peaks exceeding 2 in Senegal and Niger (on an AOD scale). The statistical study reveals intra-annual relationships in deposition. In Senegal, a significant deposition is observed.

关键词： Dust Source Area AOD 10° North - 20° North African Band Deposition Sahel

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Evaluation of the Therapeutic Management of Hypercalcemia in Myeloma at the Nephrology Department of Louis Pasteur Hospital of Chartres: About 8 Cases

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Open Journal of Nephrology 2022年第4期12卷 403-409页

作者： Modou Ndongo babacar ndiaye Nestor Nankeu Abou Sy Houyem Attia Fatiha Lahouel Djillali Ziane Berroudja Tayeb Bensalem Sid Ali Toufik Benyaghla Catherine Albert Sidy Mohamed Seck El Hadji Fary Ka Department of Nephrology Dialysis and Kidney Transplantation of Aristide Le Dantec Hospital Dakar Senegal Department of Nephrology Dialysis of Louis Pasteur Hospital Chartres France Department of Nephrology Dialysis of Ouakam Military Hospital Dakar Senegal

Introduction: Hypercalcemia is the most common metabolic complication in myeloma. The aim of this study was to evaluate the management strategy of hypercalcemia in myeloma at the nephrology department of Louis Pasteur hospital of Chartres. Patients and Methods: We carried a retrospective study of patients treated for myeloma-related hypercalcemia between January 1, 2019 to December 31, 2021. The clinical, paraclinical, therapeutic and evolutive characteristics were studied. Results: Eight patients were included in this study with a median age of 67 years [41 - 85] and a sex ratio (M/F) of 1. A quarter of patients were known with chronic kidney disease. Four patients (50%) had symptoms of hypercalcemia. Biologically, the mean hemoglobin was 9.8 ± 2.7 g/dl, all patients had an acute kidney injury with a mean creatinine level of 364.1 ± 173.3 mmol/l, a mean serum calcium of 3.42 ± 0.59 mmol/l and three quarter of patients had bone lesions. Five patients (62.5%) were rehydrated with a mean volume of saline of 2700 ± 836.7 ml/24h. Seven patients (87.5%) received biphosphonates and none received diuretics. The mean normalization time of the serum calcium was 5 days. Conclusion: Hypercalcemia is frequent in malignancy and represents a poor prognosis factor of the disease. A well-conducted therapeutic strategy allows rapid normalization.

关键词： Hypercalcemia Myeloma Treatment Malignancy Neoplasia

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