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Vaginal Carriage of Group B Streptococcus in Pregnant Women in Rural Areas in Senegal

Open Journal of Medical Microbiology 2023年第3期13卷 207-219页

作者： babacar ndiaye Fatoumata Diene Sarr Mam Coumba Diouf Rokhaya Diop Hamidou Thiam Mohamed Abass Yugo Rose Mbaye Amadou Alpha Sall Cheikh Loucoubar Abdoulaye Seck Medical Biology Laboratory Pasteur Institute of Dakar Dakar Senegal Epidemiology Clinical Research and Data Science Unit Pasteur Institute of Dakar Dakar Senegal Virology Unit Pasteur Institute of Dakar Dakar Senegal

Vaginal carriage of Group B Streptococcus (GBS) is a maternal and child health issue. Our objective was to determine the prevalence of GBS carriage;identify the factors associated with this carriage and determine the antibiotic sensitivity of the isolated strains. We conducted a cross-sectional and prospective study in rural Senegal (in the health district of Sokone). Socio-demographic, clinical and gynaeco-obstetrical data were collected. Vaginal swabs were taken by the midwives on specific settings in order to test for GBS and other High Risk Vaginal Bacteria (HRVB). Antibiotic susceptibility testing was done according to the recommendations of the CA SFM/EUCAST 2020. In total, 100 pregnant women were targeted and 97 pregnant women were included. Their age ranged from 18 to 40 years with 64.9% (63/97) of participants belonging to the “20 - 30” age group. The overall prevalence of Group B Streptococcus carriage was 15.5% (15/97). However, the proportion of women with at least one high risk infectious bacteria was 29.89% (29/97). No statistically significant differences were found between GBS carriage and the potential factors studied. However, the study also looked for the presence of other high-risk bacteria and coinfections were indeed found between GBS and E. coli and Staphylococcus aureus. Antibiotic susceptibility testing shows that GBS strains were fully susceptible to penicillin G, erythromycin, clindamycin, chloramphenicol, rifampicin and vancomycin. Sensitivities to norfloxacin and gentamycin were 73.3% and 86.7% respectively. In contrast, high resistance to tetracycline (86.7%) was observed. GBS carriage remains a major public health issue because of its consequences for the mother and the newborn. Correct screening and proper monitoring of strain susceptibility remain one of the most effective means of patient management and care.

关键词： Group B Streptococcus (Streptococcus agalactiae) Vaginal Carriage Antibiotic Susceptibility Senegal

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Minority Carrier Diffusion Coefficient <i>D</i>*(<i>B,T</i>): Study in Temperature on a Silicon Solar Cell under Magnetic Field

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Energy and Power Engineering 2017年第1期9卷 1-10页

作者： Richard Mane Ibrahima Ly mamadou Wade Ibrahima Datta Marcel S. Douf Youssou Traore Mor ndiaye Seni Tamba Grégoire Sissoko Laboratoire des Semi-conducteurs et d’Energie Solaire Facult&eacute des Sciences et Techniques Universit&eacute Cheikh Anta Diop Dakar S&eacute né gal Ecole Polytechnique de Thiè s Thi&egrave s S&eacute né gal

This work deals with minority carrier diffusion coefficient study in silicon solar cell, under both temperature and applied magnetic field. New expressions of diffusion coefficient are pointed out, which gives attention to thermal behavior of minority carrier that is better understood with Umklapp process. This study allowed to determine an optimum temperature which led to maximum diffusion coefficient value while magnetic field remained constant.

关键词： Solar cell Diffusion Coefficient Temperature Magnetic Field

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Assessment of Insulin Therapy in 281 Children and Adolescents with Type 1 Diabetes in Senegal

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Open Journal of Pediatrics 2022年第1期12卷 283-292页

作者： Djibril Boiro Amadou Sow Aliou Abdoulaye Ndongo Idrissa Basse Lamine Thiam Ndiogou Seck Cheha Fatoumia babacar Niang Modou Guéye Maïmouna Ndour Mbaye Ousmane ndiaye Abass Ndao Hospital Dakar Senegal Aristide Le Dantec Hospital Dakar Senegal Diamniadio Children’s Hospital Dakar Senegal Ziguinchor Peace Hospital Dakar Senegal Saint Louis Regional Hospital Dakar Senegal Albert Royer Children’s Hospital Dakar Senegal

Introduction: In Senegal, with the CDIC “Changing Diabetes In children” project, insulin has been made free. The objective of this study was to evaluate the accessibility and modalities of insulin therapy in the management of type 1 diabetes. Methodology: This was a retrospective study including patients followed for type 1 diabetes (T1DM) in hospital between April 2018 and December 2020. Results: 281 patients were included. The mean age was 14.22 years. The mean age at diagnosis was 11.28 years. Ketoacidosis was the main mode of discovery of diabetes at 51.6%. Premix and rapid insulins were most commonly used at 84.7% and 82.9% respectively, most often in combination. The most commonly used treatment regimen was three injections/day in 82.5% of cases. The average daily insulin dose was 0.62 IU/Kg/dr. Of the patients, 219 (78%) were self-monitoring of blood glucose. The average number of blood glucose checks was 1.78 per day. 76 patients (27%) went days without an insulin injection and up to 7 days in 51% of cases. The main reasons were forgetfulness, therapeutic errors and stock-outs. Hypoglycaemia was observed in 14.2%. The average glycated haemoglobin was 10%. Conclusion: Despite the efforts made, there are still challenges to improve access to insulin. The reinforcement of therapeutic education on insulin therapy is essential for a better quality of life of diabetic children and adolescents.

关键词： Diabetes Children Insulin Therapy Senegal

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The Scalp Involvements in the Connective Tissue Diseases

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Journal of Cosmetics, Dermatological Sciences and Applications 2011年第3期1卷 95-98页

作者： Niang Suzanne Oumou Coumé mamadou ndiaye Maodo Diop Assane Diatta Boubacar Ahy Diallo Moussa Dieng Mame Thierno Kane Assane 不详

Background: The involvements of the scalp over the connective tissue diseases (lupus, sclerodermia and dermatomyositis) are often the present complaint due to the disfigurement they cause. The aim of our study was to identify the various involvements of the scalp over the connective tissue diseases. Method: We conducted a descriptive study over a period of seven months of every instance of involvement of the scalp and hair during connective tissue diseases received in the department. A tensile test, a Trichogram and mycological sampling were performed. Results: 25/35 involvements of the scalp were noted (71.42%);all of them were female and the mean age was 32 years. It was a lupus in 17 cases, sclerodermia in 6 cases, dermatomyositis and a sclerodermatomyositis. They were the present complaint in 48% of cases within 3 years and preceding the other lesions in 32% of cases. We noted fragile and dry hair in 10 cases, straightened hair in 8 cases and hypochromic spots fleck in 5 cases. Conclusion: Connective tissue diseases cause severe injuries and often reveal a risk of permanent cicaticial alopecia and fungal superinfection. The cicatricial alopecia and straightened hair are secondary to immune disorders.

关键词： Scalp Connectivite Senegal

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Assessment Postpartum Glucose Status among Women with Gestational Diabetes: Experience of a Sub-Saharan African Endocrinology Department

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Journal of Diabetes Mellitus 2020年第3期10卷 124-131页

作者： Ngoné Diaba Diack Aminata Mbaye Nafy ndiaye Yakham Mohamed Leye Abdoul Aziz Diouf mamadou Ba Khadidja Samb Papemomar Guisse Abdoulaye Leye Alassane Diouf Endocrinology-Diabetology Department Teaching Hospital of Pikine Dakar Senegal Obstetrics and Gynécology Department Teaching Hospital of Pikine Dakar Senegal

Background: Women with gestational diabetes mellitus (GDM) have a significantly increased risk for developing type 2 diabetes after delivery. The purpose of this study was to determine the postpartum glycemic status among women with GDM in an Endocrinology-Diabetology department in Sub-Saharan Area. Methods: It was a prospective cohort study conducted between January 1, 2013, and July 31, 2018 (over period of 5 years and 7 months) at Pikine National Hospital, Dakar, Senegal. Postpartum glucose status was evaluated at least 6 weeks post-partum among women with history of GDM according to IADPSG criteria. The glycemic status after delivery was pointed referring to 2006 WHO criteria. Results: Overall 53 patients were included in this study. Fasting plasma glucose was performed as a screening test in 94% of the cases. A type 2 diabetes after GDM as diagnosed in 6 patients, accounting for a prevalence of 11.32%. An Impaired Fasting Glucose (IFG) was revealed in 5 patients (9.43%). The patients underwent a screening test in the first year after delivery in 54.70% of the cases, over a half of whom during the post-partum period range from the 6th to the 12th week. Insulin usage during pregnancy was statistically correlated with the occurrence of postpartum diabetes. Conclusion: Diabetes prevention and early diagnosis require a glycemic status monitoring among women with history of GDM.

关键词： Gestational Diabetes Mellitus Postpartum Glucose Status Type 2 Diabetes Africa IADPSG

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Assessment of a Database Management System in a Mammogram Unit of a Radiologic Department in Fann Teaching Hospital (Senegal)

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2017年第4期6卷 401-409页

作者： Mamour Gueye Awa Sadikh Badiane Sokhna Ba Diop mamadou Ly Mame Diarra ndiaye Gueye Abdoulaye Dione Diop Abdoulaye Ndoye Diop Marame Fall Gynecologic and Obstetric Clinic Aristide Le Dantec Teaching Hospital Dakar Senegal Department or Radiology Fann Teaching Hospital Dakar Senegal

Objectives: To evaluate a medical data management system of a mammogram unit in a department of Radiology. Methods: This is a qualitative and quantitative assessment study in Fann Teaching Hospital between April 2014 and June 2015 one year after its implementation. The quantitative component consisted of the audit of the database to determine the socio-demographic characteristics of patients and the results of mammograms. The qualitative component assessed users’ experience. For analysis, quantitative data were extracted and transferred to Microsoft Excel. For scale variables, we calculated the averages and extremes. For qualitative variables, we established percentages. Results: During the study period, 433 patients underwent mammograms. The average age of patients was 48 years. The completion rate maintained above 85% was below 26% in the first two months of use. As to the completeness given examinations, it was still above 83%. The results of mammogram examinations were normal in the majority of cases: 96% for the right breast and 95.2% for the left breast. All users had a favourable opinion about the database. The reasons were better work organization, comprehensiveness, accessibility and standardization of information about the patient and especially the immediate availability of statistics. For 60% of these health professionals, complaints related to the use of the software were the time-consuming of filling data. Conclusion: This study mainly describes the perception of health professionals on the computerization of radiological examinations. It offers some advantages, proposes improvements and opens avenues for reflection on the globalization of the computerization of patient records in Radiology.

关键词： Electronic Medical Records Database Mammogram Radiology Dakar

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Primary Immune Deficiencies (PID): Diagnosis Challenges

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Open Journal of Pediatrics 2021年第3期11卷 388-392页

作者： Indou Deme/ly Awa Kane Mame Sokhna Gueye Ibrahima Diop Mame Tene ndiaye Abou Ba Idrissa Demba Ba babacar Niang Aliou Thiongane Yaay Joor Dieng Yaye Fatou Mbodj/Diop Ouafae Achnin Papa Moctar Faye Amadou Lamine Fall Ibrahima Diagne Tandakha ndiaye Dièye Ousmane ndiaye Albert Royer National Children’s Hospital Center Université Cheikh Anta Diop Dakar Senegal National Blood Transfusion Center Dakar Senegal Health Science Unit Gaston Berger University Saint -Louis Senegal

Background: Primary Immune Deficiencies (PID) are rare, under-determined diseases particularly in sub-Saharan Africa. The diagnosis is often suspected with uncommon clinical signs. Infections are the main diagnostic circumstances in infants. Confirmation is often difficult because some additional examinations are unavailable in many of our countries. Aim: Our aim was to share the challenge of diagnosis and treatment in PID. Case Presentation: It is about two infants, a boy and a girl, with early several infections. Both of them presented a hypo-gammaglobulinemia and to the boy, the immuno-phenotyping lymphocyte showed a decreased level of lymphocytes CD19. We are looking for genetic confirmation but it is not easy. The treatment of these infants requires a substitution for life of immunoglobulin which is unavailable in our countries. Conclusion: PID are suspected with atypical clinical signs. Confirmation genetic diagnosis is difficult in low income countries. To improve the follow up, we need to strengthen clinical-biological collaboration.

关键词： Primary Immune Deficiencies Hypo-Gammaglobulinemia Infants

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Lamella Silicon Solar Cell under Both Temperature and Magnetic Field: Width Optimum Determination

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Journal of Electromagnetic Analysis and Applications 2020年第4期12卷 43-55页

作者： Dibor Faye Sega Gueye Mor ndiaye mamadou Lamine Ba Ibrahima Diatta Youssou Traore Masse Samba Diop Gora Diop Amadou Diao Gregoire Sissoko Laboratory of Semiconductors and Solar Energy Physics Department Faculty of Science and Technology University Cheikh Anta Diop Dakar Senegal

This work deals with determining the optimum thickness of the lamella wafer of silicon solar cell. The (p) base region makes up the bulk of the thickness of the wafer. This thickness has always been a factor limiting the performance of the solar cell, as it produces the maximum amount of electrical charges, contributing to the photocurrent. Determining the thickness of the wafer cannot be only mechanical. It takes into account the internal physical mechanisms of generation-diffusion-recombination of excess minority carriers. They are also influenced by external factors such as temperature and magnetic field. Under these conditions, magneto transport equation is required to be applied on excess minority carrier in lamella base silicon solar cell. It yields maximum diffusion coefficient which result on Lorentz law and Umklapp process. Then from photocurrent, back surface recombination velocity expressions are derived, both maximum diffusion coefficient and thickness dependent. The plot of the back surface recombination calibration curves as function of lamella width, leads to its maximum values, trough intercept points. Lamella optimum width is then obtained, both temperature and magnetic field dependent and expressed in relationships to show the required base thickness in the elaboration process.

关键词： Silicon Vertical Junction Back Surface Recombination Velocity Magnetic Field Temperature Lamella Width

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Diffusion Coefficient at Resonance Frequency as Applied to n+/p/p+ Silicon Solar Cell Optimum Base Thickness Determination

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Journal of Electromagnetic Analysis and Applications 2020年第10期12卷 145-158页

作者： Amadou Mar ndiaye Sega Gueye Mame Faty Mbaye Fall Gora Diop Amadou Mamour Ba mamadou Lamine Ba Ibrahima Diatta Lemrabott Habiboullah Gregoire Sissoko Laboratory of Semiconductors and Solar Energy Physics Department Faculty of Science and Technology University Cheikh Anta Diop Dakar Senegal Ecole Polytechnique de Thiès Thiès Sénégal Département Génie Electrique Ecole Supérieure Polytechnique de Nouakchott Nouakchott Mauritanie

The modelling and determination of the geometric parameters of a solar cell are important data, which influence the evaluation of its performance under specific operating conditions, as well as its industrial development for a low cost. In this work, an n+/p/p+ crystalline silicon solar cell is studied under monochromatic illumination in modulation and placed in a constant magnetic field. The minority carriers’ diffusion coefficient (D(ω, B), in the (p) base leads to maximum values (Dmax) at resonance frequencies (ωr). These values are used in expressions of AC minority carriers recombination velocity (Sb(Dmax, H)) in the rear of the base, to extract the optimum thickness while solar cell is subjected to these specific conditions. Optimum thickness modelling relationships, depending respectively on Dmax, ωr and B, are then established, and will be data for industrial development of low-cost solar cells for specific use.

关键词： Silicon Solar Cell Resonance Frequency Magnetic Field Recombination Velocity Base Thickness

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Predictive Significance of IL-17A Serum Levels during Chemotherapy in Senegalese Women with Cervical Cancer

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Open Journal of Immunology 2019年第4期9卷 37-47页

作者： Folly Mawulolo Gaba babacar Mbengue Maimouna Diop Doudou Diouf Sidy Ka Doudou Georges Massar Niang Ramatoulaye ndiaye Ibrahima Mounkeila Seydou Jean Pascal Demba Diop Moustapha Mbow Rokhaya ndiaye Diallo Maguette Sylla Niang Mbacké Sembene Ahmadou Dem Alioune Dieye Service d’Immunologie Faculté de Médecine de Pharmacie et d’Odontologie Université Cheikh Anta Diop (UCAD) de Dakar Dakar Sénégal Service de Cancérologie Institut Juliot Curie Hopital Aristide Le Dantec Dakar Sénégal Service de Génétique Humaine Faculté de Médecine de Pharmacie et d’Odontologie UCAD Dakar Sénégal Département de Biologie Animale Faculté des Sciences et Techniques UCAD Dakar Sénégal

Background and Objectives: Cervical cancer is a leading cause of cancer death in female populations. It is a virally induced carcinoma resulting from sexually transmitted high risk Human Papillomavirus infections (e.g. HPV-16, HPV-18). Previous studies have shown associations between IL-17A levels in cancer micro-environments and metastasis of tumor cells. In Africa, chemotherapy (CT) is the standard first-line treatment for cervical cancer and the prognosis remains poor for metastatic and recurrent cases. The impact of CT as a treatment option is still unclear. We investigated the prognostic relevance of IL-17A profiles in Cervical cancer patients (CP) patients treated with cisplatin in combination with 5-fluouracil (5FU) for three cycles. Methods: The study included 57 CP and 59 women with no history of malignancy as healthy controls (HC). IL-17A plasma levels were evaluated by ELISA. For each CP, three blood samples were collected at three-week intervals before initiation of the chemotherapy protocol. Results: Before chemotherapy CP showed higher serum levels of IL-17A compared to HCs (p = 0.035). No relation was detected between age and IL-17A levels. We observed a significant increase in serum IL-17A during treatment of the CP group (p Conclusion: Our results suggest that high serum levels of IL-17A are associated with poor responses to classical chemotherapy. However, considering these results to design CC biomarkers, we need further investigations particularly about the relevant prognostic indicator following chemotherapy.

关键词： Cervical Cancer Chemotherapy Interleukin 17A

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