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Multiple Emulsions Able to Be Used for Oral Administration of Active Pharmaceutical Ingredients: Physico-Chemical Parameters Study of Different Phases

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Journal of Modern Physics 2020年第10期11卷 1528-1535页

作者： Louis Augustin Diaga Diouf Alphonse Rodrigue Djiboune mamadou soumboundou Sidy Mouhamed Dieng Papa Mady Sy Gora Mbaye Mounibé Diarra Pharmaceutical Physics and Biophysics Laboratory Faculty of Medicine Pharmacy and Odontology Cheikh Anta Diop University of Dakar Dakar Senegal Pharmaceutical Physics and Biophysics Laboratory Healthy UFR of Thies University of Thies Thies Senegal Galenic and Industrial Pharmacy Laboratory Healthy UFR of Thies University of Thies Thies Senegal

Multiple emulsions are of great therapeutic interest especially in the administration of medicines which can be inactivated by digestive enzymes;moreover the researches of formulation not being often easy, a control of the different phases physicochemical parameters would be of great interest in rapid formulations and at low cost. When formulating emulsions, the preliminary tests, also known as formulation tests, constitute a step which can be long and expensive because of the quantity of reagents that can be used. A rigorous methodology could thus be of great interest, which is at the aim of our study which consists of evaluating the physico-chemical parameters of different phases used to make thus multiple emulsions. In our study, physico-chemical parameters such as conductivity, pH, density, viscosity, and surface tension have been studied by direct measurement using equipment and also by means of suitable mounting. The results showed that the pH and the surface tension have an important role in the prediction of the stability of emulsions, these latter must be of the same order of magnitude. For all phases conductivity does not have too much interest apart from helping to determine the type of the emulsion.

关键词： Active Pharmaceutical Ingredients Multiple Emulsions Stability Physico-Chemical Parameters

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Water/Oil Pickering Emulsion Stabilized by Magnesium Oxide Particles: A Potential System with Two Active Substances (Paracetamol and Griseofulvin)

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Open Journal of Biophysics 2018年第2期8卷 68-84页

作者： Papa Mady Sy Alphonse Rodrigue Djiboune Louis Augustin Diaga Diouf mamadou soumboundou Boucar Ndong Augustin Ndiaye Sidy M. Dieng Ousseynou Diop El Hadji A. L. Bathily Gora Mbaye Mack Faye mamadou Mbodj Mounibé Diarra Laboratory of Physics and Pharmaceutical Biophysics Faculty of Medicine Pharmacy and Odontology UCAD Dakar Senegal Laboratory of Medical Biophysics and Nuclear Medicine Faculty of Medicine Pharmacy and Odontology UCAD Dakar Senegal

Pickering emulsions are systems without surfactants, stabilized by solid particles. These emulsions are experiencing a renewed interest, on the one hand, because it is preferable to limit the use of synthetic surfactants for toxicological and environmental reasons and, on the other hand, the need to make new formulations in order to control the drug release patterns by encapsulation or controlled release. Thus, we were interested in the formulation and evaluation of W/O Pickering emulsions stabilized by particles of magnesium oxide with paracetamol in the internal phase and griseofulvin in the external phase. The Bancroft rule served as a model for the formulation. The emulsification was carried out by progressively adding an aqueous phase dispersed in an oil-dispersing phase using a turbo rotor stator mixer. The stability of these emulsions was studied using several parameters (droplet size, pH, viscosity, conductivity ...) and the qualitative and quantitative analysis of the active ingredients by UV-visible spectrophotometry. The results obtained showed that the dye test and the conductivity measurement confirmed the W/O nature of these emulsions. Some parameters such as droplet size, pH and viscosity were strongly influenced by the amounts of magnesium oxide particles and the two active ingredients used. The qualitative and quantitative analysis of the active ingredients confirmed the presence of griseofulvin in the oil phase and paracetamol in the aqueous phase. Thus, we have succeeded in developing a stable W/O Pickering emulsion with magnesium oxide particles. In addition, we were able to incorporate paracetamol into the dispersed phase and griseofulvin into the dispersing phase of the emulsion.

关键词： Emulsion Pickering-Mgo-Griseofulvin-Paracetamol

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