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Factors of Low Birth Weight Risk in the Department of Gynecology-Obstetrics of the Ignace Deen National University Teaching Hospital in Conakry, Guinea

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Open Journal of Obstetrics and Gynecology 2019年第2期9卷 251-259页

作者： Abdourahamane Diallo Ibrahima Sory baldé Ibrahima Sory Diallo mamadou Hady Diallo mamadou Cellou Diallo Elhadj Mamoudou Bah Ibrahima Koussy Bah Telly Sy Mathias Roth-Kleiner mamadou Pathé Diallo Obstetrics and Gynecology Department of the Ignace Deen National University Teaching Hospital Conakry Guinea Institute of Nutrition and Child Health (INCH) Donka Guinea Obstetrics and Gynecology Department of Donka National University Teaching Hospital Conakry Guinea Department Women-Mother-Child University Hospital and University of Lausanne Lausanne Switzerland

Introduction: The underweight at birth is recognized as a major cause of morbidity and mortality in childhood. Objective: To identify maternal and obstetric sociodemographic factors associated with low birth weight. Patients and Methods: This is a retrospective study of analytical type that examined the records of women who gave birth in the Obstetrics and Gynecology department of Ignace Deen National University Teaching Hospital from 1st December 2016 to 30th April 2017. The analysis was made with the R version 3.3.1 software. We did a univariate and multivariate analysis. Outcomes: Out of the 1633 live births of single pregnancies that occurred during the study period, 109 children were born with a low weight (<2500 g) corresponding to a rate of 6.7%. In univariate analysis, we found a significant association between low birth weight and maternal single status (p = 0.019), maternal weight less than 60 kg (p = 0.038), primary parity (p = 0.018), maternal history of abortion (p = 0.001), history of preterm birth (p < 0.001), arterial hypertension (p < 0.001), anemia (p < 0.001) and malaria (p < 0.001). In multivariate analysis, the variables associated with low birth weight were: history of preterm delivery with OR of 8.5 [1.8 - 40.1], history of abortion (OR = 4.4 [1.4 - 13.9]), malaria (OR = 23.8 [6.1 - 92.5]), anemia (OR = 11.8 [3.7 - 38.2]) and high blood pressure (OR = 5.4 [1.6 - 17.9]). Conclusion: The decrease in frequency of low birth weight in Guinea will be done by improving the quality of prenatal care with an emphasis on screening, prevention and treatment of malaria, anemia and high blood pressure during pregnancy, prevention of abortion and premature birth.

关键词： Risk Factors Low Birth Weight Ignace Deen Newborn to Term

Deep Vein Thrombosis Revealing Prostate Cancer about a Case in the Cardiology Department of the Ignace Deen National Hospital in Conakry

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World Journal of Cardiovascular Diseases 2020年第8期10卷 608-613页

作者： Ibrahima Sory Barry Hadj Yaya El balde Diarra Koivogui Abdoulaye Camara Aly Samoura mamadou Bassirou Bah mamadou Aliou balde Alpha Kone Ibrahima Sory Sylla Souleymane Diakite Moussa Kourouma Kokoulo Koivogui Mariam Beavogui mamadou dadhi.balde Mamadi Conde Cardiology Service of Ignace Deen National Hospital Conakry Guinea Cardiology Department of DONKA National Hospital Conakry Guinea Military Health Service at the Battalion of the Headquarters Camp Almamy Samory TOURE Conakry Guinea

Introduction: Deep vein thrombosis is a frequent disease, its origin is most often multifactorial. Venous thromboembolic disease (MVTE) and cancer are two frequently entangled pathologies. Here we report the diagnosis of deep vein thrombosis that discovered prostate cancer in an 88-year-old Guinean man. On clinical examination, there was a painful and hot swelling of the right leg, an absence of sloshing of the calf, a positive sign of Homans. The digital rectal examination revealed an enlarged prostate with an irregular surface. Cardiopulmonary auscultation was normal. The electrocardiogram showed a regular sinus rhythm at 65 cycles/min, with no sign of enlarged cavities or conduction disturbance. Venous Doppler ultrasound of the lower limbs showed the presence of an extensive acute deep venous thrombosis of the right sural vein extended to the popliteal and to the homolateral deep femoral. The reino-vesico-prostatic ultrasound concluded in a heterogeneous prostatic hypertrophy with projection of a median lobe associated with a bladder of fight with an important post voiding residue evaluated at 170 ml;the rate of specific antigen of the prostate PSA was at 84.87 ng/ml. The pathology analysis made after a prostate biopsy puncture concluded with an adenocarcinoma with a Gleason score of 3. Conclusion: The association of venous thromboembolic disease (MVTE) and neoplasia is frequent. The existence of active cancer in a patient is a known risk factor for MVTE and, conversely, the discovery of a first episode of deep vein thrombosis (DVT) or pulmonary embolism (PE) may be the mode of revelation of cancer.

关键词： Deep Vein Thrombosis Prostate Cancer Elderly Conakry

Evaluation of Surgical Treatment of Distal Humeral Fractures in Adults

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Open Journal of Orthopedics 2024年第7期14卷 287-294页

作者： Abdoulaye Camara Karinka Kéita Mamady Doukouré Abdoul Karim baldé Léopold Lamah Fatoumata Camara Alpha mamadou Felah Diallo Ibrahima Marie Camara mamadou Madiou Diallo mamadou Cellou Diallo Donka University Hospital Center Conakry Republic of Guinea Ignace Deen University Hospital Center Conakry Republic of Guinea

Introduction: Fractures of the distal end of the humerus are becoming increasingly frequent in young subjects because of the increase in road traffic accidents, and in elderly subjects because of osteoporosis related to aging populations. Materials and Methods: It was a prospective, monocentric study from January 2018 to December 2020 involving 14 patients who received and were treated surgically for distal humeral fractures and followed up. Results: We collected 14 patients, including 11 men (78.57%) and 3 women (21.43%), with a sex ratio of 3.7. The mean age was 36.41 years. The circumstances of onset were dominated by road traffic accidents, with 12 cases (85.71%). The dominant side was right-handed, with 11 cases (78.57%). Standard elbow radiography revealed 8 cases of type A fractures (57.14%), 4 cases of type B and 2 cases of type C fractures of the AO. We performed Lecestre plate osteosynthesis in 12 patients and external fixator in 2 others, using the trans-olecranial and transtricipital approaches. Elbow stiffness was the most frequent complication, with 6 cases (42.86%). After six months’ follow-up, our results were excellent and good in 78.57% of cases (MEPS). Conclusion: Surgical treatment with posterior approaches enabled us to achieve restitution of the articular surfaces, solid restraint and early mobilization of the elbow with satisfactory functional results.

关键词： Fracture Distal Humerus Lecestre Plate External Fixator Trans-Olecranial Transtricipital

Cystic Breast Cancer. A Confusing Entity. Study of 8 Cases at Dakar University Surgical Oncology Unit

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Advances in Breast Cancer Research 2022年第1期11卷 69-74页

作者： Sidy Ka Mamour Gueye mamadou M. Dieng Salif baldé Samuel Kobinama Jaafar Thiam Ahmadou Dem Centre Hospitalier Universitaire Le Dantec Dakar Sénégal

Introduction: Cystic breast cancer is a rare entity. Breast cysts are most often benign. The clinical characteristics of malignancy are not specific. Objective: To report a series of malignant cystic tumors of the breast and to describe their different characteristics. Materials and Methods: This was an observational study carried out between January 2018 and October 2021 at the Dakar university surgical oncology unit. We studied the clinical appearance, imaging, histopathology, extent of disease and treatment. We did not include cases of pure, single, or multiple chronically progressive cysts. Results: There were 8 patients, 6 women and 2 men. The average age was 44. All patients presented with a palpable unilateral deforming skin mass without inflammatory character. One patient presented with a bloody discharge. The cyst was multilocular without intracystic growth in 2 cases and presented a growth signal in 6 cases. Imaging was ACR 3 in 5 cases and ACR 4 in 3 cases. Histopathology found 6 inva

Epidemiological, Clinical and Biological Characteristics of Patients with Chronic Hepatitis B Infection Followed-Up at the University Hospital of Conakry, Guinea

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Open Journal of Gastroenterology 2020年第10期10卷 256-265页

作者： Djenabou Diallo Kadiatou Diallo Alpha mamadou Diallo mamadou Mansour Diallo Thierno Amadou Wann Amadou Diouldé Doumbouya Ousmane Sow Youssouf baldé Alpha Amadou Sank Dillo Department of Internal Medicine University Hospital of Donka Conakry Guinea Department of Endocrinology Diabetes and Metabolic Diseases University Hospital of Donka Conakry Guinea

Introduction: Very little information is available in Guinea on chronic hepatitis B infections. The objective of this study was to describe the epidemiological, clinical and biological features of patients who are chronic carriers of the hepatitis B virus. Patients and Methods: This is a retrospective study carried out from January 2017 to May 2020, based on the medical records of patients seen via consultation or hospitalized with a record of positive HBs antigen for more than 6 months. Clinical and paraclinical data were collected and analyzed. Results: Seven hundred and sixteen patients with a mean age of 35.6 ± 12.2 (sex ratio 2.05), were included. The HBs antigen was discovered incidentally in 36% of cases (n = 258). A history of dental care and surgical procedures was found in 46.3% (n = 290) and 21.1% (n = 138) of cases, respectively. The median value of ALAT enzymes was 34 (21 - 47) IU/L. HBeAg was positive in 20.8% (n = 55/265) of cases. The median B viral load was 458.5 (87 - 3827) IU/ml and 29% (n = 94) of patients had a viral load over 2000 IU/ml. Anti-HCV antibody was present in 10.4 % of cases (n = 39/374). HIV serology was positive in 2.7% (n = 8/298). A total of 19.4% (n = 139) of the patients had cirrhosis and 4.5% (n = 32) had hepatocellular carcinoma. Conclusion:

Epidemiological, Clinical and Therapeutic Aspects of Arterial Hypertension at the General Medicine Department of Nzerekore Regional Hospital

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World Journal of Cardiovascular Diseases 2021年第11期11卷 533-538页

作者： Beavogui Mariama balde Elhadj Yaya Doumbouya Idrissa Barry Ibrahima Sory Samoura Aly Camara Abdoulaye Bah mamadou Bassirou Mariama Sylla Ibrahima Sory balde mamadou dadhi Bah Abdoul Mazid Mariama Kone Alpha balde mamadou Aliou Conde Mamady Cardiology Department Ignace Deen National Hospital Conakry Guinea Department of Neurology Ignace Deen National Hospital Conakry Guinea Cardiology Department Donka National Hospital Conakry Guinea

Introduction: High blood pressure is a public health problem in Guinea as well as everywhere in Africa. The objective of our study was to assess the epidemiological, clinical and therapeutic aspects of High blood pressure in the general medicine department of the Nzérékoré regional hospital. Methodology:This was a prospective study of a descriptive type, lasting 06 months, from July 1 to December 31, 2014. Results: We recorded 156 cases of High blood pressure among a total of 570 patients, for a hospital frequency of 27%. The 56 - 65 age group was the most affected, at 29.4%, with a predominance of men (sex ratio: 1.5). Alcoholism was the most common cardiovascular risk factor with a frequency of 51.2%, smoking and physical inactivity were found in 35.8% and 30.7% respectively;psychosocial stress was found in 24.3% of patients. The clinic was dominated by headache (100%) and dizziness (57.6%). All our patients were subjected to a healthy diet. Fixed dual therapy was the most widely used treatment regimen, i.e. 91 patients (58.3%) and included a diuretic in 37.1% of cases, a calcium channel blocker in 25% of cases and an ACE inhibitor in 24.3%. Conclusion: This study revealed a high frequency of hypertension in the general medicine department of the regional hospital of N’zérékoré.

关键词： Epidemiology Clinical Therapeutic Hypertension

Role of Nrf2 in chronic liver disease

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World Journal of Gastroenterology 2014年第36期20卷 13079-13087页

作者： Wei Tang Yong-Fang Jiang Murugavel Ponnusamy mamadou Diallo Liver Diseases Research Center The Second Xiangya Hospital Central South University Department of Medicine Rhode Island Hospital and Alpert Medical School of Brown University Providence RI 02903 United States Department of Immunology and Infectious Diseases Harvard School of Public Health Harvard UniversityBoston MA 02115-6018 United States

Nuclear erythroid 2-related factor 2(Nrf2) is a central regulator of antioxidative response elements-mediated gene expression. It has a significant role in adaptive responses to oxidative stress by interacting with the antioxidant response element, which induces the expression of a variety of downstream targets aimed at cytoprotection. Previous studies suggested oxidative stress and associated damage could represent a common link between different forms of diseases. Oxidative stress has been implicated in various liver diseases, including viral hepatitis, nonalcoholic fatty liver disease/steatohepatitis, alcoholic liver disease and drug-induced liver injury. Nrf2 activation is initiated by oxidative or electrophilic stress, and aids in the detoxification and elimination of potentially harmful exogenous chemicals and their metabolites. The expression of Nrf2 has been observed throughout human tissue, with high expression in detoxification organs, especially the liver. Thus, Nrf2 may serve as a major regulator of several cellular defense associated pathways by which hepatic cells combat oxidative stress. We review the relevant literature concerning the crucial role of Nrf2 and its signaling pathways against oxidative stress to protect hepatic cell from oxidative damage during development of common chronic liver diseases. We also review the use of Nrf2 as a therapeutic target to prevent and treat liver diseases.

关键词： Nuclear erythroid 2-related factor 2 Chronic liver disease Oxidative stress Reactive oxygen species Hepatic injury Hepatic protection

Photoassisted Ozonation of Red Cationic X-GRL Dyeing Wastewater Treatment

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Photoassisted Ozonation of Red Cationic X-GRL Dyeing Wastewa...

作者： DIALLO mamadou DA? 浙江大学

学位级别：硕士

学位论文的主要内容及创新点：印染(阳离子红X-GRL)废水的特点是高的色度，高pH值和有机污染物质集中，从而造成景观质量变差。世界印染工业的高速发展带动了对印染废水处理的研究。然而，众所周知，印染(阳离子红X-GRL)废水... 详细信息

学位论文的主要内容及创新点：印染(阳离子红X-GRL)废水的特点是高的色度，高pH值和有机污染物质集中，从而造成景观质量变差。世界印染工业的高速发展带动了对印染废水处理的研究。然而，众所周知，印染(阳离子红X-GRL)废水很难被传统的处理方式(比如物化和生化方法)处理。臭氧氧化方法将会有助于在染工业方面保护环境和重复使用水。应用臭氧处理，虽然有很多优点，但是对许多难降解有机物却很难做到完全去除!尽管鼓励将O和UV结合起来。在这篇论文中，我们研究了这个高级氧化技术，以期达到处理的最优化，。研究了反应条件的影响：温度，时间，pH，色度，CODcr，BOD和反应机理被调查。实验的结果显示，作为一种深度处理的方式，臭氧对废水的氧化、除色以及循环使用都是非常有效的。将UV和臭氧结合起来，结果表明是很有效的。研究了臭氧+UV对印染(阳离子红X-GRL)废水的氧化处理情况。在相同的实验条件下，将这些系统的氧化产物和产量与臭氧氧化的产物和产量进行比较。臭氧氧化使得COD降解速度提高(在pH3下)。臭氧+UV体系对COD和BOD的降解都有很大的提高，这说明它是最好的氧化方式。无论是什么废水，氧化体系(脱色)与臭氧氧化本身比较。不同的动力学叁数也决定到对於被应用的氧化系统的废水反应度的量。 C，O=30mg/L，kobs=9743,66exp(-32610／RT)[HO]0.023(S) C，O=50mg／L，kobs=5024,53exp(-32610／RT)[HO]0.023(S) C，O=80mg／L kobs=3687.01exp(-32610／RT)[HO)0.023(S)

关键词：染料臭氧氧化废水处理技术研究阳离子红X-GRL 脱色反应动力学和反应机制涂颜色

Cardiac Amyloidosis: A Case Report of Seven Patients

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World Journal of Cardiovascular Diseases 2022年第3期12卷 160-167页

作者： Ngardjibem Djita Ibrahima Sory2 Sylla Aissatou Barry Murielle Ahodakin Djibril Sylla Elhadj Yaya balde mamadou Bachir Bah Houzeiph Abdou Lassissi Alpha Kone Sana Soumra mamadou Aliou balde Mariame Beavogui mamadou dadhi.balde Noura Feniche Cardiology Department Alen&#231 on-Mamers Intercommunal Hospital Alen&#231 on France Gamal Abdel Nasser University of Conakry Conakry Republic of Guinea

Introduction: Cardiac amyloidosis is a rare and under-diagnosed disease. The objective of this study was to collect cases of cardiac amyloidosis in patients hospitalized in the cardiology department of the Centre Hospitalier Intercommunal Alençon-Mamers (CHICAM). Patients and Methods: This was a retrospective descriptive study of the records of patients diagnosed with cardiac amyloidosis. The study took place in the cardiology department of the CHICAM over 12 months (from January 1, 2020 to December 31, 2020). We included the files of patients in whom the diagnosis of cardiac amyloidosis was confirmed on the basis of clinical, echocardiographic, biological, scintigraphic and cardiac MRI evidence. Results: Seven patients were included. The mean age was 86.71 years. Six men for one woman. Most of the patients were in heart failure. There was one case of periorbital ecchymosis. Troponinemia was increased in three patients, NTproBNP was always high with a mean of 1000 ng/L. Cardiac echography showed a hyperbright septum in four cases, concentric hypertrophy of the left ventricle with a mean interventricular septum in diastole of 13.85 mm. Six cases were senile transthyretin amyloidosis (TTR), one case was mutated transthyretin amyloidosis (TTRm). Two cases of death were noted. Conclusion: Cardiac amyloidosis has a poor prognosis due to delayed diagnosis.

关键词： Cardiac Amyloidosis Echocardiography Heart Failure Myocardial Scintigraphy