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The Impact of Discount Rate and Price on Intertemporal Groundwater Models in Southwest k.nsas

Journal of Water Resource and Protection 2017年第7期9卷 745-759页

作者： mallory k. vestal Bridget L. Guerrero Bill B. Golden Logan D. Hark.y Department of Agricultural Sciences West Texas A&M University Canyon TX USA Department of Agricultural Economics Kansas State University Manhattan KS USA

Agriculture plays a vital role in the growth and development of the High Plains Region of the United States. With the development and adoption of irrigation technology, this region was transformed into one of the most agriculturally productive regions in the world [1]. The primary source of irrigation in this region is the Ogallala Aquifer. Currently, water from the aquifer is being used at a much faster rate than natural recharge can occur, resulting in a high rate of depletion from this finite resource. Depletion of scarce water resources will have a significant economic impact on the long-term sustainability of the region. The objective of this study is to evaluate the impact alternative prices and discount rates have on groundwater policy recommendations. Deterministic models of groundwater withdrawals were developed and used in order to analyze and evaluate the impact of high, average, and low crop prices in a status quo scenario as well as a policy scenario reducing irrigated acreage allocation. Furthermore, this study analyzes the effects and associated consequences of alternative discount rates on net and total revenue. As indicated by results of this study, alternative prices, costs, and discount rates utilized in a model have an effect on policy effectiveness.

关键词： Acreage Reduction Discount Rate Irrigation Ogallala Aquifer Water Policy

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hGBP-1 Expression Predicts Shorter Progression-Free Survival in Ovarian Cancers, While Contributing to Paclitaxel Resistance

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Journal of Cancer Therapy 2016年第13期7卷 994-1007页

作者： Suzan Wadi Aaron R. Tipton Jill A. Trendel Sadik.A. k.uder Deborah J. vestal Department of Biological Sciences University of Toledo Toledo OH USA Department of Medicine University of Toledo Toledo OH USA

Ovarian cancer is the gynecological cancer with the poorest prognosis. One significant reason is the development of resistance to the chemotherapeutic drugs used in its treatment. The large GTPase, hGBP-1, has been implicated in paclitaxel resistance in ovarian cell lines. Forced expression of hGBP-1 in Sk.V3 ovarian cancer cells protects them from paclitaxel-induced cell death. However, prior to this study, nothing was k.own about whether hGBP-1 was expressed in ovarian tumors and whether its expression correlated with paclitaxel resistance. hGBP-1 is expressed in 17% of ovarian tumors from patients that have not yet received treatment. However, at least 80% of the ovarian tumors that recurred after therapies that included a taxane, either paclitaxel or docetaxel, were positive for hGBP-1. In addition, hGBP-1 expression predicts a significantly shorter progression-free survival in ovarian cancers. Based on these studies, hGBP-1 could prove to be a potential biomark.r for paclitaxel resistance in ovarian cancer.

关键词： Guanylate-Binding Protein Paclitaxel Ovarian Cancer Drug Resistance GTPase TUBB3

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hGBP- - 1 Expression Predicts Shorter Progression- - Free Survival in Ovarian Cancers,While Contributing to Paclitaxel Resistance

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Journal of Cancer Therapy（癌症治疗） 2016年第13期

作者： SuzanWadi AaronR.Tipton JillA.Trendel Sadik..k.uder DeborahJ.vestal

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