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Proteome-wide screening for the analysis of protein targeting of Chlamydia pneumoniae in endoplasmic reticulum of host cells and their possible implication in lung cancer development

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BIOCELL 2022年第1期46卷 87-95页

作者： YANYAN LI SHAHANAVAJ KHAN ANIS AHMAD CHAUDHARY HASSAN AHMED RUDAYNI abdul malik ASHWAG SHAMI Department of Oncology Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhou450007China Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadh11451Saudi Arabia Department of Biosciences Shri Ram Group of College(SRGC)Muzaffarnagar251001India Department of Health Sciences Novel Global Community Educational FoundationSydneyAustralia Department of Biology College of ScienceImam Mohammad Ibn Saud Islamic University(IMSUI)Riyadh11623Saudi Arabia Department of Biology College of SciencesPrincess Nourah bint Abdulrahman UniversityRiyadh11617Saudi Arabia

Available reports have confirmed a link between bacterial infection and the progression of different types of cancers,including colon,lungs,and prostate *** we report the Chlamydia pneumonia proteins targeting in endoplasmic reticulum(ER)using in-silico approaches and their possible role in lung cancer *** predicted 48 proteins that target human ER,which may be associated with protein folding and protein-protein interactions during *** results showed *** proteins targeting human ER and their implications in lung cancer *** targeted proteins may be involved in competitive interactions between host and bacterial proteins,which may change the usual pathway functions and trigger the development of lung ***,*** unfolded protein accumulation in the human ER possibly induces ER stress,consequently activating the unfolded protein response(UPR),and providing a favorable microenvironment for cancer *** current study showed the *** protein targeting in ER of host cell and their implication in lung cancer *** results may help researchers better manage lung cancer and establish a molecular mechanism for *** lung cancer association.

关键词： Bacterial infection C.pneumoniae Proteomes ER Lung cancer

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Technologies Behind the Smart Grid and Internet of Things: A System Survey

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Computers, Materials & Continua 2023年第6期75卷 5049-5072页

作者： Kuldeep Sharma Arun malik Isha Batra A.S.M.Sanwar Hosen Md abdul Latif Sarker Dong Seog Han Department of Computer Science and Engineering Lovely Professional UniversityPunjabIndia Department of Artificial Intelligence and Big Data Woosong UniversityDaejeon34606Korea Center for ICT&Automotive Convergence Kyungpook National UniversityDaegu41566Korea School of Electronics Engineering Kyungpook National UniversityDaegu41566Korea

Electric smart grids enable a bidirectional flow of electricity and information among power system *** proper monitoring and con-trolling of power quality,reliability,scalability and flexibility,there is a need for an environmentally friendly system that is transparent,sustainable,cost-saving,energy-efficient,agile and *** paper provides an overview of the emerging technologies behind smart grids and the internet of *** dependent variables are identified by analyzing the electricity consumption patterns for optimal utilization and planning preventive maintenance of their legacy assets like power distribution transformers with real-time parameters to ensure an uninterrupted and reliable power *** addition,the paper sorts out challenges in the traditional or legacy electricity grid,power generation,transmission,distribution,and revenue management challenges such as reduc-ing aggregate technical and commercial loss by reforming the existing manual or semi-automatic techniques to fully smart or automatic *** article represents a concise review of research works in creating components of the smart grid like smart metering infrastructure for postpaid as well as in prepaid mode,internal structure comparison of advanced metering methods in present scenarios,and communication systems.

关键词： Electricity consumption bidirectional advanced meter infrastructure energy internet of things smart grid smart meter

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Cluster-Based Group Mobility Support for Smart IoT

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Computers, Materials & Continua 2021年第8期68卷 2329-2347页

作者： Kanwal Imran Nasreen Anjum Saeed Mahfooz Muhammad Zubair Zhahoui Yang abdul Haseeb malik Qazi Ejaz Ali Madeeha Aman Department of Computer Science University of PeshawarPeshawar25121Pakistan Department of Computer Science Khushal Khan Khattak UniversityKarak27200Pakistan Department of Informatics King’s College LondonUK

IPv6 over Low Power Wireless Personal Area Network(6LoWPAN)connects the highly constrained sensor nodes with the internet using the IPv6 protocol.6LoWPAN has improved the scalability of the Internet of Things(IoTs)infrastructure and allows mobile nodes to send packets over the IEEE 802.15.4 wireless *** mobility managements schemes have been suggested for handling the registration and handover procedures in ***,these schemes have performance constraints,such as increased transmission cost,signalling overhead,registration,and handover *** address these issues,we propose a novel cluster-based group mobility scheme(CGM6)for *** reduce the signalling cost in the CGM6 scheme,we propose to combine the functions of the Authentication,Authorization and Accounting(AAA)server and Local Mobility Anchor(LMA)in AMAG6(AAA+MAG for 6LoWPAN).AMAG6 acts as a cluster head and exchange its information directly with its neighbouring AMAG6 during the ***,AMAG6 is responsible for the binding and authentication *** reduce the transmission cost,we also propose enhancements in registration and Handover *** performance of CGM6 is evaluated through extensive *** simulation results show that CGM6 has reduced the handoff latency by 32%,registration delay by 11%and transmission cost by 37%compared to the state-of-the-art mobility management schemes.

关键词： 6LoWPAN IoTs mobility management registration handover proxyMIPv6(PMIPv6)

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Mesuaferrea stem bark extract induces apoptosis and inhibits metastasis in human colorectal carcinoma HCT 116 cells, through modulation of multiple cell signalling pathways

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Chinese Journal of Natural Medicines 2017年第7期15卷 505-514页

作者： Muhammad Asif Armaghan Shafaei Aman Shah abdul Majid Mohammed Oday Ezzat Saad S Dahham Mohamed B.Khadeer Ahamed Chern Ein Oon Amin malik Shah abdul Majid EMAN Testing and Research Laboratory Department of Pharmacology School of Pharmaceutical Sciences Universiti Sains Malaysia Penang 11800 Malaysia Department of Pharmaceutical Chemistry School of Pharmaceutical Sciences Universiti Sains Malaysia Penang 11800 Malaysia Department of Pharmacology School of Medical Sciences Quest International University Perak Malaysia Centre for Drug Research Universiti Sains Malaysia Penang 11800 Malaysia Institute for Research in Molecular Medicine (INFORMM) Universiti Sains Malaysia Penang 11800 Malaysia

Considering the great potential of natural products as anticancer agents, the present study was designed to explore the molecular mechanisms responsible for anticancer activities of Mesua ferrea stem bark extract against human colorectal carcinoma. Based on MTT assay results, bioactive sub-fraction(SF-3) was selected for further studies using HCT 116 cells. Repeated column chromatography resulted in isolation of less active α-amyrin from SF-3, which was identified and characterized by GC-MS and HPLC methods. α-amyrin and betulinic acid contents of SF-3 were measured by HPLC methods. Fluorescent assays revealed characteristic apoptotic features, including cell shrinkage, nuclear condensation, and marked decrease in mitochondrial membrane potential in SF-3 treated cells. In addition, increased levels of caspases-9 and-3/7 levels were also observed in SF-3 treated cells. SF-3 showed promising antimetastatic properties in multiple in vitro assays. Multi-pathway analysis revealed significant down-regulation of WNT, HIF-1α, and EGFR with simultaneous up-regulation of p53, Myc/Max, and TGF-β signalling pathways in SF-3 treated cells. In addition, promising growth inhibitory effects were observed in SF-3 treated HCT 116 tumour spheroids, which give a hint about in vivo antitumor efficacy of SF-3 phytoconstituents. In conclusion, these results demonstrated that anticancer effects of SF-3 towards colon cancer are through modulation of multiple molecular pathways.

关键词： Mesua ferrea a-Amyrin Apoptotic Antimetastatic Molecular pathways

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Convergence Track Based Adaptive Differential Evolution Algorithm(CTbADE)

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Computers, Materials & Continua 2022年第7期72卷 1229-1250页

作者： Qamar Abbas Khalid Mahmood malik abdul Khader Jilani Saudagar Muhammad Badruddin Khan Mozaherul Hoque Abul Hasanat abdullah AlTameem Mohammed AlKhathami Department of Computer Science and Software Engineering International Islamic UniversityIslamabad44000Pakistan Department of Computer Science and Engineering Oakland UniversityRochesterMIUSA Information Systems Department College of Computer and Information SciencesImam Mohammad Ibn Saud Islamic University(IMSIU)RiyadhSaudi Arabia

One of the challenging problems with evolutionary computing algorithms is to maintain the balance between exploration and exploitation capability in order to search global optima.A novel convergence track based adaptive differential evolution(CTbADE)algorithm is presented in this research *** crossover rate and mutation probability parameters in a differential evolution algorithm have a significant role in searching global optima.A more diverse population improves the global searching capability and helps to escape from the local optima *** the convergence path over time helps enhance the searching speed of a differential evolution algorithm for varying *** adaptive powerful parameter-controlled sequences utilized learning period-based memory and following convergence track over time are introduced in this *** proposed algorithm will be helpful in maintaining the equilibrium between an algorithm’s exploration and exploitation capability.A comprehensive test suite of standard benchmark problems with different natures,i.e.,unimodal/multimodal and separable/non-separable,was used to test the convergence power of the proposed CTbADE *** results show the significant performance of the CTbADE algorithm in terms of average fitness,solution quality,and convergence speed when compared with standard differential evolution algorithms and a few other commonly used state-of-the-art algorithms,such as jDE,CoDE,and EPSDE *** algorithm will prove to be a significant addition to the literature in order to solve real time problems and to optimize computationalmodels with a high number of parameters to adjust during the problem-solving process.

关键词： Differential evolution function optimization convergence track parameter sequence adaptive control parameters

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溶胶-凝胶法制备用于分离极性有机化合物的毛细管气相色谱柱

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色谱 2002年第3期20卷 279-282页

作者：王东新 malik abdul 南京师范大学化学与环境科学学院江苏南京210097 Department of Chemistry University of South Florida

采用溶胶凝胶法制备了用于分离有机极性化合物的毛细管气相色谱柱 ,其制备工艺简单 ,制柱时间较传统工艺大为缩短。该柱涂层与毛细管内壁间形成的化学键使得其热稳定性好。游离的脂肪酸、有机碱可直接在该柱上得到很好的分离 ,其他极... 详细信息

采用溶胶凝胶法制备了用于分离有机极性化合物的毛细管气相色谱柱 ,其制备工艺简单 ,制柱时间较传统工艺大为缩短。该柱涂层与毛细管内壁间形成的化学键使得其热稳定性好。游离的脂肪酸、有机碱可直接在该柱上得到很好的分离 ,其他极性化合物也在该柱上得到极好的分离。该类色谱柱不仅在同一色谱柱上显示了良好的分离重复性 ,而且不同柱间在容量因子、柱效。

关键词：分离极性有机化合物溶胶-凝胶法毛细管气相色谱柱制备游离脂肪酸胺

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聚二甲基硅氧烷溶胶凝胶气相色谱毛细管柱与传统毛细管柱的柱容量比较

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色谱 2002年第6期20卷 534-536页

作者：王东新 malik abdul 南京师范大学化学与环境科学学院江苏南京210097 Department of Chemistry University of South Florida

将十一烷和荧蒽分别注入溶胶凝胶法涂渍的聚二甲基硅氧烷气相色谱毛细管柱和传统的聚二甲基硅氧烷毛细管柱并测量柱效率。在注射量增加到一定程度以后,柱效率迅速下降。能引起柱效率下降10%的注射量称之为柱容量。实验结果表明溶胶凝... 详细信息

将十一烷和荧蒽分别注入溶胶凝胶法涂渍的聚二甲基硅氧烷气相色谱毛细管柱和传统的聚二甲基硅氧烷毛细管柱并测量柱效率。在注射量增加到一定程度以后,柱效率迅速下降。能引起柱效率下降10%的注射量称之为柱容量。实验结果表明溶胶凝胶聚二甲基硅氧烷柱的柱容量远高于传统聚二甲基硅氧烷柱的柱容量。对溶胶凝胶聚二甲基硅氧烷柱有较高柱容量的原因进行了探讨。

关键词：聚二甲基硅氧烷毛细管柱气相色谱溶胶-凝胶柱容量十一烷荧蒽分离

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Calcium supplementation in colorectal cancer prevention:A systematic meta-analysis of adverse events

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BIOCELL 2022年第3期46卷 759-767页

作者： XUE MEI LUO SHAHANAVAJ KHAN abdul malik FAHAD M.ALDAKHEEL ANIS AHMAD CHAUDHARY SHOUKI BAZARBASHI FATEMEH TABATABAIE Department of General Surgery Mianzhu People’s Hospital of SichuanMianzhuChina Department of Pharmaceutics College of PharmacyKing Saud UniversityRiyadhSaudi Arabia Department of Biosciences Shri Ram Group of College(SRGC)MuzaffarnagarIndia Department of Health Sciences Novel Global Community Educational FoundationSydneyAustralia Department of Clinical Laboratory Sciences College of Applied Medical SciencesKing Saud UniversityRiyadhSaudi Arabia Department of Biology College of ScienceImam Mohammad Ibn Saud Islamic University(IMSUI)RiyadhSaudi Arabia Oncology Center King Faisal Specialist Hospital and Research CenterRiyadhSaudi Arabia Shiraz University of Medical Sciences ShirazIran

Despite the multiple systematic reviews and meta-analyses accumulating evidence on the preventive effect of calcium supplementation for colorectal cancer,most of the associated adverse effects are not systematically *** aim of the study is evaluating adverse events associated with calcium supplementation for colorectal cancer prevention through a systematic *** searched Medline,PubMed Central,EMBASE(Excerpta Medica database),Scopus,Cochrane Central Register of Controlled Trials,and Web of Science published in English from database inception up to 31 July *** the current systematic meta-analysis,we included human studies(including cohort studies,clinical trials,case-control studies)on supplementation of calcium in patients with or at risk of colorectal *** of the quality of included studies was performed by Jadad *** on the patient population,number of enrolled subjects in each group,dose of calcium supplementation,duration of calcium supplementation,and reported adverse events were *** data were pooled for incidence rates for any adverse event during the study period regardless of causality *** identified 6 studies,comprising 4583 participants that met the inclusion ***-analysis on pooled incidence rates for adverse event during study period showed no statistically significant increased risk for cancer(OR=0.92,95%CI:0.70–1.21,P=0.577;I^(2)=0.0%,P=0.731),coronary revascularization(OR=1.12,95%CI:0.79–1.59,P=0.492;I^(2)=0.0%,P=0.957),myocardial infarction(OR=0.81,95%CI:0.34–1.91,P=0.634;I^(2)=67.9%,P=0.047),stroke(OR=0.75,95%CI:0.42–1.33,P=0.332,I^(2)=0.00%,P=0.717),Transient Ischemic Attack(TIA)(OR=1.37,95%CI:0.28–6.51,P=0.692,I^(2)=81.9%,P=0.002),urolithiasis(OR=1.23,95%CI:0.75–2.01,P=0.410;I^(2)=0.0%,P=0.851),fracture(OR=0.98,95%CI:0.70–1.37,P=0.938;I^(2)=37.8%,P=0.152)and death(OR=1.05,95%CI:0.71–1.56,P=0.786,I^(2)=12.2%,P=0.317)in patients receiving calcium supplementation for colo

关键词： Colorectal cancer Calcium Supplement Adverse event Systematic reviewed Meta-analysis

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不同浓度和温度时无机盐和尿素对抗抑郁剂药物丙咪嗪盐酸盐的胶束化行为的影响(英文)

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物理化学学报 2012年第4期28卷 885-891页

作者： KABIR-UD-DIN RUB malik abdul NAQVI Andleeb Z. Department of Chemistry Aligarh Muslim UniversityAligarh 202002India

In the present study we report the micellization behavior of imipramine hydrochloride(IMP)in absence and presence of different concentrations of inorganic salts(LiCl,NaF,NaCl,NaBr,and KCl)and ureas(urea and thiourea)over the temperature range from 288.15 to 303.15 *** critical micellization concentrations(cmc)of drug and drug+additive systems were determined by conductometric technique. With increasing temperature the cmc first increases then *** cmc values were obtained at 293.15 K with or without *** presence of inorganic salts the cmc value decreases which is explained on the basis of nature and ion size of the added *** and thiourea also decrease the cmc at low concentrations(0.2 mmo·lL -1 urea and 0.1 mmo·lL -1 thiourea),but,at higher concentrations,increase in cmc is *** related thermodynamic parameters are also evaluated and discussed.

关键词：摘要编辑部编辑工作读者

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Interaction of cetyltrimethylammonium bromide with drug in aqueous/electrolyte solution:A combined conductometric and molecular dynamics method study

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Chinese Journal of Chemical Engineering 2018年第1期26卷 159-167页

作者： Md.Anamul Hoque Md.Masud Alam Mohammad Robel Molla Shahed Rana malik abdul Rub Mohammad A.Halim Mohammed abdullah Khan Farida Akhtar Department of Chemistry Jahangirnagar UniversitySavarDhaka 1342Bangladesh Chemistry Department Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Center of Excellence for Advanced Materials Research King Abdulaziz UniversityJeddah 21589Saudi Arabia Division of Quantum Chemistry BICCBThe Red-Green Computing Centre218 Elephant RoadDhaka 1205Bangladesh Institut Lumière Matière Université Lyon 1-CNRSUniversitéde Lyon69622 Villeurbanne CedexFrance

Interaction between beta-lactum antibiotic drug ciprofloxacin hydrochloride(CFH)and cationic surfactant cetyltrimethylammonium bromide(CTAB)was performed conductometrically in aqueous as well as in the occurrence of different salts(NaCl,KCl as well as NH_4Cl)over the temperature range of 298.15–323.15 K at the regular interval of 5 *** drug has been suggested for the treatment of bacterial infections such as urinary tract infections and acute sinusitis.A clear critical micelle concentration(CMC)was obtained for pure CTAB as well as(CFH+CTAB)mixed *** decrease in CMC values of CTAB caused by the addition of CFH reveals the existence of the interaction between the components and therefore it is the indication of micelle formation at lower concentration of CTAB and their CMC values further decrease in attendance of salts.A nonlinear behavior in the CMC versus T plot was observed in all the *** ΔG_m^0 values are found to be negative in present study systems demonstrated the stability of the *** values of ΔH_m^0 and ΔS_m^0 reveal the existence of hydrophobic and electrostatic interactions between CFH and *** thermodynamic properties of transfer for the micellization were also evaluated and discussed in *** dynamic simulation disclosed that environment of water and salts have impact on the hydrophobic interaction between CFH and *** water and salts,CTAB adopts spherical micelle in which charged hydrophilic groups are interacted with waters whereas hydrophobic tails form the core of the *** hydrophobic core region is highly conserved and *** addition,micelle formation is more favorable in aqueous Na Cl solution than other solutions.

关键词： Ciprofloxacin hydrochloride Cetyltrimethylammonium bromide Molecular dynamics Flydrophobic interaction Salt effect

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