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Influence of ellagic acid on prostate cancer cell proliferation:A caspase-dependent pathway

Asian Pacific Journal of Tropical Medicine 2011年第7期4卷 550-555页

作者： Arshi malik Sarah Afaq Mohammad Shahid Kafil Akhtar Abdullah Assiri Department of Clinical Biochemistry College of MedicineKing Khalid UniversityAbhaKingdom of Saudi Arabia Department of Microbiology Jawaharlal Nehru Medical CollegeAligarh Muslim UniversityAligarhIndia Department of Pathology Jawaharlal Nehru Medical CollegeAligarh Muslim UniversityAligarhIndia Interventional Cardiologist College of MedicineKing Khalid UniversityAbhaKingdom of Saudi Arabia

Objective:To evaluate the effect of allagic acid treatment on the cell viability of human prostate cancer ***:Ellagic acid(10-100 mol/L) treatment(48 h) of human prostate carcinoma PC3 cells was found to result in a dose-dependent inhibition of cell growth and apoptosis of PC3 cells as assessed by MTT assay,western *** cytometry and confocal ***:We observed that ellagic acid treatment of PC3 cells resulted in a dose dependent inhibition of cell growth/cell *** ellagic acid caused cell growth inhibition was found to be accompanied by induction of apoptosis,as assessed by the cleavage of poly (ADP-ribose) polymerase(PARP) and morphological ***,induction of apoptosis accompanied a decrease in the levels of antiapoptotic protein Bcl-2 and increase in proapoptotic protein *** shifting the Bax:Bcl-2 ratio in favor of *** acid treatment of PC3 cells was also found to result in significant activation of caspases,as shown by the dose dependent decrease in the protein expression of procaspase-3,-6.-8 and -*** ellagic acid-mediated induction of apoptosis was significantly(80%-90%) inhibited by the caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone(Z-VAD-FMK).Thus these data suggested an essential role of caspases in ellagic acid-mediated apoptosis of PC3 ***:It is tempting to suggest that consumption of tropical pigmented fruits and vegetables could be an effective strategy to combat prostate cancer.

关键词： Ellagic acid Apoptosis Prostate cancer Caspases

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Phytopharmacological potential of different species of Morus alba and their bioactive phytochemicals:A review

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Asian Pacific Journal of Tropical Biomedicine 2017年第10期7卷 950-956页

作者： Fahad Hussain Zohaib Rana Hassan Shafique Arif malik Zahid Hussain Institute of Molecular Biology and Biotechnology(IMBB) The University of LahoreRaiwind Road55150LahorePakistan Department of Pharmaceutics Faculty of PharmacyUniversiti Teknologi MARAPuncak Alam CampusBandar Puncak Alam42300SelangorMalaysia

Medicinal plants of Moraceae family have been well-recognized traditionally due to their versatile applications in various fields including agriculture, cosmetic and food as well as in pharmaceutical industries. Their biomedical and medicinal importance is reflected from their broad range of pharmacological activities for treatment of various inflammatory conditions, cancer, infectious diseases, and gastrointestinal disorders. The present review was aimed to summarize and critically discuss the biomedical implications of Morus species, their bioactive compounds, and phytochemicals. Bioactivity guided fractionation of these medicinal plants revealed that different types of bioactive phytochemicals and secondary metabolites such as steroids, saponins, alkaloids, glycosides and phenolic compounds including terpenoids, flavonoids, anthocyanins and tannins were present. The critical analysis of the literature revealed that the aqueous, methanolic, and ethanolic extracts of Morus species and their bioactive compounds exhibit remarkable anti-oxidative,anti-diabetic, anti-stress, nephroprotective, antimicrobial, anti-mutagenic, anticancer,anxiolytic, hepatoprotective, anthelmintic, antimicrobial, immune-modulatory and cholesterol lowering effects. Based on the literature review and bioactivity guided investigation of Morus species and their phytomedicinal effects, we anticipate that these herbal products hold excellent potential for future research.

关键词： Moraceae Phytochemicals Pharmacological activities Anti-inflammatory Immunomodulatory Anticancer

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Nanoscale control of low-dimensional spin structures in manganites

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Chinese Physics B 2016年第6期25卷 45-52页

作者：王静 Iftikhar Ahmed malik 梁仁荣黄文郑仁奎张金星 Department of Physics Beijing Normal University Beijing 100875 China Tsinghua National Laboratory for Information Science and Technology Institute of Microelectronics Tsinghua University Beijing 100084 China School of Microelectronics and Solid-State Electronics University of Electronic Science and Technology of China Chengdu 611731 China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China

Due to the upcoming demands of next-generation electronic/magnetoelectronic devices with low-energy consumption,emerging correlated materials（such as superconductors,topological insulators and manganites） are one of the highly promising candidates for the *** the past decades,manganites have attracted great interest due to the colossal magnetoresistance effect,charge-spin-orbital ordering,and electronic phase ***,the incapable of deterministic control of those emerging low-dimensional spin structures at ambient condition restrict their possible ***,the understanding and control of the dynamic behaviors of spin order parameters at nanoscale in manganites under external stimuli with low energy consumption,especially at room temperature is highly *** this review,we collected recent major progresses of nanoscale control of spin structures in manganites at low dimension,especially focusing on the control of their phase boundaries,domain walls as well as the topological spin structures（e.g.,skyrmions）.In addition,capacitor-based prototype spintronic devices are proposed by taking advantage of the above control methods in *** capacitor-based structure may provide a new platform for the design of future spintronic devices with low-energy consumption.

关键词： manganites spin structures nanoscale phase boundary domain wall skyrmion spintronic device capacitor

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A Color Image Encryption Scheme Based on Singular Values and Chaos

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Computer Modeling in Engineering & Sciences 2023年第10期137卷 965-999页

作者： Adnan malik Muhammad Ali Faisal S.Alsubaei Nisar Ahmed Harish Kumar Electrical Engineering Department University of Engineering and TechnologyLahore54000Pakistan Department of Cybersecurity College of Computer Science and EngineeringUniversity of JeddahJeddah21959Saudi Arabia Computer Engineering Department University of Engineering and TechnologyLahore54000Pakistan Department of Computer Science College of Computer ScienceKing Khalid UniversityAbha61421Saudi Arabia

The security of digital images transmitted via the Internet or other public media is of the utmost *** encryption is a method of keeping an image secure while it travels across a non-secure communication medium where it could be intercepted by unauthorized *** study provides an approach to color image encryption that could find practical use in various *** proposed method,which combines four chaotic systems,employs singular value decomposition and a chaotic sequence,making it both secure and *** unified average change intensity,the number of pixels’change rate,information entropy analysis,correlation coefficient analysis,compression friendliness,and security against brute force,statistical analysis and differential attacks are all used to evaluate the algorithm’s *** a thorough investigation of the experimental data,it is concluded that the proposed image encryption approach is secure against a wide range of attacks and provides superior compression friendliness when compared to chaos-based alternatives.

关键词： Encryption image encryption chaos theory color image encryption singular value decomposition compression friendliness

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Optimizing Fully Convolutional Encoder-Decoder Network for Segmentation of Diabetic Eye Disease

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Computers, Materials & Continua 2023年第11期77卷 2481-2504页

作者： Abdul Qadir Khan Guangmin Sun Yu Li Anas Bilal malik Abdul Manan Faculty of Information Technology Beijing University of TechnologyBeijing100124China College of Information Science Technology Hainan Normal UniversityHaikou571158China

In the emerging field of image segmentation,Fully Convolutional Networks(FCNs)have recently become ***,their effectiveness is intimately linked with the correct selection and fine-tuning of hyperparameters,which can often be a cumbersome manual *** main aim of this study is to propose a more efficient,less labour-intensive approach to hyperparameter optimization in FCNs for segmenting fundus *** this end,our research introduces a hyperparameter-optimized Fully Convolutional Encoder-Decoder Network(FCEDN).The optimization is handled by a novel Genetic Grey Wolf Optimization(G-GWO)*** algorithm employs the Genetic Algorithm(GA)to generate a diverse set of initial *** leverages Grey Wolf Optimization(GWO)to fine-tune these positions within the discrete search *** on the Indian Diabetic Retinopathy Image Dataset(IDRiD),Diabetic Retinopathy,Hypertension,Age-related macular degeneration and Glacuoma ImageS(DR-HAGIS),and Ocular Disease Intelligent Recognition(ODIR)datasets showed that the G-GWO method outperformed four other variants of GWO,GA,and PSO-based hyperparameter optimization *** proposed model achieved impressive segmentation results,with accuracy rates of 98.5%for IDRiD,98.7%for DR-HAGIS,and 98.4%,98.8%,and 98.5%for different sub-datasets within *** results suggest that the proposed hyperparameter-optimized FCEDN model,driven by the G-GWO algorithm,is more efficient than recent deep-learning models for image segmentation *** thereby presents the potential for increased automation and accuracy in the segmentation of fundus images,mitigating the need for extensive manual hyperparameter adjustments.

关键词： Diabetic eye disease image segmentation deep learning artificial intelligence grey wolf optimization FCN CNN

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Investigation on solidified/stabilized behavior of marine soil slurry by lime-activated incinerated sewage sludge ash-ground granulated blast furnace slag under multifactor conditions

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JOURNAL OF ROCK MECHANICS AND GEOTECHNICAL ENGINEERING 2024年第12期16卷 5264-5277页

作者： Sun, Zhao Chen, Wenbo Zhao, Rundong malik, Numan Yin, Jianhua Chen, Yonggui Hong Kong Polytech Univ Dept Civil & Environm Engn Kowloon Hong Kong 999077 Peoples R China Tongji Univ Sch Civil Engn Dept Geotech Engn Shanghai 200092 Peoples R China Shenzhen Univ Coll Civil & Transportat Engn Shenzhen 518071 Peoples R China

This study aims to evaluate the possibility of reusing treated marine clayey soils by stabilization/solidification (S/S) technology as geomaterial in reclamation projects from the aspects of engineering strength, chemical modification and environmental risk assessment. The lime-activated incinerated sewage sludge ash (ISSA) together with ground granulated blast furnace slag (GGBS) was employed as the binder. The multi-controlling factors including water content, curing time, salinity, and chemical compositions of mixing solution were taken into account to identify the S/S treated Hong Kong marine deposit (HKMD) slurry based on the strength tests, pH measurement, thermo-gravimetric (TG) analysis, X-ray diffractometer (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy coupled with energy-dispersive spectrometry (SEM-EDS) and toxicity characteristic leaching procedure (TCLP) tests, etc. The results show that the S/S treatment using lime-activated ISSA-GGBS can effectively enhance the strength of marine soil at the initial water content of 110% and 200%. The water content and curing time have a significant impact on the S/S treated HKMD. The pH of treated soils is higher than 11.1, which proves an alkaline environment for the reactions in the treated soil. A special case is the treated HKMD at 200% water content hydrated by MgCl2 solution, which has a low pH of 10.23 and maintains a slurry state. Based on the TCLP results, the leaching concentration of heavy metals from S/S treated HKMD is environmentally safe and meets Hong Kong standard for reusing treated soil with a low level of <0.2 mg/L. The content of main products such as calcium/magnesium silicate hydrate, ettringite or Friedel's salt depends on the chemical additions (e.g. distilled water, seawater, NaCl and Na2SO4). The products in the specimens mixed with MgCl2 solutions are mainly composed of Mg(OH)(2), M-S-H and MgCO3, which is distinct with the neoformations in the other c

关键词： Hong Kong marine deposits Stabilization/solidification Engineering strength Physicochemical property Environmental risk assessment

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Assessment of alpine summit flora in Kashmir Himalaya and its implications for long-term monitoring of climate change impacts

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Journal of Mountain Science 2020年第8期17卷 1974-1988页

作者： Maroof HAMID Anzar Ahmad KHUROO Akhtar Hussain malik Rameez AHMAD Chandra Prakash SINGH Centre for Biodiversity&Taxonomy Department of BotanyUniversity of KashmirSrinagar-190006J&KIndia Space Applications Centre Indian Space Research OrganizationAhmedabad-380015India

In an era of climate change,the availability of empirical data on alpine summit vegetation in the Himalaya is still *** we report the assessment of alpine summit flora in Gulmarg Wildlife Sanctuary,Kashmir *** employed a globally standardized Multi-Summit Approach and four spatially isolated summits spanning an elevation gradient of 210 m(between 3530-3740 m a.s.l.)from natural treeline to nival zone were *** of the summits was carried out in the year 2018 to collect floristic data together with records of soil temperature.A total of 142 vascular plant species were recorded in the sampled *** of the species were of herbaceous growth form and with perennial life *** on Raunkiaer’s life form,hemicryptophytes were the most dominant followed by therophytes and *** summit flora showed the predominance of narrow-endemic species,with broad-and non-endemics declining with elevation.A significant relationship between growth form,Raunkiaer’s life form,and the degree of endemism with elevation was *** species diversity and soil temperature showed a monotonic decrease with increasing ***,soil temperature clearly determined the magnitude of species diversity on the ***,based on floristic composition,the lowest summit had the highest dissimilarity with the rest of the *** present study employed globally standardized protocol to scientifically assess the patterns of plant diversity on the alpine mountain summits of Kashmir Himalaya,which in turn has wide implications towards long-term monitoring of climate change impact on alpine biodiversity in the rapidly warming Himalaya.

关键词： Alpine ecosystem Elevation gradient Endemism Himalaya Mountain summits

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Crowdsourced Requirements Engineering Challenges and Solutions:A Software Industry Perspective

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Computer Systems Science & Engineering 2021年第11期39卷 221-236页

作者： Huma Hayat Khan Muhammad Noman malik Youseef Alotaibi Abdulmajeed Alsufyani Saleh Alghamdi Department of Software Engineering National University of Modern LanguagesIslamabadPakistan Department of Computer Science National University of Modern LanguagesIslamabadPakistan Department of Computer Science College of Computer and Information SystemsUmm Al-Qura UniversityMakkahSaudi Arabia Department of Computer Science College of Computers and Information TechnologyTaif UniversityPO Box 11099TaifSaudi Arabia Department of Information Technology College of Computers and Information TechnologyTaif UniversityTaifSaudi Arabia

Software crowdsourcing(SW CS)is an evolving software development paradigm,in which crowds of people are asked to solve various problems through an open call(with the encouragement of prizes for the top solutions).Because of its dynamic nature,SW CS has been progressively accepted and adopted in the software ***,issues pertinent to the understanding of requirements among crowds of people and requirements engineers are yet to be clarified and *** the requirements are not clear to the development team,it has a significant effect on the quality of the software *** study aims to identify the potential challenges faced by requirements engineers when conducting the SW–CS based requirements engineering(RE)***,solutions to overcome these challenges are also *** data analysis is performed on the interview data collected from software industry ***,20 SW–CS based RE challenges and their subsequent proposed solutions are devised,which are further grouped under seven *** study is beneficial for academicians,researchers and practitioners by providing detailed SW–CS based RE challenges and subsequent solutions that could eventually guide them to understand and effectively implement RE in SW CS.

关键词： Software crowdsourced requirements engineering software industry software development survey challenges

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Role of endoscopic therapy in early esophageal cancer

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World Journal of Gastroenterology 2018年第35期24卷 3965-3973页

作者： Sonika malik Gautam Sharma Madhusudhan R Sanaka Prashanthi N Thota Department of Internal Medicine Cleveland Clinic Akron General Medical Center Akron Department of Anesthesiology University Hospitals Cleveland Department of Gastroenterology Digestive Disease Surgery Institute Cleveland Clinic

Esophageal carcinoma is a highly lethal cancer associated with high morbidity and mortality. Esophageal squamous cell carcinoma and esophageal adenocarcinoma are the two distinct histological types. There has been significant progress in endoscopic diagnosis and treatment of early stages of cancer using resection and ablation techniques, as shown in several trials in the recent past. Earlier detection of esophageal cancer and advances in treatment modalities have lead to improvement in the 5-year survival from 5% to about 20% in the past decade. Endoscopic eradication therapy is the preferred modality of treatment in cancer limited to mucosal layer of the esophagus as there is very low risk of lymph node metastasis, leading to high cure rates, low risk of recurrence and with few adverse effects. The most common adverse events seen are strictures, bleeding and rarely perforation which can be endoscopically managed. In patients with recurrent advanced disease or invasive tumor, esophagectomy with lymph node dissection remains the mainstay of treatment. There is debate on post-endoscopic surveillance with some studies suggesting closer follow up with upper endoscopy every 6 mo for the first 1-2 years and then annually for the 3 years while others recommending the appropriate action only if symptoms or other abnormalities develop. Overall, the field of endoscopic therapy is still evolving and focus should be placed on careful patient selection using a multidisciplinary approach.

关键词： Endoscopic mucosal resection Endoscopic submucosal dissection Radiofrequency ablation Argon plasma coagulation Esophageal cancer Photodynamic therapy Cryotherapy

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Development of a monitoring and warning system based on optical fiber sensing technology for masonry retaining walls and trees

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第4期14卷 1064-1076页

作者： Peichen Wu Daoyuan Tan Shaoqun Lin Wenbo Chen Jianhua Yin Numan malik An Li Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHong KongChina

Hong Kong has a long history of applying masonry retaining walls to provide horizontal platforms and stabilize man-made *** to the sub-tropical climate,some masonry retaining walls are colonized by *** weather,such as typhoons and heavy rains,may cause rupture or root failure of those trees,thus resulting in instability of the retaining walls.A monitoring and warning system for the movement of masonry retaining walls and sway of trees has been designed with the application of fiber Bragg grating(FBG)sensing *** monitoring system is also equipped with a solar power system and 4G data transmission *** key functions of the proposed monitoring system include remote sensing and data access,early warning,and real-time data *** setups and working principles of the monitoring systems and related transducers are *** feasibility,accuracy,serviceability and reliability of this monitoring system have been checked by in-site calibration tests and four-month ***,a two-level interface has been developed for data *** monitoring results show that the monitored masonry retaining wall had a reversible movement up to 2.5 mm during the monitoring ***,it is found that the locations of the maximum strain on trees depend on the crown spread of trees.

关键词： Masonry retaining walls Tree Monitoring Fiber Bragg grating(FBG)sensing Warning system

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