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Impact of IL28B and OAS gene family polymorphisms on interferon treatment response in Caucasian children chronically infected with hepatitis B virus

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World Journal of Gastroenterology 2016年第41期22卷 9186-9195页

作者： Krzysztof Domagalski malgorzata pawlowska Agnieszka Zalesna malgorzata Pilarczyk Pawel Rajewski Waldemar Halota Andrzej Tretyn Centre for Modern Interdisciplinary Technologies Nicolaus Copernicus University 87-100 Toruń Poland Department of Paediatric Infectious Diseases and Hepatology Faculty of Medicine Collegium Medicum Bydgoszcz Nicolaus Copernicus University Torun 85-030 Bydgoszecz Poland Provincial Infectious Diseases Hospital in Bydgoszcz 85-030 Bydgoszecz Poland Department of Plant Physiology and Biotechnology Nicolaus Copernicus University 87-100 Toruń Poland

AIM To investigate the impact of IL28 B and OAS gene polymorphisms on interferon treatment responses in children with chronic hepatitis *** We enrolled 52 children(between the ages of 4 and 18) with hepatitis B e antigen-negative chronic hepatitis B(CHB), who were treated with pegylated interferon alfa for 48 wk. Single nucleotide polymorphisms in the OAS1(rs1131476), OAS2(rs1293747),OAS3(rs2072136), OASL(rs10849829) and IL28B(rs12979860, rs12980275 and rs8099917) genes were studied to examine their associations with responses to IFN treatment in paediatric patients. We adopted two criteria for the therapeutic response, achieving an hepatitis B virus(HBV) DNA level < 2000 IU/m L and normalization of ALT activity(< 40 IU/L). To perform the analyses, we compared the patients in terms of achieving a partial response(PR) and a complete response(CR) upon measurement at the 24-wk posttreatment follow-up. RESULTS The PR and CR rates were 80.8% and 42.3%, respectively. Factors such as age, gender and liver histology had no impact on the type of response(partial or complete). A statistically significant relationship between higher baseline HBV DNA and ALT activity levels and lower rates of PR and CR was shown(P < 0.05). The allele association analysis revealed that only the IL-28 B rs12979860(C vs T) and IL28 B rs12980275(A vs G) markers significantly affected the achievement of PR(P = 0.021, OR = 3.3, 95%CI: 1.2-9.2 and P = 0.014, OR = 3.7, 95%CI: 1.3-10.1, respectively). However, in the genotype analysis, only IL-28 B rs12980275 was significantly associated with PR(AA vs AG-GG, P = 0.014, OR = 10.9, 95%CI: 1.3-93.9). The association analysis for CR showed that the TT genotype of IL28 B rs12979860 was present only in the no-CR group(P = 0.033) and the AA genotype of OASL rs10849829 was significantly more frequent in the noCR group(P = 0.044, OR = 0.26, 95%CI: 0.07-0.88). The haplotype analysis revealed significant associations between PR and CR and OAS haplotype(P = 0

关键词： Chronic hepatitis B IL28B OAS Singlenucleotide polymorphisms IFN therapy Children

What's new in hepatitis C virus infections in children?

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World Journal of Gastroenterology 2015年第38期21卷 10783-10789页

作者： malgorzata pawlowska Krzysztof Domagalski Anna Pniewska Beata Smok Waldemar Halota Andrzej Tretyn Department of Paediatric Infectious Diseases and Haepatology Faculty of MedicineCollegium Medicum BydgoszczNicolaus Copernicus University Centre for Modern Interdisciplinary Technologies Nicolaus Copernicus University Department of Plant Physiology and Biotechnology Nicolaus Copernicus University

The number of hepatitis C virus(HCV) infection cases is relatively low in children. This low number may be connected with the lack of screening tests and the asymptomatic course of infection. Currently,mother-toinfant transmission is the most common cause of HCV infection amongst children in developed countries. It is important to introduce routine screening tests for HCV in pregnant women. The risk of vertical transmission of HCV is estimated at approximately 5%(3%-10%). Currently,we do not have HCV transmission prevention methods. Some factors could potentially be eliminated by elective caesarean section. Currently,the method of prevention of perinatal HCV infection is the early identification and effective treatment of infections in young women in the preconception period. We describe genetic tests(IL-28 B single nucleotide polymorphisms) to identify children with an increased chance of spontaneous clearance or sustained virologic response achievement and vitamin D level as a potential predictor of treatment response in children. It is also important to develop non-invasive tests that can predict liver fibrosis. The existence of differences in the mechanisms leading to liver injury between children and adults creates new perspectives of action to reduce liver disease progression in children in the early years of life.

关键词： Hepatitis C virus Infection in children Single nuc

Real-world effectiveness and safety of direct-acting antivirals in hepatitis C virus patients with mental disorders

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World Journal of Gastroenterology 2023年第25期29卷 4085-4098页

作者： Dorota Dybowska Dorota Zarebska-Michaluk Piotr Rzymski Hanna Berak Beata Lorenc Marek Sitko Michal Dybowski Wlodzimierz Mazur Magdalena Tudrujek-Zdunek Justyna Janocha-Litwin Ewa Janczewska Jakub Klapaczynski Anna Parfieniuk-Kowerda Anna Piekarska Barbara Sobala-Szczygiel Krystyna Dobrowolska malgorzata pawlowska Robert Flisiak Department of Infectious Diseases and Hepatology Faculty of MedicineNicolaus Copernicus UniversityBydgoszcz 85-030Poland Department of Infectious Diseases and Allergology Jan Kochanowski UniversityKielce 25-317Poland Department of Infectious Diseases Provincial HospitalKielce 25-317Poland Department of Environmental Medicine University of Medical SciencesPoznań60-806Poland Integrated Science Association Universal Scientific Education and Research NetworkPoznań60-806Poland Outpatient Clinic Hospital for Infectious Diseases in WarsawWarsaw 01-201Poland Pomeranian Center of Infectious Diseases Medical UniversityGdańsk 80-214Poland Department of Infectious and Tropical Diseases Jagiellonian UniversityKraków 31-088Poland Utrecht University School of Economics Utrecht UniversityUtrecht 3584 ECNetherlands Clinical Department of Infectious Diseases Medical University of SilesiaChorzów 41-500Poland Department of Infectious Diseases Medical University of LublinLublin 20-059Poland Department of Infectious Diseases and Hepatology Medical University of WrocławWrocław 50-367Poland Department of Basic Medical Sciences Faculty of Public Health in BytomMedical University of SilesiaKatowice 40-007Poland Department of Internal Medicine and Hepatology Central Clinical Hospital of the Ministry of Internal Affairs and AdministrationWarsaw 00-241Poland Department of Infectious Diseases and Hepatology Medical University of BiałystokBiałystok 15-089Poland Department of Infectious Diseases and Hepatology Medical University ofŁódźŁódź91-347Poland Department of Infectious Diseases and Hepatology Medical University of SilesiaBytom 41-902Poland Collegium Medicum Jan Kochanowski UniversityKielce 25-317Poland

BACKGROUND It is estimated that 58 million people worldwide are infected with the hepatitis C virus(HCV).Patients with severe psychiatric disorders could not be treated with previously available interferon-based therapies due to their unfavorable side effect *** has changed with the introduction of direct-acting antivirals(DAA),although their real-life tolerance and effectiveness in patients with different psychiatric disorders remain to be *** To evaluate the effectiveness and safety of DAA in patients with various mental *** This was a retrospective observational study encompassing 14272 patients treated with DAA for chronic hepatitis C in 22 Polish hepatology centers,including 942 individuals diagnosed with a mental disorder(anxiety disorder,bipolar affective disorder,depression,anxiety-depressive disorder,personality disorder,schizophrenia,sleep disorder,substance abuse disorder,and mental illness without a specific diagnosis).The safety and effectiveness of DAA in this group were compared to those in a group without psychiatric illness(n=13330).Antiviral therapy was considered successful if serum ribonucleic acid(RNA)of HCV was undetectable 12 wk after its completion[sustained virologic response(SVR)].Safety data,including the incidence of adverse events(AEs),serious AEs(SAEs),and deaths,and the frequency of treatment modification and discontinuation,were collected during therapy and up to 12 wk after treatment *** entire study population was included in the intent-to-treat(ITT)***-protocol(PP)analysis concerned patients who underwent HCV RNA evaluation 12 wk after completing *** Among patients with mental illness,there was a significantly higher percentage of men,treatmentnaive patients,obese,human immunodeficiency virus and hepatitis B virus-coinfected,patients with cirrhosis,and those infected with genotype 3(GT3)while infection with GT1b was more frequent in the population without psychia

关键词： Hepatitis C Mental disorders Direct-acting antivirals

Distribution of Selected Critical Elements in the Carboniferous Coal-bearing Series of the Upper Silesian and Lublin Coal Basins(Poland)

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Acta Geologica Sinica(English Edition) 2022年第1期96卷 273-292页

作者： Ewa KRZESZOWSKA Magdalena KOKOWSKA-pawlowska Swiatoslaw KRZESZOWSKI Silesian University of Technology GliwicePoland

The distribution of selected critical elements in the sedimentary rocks of the Carboniferous coal-bearing series within the Polish Coal Basins is *** elements such as Be,Mg,Si,P,Sc,V,Co,Y,Nb,In,Sb,La,Ce,Hf,Ta,W,Bi were analysed using inductively-coupled plasma mass spectrometry(ICP/MS).Concentrations of elements such as Sb,Bi,In and,to a slightly lesser extent,Nb,as well as Sc,show average concentrations higher than those from the upper continental *** average concentrations of elements like Hf,Mg,P,Y,La,and Ce are slightly lower than in the upper continental *** elements,such as Be,Co,Si,Ta,W and V have average concentrations that are similar,but slightly enriched or slightly depleted,relative to the upper continental *** research showed enrichment of some critical elements in the analysed samples,but not high enough that extraction would be economically *** methods,which include correlation coefficients between elements and cluster analysis,reveal a strong positive correlation between elements like Be,Bi,Nb,Sc,Ta,W and *** high,almost total,positive correlation is also noted between La and Ce.

关键词： geochemistry critical elements coal-bearing series Upper Silesian Coal Basin Lublin Coal Basin

ACTUAL AND POTENTIAL MARKET FOR BIOLOGICAL CROP PROTECTION AGENTS IN POLAND

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ACTUAL AND POTENTIAL MARKET FOR BIOLOGICAL CROP PROTECTION A...

基于SPR分析的金纳米粒子-适配体传感器检测梯恩梯

The First Combined meeting of the IOBC/WPRS and IOBC/EPRS Working Group on Insect Pathogens and Insect Parasitic Nematodes

作者： Andrzej Bednarek Wojciech Goszczyński Anna pawlowska Department of Zoology Warsaw Agricultural University/SGGW/WarsawPoland Department of Applied Entomology Warsaw Agricultural University/SGGW/

＜正＞In Poland there is a relatively high horticultural production in comparison to other European countries.A total vegetable yield in 1993 reached 6138 thousand tons,of which 4.2%came from crops grown under *** the same year the commodity value of horticultural production totalled ca.100 Million ECU,i.e.15.1%of a total agricultural *** crops cover around 280 thousand Ha,where the production under cover constitutes 0.87%. Integrated production methods,in particular integrated and biological crop protection,are an essential element of modem horticultural *** Poland

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分析试验室 2018年第12期37卷 1421-1425页

作者：谭俊鹏 Natalia pawlowska 徐升晖蔡能斌杨瑞琴郝红霞证据科学教育部重点实验室(中国政法大学) 2011年计划司法文明协同创新中心北京100088 中国人民公安大学北京100038 张家口市公安局物证鉴定所张家口075000 上海市现场物证重点实验室上海200083

构建了基于表面等离子体共振(SPR)分析的金纳米粒子(Au NPs)-TNT适配体传感器。该方法将TNT适配体运用在SPR检测方法中,并与Au NPs合成复合物以提高灵敏度。传感器芯片使用聚乙二醇结合2,4,6-三硝基苯基-甘氨酸进行修饰,将Au NPs-TNT适... 详细信息

构建了基于表面等离子体共振(SPR)分析的金纳米粒子(Au NPs)-TNT适配体传感器。该方法将TNT适配体运用在SPR检测方法中,并与Au NPs合成复合物以提高灵敏度。传感器芯片使用聚乙二醇结合2,4,6-三硝基苯基-甘氨酸进行修饰,将Au NPs-TNT适配体复合物作为配体,通过间接竞争法检测TNT。实验对溶液pH、进样时间、进样流速以及孵育时间进行优化。最优条件下(溶液pH 9.62、进样时间1500S、进样流速500μL/min、孵育时间30min),检测线性范围为0.5~20ng/mL,检出限58pg/mL(S/N=3)。该传感器可用于检测实际水样中TNT,在公共安全及环境监测领域具有良好的应用前景。

关键词： 2,4,6-三硝基甲苯表面等离子体共振适配体金纳米粒子

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湿部优化：提高温强度性能效率（WSPE）

生活用纸 2014年第1期14卷 43-45页

作者： Clayton J. Campbell Vladimir Grigoriev Lucyna pawlowska 芬兰凯米拉(KEMIRA)化学品公司

介绍了利用阴离子功能促进剂和阳离子乙二醛聚丙烯酰胺干强剂，提高纸张湿强效率的应用案例。说明选择正确工艺化学品可为提高纸品质量和整体运行效率带来显著益处。

关键词：高温强度能效优化湿部聚丙烯酰胺运行效率纸品质量干强剂

核酸适配体识别技术在法医毒物分析中的应用（英文）

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刑事技术 2017年第1期42卷 52-60页

作者：曾玲蔡能斌 pawlowska Natalia 蔡伟思糜忠良郝红霞 2011计划司法文明协同创新中心北京100088 证据科学教育部重点实验室(中国政法大学) 北京100088 上海市现场物证重点实验室上海200083

本文介绍了一种非常灵敏并可应用于法医毒物分析的核酸适配体识别技术。这种技术可与多种分析技术手段联用而检测毒物和药物,技术手段包括阻抗滴定技术、表面增强拉曼技术、荧光检测技术、微流控芯片技术、表面等离子共振技术等。核酸... 详细信息

本文介绍了一种非常灵敏并可应用于法医毒物分析的核酸适配体识别技术。这种技术可与多种分析技术手段联用而检测毒物和药物,技术手段包括阻抗滴定技术、表面增强拉曼技术、荧光检测技术、微流控芯片技术、表面等离子共振技术等。核酸适配体技术的检测优势主要表现为选择性强,并且通过纳米金颗粒修饰,可以极大的增强检测信号,实现对痕量目标分子的精准检测。核酸适配体技术由于其易于合成、造价低廉、操作简便、精准识别等优势必将会受到法庭科学家的重视而广泛应用于未来的法医毒物药物分析工作中。

关键词：核酸适配体法医毒物纳米金增强技术药物分析

SWISS LIGHT SHED ON EMBRYOS FROM THE EDIACARAN AND CAMBRIAN

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SWISS LIGHT SHED ON EMBRYOS FROM THE EDIACARAN AND CAMBRIAN