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Protocadherin gamma C3:a new player in regulating vascular barrier function

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Neural Regeneration Research 2023年第1期18卷 68-73页

作者： Victoria Kaupp Kinga G.Blecharz-Lang Christina Dilling Patrick Meybohm malgorzata Burek Department of Anesthesiology Intensive CareEmergency and Pain MedicineUniversity of WürzburgUniversity Hospital WürzburgWürzburgGermany Department of Experimental Neurosurgery Charité-UniversitätsmedizinBerlinGermany

Defects in the endothelial cell barrier accompany diverse malfunctions of the central nervous system such as neurodegenerative diseases,stroke,traumatic brain injury,and systemic diseases such as sepsis,viral and bacterial infections,and *** endothelial sealing leads to leaking blood vessels,followed by vasogenic *** edema as the most common complication caused by stroke and traumatic brain injury is the leading cause of *** microvascular endothelial cells,together with astrocytes,pericytes,microglia,and neurons form a selective barrier,the so-called blood-brain barrier,which regulates the movement of molecules inside and outside of the *** that regulate blood-brain barrier permeability in health and disease are complex and not fully *** newly discovered molecules that are involved in the regulation of cellular processes in brain microvascular endothelial cells have been described in the literature in recent *** of these molecules that are highly expressed in brain microvascular endothelial cells is protocadherin gamma *** this review,we discuss recent evidence that protocadherin gamma C3 is a newly identified key player involved in the regulation of vascular barrier function.

关键词： blood-brain barrier brain microvascular endothelial cells permeability protein interaction protocadherin gamma C3 protocadherins tight junctions

Chronic allograft rejection:A significant hurdle to transplant success

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Burns & Trauma 2014年第1期2卷 3-10页

作者： malgorzata Kloc Rafik M.Ghobrial Department of Surgery Houston Methodist HospitalHouston Houston Methodist Hospital Research Institute HoustonTXUSA

The state-of-the-art immunosuppression drugs do not ensure indefi nite transplant survival,and most transplants are continuously lost to chronic rejection even years *** form of rejection is responsible for long-term failure of transplanted *** mechanisms involved in development of chronic rejection are not *** of the main features of chronic rejection is progressive luminal narrowing of graft vessels,which results in compromised blood flow,ischemia,cell death,and finally graft *** the existing immunosuppressive regimens are targeting acute rejection,and at present there is no available therapy for prevention of chronic *** rejection involves two major,but interrelated responses:The first is the host immune response against the transplant mediated primarily by alloreactive T and B cells,and the second is injury and repair of the graft(vasculopathy of graft vessels).Here we focus on recent advances in understanding the cellular and molecular aspects of chronic transplant vasculopathy and function of macrophages,topics pivotal for development of novel antichronic rejection therapies.

关键词： Chronic rejection macrophage neointima consists of smooth muscle cells vasculopathy

Should mitral valve prolapse be considered as one of the risk factors for open angle glaucoma? A preliminary observation

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International Journal of Ophthalmology(English edition) 2022年第2期15卷 346-351页

作者： Ewa Grudzińska malgorzata Peregud-Pogorzelska Daniel Zaborski Monika Modrzejewska Second Department of Ophthalmology Pomeranian Medical UniversitySzczecin 70-111Poland Department of Cardiology Pomeranian Medical UniversitySzczecin 70-111Poland Laboratory of Biostatistics West Pomeranian University of TechnologySzczecin 71-270Poland

AIM:To assess the incidence of mitral valve prolapse in patients with newly diagnosed primary open angle ***:The study included 12 patients without any other comorbidities or taking any general or local *** patient underwent a full ophthalmological examination with visual field assessment and optical computed tomography of the macula and optic nerve *** Doppler ultrasound was performed to exclude impaired blood flow in this region and transthoracic echocardiography with assessment of the function and morphology of the heart ***:In the study group,mitral valve prolapse was found in seven patients(58.3%),while mitral valve regurgitation in 11 patients(91.7%).One case of normal pressure glaucoma and four cases of juvenile glaucoma were *** were also other risk factors for glaucoma:myopia(58.3%),migraine headaches(41.7%),a positive family history of glaucoma(16.7%).CONCLUSION:Mitral valve prolapse could be indicated as a new risk factor for *** seems reasonable to conduct screening tests for glaucoma in patients with mitral valve prolapse in the course of echocardiography.

关键词： ultrasonography Doppler echocardiography heart valves mitral valve insufficiency

Deep learning enabled single-shot absolute phase recovery in high-speed composite fringe pattern profilometry of separated objects

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Opto-Electronic Advances 2023年第12期6卷 1-4页

作者： Maciej Trusiak malgorzata Kujawinska Institute of Micromechanics and Photonics Warsaw University of Technology8 Sw.A.Boboli StreetWarsaw 02-525Poland.

A recent article in the Opto-Electronic Advances(OEA)journal from *** Chen and *** Zuo’s group introduced a new and efficient 3D imaging system that captures high-speed images using deep learning-enabled fringe projection profilometry(FPP).In this News&Views article,we explore potential avenues for future advancements,including expanding the measurement range through an extended number-theoretical approach,enhancing quality through the incorporation of horizontal fringes,and integrating data from other modalities to broaden the system's applications.

关键词： system absolute separated

Dietary carnosic acid and seleno-compounds change concentrations of fatty acids, cholesterol, tocopherols and malondialdehyde in fat and heart of lambs

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Animal Nutrition 2021年第3期7卷 812-822页

作者： malgorzata Bialek Marian Czauderna Kamil Zaworski Katarzyna Krajewska The Kielanowski Institute of Animal Physiology and Nutrition Polish Academy of Sciences05-110 JablonnaPoland

The aim of the current study was to evaluate the impact of carnosic acid(CA),selenised yeast(^(Y)Se)and selenate(^(VI)Se)supplemented to diets,including fish oil(FO)and rapeseed oil(RO),on the content of fatty acids,total cholesterol(TCh),tocopherols and malondialdehyde in the fat located between the thigh muscles and the heart in ***-four male Corriedale lambs were divided into 4 groups of 6 *** were fed a diet with FO and RO(the control diet)or experimental diets containing RO,FO and CA with/without Se(as^(Y)Se or^(VI)Se).The experimental diets without/with^(Y)Se or^(VI)Se changed concentrations of fatty acids in the fat and heart compared to the *** experimental diets increased the levels of c11c14C20:2,c5c8c11c14C20:4,c5c8c11c14c17C20:5 and the sums of long-chain polyunsaturated fatty acids(LPUFA)and conjugated linoleic acid isomers in the fat compared to the *** experimental diet containing^(Y)Se or^(VI)Se increased the content of Se,TCh,c11c14C20:2,c8c11c14C20:3,c5c8c11c14C20:4,c5c8c11c14c17C20:5,c7c10c13c16c19C22:5,c4c7c10c13c16c19C22:6 and the concentration sum of n-3LPUFA,n-6LPUFA and tocopherols in the heart in comparison with the control diet and the diet containing only *** diets reduced the concentration of malon-dialdehyde in the fat and heart in comparison with the control *** dietary intervention has great potential for future practical and commercial implementations.

关键词： Selenium Carnosic acid Fatty acid Tocopherol Cholesterol Lamb

Nomenclature of Cambrian epochs and series based on GSSPs Comments on an alternative proposal by Rowland and Hicks

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Episodes 2006年第2期29卷 130-132页

作者： Shanchi Peng Loren E. Babcock Gerd Geyer malgorzata Moczydlowska State Key Laboratory on Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology CAS 39 East Beijing Road Nanjing 210008 China Department of Geological Sciences 125 South Oval Mall The Ohio State University Columbus Ohio 43210 USA Institute fǜr Palaontologie Bayerische Julius-Maximilians-Universitat Pleicherwall 1 D-97070 Würzburg Germany Department of Earth Sciences Uppsala University Norbyvaigen 22 SE-752.36 Uppsala Sweden

In this issue, Rowland ＆ Hicks advocate a nomenclature for the four epochs of the Cambrian Period that carries over the terms Early, Middle, and Late Cambrian from previous usage （but with new definitions） and introduces a non-geographically-based term, Ichnocambrian, for the earliest Cambrian epoch. The terms Lower/Early, Middle, and Late/Upper Cambrian are confusing because they connote the second, third, and fourth epochs/series of the period/system, and because each is defined in a way that is different from traditional definitions of those intervals. The use of these terms will ultimately lead to confusion between older concepts of Early, Middle, and Late Cambrian and newer, refined concepts of the epochs. The philosophy of the International Subcommission on Cambrian Stratigraphy for establishing a clear subdivision of the Cambrian on a global scale is unambiguous： stratigraphic terms previously in use lack global applicability and should not be adopted as chronostratigraphic/geochronologic units in the developing global stratigraphic chart of the Cambrian. Moreover, all series and stage names should be GSSP （stratotype section）-based.

关键词：全球界线层型剖面点罗兰环寒武纪 GSSP

Multi-layered tissue head phantoms for noninvasive optical diagnostics

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Journal of Innovative Optical Health Sciences 2015年第3期8卷 36-45页

作者： M.S.Wróbel A.P.Popov A.V.Bykov M.Kinnunen M.Jędrzejewska-szczerska V.V.Tuchin Department of Metrology and Optoelectronics Gdansk University of Technology Gabriela Narutowicza Street 11/1280-233 Gdansk Poland Optoelectronics and Measurement Techniques Laboratory Faculty of Information Technology and Electrical Engineering University of Oulu P.O.Box 4500 FI-90014 OuluFinland Research-Educational Institute of Optics and Biophotonics Saratov State University Saratov 410012Russia Institute of Precise Mechanics and Control Russian Academy of Sciences Saratov 410028Russia

Extensive research in the area of optical sensing for medical diagnostics requires development of tissue phantoms with opt ical properties similar to those of living human *** and improvement of in vivo optical measurement systems requires the 1use of stable tissue phantoms with known characteristics,which are mainly used for calibration of such systems and testing their performance over *** and mechanical properties of phantoms depend on their ***,they must accurately simulate specific tssues they are supposed to *** tsues and organs including head possess a multi-layered structure,with specifie optical properties of each ***,such a structure is not always addressed in the present-day *** this paper,we focus on the development of a plain-parallel multi-layered phantom with optical properties(reduced scattering oofficientμ'and absorption cofficientμa)corresponding to the human head layers,such as skin,skul,and gray and white matter of the brain *** phantom is intended for use in noninvasive diffuse near-infrared spectroscopy(NIRS)of humnan *** parameters of the fabricated phantoms are reconstructed using spectrophotometry and inverse adding-doubling calculation *** results show that polyinyl chloride plastisol(PVCP)and zinc oxide(ZnO)nanoparticles are suitable materials for fabrication of tissue mimicking phantoms with controlled scattering *** matching was found between optical properties of phantoms and the corresponding values found in the literature.

关键词： Tissue-mimicking phantoms optical properties near-infrared spectroscopy head model

Increased expression of PELP1 in human sperm is correlated with decreased semen quality

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Asian Journal of Andrology 2018年第5期20卷 425-431页

作者： Izabela Skibinska Miroslaw Andrusiewicz Michal Soin Magdalena Jendraszak Paulina Urbaniak Piotr Jedrzejczak malgorzata Kotwicka Department of Cell Biology Faculty of Health Sciences Poznan University of Medical Sciences Rokietnicka 5D Poznan 60-806 Poland Division of Infertility and Reproductive Endocrinology Faculty of Medicine I Poznan University of Medical Sciences Polna 33 Poznan 60-535 Poland.

Proline-, glutamic acid-, and leucine-rich protein 1 （PELP1） is a scaffolding protein involved in both genomic and nongenomic estrogen signal transduction pathways. To date, the role of PELP1 protein has yet to be characterized in human sperm and has not been associated with sperm parameters. To confirm the presence of PELP1 in human sperm, fresh semen samples were obtained from 178 donors. The study was designed to establish both mRNA and protein presence, and protein cellular localization. Additionally, the number of PELP1-positive spermatozoa was analyzed in men with normal and abnormal semen parameters. Sperm parameters were assessed according to the World Health Organization （WHO） 2010 standards. The presence of PELP1 in spermatozoa was investigated using four precise, independent techniques. The qualitative presence of transcripts and protein was assessed using reverse transcription-polymerase chain reaction （RT-PCR） and western blot protocols, respectively. The cellular localization of PELP1 was investigated by immunocytochemistry. Quantitative analysis of PELP1-positive cells was done by flow cytometry. PELP1 mRNA and protein was confirmed in spermatozoa. Immunocytochemical analysis identified the presence of PELP1 in the midpieces of human sperm irrespective of sperm parameters. Becton Dickinson fluorescence-activated cell sorting （FACSCalibur^Tm） analysis revealed a significantly lower number of PELP1-positive cells in males with normal semen parameters versus abnormal samples （42.78% ± 11.77% vs 61.05% ± 21.70%, respectively; P = 0.014）. The assessment of PELP1 may be a time-saving method used to obtain information about sperm quality. The results of our study suggest that PEPL1 may be utilized as an indicator of sperm quality; thereby, PELP1 may be an additional biomarker useful in the evaluation of male infertility.

关键词： male infertility proline glutamic acid- and leucine-rich protein 1 semen parameters sperm quality spermatozoa

Persistent ductus arteriosus in old patient with atrial fibrillation

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Journal of Geriatric Cardiology 2018年第5期15卷 372-375页

作者： Justyna Rajewska-Tabor Bartosz Zabicki: Michal Hrycow Szymon Rozmiarek malgorzata Pyda Department of Magnetic Resonance I Clinic of Cardiology Poznan University of Medical Sciences Poznan Poland Department of Diagnostic and Interventional Radiology Poznan University of Medical Sciences Poznan Poland

Persistent ductus arteriosus （PDA） is a congenital cardiovascular malformation connecting the pulmonary trunk of the proximal left pulmonary artery and the descending aorta distal to the left subclavian artery. Normally, the duct closes after birth as a result of a sudden increase in arterial oxygen saturation and a decrease in the level of vasoaetive prostaglandins. The incidence of persistent ductus arteriosus accounts for approximately 10% of all congenital heart diseases.

关键词： Angio-MR Atrial fibrillation CMR Elderly patients Persistent ductus arteriosus