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Developmental Toxicity in Mice Following Paternal Exposure to Di-N-Butyl-Phthalate (DBP)

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Biomedical and Environmental Sciences 2011年第5期24卷 569-578页

作者： malgorzata M.DOBRZY SKA Ewa J.TYRKIEL Krzysztof A.PACHOCKI Department of Radiation Protection and Radiobiology National Institute of Public Health-National Institute of Hygiene00-791 WarsawPoland Department of Environmental Toxicology National Institute of Public Health-National Institute of Hygiene00-791 WarsawPoland

Objective The aim of the present study was to investigate the effects of paternal Di‐N‐butyl‐phthalate （DBP） exposure pre‐ and postnatally on F1 generation offspring,and prenatally on F2 generation *** Male mice were exposed to either 500 mg/kg or 2 000 mg/kg of DBP for 8 weeks,and mated with non‐exposed ***‐quarters of the females were sacrificed a day prior to parturition,and examined for the number of living and dead implantations,and incidence of gross *** from the remaining females were assessed for developmental markers,growth parameters,as well as sperm quantity and *** There were no changes in the fertility of parents and in intrauterine development of the *** of DBP‐exposed males demonstrated growth‐*** paternal exposure to 500 mg/kg bw of DBP,there were almost twice the number of males than females born in the F1 generation.F1 generation females had a 2.5‐day delay in vaginal *** exposure to 2 000 mg/kg bw of DBP increased the incidence of sperm head malformations in F1 generation males;however,there were no changes in the fertility and viability of foetuses in the F2 *** Paternal DBP exposure may disturb the sex ratio of the offspring,delay female sexual maturation,and deteriorate the sperm quality of F1 generation males.

关键词： Di‐n‐butyl phthalate Paternal exposure Pre‐ and postnatal effects Male‐mediated developmental toxicity

Heparin-binding proteins from boar seminal plasma affecting the release of prostaglandins and interleukin-6 by porcine endometrial and cervical cells and bovine endometrial cells

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Natural Science 2013年第7期5卷 21-30页

作者： malgorzata Madej Claus Hansen Anders Johannisson Andrzej Madej Danish Agriculture and Food Council Copenhagen Denmark Department of Anatomy Physiology and Biochemistry Swedish University of Agricultural Sciences Uppsala Sweden

The objectives of this study were to explore whether heparin-binding proteins, separated by fast protein liquid chromatography from boar seminal plasma influence the release of prostaglandins F2α, (PGF2α), E2 (PGE2) and interleukin-6 (IL-6) by porcine endometrial and cervical cells and even bovine endometrial cells. In Experiment I, we showed that release of PGF2α by endometrial epithelial, endometrial stromal and cervical stromal cells to the medium was inhibited (p α (TNFα) stimulated release of IL-6 by endometrial and cervical stromal cells after 24 h incubation, but in the presence of heparin-binding proteins, this stimulation was attenuated. Release of PGF2α by cryopreserved (Experiment II) and primary (Experiment III) cervical stromal cells was significantly inhibited after 3 h incubation with 66 - 95.4 μg of heparin- binding proteins. A significant inhibition of PGE2 release by cryopreserved and primary cervical stromal cells was already achieved after incubation with 16.5 - 23.9 μg of heparin-binding proteins. The release of IL-6 by cryopreserved cells was stimulated after 3 h incubation with heparin- binding proteins in a dose dependent manner in contrast to the release of IL-6 by freshly isolated cervical stromal cells. We also found (Experiment IV) that porcine heparin-binding seminal plasma proteins inhibited release of PGF2α and stimulated release of IL-6 by bovine endometrial epithelial cells. In conclusion, a group of heparin-binding proteins separated by fast protein liquid chromatography from boar seminal plasma inhibit PGF2α, PGE2 and stimulate IL-6 release by porcine endometrial and cervical cells and even by bovine endometrial cells. Thus, these proteins have a similar effect as the entire seminal plasma.

关键词： Seminal Plasma Proteins Cell Culture Porcine Bovine Prostaglandins Interleukin-6

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Yb^(3+)掺杂铋酸盐玻璃的发光特性

中国激光 2017年第9期44卷 125-132页

作者：汪韬范慧艳赵国营程继萌陈伟胡丽丽 Guzik malgorzata Boulon Georges 中国科学院上海光学精密机械研究所高功率激光单元技术研发中心上海201800 中国科学院大学北京100049 弗罗茨瓦夫大学化学学院里昂大学光物质研究所

研究了Yb^(3+)掺杂铋酸盐玻璃的发光特性参数,讨论了Yb^(2+)、Bi^(3+)等缺陷淬灭中心与Yb^(3+)之间的能量转移。对于已优化的基质组成,在荧光寿命没有大幅下降的前提下,玻璃中Yb^(3+)近红外波段的发射截面明显增大,吸收截面减小,激光增... 详细信息

研究了Yb^(3+)掺杂铋酸盐玻璃的发光特性参数,讨论了Yb^(2+)、Bi^(3+)等缺陷淬灭中心与Yb^(3+)之间的能量转移。对于已优化的基质组成,在荧光寿命没有大幅下降的前提下,玻璃中Yb^(3+)近红外波段的发射截面明显增大,吸收截面减小,激光增益能力和饱和抽运强度均得到提高。采用有效的除羟基工艺,玻璃中不会产生比磷酸盐玻璃中更为严重的Yb^(3+)发光淬灭效应,但铋酸盐玻璃中还可能存在Yb^(2+)、Bi^(3+)等价态不稳定的缺陷淬灭中心。

关键词：材料 Yb3+掺杂铋酸盐玻璃光谱特性激光评估参数荧光俘获效应能量转移

DESCRIPTION OF QUANTITY AND QUALITY CHANGES ON THE MARKET OF PLASTIC PACKAGING

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DESCRIPTION OF QUANTITY AND QUALITY CHANGES ON THE MARKET OF...

Surface-Driven High-Pressure Processing

The 14th IGWT Symposium

作者： MARZENA UCHEREK malgorzata LISINSKA-KUSNIERZ Cracow University of Economics Packaging Departament Rakowicka 27 St.31-510 CracowPoland Cracow University of Economics Packaging Departament Rakowicka 27 St.31-510 CracowPoland

＜正＞The essence of this study was to analyze current tendency of the production and use of plastics packaging. Technical progress of different kind of plastics packaging were analyzed. Although that progress is still associated with the objective consisting in ensuring the best possible quality of products in the extended period of durability, yet more and more emphasis is being put on the implementation of production of packaging guaranteeing a more comfortable use and a lesser burden on the natural environment compared to the packaging used to date, for instance biodegradable packaging material.

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Engineering 2018年第3期4卷 311-320页

作者： Keith E. Gubbins Kai Gu Liangliang Huang Yun Long J. Matthew Mansell Erik E. Santiso Kaihang Shi malgorzata Sliwifiska-Bartkowiak Deepti Srivastava Department of Chemical and Biomolecular Engineering North Carolina State University Raleigh NC 27695-7905 USA Department of Chemistry Zhejiang University Hangzhou 310027 China School of Chemical Biological and Materials Engineering The University of Oklahoma Norman OK 73019 USA Department of Chemical and Biomolecular Engineering National University of Singapore Singapore 117585 Singapore Faculty of Physics Adam Mickiewicz University in Poznan Poznaan 61-614 Poland

The application of high pressure favors many chemical processes, providing higher yields or improved rates in chemical reactions and improved solvent power in separation processes, and allowing activation barriers to be overcome through the increase in molecular energy and molecular collision rates. High pressures-up to millions of bars using diamond anvil cells-can be achieved in the laboratory, and lead to many new routes for chemical synthesis and the synthesis of new materials with desirable thermody- namic, transport, and electronic properties. On the industrial scale, however, high-pressure processing is currently limited by the cost of compression and by materials limitations, so that few industrial processes are carried out at pressures above 25 MPa. An alternative approach to high-pressure processing is pro- posed here, in which very high local pressures are generated using the surface-driven interactions from a solid substrate. Recent experiments and molecular simulations show that such interactions can lead to local pressures as high as tens of thousands of bars （1 bar=1×10^5 Pa）, and even millions of bars in some cases. Since the active high-pressure processing zone is inhomogeneous, the pressure is different in dif- ferent directions. In many cases, it is the pressure in the direction parallel to the surface of the substrate （the tangential pressure） that is most greatly enhanced. This pressure is exerted on the molecules to be processed, but not on the solid substrate or the containing vessel. Current knowledge of such pressure enhancement is reviewed, and the possibility of an alternative route to high-pressure processing based on surface-driven forces is discussed. Such surface-driven high-pressure processing would have the advantage of achieving much higher pressures than are possible with traditional bulk-phase processing, since it eliminates the need for mechanical compression. Moreover, no increased pressure is exerted on the containing vessel fo

关键词： Confinement High pressure High pressure phase High pressure reaction High pressure manufacture High pressure chemical processing

Four-Week Fluoxetine(SSRI)Exposure Diminishes Aggressive Behaviour of Male Siamese Fighting Fish(Betta splendens)

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Journal of Behavioral and Brain Science 2012年第2期2卷 185-190页

作者： Bogdan F.Kania Mikolaj A.Gralak malgorzata Wielgosz Department of Physiological Sciences Faculty of Veterinary MedicineWarsaw University of Life Sciences-SGGWWarsawPoland

Aggression, especially territorial is a serious problem in farmed and ornamental fish. Especially the tropical species like Siamese fighting fish Betta splendens or marine species like blu head Thalassoma bifasciatum. Also farmed species of Salmoniformes (Coho salmon Oncorhynchus kisutch, rainbow trout Oncorhynchus mykiss) exhibit territorial aggression which is correlated with growth rate of the fish. In these species native territorial aggression occurs, and in ethology it is called stereotypical agonistic behaviour or conspecific aggression. In this type modulation of aggression serotonin (5-HT) plays a main role. A decrease of 5-HT in brain intensifies these type of aggression and in opposite an increase of 5-HT reduces it. The purpose of this study was to examine the effects of different doses of fluoxetine on male aggressive behaviors of Betta splendens fish. It was concluded that fluoxetine added to aquarium water in the doses of 4, 40 and/or 100 μg·ga–1 BW during 14 - 28 days increased synaptic levels of 5-HT what in turn resulted in the reduction of the specific aggressive behaviors. Fluoxetine caused periodic, and sometimes even total weakening of male-male type fight, which is a standard trial applied in ethological research on Siamese fighting fish. In current study, the most effective was the dose of 40 μg·g–1 BW. The mechanism of this antiaggressivity depended on an increase of serotonergic system activity in animal brain (especially, in raphe nuclei), however synaptic levels of 5-HT in brain were not measured in this experiment. Thus, the hypothesis that exposure from day 1 - 21 would reduce aggression was rejected;as was the hypothesis that exposure on fluoxetine from day 10 (16) - 14 - 28 would rapidly reduce aggression in teleost fishes. The results obtained suggests that a complex role of serotonin in the expression of aggression in teleost fish because acute treatment with 5-HT1A receptor agonist WAY-100635 did not increase aggression in fish [1]

关键词： Betta splendens Aggression Fluoxetine Chronic Dosage

Pitfalls and Uncertainties of Using Potentiometric Titration for Estimation of Plant Roots Surface Charge and Acid-Base Properties

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American Journal of Plant Sciences 2014年第13期5卷 1862-1876页

作者： Grzegorz Jozefaciuk Alicja Szatanik-Kloc malgorzata Lukowska Justyna Szerement Institute of Agrophysics of Polish Academy of Sciences Lublin Poland

Amount and properties of roots surface charge are important for nutrient uptake and balance in plants. Roots surface charge markedly varies at different rizosphere conditions (particularly pH and ionic strength), which can markedly alter during vegetation season. Among recently available measuring methods, surface charge-pH dependence of roots (as well as other biological objects) is most easily evaluated by potentiometric titration. Use of this method is also easy at different ionic strengths. Potentiometric titration also allows for estimation of the distribution of charge generating surface groups. However, many applications of this method seem to be based either on incorrect methodical or theoretical approaches. In this paper we discuss the methodical and theoretical backgrounds of the titration method. Basing on experimental titration curves of roots of barley grown in nutrient solution, we show inconsistency of surface charge results obtained at different measuring conditions. Limitations of theoretical interpretations of the results are outlined also.

关键词： Charge Density Dissociation Method Plant Root Surface Titration

D<sub>1</sub>and TrkB Receptors Take Charge of the Molecular Antidepressant Action in Cultured Astroglial Cells

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Pharmacology & Pharmacy 2013年第5期4卷 443-446页

作者： malgorzata Huzarska Marek Zielinski Zbigniew S. Herman Department of Internal Medicine and Clinical Pharmacology Medical University of Silesia Katowice Poland.

In psychopharmacology of depression, we observe two ways of research. One group is focused on catecholamines action. Second one fixes attention on neuronal morphogenesis and synaptic plasticity. The intimate connection of astrocytes, neurons and synaptic endings determines glial participation in neural homeostasis. Consequently this situation enlarges the role of astrocytes in the CNS synaptic plasticity. Brain Derived Neurotrophic factor and its receptor TrkB suppose to coordinate both of the above mentioning signaling pathways in depression disturbances. In our experiment, we have exploited striatal tissue because in our opinion this structure is misjudged in pathophysiology of depression alas;Several hypothesis proposed striatum as important in future intention activity structure. RT-PCR analysis was used to determine D1, BDNF and TrkB mRNA expression in cultured striatal astroglial cells. Administration of three representative antidepressants (ADs) like amitriptyline, moclobemide and sertraline to astroglial culture medium increase the D1, BDNF/TrkB mRNA expression. Our previous study showed that the stimulation of cAMP to CREB pathway after D1 receptors excitation constituted a common response to ADs. The present results signify that D1, BDNF/TrkB link which is next neural track (after cAMP/PKA) involved in the CNS adaptation to external conditions altered by chronic ADs treatment. Moreover, the striatum tissue appears to be important formation which takes an active part in antidepressant action thus essential in depression disorder etiology.

关键词： BDNF D1 Receptors Neurotrophins TrkB Receptors

Compression strategies for digital holograms in biomedical and multimedia applications

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Light(Advanced Manufacturing) 2022年第3期3卷 234-254页

作者： Peter Schelkens Ayyoub Ahar Antonin Gilles Raees Kizhakkumkara Muhamad Thomas J.Naughton Cristian Perra Antonio Pinheiro Piotr Stepien malgorzata Kujawinska Vrije Universiteit Brussel ETRO Dept.B-1050 BrusselsBelgium imec Digital and User-Centric Solutions(DUCS)B-3001 LeuvenBelgium Institute of Research&Technology b<>com RennesFranc Maynooth University Dept.of Computer ScienceMaynoothCo.KildareIreland University of Cagliari DIEEUdR CNITCagliariItaly Universidade da Beira Interior CovilhaPortugal Instituto de Telecomunicacoes CovilhaPortugal Warsaw University of Technology Institute of Micromechanics and Photonics02-525 WarsawPoland

While 60 years of successful application of holography is celebrated in this special issue,efficient representation and compression of holographic data has received relatively little attention in *** this observation,and particularly due to the digitization that is also penetrating the holographic domain,interest is growing on how to efficiently compress holographic data such that interactive exchange of content,as well as digital storage can be facilitated *** is a particular challenge,not only because of its interferometric nature and the various representation formats,but also the often extremely large data volumes involved in pathological,tomographic,or high-end visualization *** this paper,we provide an overview of the state of the art in compression techniques and corresponding quality metrics for various practical applications in digital *** also consider the future by analyzing the emerging trends for addressing the key challenges in this domain.

关键词： Holography Compression Image quality assessment Standardization