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Time series canopy phenotyping enables the identification of genetic variants controlling dynamic phenotypes in soybean

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Journal of Integrative Plant Biology 2023年第1期65卷 117-132页

作者： Delin Li Dong Bai Yu Tian Ying-Hui Li chaosen Zhao Qi Wang Shiyu Guo Yongzhe Gu Xiaoyan Luan Ruizhen Wang Jinliang Yang malcolm J.Hawkesford James c.Schnable Xiuliang Jin Li-Juan Qiu The National Key Facility for crop Gene Resources and Genetic Improvement(NFcRI)/Key Laboratory of crop Gene Resource and Germplasm Enhancement(MOA)/Key Laboratory of Soybean Biology(Beijing)(MOA) Institute of Crop Science Chinese Academy of Agricultural SciencesBeijing 100081 China crops Research Institute of Jiangxi Academy of Agricultural Sciences Nanchang 330200 China college of Agriculture Northeast Agricultural University Harbin 150030 China Soybean Research Institute Heilongjiang Academy of Agricultural Sciences Harbin 150086 China Department of Agronomy and Horticulture University of Nebraska-Lincoln Lincoln Nebraska 68583 USA Plant Sciences Department Rothamsted ResearchWest CommonHarpendenHertfordshire AL52JQ UK

Advances in plant phenotyping technologies are dramatically reducing the marginal costs of collecting multiple phenotypic measurements across several time ***,most current approaches and best statistical practices implemented to link genetic and phenotypic variation in plants have been developed in an era of single-time-point ***,we used time-series phenotypic data collected with an unmanned aircraft system for a large panel of soybean(Glycine max(L.)Merr.)varieties to identify previously uncharacterized ***,we focused on the dissection of canopy coverage(cc)variation from this rich data *** also inferred the speed of canopy closure,an additional dimension of cc,from the time-series data,as it may represent an important trait for weed ***-wide association studies(GWASs)identified 35 loci exhibiting dynamic associations with cc across developmental *** time-series data enabled the identification of 10 known flowering time and plant height quantitative trait loci(QTLs)detected in previous studies of adult plants and the identification of novel QTLs influencing *** novel QTLs were disproportionately likely to act earlier in development,which may explain why they were missed in previous single-time-point ***,this time-series data set contributed to the high accuracy of the GWASs,which we evaluated by permutation tests,as evidenced by the repeated identification of loci across multiple time *** novel loci showed evidence of adaptive selection during domestication,with different genotypes/haplotypes favored in different geographic *** summary,the time-series data,with soybean cc as an example,improved the accuracy and statistical power to dissect the genetic basis of traits and offered a promising opportunity for crop breeding with quantitative growth curves.

关键词： canopy coverage dynamic regulation GWAS soybean time series unmanned aircraft system

Highly efficient semiconductor modules making controllable parallel microchannels for non-compressible hemorrhages

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Bioactive Materials 2024年第6期36卷 30-47页

作者： Fengbo Yang Xiaoli Jia chao Hua Feifan Zhou Jianing Hua Yuting Ji Peng Zhao Quan Yuan malcolm Xing Guozhong Lyu Engineering Research center of the Ministry of Education for Wound Repair Technology Jiangnan UniversityAffiliated Hospital of Jiangnan UniversityWuxi214000China Wuxi School of Medicine Jiangnan UniversityWuxi214000China Medical School of Nantong University Nantong226019China Department of critical care Medicine Affiliated Hospital of Jiangnan UniversityWuxi 214000China Burn&Trauma Treatment center Affiliated Hospital of Jiangnan UniversityWuxi 214000China State Key Laboratory of Oral Diseases&National center for Stomatology&National clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu610041SichuanChina Department of Mechanical Engineering University of ManitobaWinnipegR3T 2N2Canada

Nature makes the most beautiful solution to involuted *** them,the parallel tubular structures are capable of transporting fluid quickly in plant trunks and leaf stems,which demonstrate an ingenious evolutionary *** study develops a mini-thermoelectric semiconductor P-N module to create gradient and parallel channeled *** modules decrease quickly the temperature of polymer solution from 20◦c to􀀀20◦c within 5 *** addition to the exceptional liquid absorption rate,the foams exhibited shape memory *** mini device universally makes the inspired structure in such as chitosan,gelatin,alginate and polyvinyl ***-compressible hemorrhages are the primary cause of death in *** rapid liquid absorption leads to fast activation of coagulation,which provides an efficient strategy for hemostasis *** demonstrated this by using our semiconductor modules on collagen-kaolin parallel channel foams with their high porosity(96.43%)and rapid expansion rate(2934%).They absorb liquid with 37.25 times of the own weight,show 46.5-fold liquid absorption speed and 24-fold of blood compared with random porous *** superior properties lead to strong hemostatic performance in vitro and in vivo.

关键词： Parallel microchannel Thermoelectric semiconductors Ice template Hemorrhage

SHARE-ENV:A Data Set to Advance Our Knowledge of the Environment−Wellbeing Relationship

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Environment & Health 2024年第2期2卷 95-104页

作者： catarina Midões Enrica De cian Giacomo Pasini Sara Pesenti malcolm N.Mistry Department of Economics Ca’Foscari University of Venice30121 VeneziaItaly Institute of Environmental Science and Technology of Universitat Autònoma de Barcelona 08193 Cerdanyola del VallèsBarcelonaSpain European central Bank 60314 Frankfurt am MainGermany Environment and Health Modelling(EHM)Lab Department of Public HealthEnvironments and SocietyLondon School of Hygiene and Tropical Medicine(LSHTM)London WC1E 7HTUnited Kingdom

climate change interacts with other environmental stressors and vulnerability *** places and,owing to socioeconomic conditions,some people,are far more at *** data behind current assessments of the environment−wellbeing nexus is coarse and regionally aggregated,when considering multiple regions/groups;or,when granular,comes from ad hoc samples with few *** assess the impacts of climate change,we require data that are granular and comprehensive,both in the variables and population *** build a publicly accessible data set,the SHARE-ENV data set,which fulfills these *** expand on EU representative,individual-level,longitudinal data(the SHARE survey),with environmental exposure information about temperature,radiation,precipitation,pollution,and flood *** illustrate through four simplified multilevel linear regressions,cross-sectional and longitudinal,how full-fledged studies can use SHARE-ENV to contribute to the *** studies would help assess climate impacts and estimate the effectiveness and fairness of several climate adaptation *** surveys can be expanded with environmental information to unlock different research avenues.

关键词： climate change risk environmental impacts climate adaptation population health longitudinal data

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流放者的归来二十年代的文学流浪生涯

Pilot study of a novel serum mRNA gene panel for diagnosis of acute septic arthritis

丛书名：美国文学史论译丛

1986年

作者：（美）malcolm cowley 张承谟译

本书是一部文学历史著, 作者以他的亲身经历, 从思想变化过程的角度出发写出本书, 本书对研究二十年代美国社会, 政治和文化的研究人员, 外国文学爱好者, 文艺议论工作者及高校教师, 研究生和高年级本科生具有较大的参考价值.

ISBN: (数字)7810461249

ISBN: (纸本)9787810461245

关键词：文学史地点:美国年代:现代

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World Journal of Orthopedics 2019年第12期10卷 424-433页

作者： Blake J Schultz Timothy Sweeney malcolm R DeBaun Melissa Remmel Uros Midic Purvesh Khatri Michael J Gardner Department of Orthopedic Surgery Stanford UniversityRedwood CityCA 94063United States Inflammatix Inc863 Mitten RoadSuite 104BurlingameCA 94010United States Institute for Immunity Transplantation and InfectionsCenter for Biomedical ResearchDepartment of MedicineStanford UniversityStanfordRedwood CityCA 94305United States

BAcKGROUND Septic arthritis is an orthopedic emergency requiring immediate surgical *** diagnostic standard of care is an invasive joint *** provide information about the inflammatory cells in the sample within a few hours,but there is often ambiguity about whether the source is infectious(***)or non-infectious(***).cultures can take days to result,so decisions about surgery are often made with incomplete *** diagnostics are thus ***“Sepsis MetaScore”(SMS)is an 11-mRNA host immune blood signature that can distinguish between infectious and noninfectious acute *** has been validated in multiple cohorts across heterogeneous clinical *** To study whether the SMS holds diagnostic validity in determining the etiology of acute *** We conducted a blinded,prospective,non-interventional clinical study of the *** patients undergoing work-up for a septic primary joint were *** proceeded through the normal standard-of-care pathway,including joint aspiration and inflammatory labs[white blood cell(WBc),erythrocyte sedimentation rate(ESR),c-reactive protein(cRP)].Venous blood was also drawn into PAX gene RNA-stabilizing tubes and mRNAs were measured using Nano String ncounter?.SMS was calculated blinded to clinical *** A total of 20 samples were included,of which 11 were infected based on aspiration or intra-operative *** SMS had an area under the ROc curve(AUROc)of 0.87 for separating infectious from non-infectious *** comparison,the AUROcs for ESR=0.58,cRP=0.6,and WBc=*** 100%sensitivity for infection,the specificity of the SMS was 40%,meaning nearly half of non-septic patients could have been ruled out for further *** In this pilot study,SMS showed a high level of diagnostic accuracy in predicting septic joints compared to other diagnostic *** quick blood test could be an important tool for earl

关键词： Biomarkers Bioinformatics Infection Septic arthritis Medical technology Diagnostics

Discovering genomics, proteomics, and bioinformatics

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通过cRISPR/cas9基因编辑手段构建白念珠菌caHSL1基因的失活突变体及其表型分析

2003年

作者： A malcolm campbell Laurie J Heyer

本书演示了生物化学实验中仪器设备的正确使用、实验装置的科学搭建和规范操作等实验环节。全书精选了12个实验,内容涵盖糖、脂、蛋白质、核酸和酶等领域。

ISBN: (纸本)0805347224;9780805347227

关键词： Genomics.

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中国细胞生物学学报 2018年第4期40卷 542-550页

作者：徐慧慧蒋伶活 malcolm Whiteway 江南大学生物工程学院粮食发酵工艺与技术国家工程实验室无锡214122 山东理工大学农业工程与食品科学学院淄博255000 康考迪亚大学生物学系

钙离子稳态和钙离子信号途径对白念珠菌的形态发生、耐药性以及毒力都十分重要。白念珠菌和酿酒酵母菌的细胞质膜蛋白质Rch1p均富集在母细胞和子细胞之间的芽颈部位,负向调控胞外钙离子的内流。与细胞周期调控相关的蛋白激酶Hsl1p也存... 详细信息

钙离子稳态和钙离子信号途径对白念珠菌的形态发生、耐药性以及毒力都十分重要。白念珠菌和酿酒酵母菌的细胞质膜蛋白质Rch1p均富集在母细胞和子细胞之间的芽颈部位,负向调控胞外钙离子的内流。与细胞周期调控相关的蛋白激酶Hsl1p也存在于白念珠菌和酿酒酵母菌的芽颈部位。该研究发现,抑制caHSL1基因的表达或者通过cRISPR(clustered regularly interspaced short palindromic repeat)/cas9新方法失活caHSL1基因,均可导致白念珠菌对钙离子敏感,这种钙离子敏感性可以被钙调磷酸酯酶的专一性抑制剂环孢霉素抑制。这个结果表明,钙离子稳态和钙信号转导途径可能与细胞周期调控有关。此外,caHSL1基因失活突变体对十二烷基磺酸钠、氟康唑、酮康唑、刚果红、潮霉素B、卡泊芬净和Anidualafungin敏感,表明caHsl1p与细胞质膜和细胞壁胁迫的应答相关。

关键词：白念珠菌 caHSL1 cRISPR 钙离子细胞质膜压力细胞壁压力

激素替代治疗使用者不必对妇女健康启动试验的结果感到恐慌

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英国医学杂志中文版 2003年第1期6卷 6-8页

作者： John c Stevenson malcolm I Whitehead 李湛 reader in metabolic medicine Metabolic Medicine Faculty of Medicine Imperial CollegeLondon W2 1NY consultant gynaecologist Menopause clinic King's College HospitalLondon SE5 8RX

观察性研究已经提示,绝经后激素替代治疗对健康有明显的益处,包括减少冠心病、骨质疏松性骨折和结肠癌的发生。这些研究同时提示发生乳腺癌的危险性增加和可能发生中风。已有评论指出,激素替代治疗的益处可能仅仅是健康使用者的一种偏见... 详细信息

观察性研究已经提示,绝经后激素替代治疗对健康有明显的益处,包括减少冠心病、骨质疏松性骨折和结肠癌的发生。这些研究同时提示发生乳腺癌的危险性增加和可能发生中风。已有评论指出,激素替代治疗的益处可能仅仅是健康使用者的一种偏见,并需要进行随机临床试验,但没有提及其危险性。妇女健康启动试验(WHI)是一项随机临床试验,以健康结局来评价绝经后人群使用激素干预措施的危险性及益处。该试验表明,虽然对髋骨骨折和肠癌有益,但对心血管疾病包括冠心病(主要结局)和卒中有害。

关键词：激素替代治疗绝经后妇女健康启动试验危险性性激素

Stable carbon isotope in tree rings from Huangling, china and climatic variation

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Science china Earth Sciences 1996年第2期39卷 152-161页

作者：刘禹吴祥定 Steven W.Leavitt malcolm K.Hughes National Key Laboratory of Loess and Quaternary Geology Chinese Academy of Sciences Xi'an 710054 China Laboratory of Tree-Ring Research the University of Arizona TucsonAZ 85721 USA

By using a single-year discrimination chronology detrended from a δ13c chronology from chinese pine (Pinus tabulaeformis) tree rings and meteorological data, the δ13c-climatic response is analyzed. The results show that high-frequency δ13c is significantly related to both temperatures of June (with r=-0.65) and the total precipitation of May, June and July (r=-0.46). This suggests that δ13c records reflects some features of the East Asian summer monsoon. In addition, temperature departure for June is reconstructed from a transfer function developed with δ13c-climatic response.

关键词： Huangling δ^(13)c of tree rings East Asia monsoon temperature departure reconstruction.